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Medical Forum / Diseases and Disorders / Prostate Cancer / October 2006

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Anyone has IMRT only and the results thus far?

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cmdrdata - 02 Oct 2006 23:11 GMT
My Uro says that IMRT is currently one of the best option besides RP,
but he also suggested seed implants followed by IMRT.  To those that
opted for IMRT ONLY, how did you fare with it, and how long post RT are
you now? Thanks.

I have not decided one way or the other, just still trying to learn
more.
Matti Narkia - 02 Oct 2006 23:21 GMT
>My Uro says that IMRT is currently one of the best option besides RP,
>but he also suggested seed implants followed by IMRT.  To those that
[quoted text clipped - 3 lines]
>I have not decided one way or the other, just still trying to learn
>more.

I have IMRT experience only for my throat cancer just over three years
ago, it was a complete success. But as for prostate cancer, perhaps
this just published study

Zelefsky MJ, Chan H, Hunt M, Yamada Y, Shippy AM, Amols H.    
Long-term outcome of high dose intensity modulated radiation therapy
for patients with clinically localized prostate cancer.
J Urol. 2006 Oct;176(4 Pt 1):1415-9.
PMID: 16952647 [PubMed - in process]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=16952647
>

could shed some light. It is the largest study of men with prostate
cancer treated with high-dose, intensity modulated radiation therapy
(IMRT). The majority of patients remain alive with no evidence of
disease after an average follow-up period of eight years. The 561
prostate cancer patients treated with IMRT at Memorial Sloan-Kettering
Cancer Center were classified into prognostic risk groups. After an
average of eight years, 89 percent of the men in the favorable risk
group were disease-free and none of the men in any group developed
secondary cancers as a result of the radiation therapy. This study is
the first description of long-term outcomes for prostate cancer
patients using IMRT.

For comments about this study see the news article

Long-term outcomes for prostate cancer show IMRT Curative: 89 percent
disease-free 8 years later
<http://www.eurekalert.org/pub_releases/2006-09/mscc-lof092706.php>

Signature

Matti Narkia

Doug Taylor - 03 Oct 2006 01:30 GMT
>My Uro says that IMRT is currently one of the best option besides RP,
>but he also suggested seed implants followed by IMRT.  To those that
[quoted text clipped - 3 lines]
>I have not decided one way or the other, just still trying to learn
>more.

IMRT only at age 52, 3 years post treatment, psa low and stable, zero
urinary incontinence, medium ED very successfully treatable with
Cialis.  If you have confined tumor, Gleason 6 or less, and lowish
psa, my personal opinion backed up with my own life on the line is
that RP is overkill, and the older you are the greater the overkill.
David&Joan - 03 Oct 2006 03:47 GMT
cmdrdata:

You got some very good advice from your original post to not rely on any
anecdotal data. Heed that advice. All responses on this NG from individuals
reporting their results are anecdotal.

David
Steve Kramer - 03 Oct 2006 11:25 GMT
> cmdrdata:
>
[quoted text clipped - 3 lines]
>
> David

Unfortunately, more often cited is the uncertainty about relying on
statistical reports.

The fact of the matter is, one must make decisions about this disease
without any hard and fast evidence that will apply to any unique case.  So,
one should gather ALL evidence, add to each the weight he feels appropriate,
and make a decision.

"I survived six years with RRP" is not a good reason to get RRP.  It does,
however, let the member know that it is possible to survive six years with
RRP.  Furthermore, "I survived six years, still have a fulltime job, have
fun with my grandchildren, walk five days a week, and golf" indicates that
the actual surgery is a temporary matter wherein most life activities are
concerned.

"The effects I suffered from HT have thus far been mild" not only augments
the fact that side effects are possible, but that sometimes they can be
mild.

It is just myopic to discount actual patients' experiences.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06, 6/06
PSA  .07 .05 .06 .09 .08 .132 .145
Casodex added daily 07/06
Non Illegitimi Carborundum

I.P. Freely - 03 Oct 2006 17:44 GMT
>> cmdrdata:
>>
>> You got some very good advice from your original post to not rely on any
>> anecdotal data. Heed that advice. All responses on this NG from
>> individuals reporting their results are anecdotal.

> It is just myopic to discount actual patients' experiences.

Except that they imply nothing about the next guy's outcome likelihood,
only about statistically fringe possibilities. If I wanted to choose a
tx with the fringes in mind, we'd choose WW right up to the time our
spine was on fire. Why accept knives or radiation or iceballs or drugs
if there's a slight chance we  may just spontaneously remiss with no
SEs? After all, one woman HAS been struck by a meteor and one man HAS
been struck by lightning seven times.

I.P.
peter*pan - 04 Oct 2006 22:42 GMT
<Except that they imply nothing about the next guy's outcome likelihood,
only about statistically fringe possibilities.>

This isn't really an accurate statement.  Actual patient experiences imply
possible outcomes, regardless of the statistical likelihood of that
outcome.
Steve Kramer - 05 Oct 2006 01:37 GMT
>> It is just myopic to discount actual patients' experiences.
>
[quoted text clipped - 5 lines]
> After all, one woman HAS been struck by a meteor and one man HAS been
> struck by lightning seven times.

Of course, that's a ridiculous example, but how many times do you figure
someone here was scared shitless about RP only to find that we all but slept
through it?

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06, 6/06
PSA  .07 .05 .06 .09 .08 .132 .145
Casodex added daily 07/06
Non Illegitimi Carborundum

Doug Taylor - 04 Oct 2006 22:01 GMT
>cmdrdata:
>
>You got some very good advice from your original post to not rely on any
>anecdotal data. Heed that advice. All responses on this NG from individuals
>reporting their results are anecdotal.

As my son would say:  "No sh.t, Sherlock."
c palmer - 03 Oct 2006 09:09 GMT
From: cmdrdata@mail.com (cmdrdata)

My Uro says that IMRT is currently one of the best option besides RP,
but he also suggested seed implants followed by IMRT. To those that
opted for IMRT ONLY, how did you fare with it, and how long post RT are
you now? Thanks.
I have not decided one way or the other, just still trying to learn
more.

======
i would have to throw this into the mix....

how's your prostate?..... in terms of having problems, like prostate
stones, enlargement, prostatitis, or UTI's?

if one has had prostate problems on and off up till now,  having
radiation isn't going to make them go away, whereas the RP would rid
this problem.  

it all goes back to the same basic theme.  there is no one solution to
the pca condition.

~ curtis

knowledge is power - growing old is mandatory - growing wise is optional    
"Many more men die with prostate cancer than of it. Growing old is
invariably fatal. Prostate cancer is only sometimes so."
http://community.webtv.net/PALMER_ENT/doc
I.P. Freely - 03 Oct 2006 17:32 GMT
> From: cmdrdata@mail.com (cmdrdata)
>
[quoted text clipped - 14 lines]
> radiation isn't going to make them go away, whereas the RP would rid
> this problem.  

Ditto pre-existing bowel problems. As soon as I told my rad onc I have
mild IBS (pretty much controlled by diet) and do NOT want to risk
long-term bowel incontinence, she recommended surgery, citing that
"radiation never improves one's bowel function, and may harm it".

I.P.
Alan Meyer - 03 Oct 2006 21:24 GMT
> ...
> how's your prostate?..... in terms of having problems, like prostate
[quoted text clipped - 4 lines]
> this problem.
> ...

I can testify to that.  I had prostatitis before radiation, and
I had it after.  It probably got worse after, though it did
eventually go away.

   Alan
 
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