Medical Forum / Diseases and Disorders / Prostate Cancer / May 2006
atypia, diet and supplements
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devajayapal@gmail.com - 26 May 2006 15:43 GMT yesterday evening my doctor called with the results of my biopsy (provoked by psa 8.8, free psa 19.5). there was no cancer however he said that there were atypia cells and that i should re-biopsy in 4-6 months and that the chances of cancer showing up was 40%. any feedback on this? also, thoughts on diet and supplements to reduce these odds? many thanks jay
Steve Kramer - 26 May 2006 17:33 GMT How many needles were used, Jay?
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05, 2/06 PSA .07 .05 .06 .09 .08 .132 Non Illegitimi Carborundum
> yesterday evening my doctor called with the results of my biopsy > (provoked by psa 8.8, free psa 19.5). there was no cancer however he [quoted text clipped - 3 lines] > many thanks > jay devajayapal@gmail.com - 28 May 2006 06:10 GMT devajayapal@gmail.com - 30 May 2006 14:30 GMT steve do you mean how many snips were taken in doing the biopsy? 12 or did i not understand the question. jay
I.P. Freely - 26 May 2006 20:30 GMT > yesterday evening my doctor called with the results of my biopsy > (provoked by psa 8.8, free psa 19.5). there was no cancer however he [quoted text clipped - 3 lines] > many thanks > jay Even if there were, any PC you have began growing decades ago; a few frog's lips and pomegranate smoothies ain't gonna halt your cancer in 4-6 years, let alone 4-6 months. At best it might artificially lower your PSA, HIDING any PC you may have.
I.P.
juniper - 29 May 2006 20:27 GMT > yesterday evening my doctor called with the results of my biopsy > (provoked by psa 8.8, free psa 19.5). there was no cancer however he [quoted text clipped - 3 lines] > many thanks > jay Jay,
Its so complicated. Biopsies are not all that accurate. My husband showed very tiny amounts of cancer in 2/10 cores but it turns out that cancer was extensive throughout and outside his prostate (his PSA was in the 20s). So it would be easy to miss cancer in a biopsy. You can't really say you *do* or *don't* have prostate cancer with those results. The only thing that would be unequivocal would be if it did find it.
I'm assuming you know about getting a 2nd opinion on the biopsy samples? From a PCa specialist pathologist.
The thing is, you need lots of information, sorting through it to make an educated guess about the liklihood. The free PSA is iffy, huh? Drag. So far, all we know (a PSA of 8.8, no dates, and a biopsy that did not confirm cancer) are iffy. Why don't you post your history, so the guys in the group have something to look at as far as your current information. You would be more likely to get useful responses. This would mean 1. List all your PSA tests, month, year, and #. What did your DREs show? 2. Post the results of your pathology report from the biopsy. 1 small % of atypia cells in one sample might be different from atypia found throughout.
As far as diet and supplements, you can look at www.lef.org and the site below. The body does fight and kill cancer cells, and I think you can help it do that even now, even if you did have PCa. It may not be enough by itself to get all the cancer, if you do have cancer, but if you get even a % increase in chances, go for it. It only makes sense to do all you can, and to give your body the tools it needs for health. I disagree that going on a healthy diet will only mask PSA. Many men have managed PCa and PSAs with diet, some more or less successfully. Can Diet Really Control Prostate Cancer? http://www.prostate-cancer.org/education/nutrprod/ScholzBlum_Nutrition_Prostate_ Cancer.html or http://tinyurl.com/hmtyh
Regards, laurel
devajayapal@gmail.com - 30 May 2006 14:35 GMT laurel this is very helpful. when you refer to a second opinion do you mean a second opinion of someone reading the pathology report or a second opinion of smeone seeing the actual biopsies under a microscope. i'll post the details of the report as you have suggested when i get a moment. many thanks jay
juniper - 30 May 2006 15:43 GMT > laurel > this is very helpful. when you refer to a second opinion do you mean a [quoted text clipped - 4 lines] > many thanks > jay A second opinion of a pathologist who specializes in prostate cancer. He will look at the biopsies under a microscope. Your lab will send the samples including the paraffin blocks to the specialist lab, who re-assesses it completely. When they do the biopsies, they put the samples inside paraffin to preserve it, and then take slices of that to look at the samples.
Jay, this is of particular interest to you because of the urology link that Steve posted that said only a small percent of "atypical" diagnoses are confirmed on 2nd opinions. To me, that means that they must usually find a different diagnosis--maybe cancer?-- when looked at by a specialist.
See http://psa-rising.com/medicalpike/biopsyopinion120199.htm See also http://www.prostate-cancer.org/tools/forms/biopsy_report.html
A list of specialists is here http://www.prostate-cancer.org/resource/special.html#pathology
Essentially, you just give the lab that has your biopsy a written release to send the samples INCLUDING THE PARAFFIN BLOCKS to the pathologist you choose. This should be a very easy, one-step procedure on your part. However, when my husband requested this from Mayo, they had a fit. It took multiple phone calls, etc. Call the lab you choose and ask them exactly what they need. If you email me I can send you the fax we used to request the samples and paraffin blocks.
