Medical Forum / Diseases and Disorders / Prostate Cancer / August 2006
Dad diagnosed. Next step?
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paul.groves@gmail.com - 14 Aug 2006 12:04 GMT Hi.
Dad was disagnosed with T3 stage prostate cancer today. The doctor gave him a booklet and told him to go away to choose the form of treatment he wanted. He doctor did heavily lean toward hormone therapy.
Dad is only 64, would removal of the prostate not help someone with a T3 tumor? What about experiences with radio therapy?
Surely a man so 'young' should be having more radical surgury?
Thanks, any thoughts appreciated. paul
Steve Kramer - 14 Aug 2006 12:54 GMT > Dad was disagnosed with T3 stage prostate cancer today. The doctor > gave him a booklet and told him to go away to choose the form of [quoted text clipped - 7 lines] > > Thanks, any thoughts appreciated. In order to diagnose a T3, one would have to determine that the cancer has penetrated the wall of the prostate and/or involves the seminal vesicles. I am not expert on this (nor are any of us doctors), but I would imagine that it is very difficult, using a needle biopsy, that a T3 is not a T4.
The medical community has wavered on the treatment of T3/T4 PCa. When my father was dx'd with T4 (with a spot on his pelvis), they took out his prostate and radiated his pelvis with cobalt. That was about 1974. When I was dx'd 26 years later, the accepted procedure was to leave the prostate in if the cancer was already outside the prostate. More recently, I have heard some doctors are removing the prostate anyway, just to get out the mass that they know about.
If you dad was 64 with a T2, I'd be a supporting surgery. But T3 is a whole different ballgame and I believe the majority of the medical community is still on the side of leaving it in.
However, if you have accurately described your father's doctor's "counseling", I would seriously consider a different doctor. And, in any case, your father should seek out a medical oncologist and maybe a second for another opinion.
What he does not will likely determine how long he has to live.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05, 2/06, 6/06 PSA .07 .05 .06 .09 .08 .132 .145 Casodex added daily 07/06 Non Illegitimi Carborundum
paul.groves@gmail.com - 14 Aug 2006 13:23 GMT Thanks for the speedy reply.
He had his biopsy/trans rectal ultrasound last week, the specialist who preformed that procedure had someone with him (training them, perhaps) and they were overheard talking.. Basically dad heard them use the phrases T2 and T3, and talk about nodules on the surface of the left side of prostate.
So we knew it wasn't good.
>From what I've read (and I freely admit I'm no expert on the matter), I'd take the hormone treatment as quickly as possible then start asking about radio therapy to shrink the tumor. Does this sound reasonable? Is it worth it?
Dad unfortunately isn't the type to argue his case with a doctor or anyone else for that matter. To his detriment in this case, he's far too laid back.
Thanks again, Hope your treatment continues to go well, paul
Steve Kramer - 14 Aug 2006 14:39 GMT > He had his biopsy/trans rectal ultrasound last week, the specialist who > preformed that procedure had someone with him (training them, perhaps) [quoted text clipped - 3 lines] > > So we knew it wasn't good. That is your T3. If they had been talking about nodules "in" rather than "on" the prostate, it might have been a T2.
>>From what I've read (and I freely admit I'm no expert on the matter), > I'd take the hormone treatment as quickly as possible then start asking > about radio therapy to shrink the tumor. Does this sound reasonable? > Is it worth it? Personally, I think a shot of HT prior to radiation is a good idea. Starve the little bastards and then fry them. It's a lot more satisfying than just killing them outright :-)
But, pratcially speaking, I would still say yes. I can see some value in shrinking a tumor before radiating it. That is what an oncologist needs to discuss with your dad. I am neither a doctor or an expert.
> Dad unfortunately isn't the type to argue his case with a doctor or > anyone else for that matter. To his detriment in this case, he's far > too laid back. Questioning a doctor was something completely foreign to me before PCa. I think very few in this NG questioned their dx or tx before coming to this NG or before reading a book like Dr. Patrick Walsh's. There are prominent members here who can probably blame their eventual deaths on implicitly trusting their doctors. Furthermore, I recall only one time in all my reading or watching t.v. or movies where a doctor was mistrusted unders normal circumstances. John Wayne traveled a great distance to get a second opinion from James Stewart in The Shootist. At the time, I thought that didn't bow well for the trust of the medical profession in the early 1900s. But, now I see it is still a valid idea 100 years later.
BTW, what was his Gleason and PSA? Those are tremendously important criteria for decision making.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05, 2/06, 6/06 PSA .07 .05 .06 .09 .08 .132 .145 Casodex added daily 07/06 Non Illegitimi Carborundum
paul.groves@gmail.com - 14 Aug 2006 15:12 GMT This all started about 2 months ago when he had trouble urinating. Our GP performed a PSA test - the result of which was 5.8. Not too alarming, but he did a DRE too and decided to refer him to the hospital specialist.
