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Medical Forum / Diseases and Disorders / Prostate Cancer / October 2006More evidence about the benefits of aspirin in cancer
According to the article ScienceDaily: Fighting Cancer With Aspirin? <http://www.sciencedaily.com/releases/2006/10/061002215512.htm> aspirin seems to inhibit tumor angiogenesis. The article refers to the study Borthwick GM, Johnson AS, Partington M, Burn J, Wilson R, Arthur HM. Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a Cox-independent mechanism. FASEB J. 2006 Oct;20(12):2009-16. PMID: 17012253 [PubMed - in process] <http://www.fasebj.org/cgi/content/abstract/20/12/2009>  SignatureMatti Narkia Aspirin MAY help some cancer pts. It DOES kill a couple of thousand Americans annually. Which odds do we play? I.P. >Aspirin MAY help some cancer pts. >It DOES kill a couple of thousand Americans annually. >Which odds do we play? I wonder how many of these deaths have been results of intentional overdosing or careless self-administration of mega-doses? Low or moderate dose aspirin therapy under physician's supervision, taking into consideration all possible contraindications, should be safe. As for odds, aspirin reduces also the risk of thromboembolic and cardiac events, which should be taken into consideration. For cancer we haven't had many trials yet. A 2005 trial published in JAMA did not find benefif from 100 mg every other day. A 2003 trial published in NEJM found that aspirin prevented colorectal adenomas in patients with previous colorectal cancer. It's still early days to say anything definite certain about effects on cancer and required doses. SignatureMatti Narkia >> Aspirin MAY help some cancer pts. >> It DOES kill a couple of thousand Americans annually. [quoted text clipped - 4 lines] > moderate dose aspirin therapy under physician's supervision, taking > into consideration all possible contraindications, should be safe. I agree, but how many pts take their aspirin "under physician supervision"? Many millions of pts don't follow their doctors' medication orders even on serious life-affecting prescription meds, and a few -- million? -- idiots pop unknown pills like they were M&Ms at parties. Aspirin and most OTC NSAIDS are like popcorn to most people; I see people gobbling them daily before playing recreational sports and joking about "Team Advil", yet only 8-11% of adolescent drug-based suicide attempts reaching ERs nationwide are based on aspirin or combinations thereof (Google <DAWN drug>) despite their total accessibility. Aspirin just isn't taken seriously, as implied by its position as THE most common ER OD cause, according to a well-educated ER nurse friend, despite its documented low incidence with suicide attempts. Anecdotally, but representative of those who can't tolerate NSAIDS including aspirin, three successive days of one enteric-coated baby aspirin leave me bent over with abdominal pain -- despite my being on a PPI for GERD -- and a couple of weeks on Motrin has twice produced pyloric channel ulcers verified by UGI and/or endoscopy. Aspirin isn't the child's toy most people treat it as, and SURELY isn't the innocuous broad-spectrum "bandaid" many people assume it to be. I.P. I'm curious I.P., were you always sensitive to aspirin and NSAIDs, or did the sensitivity develop later in life? If later, can you think of any specific event that seemed to bring it on? Alan > I'm curious I.P., were you always sensitive to aspirin > and NSAIDs, or did the sensitivity develop later in life? > If later, can you think of any specific event that seemed > to bring it on? My first ulcer was diagnosed in 1983 (age 40) following a couple of weeks on prescription levels of Motrin. I don't recall earlier regular NSAID use or ulcer symptoms, but the latter could easily be confused by many prior years of intermittent abdominal pain diagnosed (and often verified) as colon cramps. Those were attributed to IBS, but some were awfully similar to cramps triggered, I believe, by ulcers. Tip for people with GI pain: stay AWAY from laxatives which include senna (e.g., Per Diem). The only time I've cried from pain since I was a kid was about 20 years ago after taking senna while I had an ulcer. Only after the fact was I smart enough to read the PDR data: "This product may exacerbate GI pain", or something to that effect. I had to all but fight my nurses after colon surgery two years ago to keep that stuff away from me; my split abs weren't 20% of the pain level of an ulcer on senna. I.P. From: mna@mbnet.fi (Matti Narkia) According to the article ScienceDaily: Fighting Cancer With Aspirin? <http://www.sciencedaily.com/releases/2006/10/061002215512.htm> aspirin seems to inhibit tumor angiogenesis. The article refers to the study Borthwick GM, Johnson AS, Partington M, Burn J, Wilson R, Arthur HM. Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a Cox-independent mechanism. FASEB J. 2006 Oct;20(12):2009-16. PMID: 17012253 [PubMed - in process] <http://www.fasebj.org/cgi/content/abstract/20/12/2009> SignatureMatti Narkia ====================== while aspirin is asprin, here's another thought thrown into the brain pot....... ~ curtis ============== Pain relievers may block erections Here's yet another reason for men to use pain relievers cautiously: The largest class of those drugs may cause erectile dysfunction. Finnish researchers surveyed some 1,100 men ages 50 to 70 about their use of nonsteroidal anti-inflammatory drugs (NSAIDs), which include most over-the-counter pain relievers, such as aspirin, ibuprofen (generic, Advil, Motrin IB), and naproxen (generic, Aleve). They also asked how often the men experienced erectile dysfunction, the inability to achieve or maintain an erection. The men who were taking NSAIDs were nearly twice as likely to have erectile dysfunction as the nonusers. (That figure was statistically