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Medical Forum / Diseases and Disorders / Prostate Cancer / August 2006

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Dad diagnosed.  Next step?

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paul.groves@gmail.com - 14 Aug 2006 12:04 GMT
Hi.

Dad was disagnosed with T3 stage prostate cancer today.  The doctor
gave him a booklet and told him to go away to choose the form of
treatment he wanted.  He doctor did heavily lean toward hormone
therapy.

Dad is only 64, would removal of the prostate not help someone with a
T3 tumor?  What about experiences with radio therapy?

Surely a man so 'young' should be having more radical surgury?

Thanks, any thoughts appreciated.
paul
Steve Kramer - 14 Aug 2006 12:54 GMT
> Dad was disagnosed with T3 stage prostate cancer today.  The doctor
> gave him a booklet and told him to go away to choose the form of
[quoted text clipped - 7 lines]
>
> Thanks, any thoughts appreciated.

In order to diagnose a T3, one would have to determine that the cancer has
penetrated the wall of the prostate and/or involves the seminal vesicles.  I
am not expert on this (nor are any of us doctors), but I would imagine that
it is very difficult, using a needle biopsy, that a T3 is not a T4.

The medical community has wavered on the treatment of T3/T4 PCa.  When my
father was dx'd with T4 (with a spot on his pelvis), they took out his
prostate and radiated his pelvis with cobalt.  That was about 1974.  When I
was dx'd 26 years later, the accepted procedure was to leave the prostate in
if the cancer was already outside the prostate.  More recently, I have heard
some doctors are removing the prostate anyway, just to get out the mass that
they know about.

If you dad was 64 with a T2, I'd be a supporting surgery.  But T3 is a whole
different ballgame and I believe the majority of the medical community is
still on the side of leaving it in.

However, if you have accurately described your father's doctor's
"counseling", I would seriously consider a different doctor.  And, in any
case, your father should seek out a medical oncologist and maybe a second
for another opinion.

What he does not will likely determine how long he has to live.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06, 6/06
PSA  .07 .05 .06 .09 .08 .132 .145
Casodex added daily 07/06
Non Illegitimi Carborundum

paul.groves@gmail.com - 14 Aug 2006 13:23 GMT
Thanks for the speedy reply.

He had his biopsy/trans rectal ultrasound last week, the specialist who
preformed that procedure had someone with him (training them, perhaps)
and they were overheard talking..  Basically dad heard them use the
phrases T2 and T3, and talk about nodules on the surface of the left
side of prostate.

So we knew it wasn't good.

>From what I've read (and I freely admit I'm no expert on the matter),
I'd take the hormone treatment as quickly as possible then start asking
about radio therapy to shrink the tumor.  Does this sound reasonable?
Is it worth it?

Dad unfortunately isn't the type to argue his case with a doctor or
anyone else for that matter.  To his detriment in this case, he's far
too laid back.

Thanks again,
Hope your treatment continues to go well,
paul
Steve Kramer - 14 Aug 2006 14:39 GMT
> He had his biopsy/trans rectal ultrasound last week, the specialist who
> preformed that procedure had someone with him (training them, perhaps)
[quoted text clipped - 3 lines]
>
> So we knew it wasn't good.

That is your T3.  If they had been talking about nodules "in" rather than
"on" the prostate, it might have been a T2.

>>From what I've read (and I freely admit I'm no expert on the matter),
> I'd take the hormone treatment as quickly as possible then start asking
> about radio therapy to shrink the tumor.  Does this sound reasonable?
> Is it worth it?

Personally, I think a shot of HT prior to radiation is a good idea.  Starve
the little bastards and then fry them.  It's a lot more satisfying than just
killing them outright  :-)

But, pratcially speaking, I would still say yes.  I can see some value in
shrinking a tumor before radiating it.  That is what an oncologist needs to
discuss with your dad.  I am neither a doctor or an expert.

> Dad unfortunately isn't the type to argue his case with a doctor or
> anyone else for that matter.  To his detriment in this case, he's far
> too laid back.

Questioning a doctor was something completely foreign to me before PCa.  I
think very few in this NG questioned their dx or tx before coming to this NG
or before reading a book like Dr. Patrick Walsh's.  There are prominent
members here who can probably blame their eventual deaths on implicitly
trusting their doctors.  Furthermore, I recall only one time in all my
reading or watching t.v. or movies where a doctor was mistrusted unders
normal circumstances.  John Wayne traveled a great distance to get a second
opinion from James Stewart in The Shootist.  At the time, I thought that
didn't bow well for the trust of the medical profession in the early 1900s.
But, now I see it is still a valid idea 100 years later.

BTW, what was his Gleason and PSA?  Those are tremendously important
criteria for decision making.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06, 6/06
PSA  .07 .05 .06 .09 .08 .132 .145
Casodex added daily 07/06
Non Illegitimi Carborundum

paul.groves@gmail.com - 14 Aug 2006 15:12 GMT
This all started about 2 months ago when he had trouble urinating.  Our
GP performed a PSA test - the result of which was 5.8.  Not too
alarming, but he did a DRE too and decided to refer him to the hospital
specialist.