The specialist did another DRE and PSA test - the result of that was 6.7. That was about 2 weeks ago.
He had the transrectal ultrasound at the end of last week.
Dad's had a bad back for years (and years and years), the specialist is worried that this has masked other possible symptoms of the cancer - so has at least ordered a bone scan for him.
His Gleason was G2 (GL 5-7).
I get the feeling that he'll just try to push dad off with the hormones. That was certainly the impression that my parents gave me when they got back from the hospital - that the specialist was talking up the hormone therapy and playing down removal of the prostate and radiotherapy.
Again, many thanks for your experiences in the matter :) paul
Bill - 14 Aug 2006 15:47 GMT Paul, over here in the PCa world we don't talk stages as much as they do over in breast/lung areas or in lay discourse in general. Over here we are more concerned at the clinical stage about PSA dynamics (how much and fast it rose over time) and Gleason Score. There are other tests that I am not really familiar w/ like free-PSA and PAP that also seem to offer valuable diagnostic info. If your dad had trouble urinating, he very probably has an enlarged prostate and, if it is due to PCa, he has had it for awhile. That does not mean he has systemic disease. Has he been diagnosed w/ BPH before? What were his previous PSAs? I am not aware that extracapsular extensions or lymph nodes can be palpated by DRE, and if you are basing your conclusions simply on some second-hand overheard conversation - DON"T! They could have been discussing nodules on one side of his prostate - and that would be a T2b. And I don't think there is any such thing as a "G2 (GL 5-7)" Either your dad does not have all or the precise info he needs or he hasn't passed it on to you. He may not want to. But SOMEONE on the Pt side needs to know the facts. The doctor evidently suspects systemic disease and that's why he is not recommending local Tx. That can be a life or death decision so your dad needs to be advised in detail exactly what the doctor thinks and the evidence that leads him to that conclusion. He should demand it if he has to. Unless, of course, he simply trusts his doctor and does not want to be involved. I haven't yet met one deserving of that much trust.
Bill Denton RP 2/12/02 PSA .96 Memphis
paul.groves@gmail.com - 14 Aug 2006 17:23 GMT The problem is, they were given a little booklet. The booklet had three 'Gleason diagrams' in it. The consultant pointed at picture number two. The words next to that are G2 (GL 5 -7). Really, that is all the information he gave them. Other than steering them away from both radiotherapy and a removal job. He talked up the side effects of those surgeries.
But yeah, the consultant's obviously worried about secondaries which is why I assume he didn't suggest removing his prostate.
Do they do scans for these par for the course? Do you have to ask for them? How would they know if it'd gotten into his lymph nodes down there?
paul.
Leonard Evens - 14 Aug 2006 21:26 GMT > The problem is, they were given a little booklet. The booklet had > three 'Gleason diagrams' in it. The consultant pointed at picture > number two. The words next to that are G2 (GL 5 -7). All that means is that the Gleason score was between 5 and 7. Such cancers are considered intermediate by many doctors. 8-10 is considered aggressive. Other doctors divide things up differently and would disinguish 5-6 from 7. There is also a subtle distinction between different ways to get 7.
I think that your father's doctors clearly are concerned that the cancer has penetrated the prostate. But with the moderate PSA value you describe, if the Gleason score is at most 7, it is not clear to me that radiation might not be a good choice. As Steve said, often radiation is helped by short term hormone therapy, and if that is what the doctors are suggesting, there is nothing unusual about it. However, if they are discouraging any treatment but hormone therapy, it does sound strange to me. It would be wise to find out just what they are recommending and why. One other question would be your father's overall health. If he is in poor health otherwise, aggressive treatment might not be meritied. Even aggressive cancers take a while to develop, and treatment can be hard on a weakened patient.
There is a possibility of remote bone metastases, but back problems are very common, and it is rare that prostate cancer, even if it has penetrated the prostate, produces bone symptoms that early. Unfortunately, unless such metastases are well advanced, a bone scan might not provide any definitive information.
I suggest you get hold of the book "The Prostate" by Peter Scardino. It explains everything you need to know in relatively plain language. Also, find out just exactly what the doctors have recommended and more important why. If you are not satisfied they have it right, suggest that your father try another urologist.
Really, that is
> all the information he gave them. Other than steering them away from > both radiotherapy and a removal job. He talked up the side effects of > those surgeries. I think there are reasonably good arguments against surgery in a case like this, but I don't see what would be wrong with radiation, provided there is a reasonable chance it would do some good. Radiation can destroy both the cancer in the prostate and a local extension beyond it. It can't do anything about cancer that has got to remote sites, but you haven't given us much evidence as to why they think that is a strong likelihood.