adjusted to account for various medical conditions that could distort the results.) The researchers theorize that NSAIDs may diminish the body's release of nitric oxide, a chemical needed to achieve erections. Erectile-dysfunction drugs such as sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra) work by stimulating nitric-oxide release. In addition to that side effect, prolonged use of NSAIDs increases certain serious risks: high blood pressure, heart attack, stomach bleeding, and kidney and liver damage. So an alternative drug, acetaminophen (generic, Panadol, Tylenol), is generally the best first choice for mild-to-moderate pain, though it too may harm the liver. Men who experience erectile problems should consult their physician to rule out an underlying disorder that could be causing the problem, such as cardiovascular disease. If they're taking an NSAID and have no such disorder, they should consider switching to acetaminophen--or asking their physician to prescribe an erection-boosting medication. This article first appeared in the October 2006 issue of Consumer Reports on Health. knowledge is power - growing old is mandatory - growing wise is optional "Many more men die with prostate cancer than of it. Growing old is invariably fatal. Prostate cancer is only sometimes so." http://community.webtv.net/PALMER_ENT/doc > Pain relievers may block erections Well, that's something to think about. Thanks for the tip. The study seems to be Shiri R, Koskimaki J, Hakkinen J, Tammela TL, Auvinen A, Hakama M. Effect of nonsteroidal anti-inflammatory drug use on the incidence of erectile dysfunction. J Urol. 2006 May;175(5):1812-5; discussion 1815-6. PMID: 16600768 [PubMed - indexed for MEDLINE] <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra ctPlus&list_uids=16600768> SignatureMatti Narkia >> Pain relievers may block erections And we've been told since childhood that the surest means of contraception is an aspirin . . . held firmly between the girl's knees. I'm guessing THAT application represents aspirin's greatest ratio of benefit to SEs. I.P. From: fuhgheddaboutit@noway.nohow (I.P. Freely) c palmer wrote: Pain relievers may block erections --------- And we've been told since childhood that the surest means of contraception is an aspirin . . . held firmly between the girl's knees. I'm guessing THAT application represents aspirin's greatest ratio of benefit to SEs. I.P. ====> thanks I.P. - you gave me the chuckle of the day.. :) ~ curtis knowledge is power - growing old is mandatory - growing wise is optional "Many more men die with prostate cancer than of it. Growing old is invariably fatal. Prostate cancer is only sometimes so." http://community.webtv.net/PALMER_ENT/doc > Pain relievers may block erections I'm wondering which partner in this process takes the aspirin in order to block the erection. "Sorry dear, I have a headache". Alan > aspirin seems to inhibit tumor angiogenesis. The article refers to the study I have been using a two-pronged approach to limit inflammation. For systemic balance, I prefer to take a fish source of omega-3 (EPA/DHA) & limit omega-6 intake (linoleic acid & arachidonic acid). For my tumor control, the key to suppressing inflammatory proteins in PC cells seems to be to inhibit nuclear factor-kappa B [NFkB]. There are many phytochemicals that can do this & it is interesting that aspirin also turns out to be a NFkB inhibitor. NFkB activation is responsible for the creation of many (often inflammatory) cell-survival substances. One of these is COX-2. However, NFkB also stimulates vascular endothelial growth factor [VEGF] production, which is needed for angiogenesis. The supplements that may control NFkB in men, & which have been shown to control angiogenesis in studies, include: Curcumin (from turmeric) EGCG (from green tea) Genistein (from soy) Silibinin (from milk thistle) Resveratrol (from red grape skins) Pomegranate juice (possible due to Ellagic acid) Sulforaphane (from cruciferous vegetables, particularly broccoli sprouts) Other known inhibitors of NFkB: Capsaicin (from red chili peppers) Gingerol (from ginger) S-allyl cysteine (from garlic) Ursolic acid (from holy basil & rosemary) Ellagic acid (from raspberries & pomegranates) Note that visceral fat is associated with poorer prognosis. High levels of WAT [white adipose tissue - not subcutaneous fat] has many disruptive effects on the endocrine system, involving estrogen/testosterone/insulin/IGF-I/etc. One of the needs of a growing gut is an extension of the blood supply system. An increase in WAT causes an increase in leptin & a decrease in adiponectin (both produced by WAT). The former is pro-angio, the later anti. Hence, there is a good case for reducing WAT when PC is diagnosed. Not easy, I know, but probably essential. Another angiogenesis need is copper. Zinc, which is protective of the prostate, & probably beneficial in dealing with PC, is a copper antagonist. Dietary control? - stay away from shellfish (although oysters are high in zinc) & don't take a supplement. Many men get much of their copper from their plumbing. Copper levels are higher in water standing in pipes overnight, so run the tap before making that coffee. The skin will absorb copper, so don't be the first to shower! A mild copper deficiency will produce borderline anemia indicators in a blood test (but probably no symptoms) - and this must not be mis-read as an iron deficiency. There has been much recent interest in an anti-angiogenesis approach to cancer control, including studies using a drug that has been safely used to treat Wilson's Disease (unnatural retention of copper). Overall, angiogenesis (& COX-2) can probably be controlled without taking aspirin (after all, a COX-1 inhibitor). And, NFkB/VEGF inhibition is only one aspect of angiogenesis control. -Patrick |
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