The specialist did another DRE and PSA test - the result of that was
6.7.  That was about 2 weeks ago.

He had the transrectal ultrasound at the end of last week.

Dad's had a bad back for years (and years and years), the specialist is
worried that this has masked other possible symptoms of the cancer - so
has at least ordered a bone scan for him.

His Gleason was G2 (GL 5-7).

I get the feeling that he'll just try to push dad off with the
hormones.  That was certainly the impression that my parents gave me
when they got back from the hospital - that the specialist was talking
up the hormone therapy and playing down removal of the prostate and
radiotherapy.

Again, many thanks for your experiences in the matter :)
paul
Bill - 14 Aug 2006 15:47 GMT
Paul, over here in the PCa world we don't talk stages as much as they
do over in breast/lung areas or in lay discourse in general. Over here
we are more concerned at the clinical stage about PSA dynamics (how
much and fast it rose over time) and Gleason Score. There are other
tests that I am not really familiar w/ like free-PSA and PAP that also
seem to offer valuable diagnostic info. If your dad had trouble
urinating, he very probably has an enlarged prostate and, if it is due
to PCa, he has had it for awhile. That does not mean he has systemic
disease. Has he been diagnosed w/ BPH before? What were his previous
PSAs? I am not aware that extracapsular extensions or lymph nodes can
be palpated by DRE, and if you are basing your conclusions simply on
some second-hand overheard conversation - DON"T! They could have been
discussing nodules on one side of his prostate - and that would be a
T2b. And I don't think there is any such thing as a "G2 (GL 5-7)"
Either your dad does not have all or the precise info he needs or he
hasn't passed it on to you. He may not want to. But SOMEONE on the Pt
side needs to know the facts. The doctor evidently suspects systemic
disease and that's why he is not recommending local Tx. That can be a
life or death decision so your dad needs to be advised in detail
exactly what the doctor thinks and the evidence that leads him to that
conclusion. He should demand it if he has to. Unless, of course, he
simply trusts his doctor and does not want to be involved. I haven't
yet met one deserving of that much trust.

Bill Denton
RP 2/12/02
PSA .96
Memphis
paul.groves@gmail.com - 14 Aug 2006 17:23 GMT
The problem is, they were given a little booklet.  The booklet had
three 'Gleason diagrams' in it.  The consultant pointed at picture
number two.  The words next to that are G2 (GL 5 -7).  Really, that is
all the information he gave them.  Other than steering them away from
both radiotherapy and a removal job.  He talked up the side effects of
those surgeries.

But yeah, the consultant's obviously worried about secondaries which is
why I assume he didn't suggest removing his prostate.

Do they do scans for these par for the course?  Do you have to ask for
them?  How would they know if it'd gotten into his lymph nodes down
there?

paul.
Leonard Evens - 14 Aug 2006 21:26 GMT
> The problem is, they were given a little booklet.  The booklet had
> three 'Gleason diagrams' in it.  The consultant pointed at picture
> number two.  The words next to that are G2 (GL 5 -7).

All that means is that the Gleason score was between 5 and 7.  Such
cancers are considered intermediate by many doctors.  8-10 is considered
aggressive.  Other doctors divide things up differently and would
disinguish 5-6 from 7.   There is also a subtle distinction between
different ways to get 7.

I think that your father's doctors clearly are concerned that the cancer
has penetrated the prostate.  But with the moderate PSA value you
describe, if the  Gleason score is at most 7,  it is not clear to me
that radiation might not be a good choice.  As Steve said, often
radiation is helped by short term hormone therapy, and if that is what
the doctors are suggesting, there is nothing unusual about it.
However, if they are discouraging any treatment but hormone therapy, it
does sound strange to me. It would be wise to find out just what they
are recommending and why.   One other question would be your father's
overall health.  If he is in poor health otherwise, aggressive treatment
might not be meritied.  Even aggressive cancers take a while to develop,
and treatment can be hard on a weakened patient.

There is a possibility of remote bone metastases, but back problems are
very common, and it is rare that prostate cancer, even if it has
penetrated the prostate, produces bone symptoms that early.
Unfortunately, unless such metastases are well advanced, a bone scan
might not provide any definitive information.

I suggest you get hold of the book "The Prostate" by Peter Scardino.  It
explains everything you need to know in relatively plain language.
Also, find out just exactly what the doctors have recommended and more
important why.  If you are not satisfied they have it right, suggest
that your father try another urologist.

 Really, that is
> all the information he gave them.  Other than steering them away from
> both radiotherapy and a removal job.  He talked up the side effects of
> those surgeries.