> But yeah, the consultant's obviously worried about secondaries which is > why I assume he didn't suggest removing his prostate.
> Do they do scans for these par for the course? Do you have to ask for > them? How would they know if it'd gotten into his lymph nodes down > there? > > paul. I just went to the Slaon Kettering website and used their calculator. I put in what seemed like the worst case analysis on the basis of the information you gave. Using high dose radiation supplemented by short term hormone therapy, they estimate a 77 percent likelihood of being progression free at 5 years. Keep in mind that I'm not a physician, and in any case, I don't know all the facts, so I could be way off base on this. But it would seem reasonable to seek further information and possibly an independent medical opinion.
Steve Kramer - 14 Aug 2006 23:04 GMT > The problem is, they were given a little booklet. The booklet had > three 'Gleason diagrams' in it. The consultant pointed at picture > number two. The words next to that are G2 (GL 5 -7). Really, that is > all the information he gave them. Holy crap! Disregard my last post. Your father was not given the basic criteria needed for a decision. That is about as simple as it gets. They asked him to decide and withheld, purposefully or negligently, the information he needs to decide.
> Do they do scans for these par for the course? Do you have to ask for > them? Normally, at this point, a CAT scan and bone scan are done.
> How would they know if it'd gotten into his lymph nodes down > there? Surgery to perform a lymphectomy is the only way, but if he has beeen dx'd as a T3, then that would be moot.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05, 2/06, 6/06 PSA .07 .05 .06 .09 .08 .132 .145 Casodex added daily 07/06 Non Illegitimi Carborundum
I.P. Freely - 14 Aug 2006 23:13 GMT > <paul.groves@gmail.com> wrote > [quoted text clipped - 3 lines] > Surgery to perform a lymphectomy is the only way, but if he has beeen dx'd > as a T3, then that would be moot. Izzat true? How about the case of seminal vesicle invasion (SVI) w/o lymph node involvement, or minimal lymph node involvement? The former still permits surgery, and many surgeons will operate with limited lymph node involvement (in the hope, I presume, of catching slight excursions and reducing tumor burden).
I.P.
Steve Kramer - 14 Aug 2006 23:42 GMT >>> How would they know if it'd gotten into his lymph nodes down >>> there? [quoted text clipped - 4 lines] > Izzat true? How about the case of seminal vesicle invasion (SVI) w/o lymph > node involvement, or minimal lymph node involvement? I took the question as asking how they would know if it got to the lymph nodes. I answered that you'd have to go in and grab a lymph node. I know no other way, but I could be wrong.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05, 2/06, 6/06 PSA .07 .05 .06 .09 .08 .132 .145 Casodex added daily 07/06 Non Illegitimi Carborundum
I.P. Freely - 15 Aug 2006 01:21 GMT > I took the question as asking how they would know if it got to the lymph > nodes. I answered that you'd have to go in and grab a lymph node. I know > no other way, but I could be wrong. I believe that's right, but don't see why finding a couple of cancerous lymph nodes would be moot. Some docs would press on and remove the prostate, others would sigh, sew the pt back up, and realize it was time to pony up some of their savings for that yacht payment.
I.P.
paul.groves@gmail.com - 15 Aug 2006 02:07 GMT Thanks again for all the discourse guys, I really appreciate it.
Tomorrow, dad will phone up the nurse probably ask to start the HT.
Will they order a scan to check if it's spread anywhere else, or will he have to ask for that?
Should he wait to start HT until after the results of this 'scan' (assuming it happens)?
If it hasn't spread anywhere else, and taking into account his age, staging, PSA and Gleason scores would radiotherapy do him any good? (IE give him any more years)
Thanks everyone, this has been a great help so far and you've all given some excellent advice.
paul.
Steve Kramer - 15 Aug 2006 13:06 GMT > Tomorrow, dad will phone up the nurse probably ask to start the HT. > [quoted text clipped - 3 lines] > Should he wait to start HT until after the results of this 'scan' > (assuming it happens)? If they are going to do a bone scan, CAT scan, PET scan or prostascint scan, etc., then the scan will have to be done before the HT. It is hard enough to find prostate cancer outside the prostate when you only have a 9.9 PSA (keeping in mind that you might have 9.8 to 9.9 right there in, on or near the prostate). If he takes HT and the sites (if they exist) shrink, then the scans are doomed before they are given.
It seems to me that your father's doctor has already decided that scans are unnecessary. This might be the case if he has already decided that your father is a T4.
