Medical Forum / Diseases and Disorders / Prostate Cancer / July 2006
Post Op psa level
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dakine - 29 Jul 2006 05:47 GMT on tuesday i had my first PSA level done since i had a radical retropubic prostatectomy done in early march. the current level is 0.1...it seems that this level should be 0, since i have no gland to secrete any antigen. does this mean that there has been metastasis and i still have cancer and that it will find a spot to stop and grow? i wont be able to ask my doc till monday and dont want to wait all weekend for a response. tks and aloha
Buck - 29 Jul 2006 06:01 GMT My understanding is that 0.1 is the lowest level that can be measured and less than 0.1 is the statistical equivalent of zero.
Steve Jordan - 29 Jul 2006 07:54 GMT On July 28, Buck replied to "dakine":
> My understanding is that 0.1 is the lowest level that can be measured > and less than 0.1 is the statistical equivalent of zero. > It is likely the lowest level that the sensitivity of the particular test will measure.
The ultrasensitive PSA test results can be reported as low as "<0.01".
In and of itself, one PSA test means little. It's the results of a series that give one a basis upon which to judge how things are going.
Relax.
Regards,
Steve J
Steve Kramer - 29 Jul 2006 11:57 GMT > on tuesday i had my first PSA level done since i had a radical > retropubic prostatectomy done in early march. the current level is [quoted text clipped - 3 lines] > wont be able to ask my doc till monday and dont want to wait all > weekend for a response. tks and aloha The first PSA you want to see is < 0.1 (less than 1/10th of a nanogram). For assays that are not ultra-sensitive, that is considered "virtually undetectable". You're doing well!
It would be a very good idea for you to start researching. Dr. Patrick Walsh's Guide to Surviving Prostate Cancer and Dr. Peter Scardino's Prostate Book are good places to start. www.phoenix5.org is a good website. All these will give you a fundamental understanding and expectations. Then you can go on to bigger and better research. This is a lifelong and life-altering disease and you are best able to handle it if you're prepared.
Welcome to the family.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05, 2/06, 6/06 PSA .07 .05 .06 .09 .08 .132 .145 Casodex added daily 07/06 Non Illegitimi Carborundum
ron - 29 Jul 2006 14:00 GMT > on tuesday i had my first PSA level done since i had a radical > retropubic prostatectomy done in early march. the current level is [quoted text clipped - 3 lines] > wont be able to ask my doc till monday and dont want to wait all > weekend for a response. tks and aloha There are other organs in addition to the prostate that produce very small amounts of PSA, so PSA will never be "0"; even women have measurable PSA's. Did someone call you on the phone and tell you your results or did you receive a copy of the test results? If the latter, is there a "<" (less than) symbol by the zero as in "<0.1", and what test does the report say was used? The standard test cannot read accurately below 0.1 ng/ml of PSA, so the "<0.1" is the best result (considered undetectable) you can achieve with this test. As others have mentioned the ultrasensitive test can read lower (<0.04, <0.01 and <0.003, depending on the test and the lab). If the result was reported as "0.1" this would mean that some PSA was actually detected. But even in this case, sometimes the lab will make an error on the report by ommitting the "<" symbol...Best wishes and good health, ron
Tee Doubleyou - 29 Jul 2006 18:59 GMT >>There are other organs in addition to the prostate that produce very >small amounts of PSA, so PSA will never be "0"; even women have >measurable PSA's. ----------------------cut--------------------------------------------- ..Best wishes and good health, ron
What are those "other organs"? Can you name a few, please? Tad -- Verba volant, scripta manent.
ron - 29 Jul 2006 19:42 GMT Tad...PSA has been found to be present in very low levels in epithelial cells of the trachea, thyroid gland, mammary gland, salivary gland, pancreatic exocrine glands, jejunum, ileum, epididymis, seminal vesicle and urethra, as well as in Leydig cells and epidermis pituitary tissue and adrenal tissue. It is found in many tumors (e.g. lung, colon, ovary, liver, kidney, adrenal and paroria). As expected from the above, PSA has also been found in women (breast and ovarian tissue). PSA in women can occasionally exceed 0.1 ng/ml depending upon BCa status, age, time in the menstrual cycle, etc...Best wishes and good health, ron
> >>There are other organs in addition to the prostate that produce very > >small amounts of PSA, so PSA will never be "0"; even women have [quoted text clipped - 6 lines] > -- > Verba volant, scripta manent. Steve Kramer - 29 Jul 2006 21:56 GMT Hey, Tee Dub! Haven't heard from you in a long while. How's the PSA as you inch towards the 3-year mark?
I'm going to read forward. If your question isn't answered, I'll look it up. I know right where to go in Walsh's book.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05, 2/06, 6/06 PSA .07 .05 .06 .09 .08 .132 .145 Casodex added daily 07/06 Non Illegitimi Carborundum
>>>There are other organs in addition to the prostate that produce very >>small amounts of PSA, so PSA will never be "0"; even women have [quoted text clipped - 6 lines] > -- > Verba volant, scripta manent. Dennis D - 30 Jul 2006 10:13 GMT >on tuesday i had my first PSA level done since i had a radical >retropubic prostatectomy done in early march. the current level is [quoted text clipped - 3 lines] >wont be able to ask my doc till monday and dont want to wait all >weekend for a response. tks and aloha The surgeon could also have left some benign prostate tissue behind. This could result in the production of a small but detectable PSA level of 0.1. My own PSA has been 0.1 or 0.2 over a three year period following RP.
Dennis
Bill - 31 Jul 2006 16:14 GMT But, Dakine, the bottom line is that if your PSA result was actually .1 (w/o the <), that is detecable PSA and is not what you want to have. It does NOT mean you have a recurrence at all, much less metastatic disease, but it is a signal to watch it carefully. Insist on ultrasenstive testing and get a copy of the lab result - do not rely on verbal reporting.
The adrenal glands alss produce PSA. The existence of benign sources is why most doctors do not deem a biological failure until .2.
Bill Denton RP 2/12/02 PSA .93 Memphis
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