I think there are reasonably good arguments against surgery in a case
like this,  but I don't see what would be wrong with radiation, provided
there is a reasonable chance it would do some good.  Radiation can
destroy both the cancer in the prostate and a local extension beyond it.
 It can't do anything about cancer that has got to remote sites, but
you haven't given us much evidence as to why they think that is a strong
likelihood.

> But yeah, the consultant's obviously worried about secondaries which is
> why I assume he didn't suggest removing his prostate.

> Do they do scans for these par for the course?  Do you have to ask for
> them?  How would they know if it'd gotten into his lymph nodes down
> there?
>
> paul.

I just went to the Slaon Kettering website and used their calculator.  I
put in what seemed like the worst case analysis on the basis of the
information you gave.   Using high dose radiation supplemented by short
term hormone therapy, they estimate a 77 percent likelihood of being
progression free at 5 years.   Keep in mind that I'm not a physician,
and in any case, I don't know all the facts, so I could be way off base
on this.  But it would seem reasonable to seek further information and
possibly an independent medical opinion.
Steve Kramer - 14 Aug 2006 23:04 GMT
> The problem is, they were given a little booklet.  The booklet had
> three 'Gleason diagrams' in it.  The consultant pointed at picture
> number two.  The words next to that are G2 (GL 5 -7).  Really, that is
> all the information he gave them.

Holy crap!  Disregard my last post.  Your father was not given the basic
criteria needed for a decision.  That is about as simple as it gets.  They
asked him to decide and withheld, purposefully or negligently, the
information he needs to decide.

> Do they do scans for these par for the course?  Do you have to ask for
> them?

Normally, at this point, a CAT scan and bone scan are done.

>  How would they know if it'd gotten into his lymph nodes down
> there?

Surgery to perform a lymphectomy is the only way, but if he has beeen dx'd
as a T3, then that would be moot.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06, 6/06
PSA  .07 .05 .06 .09 .08 .132 .145
Casodex added daily 07/06
Non Illegitimi Carborundum

I.P. Freely - 14 Aug 2006 23:13 GMT
> <paul.groves@gmail.com> wrote  
>
[quoted text clipped - 3 lines]
> Surgery to perform a lymphectomy is the only way, but if he has beeen dx'd
> as a T3, then that would be moot.

Izzat true? How about the case of seminal vesicle invasion (SVI) w/o
lymph node involvement, or minimal lymph node involvement? The former
still permits surgery, and many surgeons will operate with limited lymph
node involvement (in the hope, I presume, of catching slight excursions
and reducing tumor burden).

I.P.
Steve Kramer - 14 Aug 2006 23:42 GMT
>>>  How would they know if it'd gotten into his lymph nodes down
>>> there?
[quoted text clipped - 4 lines]
> Izzat true? How about the case of seminal vesicle invasion (SVI) w/o lymph
> node involvement, or minimal lymph node involvement?

I took the question as asking how they would know if it got to the lymph
nodes.  I answered that you'd have to go in and grab a lymph node.  I know
no other way, but I could be wrong.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06, 6/06
PSA  .07 .05 .06 .09 .08 .132 .145
Casodex added daily 07/06
Non Illegitimi Carborundum

I.P. Freely - 15 Aug 2006 01:21 GMT
> I took the question as asking how they would know if it got to the lymph
> nodes.  I answered that you'd have to go in and grab a lymph node.  I know
> no other way, but I could be wrong.

I believe that's right, but don't see why finding a couple of cancerous
lymph nodes would be moot. Some docs would press on and remove the
prostate, others would sigh, sew the pt back up, and realize it was time
to pony up some of their savings for that yacht payment.

I.P.
paul.groves@gmail.com - 15 Aug 2006 02:07 GMT
Thanks again for all the discourse guys, I really appreciate it.

Tomorrow, dad will phone up the nurse probably ask to start the HT.

Will they order a scan to check if it's spread anywhere else, or will
he have to ask for that?

Should he wait to start HT until after the results of this 'scan'
(assuming it happens)?

If it hasn't spread anywhere else, and taking into account his age,
staging, PSA and Gleason scores would radiotherapy do him any good?
(IE give him any more years)

Thanks everyone, this has been a great help so far and you've all given
some excellent advice.

paul.
Steve Kramer - 15 Aug 2006 13:06 GMT
> Tomorrow, dad will phone up the nurse probably ask to start the HT.
>
[quoted text clipped - 3 lines]
> Should he wait to start HT until after the results of this 'scan'
> (assuming it happens)?

If they are going to do a bone scan, CAT scan, PET scan or prostascint scan,
etc., then the scan will have to be done before the HT.  It is hard enough
to find prostate cancer outside the prostate when you only have a 9.9 PSA
(keeping in mind that you might have 9.8 to 9.9 right there in, on or near
the prostate).  If he takes HT and the sites (if they exist) shrink, then
the scans are doomed before they are given.

It seems to me that your father's doctor has already decided that scans are
unnecessary.  This might be the case if he has already decided that your
father is a T4.