When I say that your father (or at least you) weren't given sufficient information to make a decision, I meant it. You cannot even decided on taking the HT.
You are, however, able to decide to trust in your doctor, which is a course most of us took at diagnosis. In that case, you and your father do not have to research or worry about what scans or treatments are available and advised. Just do what the doctor says.
> If it hasn't spread anywhere else, and taking into account his age, > staging, PSA and Gleason scores would radiotherapy do him any good? > (IE give him any more years) IF it hasn't spready, he is a candidate for surgery or radiation, either of which could cure him completely.
I cannot impress on you enough, however, that him "hearing" them talking about nodules on the prostate while he's anesthesized and the doctor pointing to a block on a piece of paper is not sufficient information to warrant a perceived Stage of T3!!!! I'm getting mad thinking about it.
Get the facts!
AGE PSA GLEASON STAGE
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05, 2/06, 6/06 PSA .07 .05 .06 .09 .08 .132 .145 Casodex added daily 07/06 Non Illegitimi Carborundum
Leonard Evens - 15 Aug 2006 20:28 GMT > Thanks again for all the discourse guys, I really appreciate it. > > Tomorrow, dad will phone up the nurse probably ask to start the HT. Without knowing more, it is hard to know if the hormone therapy is approriate at this point.
> Will they order a scan to check if it's spread anywhere else, or will > he have to ask for that? It is fairly normal to do a bone scan when there is a reasonable chance of remote spread. Even if the results are inconclusive, they provide a baseline to which future bone scans can be compared. Your father should ask if they plan to do a bone scan and, if not, why not. Bone scans are often not ordered if remote spread is highly unlikely, but, if they thought that, foregoing any therapy except hormone therapy for a 64 year old man would be highly unusual.
> Should he wait to start HT until after the results of this 'scan' > (assuming it happens)? Not necessarily. Bone scans don't necessarily show anything until the disease is fairly advanced. Hormone therapy is often ordered when they think that spread to remote sites has taken place even if it is not yet detectable on a bone scan. What has been unclear in all this is whether they think that and if so why. The only factors you've mentioned which would suggest that is the T3 staging. That means that the cancer has penetrated beyond the prostate. It could still be localized in the prosate bed or it could have also extended to remote sites. But physicians in this country, at least, wouldn't automatically decide not to treat such a case with radiation. So there may be some other factor.
> If it hasn't spread anywhere else, and taking into account his age, > staging, PSA and Gleason scores would radiotherapy do him any good? At least according to the Sloan Kettering nomogram, as I read it. But don't trust me. Go to
www.mskcc.org/mskcc/html/10088.cfm
and click on the icon for the prostate cancer prediction tool. Enter the pre-treatment PSA---I used 6.2---4 for the Biopsy Primary Gleason and 3 for the Biopsy Secondary Gleason, T3b as a choice for the 1992 Clinical Tumor Stage, and 80 for the radiation dose. Click the box for the non-adjuvant hormones, and the calculate box.
I am guessing at some of these choices based on what you have told us. For example, it is most likely it is a Gleason 7 tumor, but 4 + 3 is worse than 3 + 4, although in this case it doesn't seem to make any difference. The 5 year progression free probability is highly dependent on the radiation dose. 80 is fairly high and requires sophisticated X-ray equipment. That equipment is readily available in the US, but I don't know if it is available for your father. But even if you put in 70 for the radiation dose, the 5 year progression free rate is still 61 percent.
Note that 5 years progression free doesn't mean the disease has been cured. The disease could easily recur. But if radiation kept him disease free for some period of time, he could still start hormone therapy if it failed. In combination, all these approaches could keep him alive and well until he died of old age.
> (IE give him any more years) > > Thanks everyone, this has been a great help so far and you've all given > some excellent advice. > > paul. Steve Kramer - 15 Aug 2006 12:56 GMT >> I took the question as asking how they would know if it got to the lymph >> nodes. I answered that you'd have to go in and grab a lymph node. I [quoted text clipped - 4 lines] > prostate, others would sigh, sew the pt back up, and realize it was time > to pony up some of their savings for that yacht payment. Oooooooooooooooohhhhhhh. Okay.
Let my first qualify this response by asserting that I do not consider this an answer to Paul's dad's case. He clearly has not been given sufficient information to make any decision at all, other than who his new doctor is.
As to moot, I was of the impression that the Staging was T3. I was worried that a needle biopsy showing a T3 could very easily be a T4 in actuality. Furthermore, I think Paul was asking about checking lymph nodes prior to treatment.
