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Medical Forum / Diseases and Disorders / Prostate Cancer / October 2006

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You smiled, you spoke, and I believed - 01 Oct 2006 21:45 GMT
had my second post brachy psa last week.

last time it was 1.3

this time it is 1.6

dr told me not to worry if it went up, prior to test.

jerry

so far I am not concerned, if it goes to 10, then I'll worry.

jerry
Steve Jordan - 02 Oct 2006 01:16 GMT
On October 1, Jerry wrote:

> had my second post brachy psa last week.
>
[quoted text clipped - 7 lines]
>
> jerry
Is Jerry's medic a urologist?

A PSA of 10 is dangerous! Get thee to a medical oncologist, a cancer
specialist, who is trained in tx of PCa!

Sitting around watching one's PSA rise to 10 is little short of suicidal.

See the website of the Prostate Cancer Research Institute at
http://prostate-cancer.org/index.html
and learn what the medic is not saying -- or, more likely, does not know.

Regards,

Steve J

"Flagrantly, we docs ignore the declaration of biology. We do this out
of ignorance, greed or both. The prime directive of the physician, the
real physician, is patient outcome, & not physician income (or ego)."
-- Stephen B. Strum, MD
Greg Louis - 02 Oct 2006 13:25 GMT
> On October 1, Jerry wrote:
>>
[quoted text clipped - 3 lines]
>>
>> this time it is 1.6

So far I've had
Days     PSA
121    1.70
233    0.59
316    0.62
456    0.85
575    0.75

>> dr told me not to worry if it went up, prior to test.

Mine (rad onc) said the same: it will vary some.

>> so far I am not concerned, if it goes to 10, then I'll worry.
>>
[quoted text clipped - 3 lines]
> A PSA of 10 is dangerous! Get thee to a medical oncologist, a cancer
> specialist, who is trained in tx of PCa!

Jerry not his medic mentions 10.  Jerry, I'd worry if I had 3 consecutive
PSA increases and a doubling time (extrapolated least squares straight
line) of one year or less.  As you see, I found myself in that
situation -- but the next reading flattened the curve (whew).  Letting the
PSA go to 10 is indeed risky.

> Sitting around watching one's PSA rise to 10 is little short of
> suicidal.
[quoted text clipped - 6 lines]
>
> Steve J

Best of luck
Signature

Greg Louis
At age 58, PSA 5.4 rising triggered biopsy 2004-06-22, Gleason 3+3, T1c,
prostate volume 27 cc.  Monotherapy, 55 I-125 seeds implanted 2004-11-16.

Steve Kramer - 02 Oct 2006 15:31 GMT
> So far I've had
> Days     PSA
[quoted text clipped - 3 lines]
> 456 0.85
> 575 0.75

Greg,

Good to hear from you again.  It does appear you are hovering in brachy
territory.

Yours is a good comparison to Jerry's.  You both started out with similar
PSAs.  Yours fell from 5.4 to 1.7 in four months.  His took seven months.
Yours continued to 0.59.  His went back up.

Another possible comparison is Bev's George.  He was 4.9 and four years
later is 0.01.  I forget his path to 0.01, but it seems it also started with
a quick decent into sub 1.0 range.

I'd like to here from someone as to how far down brachy should take a
patient at the outset.  And what is a "bounce" as opposed to an increase to
be concerned with?  Do bounces occur at levels over 1.0?

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06, 6/06
PSA  .07 .05 .06 .09 .08 .132 .145
Casodex added daily 07/06

Alan Meyer - 02 Oct 2006 19:39 GMT
> ...
> I'd like to here from someone as to how far down brachy should take a patient at the
> outset.  And what is a "bounce" as opposed to an increase to be concerned with?  Do
> bounces occur at levels over 1.0?
> ...

Having the experience myself, I did some reading on PSA
bounce.  What I read was as follows:

The definition of a "bounce" is a PSA that rises and falls again.

The usual criterion for failure is 3 PSA readings at least
3 months apart, with a clear rise in each one.  Even that may
not be ironclad since I'm not sure it's unheard of for the PSA
to go up 3 times and come down again.  I know that my own
PSA readings could have been made to look any way you
liked, depending on what dates they were measured on.