When I say that your father (or at least you) weren't given sufficient
information to make a decision, I meant it.  You cannot even decided on
taking the HT.

You are, however, able to decide to trust in your doctor, which is a course
most of us took at diagnosis.  In that case, you and your father do not have
to research or worry about what scans or treatments are available and
advised.  Just do what the doctor says.

> If it hasn't spread anywhere else, and taking into account his age,
> staging, PSA and Gleason scores would radiotherapy do him any good?
> (IE give him any more years)

IF it hasn't spready, he is a candidate for surgery or radiation, either of
which could cure him completely.

I cannot impress on you enough, however, that him "hearing" them talking
about nodules on the prostate while he's anesthesized and the doctor
pointing to a block on a piece of paper is not sufficient information to
warrant a perceived Stage of T3!!!!  I'm getting mad thinking about it.

Get the facts!

AGE
PSA
GLEASON
STAGE

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06, 6/06
PSA  .07 .05 .06 .09 .08 .132 .145
Casodex added daily 07/06
Non Illegitimi Carborundum

Leonard Evens - 15 Aug 2006 20:28 GMT
> Thanks again for all the discourse guys, I really appreciate it.
>
> Tomorrow, dad will phone up the nurse probably ask to start the HT.

Without knowing more, it is hard to know if the hormone therapy is
approriate at this point.

> Will they order a scan to check if it's spread anywhere else, or will
> he have to ask for that?

It is fairly normal to do a bone scan when there is a reasonable chance
of remote spread.  Even if the results are inconclusive, they provide a
baseline to which future bone scans can be compared.    Your father
should ask if they plan to do a bone scan and, if not, why not.   Bone
scans are often not ordered if remote spread is highly unlikely, but, if
 they thought that, foregoing any therapy except hormone therapy for a
64 year old man would be highly unusual.

> Should he wait to start HT until after the results of this 'scan'
> (assuming it happens)?

Not necessarily.  Bone scans don't necessarily show anything until the
disease is fairly advanced.  Hormone therapy is often ordered when they
think that spread to remote sites has taken place even if it is not yet
detectable on a bone scan.   What has been unclear in all this is
whether they think that and if so why.   The only factors you've
mentioned which would suggest that is the T3 staging.  That means that
the cancer has penetrated beyond the prostate.  It could still be
localized in the prosate bed or it could have also extended to remote
sites.   But physicians in this country, at least, wouldn't
automatically decide not to treat such a case with radiation.  So there
may be some other factor.

> If it hasn't spread anywhere else, and taking into account his age,
> staging, PSA and Gleason scores would radiotherapy do him any good?

At least according to the Sloan Kettering nomogram, as I read it.   But
don't trust me.  Go to

www.mskcc.org/mskcc/html/10088.cfm

and click on the icon for the prostate cancer prediction tool.  Enter
the pre-treatment PSA---I used 6.2---4 for the Biopsy Primary Gleason
and 3 for the Biopsy Secondary Gleason, T3b as a choice for the 1992
Clinical Tumor Stage, and 80 for the radiation dose.   Click the box for
the non-adjuvant hormones, and the calculate box.

I am guessing at some of these choices based on what you have told us.
For example, it is most likely it is a Gleason 7 tumor, but 4 + 3 is
worse than 3 + 4, although in this case it doesn't seem to make any
difference.   The 5 year progression free probability is highly
dependent on the radiation dose.   80 is fairly  high and requires
sophisticated X-ray equipment.  That equipment is readily available in
the US, but I don't know if it is available for your father.  But even
if you put in 70 for the radiation dose, the 5 year progression free
rate is still 61 percent.

Note that 5 years progression free doesn't mean the disease has been
cured.   The disease could easily recur.  But if radiation kept him
disease free for some period of time,  he could still start hormone
therapy if it failed.  In combination, all these approaches could keep
him alive and well until he died of old age.

> (IE give him any more years)
>
> Thanks everyone, this has been a great help so far and you've all given
> some excellent advice.
>
> paul.
Steve Kramer - 15 Aug 2006 12:56 GMT
>> I took the question as asking how they would know if it got to the lymph
>> nodes.  I answered that you'd have to go in and grab a lymph node.  I
[quoted text clipped - 4 lines]
> prostate, others would sigh, sew the pt back up, and realize it was time
> to pony up some of their savings for that yacht payment.

Oooooooooooooooohhhhhhh.  Okay.

Let my first qualify this response by asserting that I do not consider this
an answer to Paul's dad's case.  He clearly has not been given sufficient
information to make any decision at all, other than who his new doctor is.

As to moot, I was of the impression that the Staging was T3.  I was worried
that a needle biopsy showing a T3 could very easily be a T4 in actuality.
Furthermore, I think Paul was asking about checking lymph nodes prior to
treatment.