As such, I imagine that a doctor who does not take prostate glands when there is evidence of extra-organ disease is certainly not going to do so if there is cancer in the lymph. Conversely, a doctor who believes in taking the gland merely as a mass-PCa-producing organ would obviously take the gland if cancer were found in the lymph. So, a diagnostic lymphectomy for the sole purpose of biopsy would seem to be moot in a T3/T4 environment.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05, 2/06, 6/06 PSA .07 .05 .06 .09 .08 .132 .145 Casodex added daily 07/06 Non Illegitimi Carborundum
I.P. Freely - 14 Aug 2006 17:44 GMT Paul -- Get thee to the bookstore, take a day or three off work if feasible or if urgency commands, and read a PC book or three. Good authors include, in no particular order, Walsh, Scardino, Lange (Dummies), Bubley, and Marks. I've seen Strum in at least one bookstore; it's primarily available online.
Simplistic thumbnail:
Hormone therapy (actually androgen deprivation therapy. ADT) does not cure; it just delays the inevitable until, with any luck, we die of something less obnoxious. But if our PC has spread beyond the immediate area of the prostate, it's all we have.
Surgery may cure, and will probably prolong life and/or vitality if the cancer is still local (in and/or on the prostate) + maybe reached a few lymph nodes.
Radiation can cure if the cancer is confined in or at the prostate, and can be applied if cancer returns TO THE PROSTATE BED after surgery. Surgery after failed radiation is generally not feasible.
The other options are desperation voodoo at present.
You'll notice I didn't even mention side effects (SEs). That's because even a simplistic thumbnail of SEs would take pages. Buy the books.
Your dad -- or you if he will not -- must step up to the plate, do the research, weigh the pros and cons, and make an initial treatment (tx) decision. Because of treatment's complexities and personal choices, that choice is seldom made by good oncologists (you don't want a mere doctor or urologist to decide your fate) unless the cancer's or patient's status leaves virtually no choice.
I.P.
Steve Kramer - 14 Aug 2006 23:07 GMT Okay. Who are you and what did you do with I.P. Freely?
> Paul -- > Get thee to the bookstore, take a day or three off work if feasible or if [quoted text clipped - 31 lines] > > I.P. I.P. Freely - 14 Aug 2006 23:22 GMT > Okay. Who are you and what did you do with I.P. Freely? > [quoted text clipped - 33 lines] >> >> I.P. You'll have to explain. I don't see any departure from my usual positions.
I.P.
Steve Kramer - 14 Aug 2006 23:48 GMT > You'll have to explain. I don't see any departure from my usual positions. > > I.P. You were brief, concise and conformed to consensuses that, heretofore, you questioned the existence of. Why, you even referred him to Strum. I was so happy, I formed a tear -- Lupron and Cosedex I'm sure. :-)
Steve Jordan - 15 Aug 2006 00:27 GMT Quoting IP,
>> You'll have to explain. I don't see any departure from my usual positions. >> >> I.P. >> He replied:
> You were brief, concise and conformed to consensuses that, heretofore, you > questioned the existence of. Why, you even referred him to Strum. I was so > happy, I formed a tear -- Lupron and Cosedex I'm sure. :-) > Snert! Keyboard!
Oh Kramer, you devil, you! Hee hee.
Regards,
Steve J
"The author of the Iliad is either Homer or, if not Homer, somebody else of the same name." -- Aldous Huxley
I.P. Freely - 15 Aug 2006 01:38 GMT > I.P. wrote >> You'll have to explain. I don't see any departure from my usual positions.
> You were brief Ya got me there. ;-)
> concise I always try to be. But as I said, I learned in 1968 that perfection is not all it's cracked up to be.
> and conformed to consensuses that, heretofore, you > questioned the existence of. I still don't know which consensuses those were. If I seem inconsistent, I'd appreciate knowing about it so I can correct the problem.
> Why, you even referred him to Strum. I was so > happy, I formed a tear -- Lupron and Cosedex I'm sure. :-) I'm chuckling, too, but my only concern about Strum is that so many experts question his work. They don't so much say he's WRONG -- often -- but they aren't willing to base big decisions on his claims. I have always considered his books and papers as valuable resources, but I'll still look for corroborating data before basing major decisions on him. Lacking those, it becomes a judgment call. After all, I've repeatedly been the forum's staunchest DEFENDER of Strum's ADT Syndrome "bible", to the point of having to offend one or two people who contradict it without counterevidence.
I.P.
