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Medical Forum / Diseases and Disorders / Prostate Cancer / October 2006

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Redefining "Tolerable" Pain

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Elliott Reinhardt - 29 Sep 2006 21:19 GMT
Biopsy of the Prostate Can Be Less Painful

NEW YORK (Reuters Health) Sept 18 - Prostate biopsy need not be the painful
ordeal that many men anticipate, according to findings presented at the
annual meeting of North Central Section of the American Urological
Association in San Diego.

By administering topical anesthetic several minutes prior to lidocaine
injection at the prostate apex and the surrounding rectal tissue
significantly reduces pain during the procedure, investigators at the Mayo
Clinic in Rochester, Minnesota, report.

Typically, local anesthetic has been injected between the prostate base and
seminal vesicle where the neurovascular bundle lies, presenter Dr. Richard
Ashley told Reuters Health.

"But what we find is that, when we inject at that location, even though it
is anatomically correct, the patient still experiences a lot of pain," he
said.

Dr. Ashley and his associates, performed a prospective study evaluating
aspects of prostate biopsy that predicted a pain level of at least 5 on a
10-point visual analog scale in 243 men scheduled for an office biopsy.
Topical anesthetic with 20% benzocaine jelly 5 minutes was administered
before injecting 1% lidocaine.

The urologists randomly assigned patients to one of three groups based on
placement of the lidocaine injection, then obtained 12 to 15 biopsies per
patient.

Age, prostate volume, body mass index, inflammation and presence of cancer
were not predictive of the level of pain experienced.

However, injecting lidocaine into prostate apex and the rectal wall was
associated with significantly less pain during the procedure compared with
intraprostatic injection or injection between the prostatic base and the
seminal vesicle.

In other studies, insertion of the ultrasound probe into the rectum was the
most painful part of the procedure. However, "topical anesthetic abolishes
the pain associated with distention of the rectum as the ultrasound probe
is inserted," Dr. Ashley noted.

Overall, the procedures were well tolerated, with 84% of patients reporting
a pain score of less than 5.

Summing up, Dr. Ashley said, "Multiple methods of pain control are
warranted, and it appears that the best pain control is obtained when
numbing the apex of the gland and some of the rectal wall."

"It's so cheap and easy to use topical and injected anesthetic, that it
should be the standard of practice for prostate biopsies," he concluded.
NICK - 29 Sep 2006 23:28 GMT
> Biopsy of the Prostate Can Be Less Painful
> Typically, local anesthetic has been injected between the prostate base and
> "It's so cheap and easy to use topical and injected anesthetic, that it
> should be the standard of practice for prostate biopsies," he concluded.

Hell, I had absolutely NO anesthetic when I had biopsies in 2001
and 2002.  Think I can get some $$$$ out of those doctors?  <g>
Bill - 30 Sep 2006 15:23 GMT
Nor I, Nick. Frankly, I thought the ultrasound wand was the most
uncomfortable part of it and a topical is not going to do a thing for
that. They should either give you the stuff they do when you have a
colonoscopy or at least have you breathe NO2 like some dentists do.

Bill Denton
RP 2/12/02
PSA .96
Memphis
DrYew.com - 01 Oct 2006 05:26 GMT
I find it interesting that this was found newsworthy enough for
Reuters.
I'd guess that any urologist younger than 40 is probably doing this
protocol already. The concept of injecting lidocaine was first
described
and published by Dr. Shinohara from UCSF several years ago.. and I
think has become the standard. I also do the lidocaine jelly. My RN
makes a mixture of lidocaine jelly and betadine that she uses to clean
the area (and hopefully numb the anus some), then injects the rest
inside. I usually come in to do the biopsy 5-10min later. My patients
also usually take a small dose of valium 1-hr prior. I haven't had a
patient complain yet about the procedure.

> Biopsy of the Prostate Can Be Less Painful
>
[quoted text clipped - 48 lines]
> "It's so cheap and easy to use topical and injected anesthetic, that it
> should be the standard of practice for prostate biopsies," he concluded.
Roy - 02 Oct 2006 22:38 GMT
To reiterate a previous response from me on this issue, my urologist does
his prostate biopsies with the patient under total anesthesia because it is
the best experience for the patient. It certainly will be more costly, but
for me, I am glad of his position. I had no discomfort whatsoever.

> Biopsy of the Prostate Can Be Less Painful
>
[quoted text clipped - 52 lines]
> "It's so cheap and easy to use topical and injected anesthetic, that it
> should be the standard of practice for prostate biopsies," he concluded.
I.P. Freely - 03 Oct 2006 06:28 GMT
> To reiterate a previous response from me on this issue, my urologist does
> his prostate biopsies with the patient under total anesthesia because it is
> the best experience for the patient.

Except, of course, those who experience SEs, some of which can be
serious. Many doctors -- and some whole countries -- would object
strongly to using a general just to avoid some possible, very
controllable, discomfort. It's even banned in Great Britain for some
tasks such as routine dentistry, which hurts one helluva lot more than
any prostate biopsy. And, of course, it must be administered and the pt
monitored only by a certified anesthesiology team and is highly advised
to be done only in a hospital that can handle full-scale
life-threatening emergencies.

And "best experience" is in the eye of the beholder, considering some of
its more common and mild SEs such as grogginess or nausea. Many of us
aren't willing to forego driving (by law) for at least 24 hours or to
risk some nausea and/or giving up a day or three of clarity just to
avoid a 20 minute nuisance. Then there are the hassles like fasting,
avoiding some common meds, avoiding making important decisions for a day
or two, etc. (If your uro didn't do all that with general anesthesia,
I'd not let him NEAR my prostate or a bad pimple.)

At the very most, for the most fearful of patients, who won't even TRY
doing it the usual way, I suspect more prudent doctors would recommend a
lighter sedative just to reduce the fear (anesthesiology doesn't curb
fear), and, if they are still truly scared to death of all this despite
its benign track record, maybe having the anesthesiologist hook
everything up, stand by, and see how the pt tolerates that first core
sample (I'd bet most pts wouldn't even realize that first core had been
taken if the doc kept his mouth shut). Then if the pt still couldn't
stand the pain of the first sample, he'd be under in seconds for the
rest of the procedure. At least that way he's risking a long list of SEs
for a reason other than simple uncertainty and a very slight risk of one
second of pain. No one ever dies from not using a general for a prostate
bx, but at least four would die in the U.S. alone just from the general
if we all got generals for our biopsies.

I also advice anyone that worried about and intolerant of pain to avoid
ANY surgery for ANY reason . . . CERTAINLY if it involves cutting a
muscle. A bx carries a very slight risk of 12 or 16 seconds of pain; the
slightest surgery (not to mention jamming a finger) virtually PROMISES
many hours of some degree of discomfort or even pain.

Once again, Dr. Yew . . . how do you feel about using a general for a
routine prostate bx? Am I being overly cautious?

I.P.
Bill - 03 Oct 2006 15:57 GMT
I agree that a general is probably overkill, especially when they can
just have you breathe a mixture of NO2 and O2 like my dentist does when
he's doing serious work. I had an impacted wisdom tooth extracted w/ it
and I didn't care what he did to me because I was in la la land. A few
drags of "100%" O2 and I was wide awake.

Bill Denton
RP 2/12/02
PSA .96
Memphis
 
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