As such, I imagine that a doctor who does not take prostate glands when
there is evidence of extra-organ disease is certainly not going to do so if
there is cancer in the lymph.  Conversely, a doctor who believes in taking
the gland merely as a mass-PCa-producing organ would obviously take the
gland if cancer were found in the lymph.  So, a diagnostic lymphectomy for
the sole purpose of biopsy would seem to be moot in a T3/T4 environment.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06, 6/06
PSA  .07 .05 .06 .09 .08 .132 .145
Casodex added daily 07/06
Non Illegitimi Carborundum

I.P. Freely - 14 Aug 2006 17:44 GMT
Paul --
Get thee to the bookstore, take a day or three off work if feasible or
if urgency commands, and read a PC book or three. Good authors include,
in no particular order, Walsh, Scardino, Lange (Dummies), Bubley, and
Marks. I've seen Strum in at least one bookstore; it's primarily
available online.

Simplistic thumbnail:

Hormone therapy (actually androgen deprivation therapy. ADT) does not
cure; it just delays the inevitable until, with any luck, we die of
something less obnoxious. But if our PC has spread beyond the immediate
area of the prostate, it's all we have.

Surgery may cure, and will probably prolong life and/or vitality if the
cancer is still local (in and/or on the prostate) + maybe reached a few
lymph nodes.

Radiation can cure if the cancer is confined in or at the prostate, and
can be applied if cancer returns TO THE PROSTATE BED after surgery.
Surgery after failed radiation is generally not feasible.

The other options are desperation voodoo at present.

You'll notice I didn't even mention side effects (SEs). That's because
even a simplistic thumbnail of SEs would take pages. Buy the books.

Your dad -- or you if he will not -- must step up to the plate, do the
research, weigh the pros and cons, and make an initial treatment (tx)
decision. Because of treatment's complexities and personal choices, that
choice is seldom made by good oncologists (you don't want a mere doctor
or urologist to decide your fate) unless the cancer's or patient's
status leaves virtually no choice.

I.P.
Steve Kramer - 14 Aug 2006 23:07 GMT
Okay.  Who are you and what did you do with I.P. Freely?

> Paul --
> Get thee to the bookstore, take a day or three off work if feasible or if
[quoted text clipped - 31 lines]
>
> I.P.
I.P. Freely - 14 Aug 2006 23:22 GMT
> Okay.  Who are you and what did you do with I.P. Freely?
>
[quoted text clipped - 33 lines]
>>
>> I.P.

You'll have to explain. I don't see any departure from my usual positions.

I.P.
Steve Kramer - 14 Aug 2006 23:48 GMT
> You'll have to explain. I don't see any departure from my usual positions.
>
> I.P.

You were brief, concise and conformed to consensuses that, heretofore, you
questioned the existence of.  Why, you even referred him to Strum.  I was so
happy, I formed a tear -- Lupron and Cosedex I'm sure.   :-)
Steve Jordan - 15 Aug 2006 00:27 GMT
Quoting IP,
>> You'll have to explain. I don't see any departure from my usual positions.
>>
>> I.P.
>>    
He replied:
> You were brief, concise and conformed to consensuses that, heretofore, you
> questioned the existence of.  Why, you even referred him to Strum.  I was so
> happy, I formed a tear -- Lupron and Cosedex I'm sure.   :-)
>  
Snert! Keyboard!

Oh Kramer, you devil, you! Hee hee.

Regards,

Steve J

"The author of the Iliad is either Homer or, if not Homer, somebody else
of the same name."
-- Aldous Huxley
I.P. Freely - 15 Aug 2006 01:38 GMT
> I.P. wrote
>> You'll have to explain. I don't see any departure from my usual positions.

> You were brief

Ya got me there.  ;-)

> concise
I always try to be. But as I said, I learned in 1968 that perfection is
not all it's cracked up to be.

> and conformed to consensuses that, heretofore, you
> questioned the existence of.  

I still don't know which consensuses those were. If I seem inconsistent,
I'd appreciate knowing about it so I can correct the problem.

> Why, you even referred him to Strum.  I was so
> happy, I formed a tear -- Lupron and Cosedex I'm sure.   :-)

I'm chuckling, too, but my only concern about Strum is that so many
experts question his work. They don't so much say he's WRONG -- often --
but they aren't willing to base big decisions on his claims. I have
always considered his books and papers as valuable resources, but I'll
still look for corroborating data before basing major decisions on him.
Lacking those, it becomes a judgment call. After all, I've repeatedly
been the forum's staunchest DEFENDER of Strum's ADT Syndrome "bible", to
the point of having to offend one or two people who contradict it
without counterevidence.

I.P.
I.P. Freely - 14 Aug 2006 18:01 GMT
> Paul, over here in the PCa world we don't talk stages as much as they
> do over in breast/lung areas or in lay discourse in general. Over here
> we are more concerned at the clinical stage about PSA dynamics (how
> much and fast it rose over time) and Gleason Score.