I.P. Freely - 14 Aug 2006 18:01 GMT > Paul, over here in the PCa world we don't talk stages as much as they > do over in breast/lung areas or in lay discourse in general. Over here > we are more concerned at the clinical stage about PSA dynamics (how > much and fast it rose over time) and Gleason Score. I wallowed -- and advise other newbies to wallow -- in staging. Aren't PSA dynamics more suitable to prognosis than to initial tx decisions? Don't I care much more about my PCs STAGE (location) than its dynamics (growth speed) if I'm trying to choose among surgery, RT, and ADT? I can see where dynamics may help fine tune a truly and medically difficult initial tx choice, but that initial tx choice often becomes a pretty clear choice if staging is fairly clear and the pt has done his homework.
Your second sentence caveat -- "at the clinical stage" -- helps, but may zoom right over Paul's shiny newbie pate. Staging is critical to his dad's tx choice, I'd guess, whereas dynamics are more important to whether he buys that yacht and moves to the Bahamas or worries about his cholesterol.
I.P.
paul.groves@gmail.com - 14 Aug 2006 19:12 GMT Ok, thanks for the further input and advise everyone.
Clearly he needs more facts before deciding if some kind of surgery or radiotherapy is the correct choice for him. But can he just get started on the androgen hormone therapy and sort the surgical aspect out later?
Do they routinely do scans to see if it's spread? Do you have to ask for those?
Sorry to be a burden with all the questions. :o) paul
Steve Kramer - 14 Aug 2006 23:06 GMT > Sorry to be a burden with all the questions. :o) Nonsense!!! If we didn't want to help you out, we wouldn't look to see who logged in.
NICK - 16 Aug 2006 23:20 GMT Paul wrote:
> Clearly he needs more facts before deciding if some kind of surgery > or radiotherapy is the correct choice for him. But can he just get > started on the androgen hormone therapy and sort the surgical aspect > out later? Hormone threrapy can have some nasty side effects. Some drugs "attack" bones, some cause arthritis, i.e. ankylosing spondylitis - in men who otherwise wouldn't develop arthritis.
Before he decides on HT or any other treatment, I hope he waits to read any of the books recommended in other posts, and visits prostate-cancer.org (already suggested) as well as UsTOO, UrologyHealth.org, MaleCare, CancerCare, National Cancer Institute and John Hopkins Prostate Disorders.
Also, as suggested, he should seek a second opinion. I would not rely much on a doctor who tells a patient "read these" and doesn't discuss the various treatments verbally. Is the doctor trying to squeeze as many 15-minute appointments into an hour that he possibly can, rather than sitting down and having a long talk with your dad?
paul.groves@gmail.com - 17 Aug 2006 16:43 GMT >.... Is the doctor > trying to squeeze as many 15-minute appointments into an hour > that he possibly can, rather than sitting down and having a long > talk with your dad? Actually, it seemed like he was.
Monday morning is apparently 'bad news morning'. All the people in the waiting room sat with mum and dad all got bad news.
The number he telephoned yesterday, was the number of his nurse who is his first point of contact with the hospital. You can ring her anytime (in working hours) and ask her anything.
Anyway. He couldn't just 'ring up and start a treatment' like the doctor eluded to, he rung the number, the nurse was expecting his call. She mentioned he'd be getting his appointment for his bone scan through the post any time soon. She said the results of which would be known within the next two weeks.
After this, she said, the doctor will proabaly order more scans and then sit down and talk properly over the options with them. MAKING SUGGESTIONS BASED ON HIS EXPERIENCE. Which, I think, is key. And was sorely lacking from his first consultation.
It seems they don't purposely 'keep you in the dark', they just break the news, and give you some time to get your head around it. Unfortunately for me, and dad too, that's not how we operate. If something's wrong, it kinda needs addressing right away and you go away and read up as much as you can about it in the shortest space of time as you can. Heh.
Anyway. We all feel a bit better about the situation now.
Hopefully post-bone scan, they'll order a CT scan of the surrounding area (and if they don't i've told dad to ask them why not!), when he gets those results his prostate will have probably healed enough from the biopsy to have another PSA and we'll be taking it from there.
Again, and I keep saying this, but thanks for all the discussion in this thread. I really appreciate it.
paul.
Steve Kramer - 14 Aug 2006 23:00 GMT > His Gleason was G2 (GL 5-7). I suspect his Gleason is reportable as a 7. Gleasons are determined by adding to scores together; one being the rating of the most present cancer and the other being the rating of the second most present cancer. It looks like he might have give a Gleason for both halves. It might be of some interest to find out whether the 7 is a 3+4 or a 4+3.
> I get the feeling that he'll just try to push dad off with the > hormones. That was certainly the impression that my parents gave me > when they got back from the hospital - that the specialist was talking > up the hormone therapy and playing down removal of the prostate and > radiotherapy. Either he or you will have to get educated on PCa quickly. However, hormone therapy will give you some time to bring yourself up to date on PCa treatment and also enough time to find a medical oncologist.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05, 2/06, 6/06 PSA .07 .05 .06 .09 .08 .132 .145 Casodex added daily 07/06 Non Illegitimi Carborundum
Alan Meyer - 14 Aug 2006 20:22 GMT Paul,
One of the problem with this disease is that there is no universal agreement on what is the right treatments.