Bounces commonly occur at values over 1.0.  Mine went to 1.8
before coming back down and was last measured at .25.  The
maximum I read about was above 15.  I think it is common for
a bounce to go above 2.0.

Depending on how you count them, I've had 4 bounces so far.
If I remember correctly:

  .2 .8 .6 .9 .8 1.8 .5 .2 .25

   Alan
I.P. Freely - 02 Oct 2006 20:02 GMT
> The usual criterion for failure is 3 PSA readings at least
> 3 months apart, with a clear rise in each one.

Another, although anecdotal, indication of the perils of ultrasensitive
PSA readings. Mine almost exactly doubled every quarter (and thus maybe
credibly?) . . . 0.006. 0.012, 0.023, 0.029 . . . until they collapsed
to 0.017 four months later -- all from the same testing lab. Random
noise? Measurement error? Real bounce?

If one hangs a lot of credibility in ultrasensitive testing, I had a
failure and/or a bounce . . . after RP. Or one could just agree with my
oncs that ultrasensitive testing is, in my words, just so much cute
technology at this point, worth studying but not worth getting worked up
over.

I'll get back with a different opinion if mine resumes a quarterly
doubling time and maintains it for several quarters.

I.P.
Steve Kramer - 02 Oct 2006 22:30 GMT
>> ...
>> I'd like to here from someone as to how far down brachy should take a
>> patient at the outset.  And what is a "bounce" as opposed to an increase
>> to be concerned with?  Do bounces occur at levels over 1.0?

> Depending on how you count them, I've had 4 bounces so far.
> If I remember correctly:
>
>   .2 .8 .6 .9 .8 1.8 .5 .2 .25
>
>    Alan

Good.  I am less worried about Jerry then.  Thanks for the reply.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06, 6/06
PSA  .07 .05 .06 .09 .08 .132 .145
Casodex added daily 07/06
Non Illegitimi Carborundum

Alan Meyer - 02 Oct 2006 23:57 GMT
> ...  I know that my own
> PSA readings could have been made to look any way you
[quoted text clipped - 4 lines]
>
>   .2 .8 .6 .9 .8 1.8 .5 .2 .25

If, by chance, the only PSA tests I had were the 1st, 3rd,
4th, and 6th, in the above series, it would look like 3 rises
in a row - .2, .6, .9, 1.8.

I'd have been pretty scared (more even than I actually was :)
and I'd probably have asked for Lupron.

   Alan
Beverley - 02 Oct 2006 02:44 GMT
Oops, I think that's a bounce! How many months out are you? (I'm sorry I
can't remember when you had brachy.) Bounces are common but my hubby never
saw one, probably happened between testings.
Bev

> had my second post brachy psa last week.
>
[quoted text clipped - 9 lines]
>
> jerry
tchtic@yahoo.com - 02 Oct 2006 11:38 GMT
> had my second post brachy psa last week.
>
[quoted text clipped - 7 lines]
>
> so far I am not concerned, if it goes to 10, then I'll worry.

This is very interesting.  Please share more.

When were you treated and what did they do?   Also what were your stats
going in?

There's some info on the web that younger men, who have more modern
treatment, are seeing higher PSA's during the bounce period, which is
very roughly 18-24 months after seeding.

In addition, the higher bounces "seem to" correlate with better long
term outcomes.  None of this is "solid" but that's the nature of
science,  as events change, it gets harder to tease information out of
the data.

How are you doing otherwise?   Urinary symptoms, ED? Anything else?  I
don't want to bias your thinking but at the start of the 18-24 month
period, I noticed a slight upswing of urinary symptoms, a little more
stinging and burning, some difficulty starting the stream.   That's
fading now.

On the other hand, erections are getting firmer and lasting slightly
longer.  These are serviceable without Vitamin-V but it takes a lot of
thinking fun thoughts and manual effort to get started.

One thing that's helped is a naked woman stretched out,  give her a
backrub starting at the muscles along side the spine.  Using a massage
lotion or just olive oil, work the lower back, then move up and across
in sweeping motions.