I wallowed -- and advise other newbies to wallow -- in staging. Aren't
PSA dynamics more suitable to prognosis than to initial tx decisions?
Don't I care much more about my PCs STAGE (location) than its dynamics
(growth speed) if I'm trying to choose among surgery, RT, and ADT? I can
see where dynamics may help fine tune a truly and medically difficult
initial tx choice, but that initial tx choice often becomes a pretty
clear choice if staging is fairly clear and the pt has done his homework.

Your second sentence caveat -- "at the clinical stage" -- helps, but may
 zoom right over Paul's shiny newbie pate. Staging is critical to his
dad's tx choice, I'd guess, whereas dynamics are more important to
whether he buys that yacht and moves to the Bahamas or worries about his
cholesterol.

I.P.
paul.groves@gmail.com - 14 Aug 2006 19:12 GMT
Ok, thanks for the further input and advise everyone.

Clearly he needs more facts before deciding if some kind of surgery or
radiotherapy is the correct choice for him.  But can he just get
started on the androgen hormone therapy and sort the surgical aspect
out later?

Do they routinely do scans to see if it's spread?  Do you have to ask
for those?

Sorry to be a burden with all the questions. :o)
paul
Steve Kramer - 14 Aug 2006 23:06 GMT
> Sorry to be a burden with all the questions. :o)

Nonsense!!!  If we didn't want to help you out, we wouldn't look to see who
logged in.
NICK - 16 Aug 2006 23:20 GMT
Paul wrote:

> Clearly he needs more facts before deciding if some kind of surgery
> or radiotherapy is the correct choice for him.  But can he just get
> started on the androgen hormone therapy and sort the surgical aspect
> out later?

Hormone threrapy can have some nasty side effects.  Some
drugs "attack" bones, some cause arthritis,  i.e. ankylosing
spondylitis - in men who otherwise wouldn't develop arthritis.

Before he decides on HT or any other treatment, I hope he waits
to read any of the books recommended in other posts, and visits
prostate-cancer.org (already suggested) as well as UsTOO,
UrologyHealth.org, MaleCare, CancerCare, National Cancer
Institute and John Hopkins Prostate Disorders.

Also, as suggested, he should seek a second opinion.  I would
not rely much on a doctor who tells a patient "read these" and
doesn't discuss the various treatments verbally.  Is the doctor
trying to squeeze as many 15-minute appointments into an hour
that he possibly can, rather than sitting down and having a long
talk with your dad?
paul.groves@gmail.com - 17 Aug 2006 16:43 GMT
>....  Is the doctor
>  trying to squeeze as many 15-minute appointments into an hour
>  that he possibly can, rather than sitting down and having a long
>  talk with your dad?

Actually, it seemed like he was.

Monday morning is apparently 'bad news morning'.  All the people in the
waiting room sat with mum and dad all got bad news.

The number he telephoned yesterday, was the number of his nurse who is
his first point of contact with the hospital.  You can ring her anytime
(in working hours) and ask her anything.

Anyway.  He couldn't just 'ring up and start a treatment' like the
doctor eluded to, he rung the number, the nurse was expecting his call.
She mentioned he'd be getting his appointment for his bone scan
through the post any time soon.  She said the results of which would be
known within the next two weeks.

After this, she said, the doctor will proabaly order more scans and
then sit down and talk properly over the options with them.  MAKING
SUGGESTIONS BASED ON HIS EXPERIENCE.  Which, I think, is key.  And was
sorely lacking from his first consultation.

It seems they don't purposely 'keep you in the dark', they just break
the news, and give you some time to get your head around it.
Unfortunately for me, and dad too, that's not how we operate.  If
something's wrong, it kinda needs addressing right away and you go away
and read up as much as you can about it in the shortest space of time
as you can.  Heh.

Anyway.  We all feel a bit better about the situation now.

Hopefully post-bone scan, they'll order a CT scan of the surrounding
area (and if they don't i've told dad to ask them why not!), when he
gets those results his prostate will have probably healed enough from
the biopsy to have another PSA and we'll be taking it from there.

Again, and I keep saying this, but thanks for all the discussion in
this thread.  I really appreciate it.

paul.
Steve Kramer - 14 Aug 2006 23:00 GMT
> His Gleason was G2 (GL 5-7).

I suspect his Gleason is reportable as a 7.  Gleasons are determined by
adding to scores together; one being the rating of the most present cancer
and the other being the rating of the second most present cancer.  It looks
like he might have give a Gleason for both halves.  It might be of some
interest to find out whether the 7 is a 3+4 or a 4+3.

> I get the feeling that he'll just try to push dad off with the
> hormones.  That was certainly the impression that my parents gave me
> when they got back from the hospital - that the specialist was talking
> up the hormone therapy and playing down removal of the prostate and
> radiotherapy.