There are many doctors - probably many more in the UK than in the US, but some here too - who believe that primary treatment for prostate cancer (surgery or radiation) does no real good.
Your Dad may be seeing one of those doctors.
It is true that some men get primary treatment and then die of prostate cancer anyway. It's also true that some men do not get primary treatment and live on to die of something else.
In my humble and non-expert opinion, the key issues are:
1. Is the cancer confined to the prostate - where surgery or radiation can reach it?
2. Is the patient young enough that he might live 10, 15, or more years if his cancer doesn't kill him?
With a PSA below 10 there is a very good chance that the cancer is confined to the prostate. And at an age of 64, assuming your Dad is otherwise in good health (back pain is debilitating, but not life threatening), your Dad might well live 10 or 20 more years - during which time the cancer may well kill him if it is not treated.
So it seems to me that primary treatment IS indicated and, unless there is evidence of metastasis, should be attempted.
My personal view is that, if the disease is confined to the prostate, the success of treatment is highly dependent on the skill of the surgeon or radiation oncologist. A specialist who is committed to his patients and his craft, and who treats many PCa patients, often has a much higher successs rate than a general surgeon or radiation oncologist who only does a few prostate cases a year.
As to your question about getting hormone therapy now, I think that can be a valid strategy. It will shrink the prostate and will temporarily slow or halt the progress of the disease, giving you more time to investigate options. HT is often given as a preparatory treatment before radiation. It is sometimes but not often given before surgery. I think the theory is that it does not increase the survival rates for surgery patients, but there is debate about that and I'm not aware of it doing any harm - other than the normal unpleasant effects of hormone therapy.
Best of luck.
Alan
ron - 14 Aug 2006 21:59 GMT Alan Meyer wrote...snip...:
> HT is often > given as a preparatory treatment before radiation. It is > sometimes but not often given before surgery. I think the > theory is that it does not increase the survival rates for > surgery patients, but there is debate about that and
> I'm not aware of it doing any harm
> - other than the normal unpleasant > effects of hormone therapy. Just a note, most surgeons don't like to use HT prior to prostatectomy because hormones affect how the tumor attaches itself to adjacent, non-cancerous tissue. During surgery, excised cancerous tissue peels off cleanly from adjacent healthy tissue. However, use of HT affects the cancerous tissue's ability to be easily removed. This "tactile" information is then lost and surgeons have a harder time identifying the boundaries of the tumor(s)...ron
Alan Meyer - 15 Aug 2006 00:20 GMT > Alan Meyer wrote...snip...: >> HT is often [quoted text clipped - 15 lines] > information is then lost and surgeons have a harder time identifying > the boundaries of the tumor(s)...ron Thanks for that clarification. Now that you bring it up, I seem to recall reading that somewhere too.
There have been trials of HT before RP. Apparently, a trial in Canada found no benefit from 3 months of HT before RP. However I think another trial is either suggested or being organized (I wasn't sure which from what I read) for 8 months of HT before RP.
The value of HT before RT seems to be in dispute. IIRC different studies have come up with different and seemingly contradictory results. However I haven't seen anything that says HT before RT is in any way harmful - except of course for whatever ways that HT is harmful by itself.
Alan
Steve Jordan - 14 Aug 2006 20:32 GMT > Dad was disagnosed with T3 stage prostate cancer today. The doctor > gave him a booklet and told him to go away to choose the form of [quoted text clipped - 6 lines] > Surely a man so 'young' should be having more radical surgury? > There is no good way for a patient to select a treatment (tx) unless he has educated and empowered himself such that his decision is well-founded.
Some good advice has been given here.
I would add that the one book that virtually saved my life (Gleason 9, etc.) is _A Primer on Prostate Cancer_, now in its second edition. Its subtitle is, "The Empowered Patient's Guide." Co-authors are medical oncologist and PCa specialist Stephen B. Strum, MD, and PCa warrior Donna Pogliano.
Secondly, refer to the authoritative website of the Prostate Cancer Research Institute at: http://prostate-cancer.org/index.html Go to the pages entitled, "Newly Diagnosed."
This patient, as have we all, has been drafted into a war against a relentless enemy. It is necessary to prepare for combat by education on the nature of the enemy. *That* is the next step. The task is difficult but not impossible
Good luck. Let us know how it goes.
