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Medical Forum / Diseases and Disorders / Prostate Cancer / September 2006

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Hormone Therapy & Heart, Diabetes Risk?

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Tom Cular - 20 Sep 2006 10:39 GMT
The following link is to an article in Scientific American that suggests a
link between Lupron like drugs and elevated risk of coronary disease and
diabetes.

http://www.sciam.com/article.cfm?articleID=F94778DF58FEC780FF952344AC5A2442&ref=
sciam&chanID=sa003">Scientific


Tom
tchtic@yahoo.com - 20 Sep 2006 11:55 GMT
Tom Cular's link says:

""Our study found that men with local or regional prostate cancer
receiving a GnRH agonist had a 44 percent higher risk of developing
diabetes and a 16 percent higher risk of developing coronary heart
disease than men who were not receiving hormone therapy," Keating
said."

Now you tell me!!!!  On Lupron, my fasting blood sugar went from
120-130 to 300+ (A1c 11) and my triglycerides went from 190 to 800.

I asked all three docs if it was the Lupron, they said they didn't
think so.

6 months (roughly) after declining the 3rd four month Lupron shot, my
fasting blood sugars were dropping back to the 120-130 range and my
Triglycerides were 190 again.  

I'm not taking any more Lupron.  

-kh
I.P. Freely - 23 Sep 2006 01:39 GMT
> Now you tell me!!!!  On Lupron, my fasting blood sugar went from
> 120-130 to 300+ (A1c 11) and my triglycerides went from 190 to 800.
[quoted text clipped - 7 lines]
>
> I'm not taking any more Lupron.  

Yet people criticize me for harping on such commonly known and widely
documented SEs as these and on the doctors who deny them. Once more,
folks: verify darn near everything your doctors tell you.

I.P.
I.P. Freely - 23 Sep 2006 01:34 GMT
> The following link is to an article in Scientific American that suggests a
> link between Lupron like drugs and elevated risk of coronary disease and
> diabetes.
>
> http://www.sciam.com/article.cfm?articleID=F94778DF58FEC780FF952344AC5A2442&ref=
sciam&chanID=sa003">Scientific

Yup . . . as do Strum and most other sources.

I.P.
Steve Jordan - 23 Sep 2006 23:15 GMT
> The following link is to an article in Scientific American that suggests a
> link between Lupron like drugs and elevated risk of coronary disease and
> diabetes.
>  
(snip)

And here's the final two paragraphs of WebMD's report:

"Study's Limits

The study doesn't show that androgen deprivation therapy was responsible
for diabetes, heart disease, heart attacks, or sudden death in any of
the patients.

Observational studies, like this one, don't prove cause and effect.

The researchers call for more studies on the topic. They note that
diabetes and heart disease become more common with age; their findings
didn't change when they took that into account."

See, http://www.webmd.com/content/Article/127/116749.htm?pagenumber=1

In short, it proved nothing about, nor was it evidence of, any "link,"
and I'm glad to see that Tom carefully used the word, "suggests."

This is not often covered, gloom & doom being more exciting.

OTOH, there may be something to it. I dunno and neither do the researchers.

I do note that IP (Mike) Freely claims that Dr. Strum also suggests such
a "link." I cannot find any of his writings that say so. And of course
Mike as usual will not cite his sources.

My sources are Strum's 1999 article on androgen deprivation syndrome
(ADS) on the PCRI website, and Strum & Pogliano's _A Primer on Prostate
Cancer_ 2nd ed., published a few months ago.

Regards,

Steve J

PS: "Link" is a journalistic weasel-word, essentially promising all and
delivering nothing.

"A man's most valuable trait is a judicious sense of what not to believe."
-- Euripides
 
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