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Medical Forum / Diseases and Disorders / Prostate Cancer / August 2006

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Is this a good thing?

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Slightly Unsure - 01 Aug 2006 00:05 GMT
Sorry to interrupt. I wont hang around and be a nuisance.

Some time back, a person I know accidentally discovered he had a slightly
elevated PSA count after pressuring his doctor about it. Anyway, cut a long
story short, he had an aggressive prostate cancer which was apparently not
far off breaking loose. So, obviously, as an overweight 51 year old, I got a
bit of a scare. It took me some time but I went for the PSA test - back in
February. I went for my results last week. My PSA was 0.98 which I thought
was excellent.

I was talking to yet another person I know, who is 70 and mentioned my 0.98.
He said he is 0.6. So, as this is my FIRST EVER PSA score, I thought it was
STILL good but now am not really 100% sure.

Can any of you who DO know let me know please? The doctor said that all it
really is is just a baseline so that when I next get one done, if it is 2,
we ask why. Medicine isn't very accurate when it comes to men's problems, is
it?
Bob Anthony - 01 Aug 2006 00:33 GMT
0.98 is not bad, but not great as going only by the numbers. BUT, that
may mean absolutely nothing as far as Psa is concerned. Anything can
increase one's psa's, from infections, to some kind of prostate massage,
to sex a day or so before the exam.
The psa system is a closed system similar to a pool pump. If the psa
rises, and at what velocity, then you can decide on what you're next
move may be. (new psa tests or biopsy).
If velocity exceeds .75 points as by consensus, then there is some
concern for further investigation. It does not mean prostate cancer
though. Recently, I've heard of .50 as substituting the .75 points.
0.98 is not terrible and it may mean nothing at all more than likely.

B.A.
Steve Jordan - 01 Aug 2006 00:42 GMT
> Sorry to interrupt. I wont hang around and be a nuisance.
>  
Fear not.

(snip)
> So, obviously, as an overweight 51 year old, I got a
> bit of a scare. It took me some time but I went for the PSA test - back in
> February. I went for my results last week.
Five months later? Huh? How much of a scare was that?
> My PSA was 0.98 which I thought was excellent.
>  
Correct. It was excellent.
> I was talking to yet another person I know, who is 70 and mentioned my 0.98.
> He said he is 0.6. So, as this is my FIRST EVER PSA score, I thought it was
> STILL good but now am not really 100% sure.
>  
Each of us is different. The test results of someone else are meaningless.

(snip)
> The doctor said that all it really is is just a baseline so that when I next get one done, if it is 2,
> we ask why.
He's right.
> Medicine isn't very accurate when it comes to men's problems, is it?
>  
That's why it's called an art. Which medics *practice*. And it really
isn't just "men's problems." At my last meeting with my cardiologist I
mentioned the fact that there's little uniformity of opinion re: PCa tx.
She laughed and said that it's the same in cardiology and other branches
of medicine.

Of course, there are medics who are scientists, but IMO they're few and
far between. And I have seen that scientists can be vicious when arguing
with one another. All we pts can do is study, learn, and take charge of
our tx. Anything short of that is a gamble on the professional
competence and attitude of our medics.

So much for philosophy.

Regards,

Steve J

"Flagrantly, we docs ignore the declaration of biology. We do this out
of ignorance, greed or both. The prime directive of the physician, the
real physician, is patient outcome, & not physician income (or ego)."
-- Stephen B. Strum, MD
ron - 01 Aug 2006 01:27 GMT
Slightly Unsure wrote...snip...
> So, obviously, as an overweight 51 year old, I got a
> bit of a scare. It took me some time but I went for the PSA test - back in
> February. I went for my results last week. My PSA was 0.98 which I thought
> was excellent.

> Can any of you who DO know let me know please? The doctor said that all it
> really is is just a baseline so that when I next get one done, if it is 2,
> we ask why. Medicine isn't very accurate when it comes to men's problems, is
> it?