Do it in phases, fingertips together like a cat's paws walking up and
down her back; next, palms open and rubbing slow.  Switch to
fingernails lightly scratching the length of her back.

Pinch the muscles at her shoulders, knead them slow, and move up,
fingertips again on her temples and scalp.  Press with your fingertips.

Spend 5 minutes on each phase, 30 minutes, maybe 40 total.  If she's
making interesting sounds.  Turn her over and kiss her nipples.  

-kh
Steve Kramer - 02 Oct 2006 11:53 GMT
> had my second post brachy psa last week.
> last time it was 1.3
> this time it is 1.6
> dr told me not to worry if it went up, prior to test.
> so far I am not concerned, if it goes to 10, then I'll worry.

Jerry,

I am not an expert on brachy, but....

Based on a PSA 5, brachy in November, a PSA 3.1 in February and a 1.3 in
June, I would view a 1.6 with some guarded anticipation.  I've heard of
"bounces" in brachy aftermath, but you may be experiencing a pattern
indicating brachy failure.  Unfortunately, you may not be able to make such
an assessment based on so short a history.  Maybe your doc was merely
telling you that, if it did rise, it would not give you sufficient evidence
to take any immediate action on it.

But, I do know enough about treatments that waiting for it to go up to 10 is
only legal in Oregon.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06, 6/06
PSA  .07 .05 .06 .09 .08 .132 .145
Casodex added daily 07/06
Non Illegitimi Carborundum

Alan Meyer - 02 Oct 2006 15:37 GMT
> had my second post brachy psa last week.
>
[quoted text clipped - 9 lines]
>
> jerry

I had HDR brachytherapy and my PSA bounced around a lot.
The first reading after Lupron wore off was .8.  Then it went
down, then up, then down, then up, about 3 times total.  My
high point was 1.8, my most recent was .25.

As others have said, I would be concerned if it got near 10,
but I agree with you that you shouldn't worry now.  There's
no point.  The odds are good that you're seeing a little
bounce.  My understanding is that bounces into the 2+
range are common.  The highest bounce recorded that
I could find was around 15 - but that was exceptional.

Good luck.

   Alan
You smiled, you spoke, and I believed - 02 Oct 2006 16:43 GMT
> had my second post brachy psa last week.
>
[quoted text clipped - 9 lines]
>
> jerry

OK

Further data,

Brachetherapy in late Nov, 2005.

I am still taking Flo-Max, once a day.  If I miss a day, urination
becomes somewhat painful.

no problem sexually, on orgasm, semen does not make it out, comes out
during after sex urination.

I bicycle a lot, switched to a recumbent years ago due to prostate and
penile numbness.  I have been going to the hotter than hell hundred bike
ride for about 16 years.

Did not finish this year due to equipment problems and subsequent wreck.

Have noticed this Summer that riding a wedgie, a regular bike, does not
cause the same discomfort as before.

I am 63 years old.

j.
You smiled, you spoke, and I believed - 02 Oct 2006 16:46 GMT
> had my second post brachy psa last week.
>
[quoted text clipped - 9 lines]
>
> jerry

what I meannt was that I was not going to obsess about the psa values,
minor changes up and down could be due to many factors, including
instrumentation.

From what I have read, this analysis is not very precise, there is
variation between laboratories and between instrumentation.

Hopefully, a more precise analytical procedure will be developed over time.

jerry

PS, I used to be an analytical chemist.
Alan Meyer - 02 Oct 2006 19:28 GMT
> ...
> what I meannt was that I was not going to obsess about the psa values, minor changes up
> and down could be due to many factors, including instrumentation.
> ...

A big factor in brachytherapy patients is that prostate cells continue
to die for several years after the treatment.  They apparently put out
extra PSA under these stressful conditions.  So the PSA goes up
and down.

Also, because you still have a prostate, you are still subject to
prostatitis and to variations due to sex or other stressors
before the exam.

So the actual PSA does vary a lot in brachytherapy patients.  It's
not necessarily due to variations in testing.  But it doesn't indicate
treatment failure.  Failure is indicated by a steady increase that
never goes back down.

As another poster noted, a recent study found that patients with
PSA bounce actually had better outcomes than those without it.
Go figure.

    Alan
 
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