Steve J
"We must tailor the treatment to the nature of the disease. We must listen to the biology." -- Stephen B. Strum, MD
Bob C - 15 Aug 2006 13:47 GMT Paul, I have read the many good replies of 8/14 and have little to add of a medical nature, but I have been going down this road for almost six years now and vividly remember being bogged down with information and facts and figures and statistics in the beginning. Early on, in the learning process, it would be nice to have just one road to follow, one course of action that was appropriate for your specific situation, but the medical community is not anywhere near being that far along. There are more questions than answers, and some of the questions can be answered only by your Dad.
As you and your Dad begin this battle, it might be helpful to look early on at the standard approaches, and the side effects associated with each, and decide just how aggressively he wants to fight this thing, what possible side effects are worth risking. A cure may or may not be possible, but even if not, surgery for the purpose of debulking is not totally out of the question. That is the type of personal decision you have to make. Some men will opt for fighting as aggressively as possible and let the SE's fall where they may. Others will make an educated decision to temper their treatment plans with a closer eye to quality of life issues.
My own battle began at age 55 with a psa of 55. A mind boggling crash course in pca told me that it's going to get me. I did the surgery, with its side effects, and radiation with it's side effects, and several years of Lupron with it's side effects, and now my psa has begun to rise again. More drugs are coming up soon. And many more prayers. Has all of this prolonged my life? Beats me, but right now, today, life is pretty good. It would be devastating to me to look back on my final day on earth and see that I maybe could have done better by fighting a little harder. This is just one mans fight, against his specific cancer, and no way would I suggest that anyone go down the same path. You have to decide what's right for you.
Keep getting educated, but try not to get bogged down with all of this information, and by all means ask all the questions you want of this newsgroup. It has been a huge help to me, both as a support group and as a source of information. These guys have been there, and want to help. Best of luck to you.
> Surely a man so 'young' should be having more radical surgury? Bill - 15 Aug 2006 17:30 GMT IMO telling a man he has PCa w/ G.S. somewhere between 2+3 and 4+3, and making Tx decisions based on that, is malpractice. Indeed, that G.S. range probably identifies 90% of all men diagnosed w/ PCa! It is too general to be of value. Get the pathology report.
I.P., I do not think that Tx decisions are or should be heavily weighted on clinical stage. We have had many men here who had high-G.S. T1 PCa and, on the other hand, low G.S. T2 PCa. And that observation has also extended into the pathological stage where clinical T1s become T3s or worse. The main thing any man wants to know is whether his disease is organ-confined or not - that primarily determines Tx modality. And neither the DRE or even biopsy can tell you that. I don't know how this guy's doctors can tell him he is stage 3 - at best they can say T2c. Indeed, the 2001 Partin (clinical stage) tables do not even go past T2c. And the difference in probability of organ-confined disease between T2a and T2c is 81% to 73% w/ G.S. 5 to 6, and 64% to 51% w/ G.S. 3+4. While those may be statistically significant, I don't think many men are going to decide on local vs. systemic Tx based on those differences. From what I've seen and read, I want to know G.S., how many samples were affected and to what degree [this does not affect staging], and pre-biopsy PSA level and DT. In my own case I was diagnosed w/ G.S. 5 T2a, which is the lowest palpable stage. That was good news and weighed in favor of local Tx. However, my PSA was 33. In my case the low staging and G.S. caused me to have local Tx despite the counter-indicative PSA. It turned out that I had pathological G.S. 7 T3 w/ SVI and positive margins - and systemic disease.
Bill Denton RP 2/12/02 PSA .96 Memphis
Leonard Evens - 15 Aug 2006 20:32 GMT > IMO telling a man he has PCa w/ G.S. somewhere between 2+3 and 4+3, and > making Tx decisions based on that, is malpractice. Indeed, that G.S. [quoted text clipped - 10 lines] > know how this guy's doctors can tell him he is stage 3 - at best they > can say T2c. I believe that in certain cases, digital rectal examination and imaging studies can indicate that T3 staging is highly likely. At least that was my impression from reading Scardino on the subject. Also, the Sloan Kettering nomogram lets you enter T3 as the stage.
> Indeed, the 2001 Partin (clinical stage) tables do not > even go past T2c. And the difference in probability of organ-confined [quoted text clipped - 14 lines] > PSA .96 > Memphis I.P. Freely - 18 Aug 2006 03:49 GMT > I.P., I do not think that Tx decisions are or should be heavily > weighted on clinical stage. All I'm getting at is that if the specialists' consensus is that my cancer is organ-confined, surgery is a sound option. If the consensus includes mets, surgery is far less likely to help. G6 in my spine is a much less operable disease than G8 confined to my prostate.
I.P.
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