SU...Your doc is right.  One point makes for the start of a baseline.
The rate of change of the PSA over time is usually the key.  PSA
measurement and digital rectal exam (DRE) are two simple ways to try
and screen for PCa.  Neither test is foolproof.  In the case of PSA,
there is no value above which you always have PCa, nor is there is
value below which you can't have PCa.  For reference, one study found
that for men 50-59, the median PSA is 0.80 ng/ml (+/- 95% range:
0.25-2.60).  Another study found that 10.1% of men with PSA  between
0.6-1.0 ng/ml have PCa...Best wishes and good health, ron
Leonard Evens - 01 Aug 2006 16:25 GMT
> Slightly Unsure wrote...snip...
>
[quoted text clipped - 17 lines]
> 0.25-2.60).  Another study found that 10.1% of men with PSA  between
> 0.6-1.0 ng/ml have PCa...Best wishes and good health, ron

Perhaps it should be added that some small number of prostate cancers
don't produce much PSA.  That explains why 10 percent of men with PSAs
less than 1 ng/ml might have prostate cancer.   In those cases the PSA
value doesn't result from the cancer.
Steve Kramer - 01 Aug 2006 01:59 GMT
> Sorry to interrupt. I wont hang around and be a nuisance.

> I was talking to yet another person I know, who is 70 and mentioned my
> 0.98. He said he is 0.6. So, as this is my FIRST EVER PSA score, I thought
> it was STILL good but now am not really 100% sure.

No need to apologize.  It is a very reasonable question.  The fact is, at
your age, 0.98 is a good first time PSA.  Relax and get on with your life.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06, 6/06
PSA  .07 .05 .06 .09 .08 .132 .145
Casodex added daily 07/06
Non Illegitimi Carborundum

Alan Meyer - 01 Aug 2006 04:28 GMT
> ...
> I was talking to yet another person I know, who is 70 and mentioned my 0.98. He said he
> is 0.6. So, as this is my FIRST EVER PSA score, I thought it was STILL good but now am
> not really 100% sure.
...

As others have said, .98 is just fine.

I've never heard or read anything by any cancer expert who said
otherwise, the most radical statement I've ever seen by any doctor
was that 2.5 might possibly show some cancer.  Most doctors
set the bar higher than that.

Some PSA is normal.  I'd say your 70 year old friend has an
unusually low PSA for his age, not that you have a high one.

   Alan
glassman - 01 Aug 2006 23:06 GMT
> Sorry to interrupt. I wont hang around and be a nuisance.
>
[quoted text clipped - 14 lines]
> we ask why. Medicine isn't very accurate when it comes to men's problems,
> is it?

 This is an interesting new era alright. One where folks won't trust their
docs, but will rely on the word of total strangers on a message board!

Signature

JK Sinrod
www.SinrodStudios.com
www.MyConeyIslandMemories.com

I.P. Freely - 02 Aug 2006 01:12 GMT
>  This is an interesting new era alright. One where folks won't trust their
> docs, but will rely on the word of total strangers on a message board!

Including ANONYMOUS strangers obviously hiding behind nom de plumes.

I. P. Freely, my a.s!  '-)
Steve Kramer - 04 Aug 2006 11:30 GMT
>  This is an interesting new era alright. One where folks won't trust their
> docs, but will rely on the word of total strangers on a message board!

I don't think a consensus here has ever been wrong.  I imagine Steve and
I.P., in particular, and probably several others, would say the consensuses
here have been more accurate than their initial doctors' recommendations and
treatments.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06, 6/06
PSA  .07 .05 .06 .09 .08 .132 .145
Casodex added daily 07/06
Non Illegitimi Carborundum

I.P. Freely - 04 Aug 2006 18:46 GMT
>>  This is an interesting new era alright. One where folks won't trust their
>> docs, but will rely on the word of total strangers on a message board!
[quoted text clipped - 3 lines]
> here have been more accurate than their initial doctors' recommendations and
> treatments.

I HOPE this forum's consensus on ADT SEs is wrong, that Steve's
statements (and my doctors') are closer to fact. This forum's
respondents to my ADT SE poll concurred with Strum and the PCRI, whereas
Steve and my docs painted a much less alarming picture, with one
exception: all those parties agree (some in words, some in evidence) on
the fatigue issue.

Beyond that, I'd have a hard time identifying this forum's consensus on
any topics. We seem to me to be all over the map on most topics, divided
in part by at least two factions: one group favors large-population
studies, facts and conclusions; the other prefers relegating life's
major decisions to their emotions. (Funny how similar politics and
health care are.)

I.P.
Steve Kramer - 05 Aug 2006 18:27 GMT
>>>  This is an interesting new era alright. One where folks won't trust
>>> their docs, but will rely on the word of total strangers on a message
[quoted text clipped - 13 lines]
> Beyond that, I'd have a hard time identifying this forum's consensus on
> any topics.

