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Medical Forum / Diseases and Disorders / Prostate Cancer / August 2006

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CyberKnife(c)

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NICK - 09 Aug 2006 21:03 GMT
Has anyone heard of this machine?
ron - 09 Aug 2006 21:26 GMT
> Has anyone heard of this machine?

Nick..It is a precision RT technique, typically used in cases were a
single tumor with a precise location exists, e.g. a brain tumor.  Since
PCa is usually multifocal, irradiation at a single spot is not normally
practiced...Best wishes and good health, ron
Steve Jordan - 09 Aug 2006 21:28 GMT
On August 9, NICK inquired:
>  Has anyone heard of this machine?
>  
Yes, but I don't know much about it. Google will produce 213,000 hits,
enough to keep Nick busy for a while  ;-)

Regards,

Steve J
NICK - 09 Aug 2006 22:44 GMT
NICK asked:

>>  Has anyone heard of this machine?

And Steve replied:

> Yes, but I don't know much about it. Google will produce 213,000 hits,
> enough to keep Nick busy for a while  ;-)

Originally for brain tumors, later FDA approved for lung cancer.

The CyberKnife facility was installed here June 12.  A radiation
Oncologist who is board certified by the American Board of Radiology
(so his business card says) is trying to get PCa patients to submit to
treatments.

If one visits the CyberKnife site, about all they'll see is a ton of
"breast pounding" and
"back patting" about how great this newfangled machine is.
Steve Jordan - 09 Aug 2006 23:30 GMT
On August 9, NICK replied:
>  Originally for brain tumors, later FDA approved for lung cancer.
>
[quoted text clipped - 7 lines]
> "back patting" about how great this newfangled machine is.
>  
FWIW, I understand that they claim that the procedure is "non-invasive."
*But* they must implant gold guide markers. That's invasive, in my view.
I have no problem with it except that the claim that it's non-invasive
is, to be charitable, misleading.

If Nick is seeking accuracy, IMRT is purty good. The very latest
improvement on IMRT is "IGRT" or Image-Guided Radiation Therapy, also
called tomotherapy. The "image" is generated by a CAT scan before each
daily session (x weekends & holidays) rather than ultrasound as with IMRT.

I've met (and referred two patients to) a rad onc who is very high on
IGRT. As well he should be; he bought two of the machines. One patient
is delighted. The other just completed the regimen last Friday, so it's
too early to know the result.

Regards,

Steve J
NICK - 10 Aug 2006 00:30 GMT
> FWIW, I understand that they claim that the procedure is "non-invasive."
> *But* they must implant gold guide markers. That's invasive, in my view.
> I have no problem with it except that the claim that it's non-invasive
> is, to be charitable, misleading.

2001-2005 they claimed "non-invasive" while referring to
treatment of brain tumors and lung cancer.  None of the
2006 literature -- March 7 is the first mention of prostrate
I could find -- uses the term "non-invasive".
Eric - 11 Aug 2006 03:29 GMT
>  Has anyone heard of this machine?

Hi,
Full disclosure, I am an engineer at the company that builds the
CyberKnife...

I wanted to point you to:

http://www.cksociety.org/

where there is some info on use of the CyberKnife on prostate cancer;
probably more useful than the www.accuray.com site which is run by the
marketing department (I will probably get phone calls...).

Expounding on some points in the other replies you had:
*  The CyberKnife is not limited to treating at a single location, it is
very versatile in its ability to point the radiation beam so it can
shoot/paint spherical targets, very irregularly shaped targets, targets
wrapped around critical structures and multiple targets in a single
treatment.

*  The system was FDA cleared in 8/01 (terminology, the FDA doesn't
*approve* a device like this).  The intended use is:

"To provide treatment planning and image guided stereotactic
radiosurgery and precision radiotheraphy for lesions, tumors and
conditions anywhere in the body where radiation treatment is indicated."

So doctors can use it for brain tumors, spine, lung, pancreas, bone,
prostate, etc.

*  IMRT is a way of shaping the beam from a conventional linear
accelerator to help it spare healthy tissue but it doesn't address the
difficulty of locating the tumor so you know where to point.  I think
most linear accelerator manufacturers have added x-ray imaging systems
at this point but, other than tomotheraphy, I believe they are only used
for initial alignment of the patient.  In the CyberKnife world, we know
that patients move during treatments, degrading the accuracy of delivery
unless you can compensate by imaging and adjusting during treatment.
The movement is, of course, dramatic for sites affected by the breathing
cycle, with the best example being the lung.

*  Doctors are almost always delighted by the equipment they have, after
all they have made a huge investment in training, time to gain
experience, and dollars to obtain.  How the medical industry operates
was one of the eye openers for me when I left the aerospace world for
the medical device world many years ago...  This isn't a slam against
any medical folks, just recognition of human nature.

Good luck,
Eric
 
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