Either he or you will have to get educated on PCa quickly.  However, hormone
therapy will give you some time to bring yourself up to date on PCa
treatment and also enough time to find a medical oncologist.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06, 6/06
PSA  .07 .05 .06 .09 .08 .132 .145
Casodex added daily 07/06
Non Illegitimi Carborundum

Alan Meyer - 14 Aug 2006 20:22 GMT
Paul,

One of the problem with this disease is that there is no universal
agreement on what is the right treatments.

There are many doctors - probably many more in the UK than in
the US, but some here too - who believe that primary treatment
for prostate cancer (surgery or radiation) does no real good.

Your Dad may be seeing one of those doctors.

It is true that some men get primary treatment and then die of
prostate cancer anyway.  It's also true that some men do not
get primary treatment and live on to die of something else.

In my humble and non-expert opinion, the key issues are:

1. Is the cancer confined to the prostate - where surgery or
   radiation can reach it?

2. Is the patient young enough that he might live 10, 15, or
   more years if his cancer doesn't kill him?

With a PSA below 10 there is a very good chance that the
cancer is confined to the prostate.  And at an age of 64,
assuming your Dad is otherwise in good health (back pain
is debilitating, but not life threatening), your Dad might well
live 10 or 20 more years - during which time the cancer may
well kill him if it is not treated.

So it seems to me that primary treatment IS indicated and,
unless there is evidence of metastasis, should be attempted.

My personal view is that, if the disease is confined to the
prostate, the success of treatment is highly dependent on
the skill of the surgeon or radiation oncologist.  A specialist
who is committed to his patients and his craft, and who treats
many PCa patients, often has a much higher successs rate
than a general surgeon or radiation oncologist who only does
a few prostate cases a year.

As to your question about getting hormone therapy now, I
think that can be a valid strategy.  It will shrink the prostate
and will temporarily slow or halt the progress of the disease,
giving you more time to investigate options.  HT is often
given as a preparatory treatment before radiation.  It is
sometimes but not often given before surgery.  I think the
theory is that it does not increase the survival rates for
surgery patients, but there is debate about that and I'm not
aware of it doing any harm - other than the normal unpleasant
effects of hormone therapy.

Best of luck.

   Alan
ron - 14 Aug 2006 21:59 GMT
Alan Meyer wrote...snip...:
> HT is often
> given as a preparatory treatment before radiation.  It is
> sometimes but not often given before surgery.  I think the
> theory is that it does not increase the survival rates for
> surgery patients, but there is debate about that and

> I'm not aware of it doing any harm

> - other than the normal unpleasant
> effects of hormone therapy.

Just a note, most surgeons don't like to use HT prior to prostatectomy
because hormones affect how the tumor attaches itself to adjacent,
non-cancerous tissue.  During surgery, excised cancerous tissue peels
off cleanly from adjacent healthy tissue.  However, use of HT affects
the cancerous tissue's ability to be easily removed.  This "tactile"
information is then lost and surgeons have a harder time identifying
the boundaries of the tumor(s)...ron
Alan Meyer - 15 Aug 2006 00:20 GMT
> Alan Meyer wrote...snip...:
>> HT is often
[quoted text clipped - 15 lines]
> information is then lost and surgeons have a harder time identifying
> the boundaries of the tumor(s)...ron

Thanks for that clarification.  Now that you bring it up, I
seem to recall reading that somewhere too.

There have been trials of HT before RP.  Apparently, a trial in Canada
found no benefit from 3 months of HT before RP.  However I think
another trial is either suggested or being organized (I wasn't sure which
from what I read) for 8 months of HT before RP.

The value of HT before RT seems to be in dispute.  IIRC different studies
have come up with different and seemingly contradictory results.
However I haven't seen anything that says HT before RT is in any
way harmful - except of course for whatever ways that HT is
harmful by itself.

   Alan
Steve Jordan - 14 Aug 2006 20:32 GMT
> Dad was disagnosed with T3 stage prostate cancer today.  The doctor
> gave him a booklet and told him to go away to choose the form of
[quoted text clipped - 6 lines]
> Surely a man so 'young' should be having more radical surgury?
>  
There is no good way for a patient to select a treatment (tx) unless he
has educated and empowered himself such that his decision is well-founded.

Some good advice has been given here.

I would add that the one book that virtually saved my life (Gleason 9,
etc.) is _A Primer on Prostate Cancer_, now in its second edition. Its
subtitle is, "The Empowered Patient's Guide." Co-authors are medical
oncologist and PCa specialist Stephen B. Strum, MD, and PCa warrior
Donna Pogliano.

Secondly, refer to the authoritative website of the Prostate Cancer
Research Institute at:
http://prostate-cancer.org/index.html
Go to the pages entitled, "Newly Diagnosed."

This patient, as have we all, has been drafted into a war against a
relentless enemy. It is necessary to prepare for combat by education on
the nature of the enemy. *That* is the next step. The task is difficult
but not impossible

Good luck. Let us know how it goes.