I think there is a consensus that:

1.  HT is the way to go when all else has failed
2.  The SEs are nothing to ignore
3.  Once begun, quitting HT is an option of the SEs are too bad.

Really, I think the only disagreement is how soon.
I.P. Freely - 06 Aug 2006 18:39 GMT
>  I think there is a consensus that:
>
[quoted text clipped - 3 lines]
>
> Really, I think the only disagreement is how soon.

1. Studies, symposium panel discussions among PC professionals and pts,
and some pts here disagree that ADT is always preferable to no tx after
everything else has failed. It depends heavily on the SEs each pt incurs.

3. Older pts need to be aware that quitting does not always stop the SEs.

I.P.
Steve Kramer - 06 Aug 2006 19:12 GMT
>>  I think there is a consensus that:
>>
[quoted text clipped - 9 lines]
>
> 3. Older pts need to be aware that quitting does not always stop the SEs.

El I.Pio, I know that I, Esteben, do not have your superior intellect and
education, but could it be that once again, you are angry at something else,
and are looking to muddle this issue?

Surely, you're not trying to make the argument that any patient may know,
prior to trying the treatment, what SEs they will incur.  Or, that older
patients should be more concerned or as concerned about the reversal of SEs
than that which they would, at that point, have already  and have come to
accept.
I.P. Freely - 07 Aug 2006 00:56 GMT
>> Steve Kramer wrote:
>>>  I think there is a consensus that:
[quoted text clipped - 4 lines]
>>>
>>> Really, I think the only disagreement is how soon.

>> 1. Studies, symposium panel discussions among PC professionals and pts,
>> and some pts here disagree that ADT is always preferable to no tx after
>> everything else has failed. It depends heavily on the SEs each pt incurs.
>>
>> 3. Older pts need to be aware that quitting does not always stop the SEs.

> El I.Pio, I know that I, Esteben, do not have your superior intellect
> and education, but could it be that once again, you are angry at
> something else, and are looking to muddle this issue?

Just the opposite on both counts: just trying to CLARIFY the facts (and
still totally puzzled as to why some folks attribute emotions to facts.
Facts are our FRIENDS when they help us deal with other, unwelcome,
facts.)

> Surely, you're not trying to make the argument that any patient may
> know prior to trying the treatment, what SEs they will incur.

KNOW? For CERTAIN? No. But BELIEVE they will incur some of the VIRTUALLY
certain SEs? Yes. I think it's folly to assume we could escape SEs with
statistical likelihoods exceeding 0.9 or PCRI expectations pegged at
100% occurrence. Thus #3 above.

> Or, that older patients should be more concerned or as concerned about
> the reversal of SEs than that which they would, at that point, have
> already and have come to accept.

If they already have SEs and know for a fact they are irreversible, I
agree that concern is probably useless. But IMO it benefits pts
considering ADT to be aware before beginning it that:
a. Some of the virtually certain SEs (they were EXTREMELY valuable in my
ADT decision) may become permanent.
b. If they decide early enough in ADT trials that their SEs are
intolerable, as many do, their odds of reversibility decline with age
and with greater time on ADT.

I don't know at what age the threat of irreversibility becomes
significant, but if I were "old" and contemplating ADT, I'd find out.

I.P.
glassman - 05 Aug 2006 03:16 GMT
>>  This is an interesting new era alright. One where folks won't trust
>> their docs, but will rely on the word of total strangers on a message
[quoted text clipped - 4 lines]
> consensuses here have been more accurate than their initial doctors'
> recommendations and treatments.

   Yeah but which 8 members will happen to respond, and what's a
consensus..... is 5 of 8 enough?  I never said that our opinions weren't
wonderfully accurate, only commenting on those that seek us out after
getting a clear response from their learned docs.

Signature

JK Sinrod
www.SinrodStudios.com
www.MyConeyIslandMemories.com

Pops - 02 Aug 2006 14:21 GMT
> Sorry to interrupt. I wont hang around and be a nuisance.
>
[quoted text clipped - 14 lines]
> we ask why. Medicine isn't very accurate when it comes to men's problems, is
> it?

Take a chill pill. You're just fine!

Get an annual checkup, including PSA. Deal with ALL the information you
get back, but don't fixate on it.

(You didn't say wether there is any family history, but even then
you're still fine!!)

I'm sure you've got much bigger fish to fry!!
 
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