Steve J

"We must tailor the treatment to the nature of the disease. We must
listen to the biology."
-- Stephen B. Strum, MD
Bob C - 15 Aug 2006 13:47 GMT
Paul, I have read the many good replies of 8/14 and have little to add of a
medical nature, but I have been going down this road for almost six years
now and vividly remember being bogged down with information and facts and
figures and statistics in the beginning. Early on, in the learning process,
it would be nice to have just one road to follow, one course of action that
was appropriate for your specific situation, but the medical community is
not anywhere near being that far along. There are more questions than
answers, and some of the questions can be answered only by your Dad.

As you and your Dad begin this battle, it might be helpful to look early on
at the standard approaches, and the side effects associated with each, and
decide just how aggressively  he wants to fight this thing, what possible
side effects are worth risking. A cure may or may not be possible, but even
if not, surgery for the purpose of debulking is not totally out of the
question. That is the type of personal decision you have to make. Some men
will opt for fighting as aggressively as possible and let the SE's fall
where they may. Others will make an educated decision to temper their
treatment plans with a closer eye to quality of life issues.

My own battle began at age 55 with a psa of 55. A  mind boggling crash
course in pca told me that it's going to get me. I did the surgery, with its
side effects, and radiation with it's side effects, and several years of
Lupron with it's side effects, and now my psa has begun to rise again. More
drugs are coming up soon. And many more prayers. Has all of this prolonged
my life? Beats me, but right now, today, life is pretty good. It would be
devastating to me to  look back on my final day on earth and see that I
maybe could have done better by fighting a little harder.  This is just one
mans fight, against his specific cancer, and no way would I suggest that
anyone go down the same path. You have to decide what's right for you.

Keep getting educated, but try not to get bogged down with all of this
information, and by all means ask all the questions you want of this
newsgroup. It has been a huge help to me, both as a support group and as a
source of information. These guys have been there, and want to help. Best of
luck to you.
> Surely a man so 'young' should be having more radical surgury?
Bill - 15 Aug 2006 17:30 GMT
IMO telling a man he has PCa w/ G.S. somewhere between 2+3 and 4+3, and
making Tx decisions based on that, is malpractice. Indeed, that G.S.
range probably identifies 90% of all men diagnosed w/ PCa! It is too
general to be of value. Get the pathology report.

I.P., I do not think that Tx decisions are or should be heavily
weighted on clinical stage. We have had many men here who had high-G.S.
T1 PCa and, on the other hand, low G.S. T2 PCa. And that observation
has also extended into the pathological stage where clinical T1s become
T3s or worse. The main thing any man wants to know is whether his
disease is organ-confined or not - that primarily determines Tx
modality. And neither the DRE or even biopsy can tell you that. I don't
know how this guy's doctors can tell him he is stage 3 - at best they
can say T2c. Indeed, the 2001 Partin (clinical stage) tables do not
even go past T2c. And the difference in probability of organ-confined
disease between T2a and T2c is 81% to 73% w/ G.S. 5 to 6, and 64% to
51% w/ G.S. 3+4. While those may be statistically significant, I don't
think many men are going to decide on local vs. systemic Tx based on
those differences. From what I've seen and read, I want to know G.S.,
how many samples were affected and to what degree [this does not affect
staging], and pre-biopsy PSA level and DT. In my own case I was
diagnosed w/ G.S. 5 T2a, which is the lowest palpable stage. That was
good news and weighed in favor of local Tx. However, my PSA was 33. In
my case the low staging and G.S. caused me to have local Tx despite the
counter-indicative PSA. It turned out that I had pathological G.S. 7 T3
w/ SVI and positive margins - and systemic disease.

Bill Denton
RP 2/12/02
PSA .96
Memphis
Leonard Evens - 15 Aug 2006 20:32 GMT
> IMO telling a man he has PCa w/ G.S. somewhere between 2+3 and 4+3, and
> making Tx decisions based on that, is malpractice. Indeed, that G.S.
[quoted text clipped - 10 lines]
> know how this guy's doctors can tell him he is stage 3 - at best they
> can say T2c.

I believe that in certain cases, digital rectal examination and imaging
studies can indicate that T3 staging is highly likely.  At least that
was my impression from reading Scardino on the subject.  Also, the Sloan
Kettering nomogram lets you enter T3 as the stage.

> Indeed, the 2001 Partin (clinical stage) tables do not
> even go past T2c. And the difference in probability of organ-confined
[quoted text clipped - 14 lines]
> PSA .96
> Memphis
I.P. Freely - 18 Aug 2006 03:49 GMT
> I.P., I do not think that Tx decisions are or should be heavily
> weighted on clinical stage.

All I'm getting at is that if the specialists' consensus is that my
cancer is organ-confined, surgery is a sound option. If the consensus
includes mets, surgery is far less likely to help. G6 in my spine is a
much less operable disease than G8 confined to my prostate.

I.P.
 
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