Keep working, Jay, you are on the right track. I'm glad you posted your situation here.
laurel
devajayapal@gmail.com - 31 May 2006 12:48 GMT laurel thanks so much for your kind replies. i'm betwixt and between on this thing. speaking to my urologist he seems comfortable with my taking another psa test in september and in all likelihood waiting until next year to do another biopsy. since there is no clear cut diagnosis of cancer cells things would at the very least be moving very slowly. i may investigate your suggestion, however, to have a pathologist who specializes in prostate cancer to have a look. as i am with kaiser out here the red tape will be onerous so please send me the fax that you used to devajayapal@gmail.com. cheers jay
> > laurel > > this is very helpful. when you refer to a second opinion do you mean a [quoted text clipped - 36 lines] > > laurel Steve Jordan - 29 May 2006 23:41 GMT On May 26, Jay inquired:
> yesterday evening my doctor called with the results of my biopsy > (provoked by psa 8.8, free psa 19.5). there was no cancer however he > said that there were atypia cells and that i should re-biopsy in 4-6 > months and that the chances of cancer showing up was 40%. any feedback > on this? (snip)
On May 23, Jon Epstein, MD, presented a paper at the AUA meeting entitled, "Significance of PIN, Atypia and Atrophy on Prostate Biopsy."
Jay might find it to be of interest. See: http://www.urotoday.com/prod/contents/common/print.asp?cat=prosCan&sid=&tid=&aid=4988
Or, better: http://tinyurl.com/p5d56
Regards,
Steve J
juniper - 30 May 2006 00:01 GMT great little piece of information.
> On May 26, Jay inquired: > > yesterday evening my doctor called with the results of my biopsy [quoted text clipped - 15 lines] > > Steve J Alan Meyer - 30 May 2006 00:37 GMT > ... > On May 23, Jon Epstein, MD, presented a paper at the AUA meeting entitled, "Significance > of PIN, Atypia and Atrophy on Prostate Biopsy." > ... If I read that article correctly (I'm not sure I did), it seemed to be saying that PIN by itself is not dangerous, but it may indicate that cancer cells are nearby - though the likelihood is that they are not.
Is that right?
Alan
juniper - 30 May 2006 03:07 GMT > > ... > > On May 23, Jon Epstein, MD, presented a paper at the AUA meeting entitled, "Significance [quoted text clipped - 4 lines] > saying that PIN by itself is not dangerous, but it may indicate that > cancer cells are nearby - though the likelihood is that they are not. This is how I read it. Well, "atypia" not PIN. Are they the same thing, or different?
> Is that right? > > Alan I saw a distinction between low grade PIN and high grade PIN. Low grade PIN is not reproducable (on another biopsy?) and is rarely associated with cancer.
Two things stood out: "Better sampling on rebiopsy results in an almost 2-fold increase in finding CaP" AND (this is a GOOD reason for a 2nd opinion on the samples) "He found only 37% of his second opinion pathology reviews of atypia sent at the request of the patient or clinician were confirmed as atypia."
Meaning, I presume, that some of them are confirmed as something else, like maybe cancer?
laurel
Alan Meyer - 30 May 2006 00:46 GMT > yesterday evening my doctor called with the results of my biopsy > (provoked by psa 8.8, free psa 19.5). there was no cancer however he [quoted text clipped - 3 lines] > many thanks > jay There are many opinions about diet and prostate cancer, but few hard facts. A lot of research has been published that says that putting such and such a chemical in a test tube with cancer cells kills off some of the cancer. Then there are experiments with mice where some cancer is killed with some supplements.
But studies in people are less conclusive. Knowing that a particular supplement kills cancer cells in a test tube or a mouse doesn't prove it will in humans, in part because many things can happen to the supplement that keep it from affecting, or even reaching, the cancer cells in humans.
Nevertheless, I believe in playing the odds. Claims have been made for lycopene (e.g., in tomato juice and watermelon), vitamin E, selenium, EGCG, turmeric and some other supplements with good support from test tube and mouse studies. As long as the supplements and dosages are safe (for example vitamin E and selenium are _not_ safe when taken in very large quantity) why not take them? They don't cost a lot and some (lycopene, EGCG from green tea, turmeric) have been used, apparently very safely, for centuries.
I think it was Steve Jordan who once said on this newsgroup that in any given patient there is a certain rate of cell division and growth among cancer cells, and a certain rate of cell death among cancer cells. If the two are close, maybe we can tip the scales one way or the other with proper diet and lifestyle.
Alan
Steve Kramer - 30 May 2006 02:38 GMT > Nevertheless, I believe in playing the odds. Claims have been > made for lycopene (e.g., in tomato juice and watermelon), vitamin > E, selenium, My GP asked be to 86 the Vit E. Said it was shown to be bad for hearts.
Tough decision. Heart attack or PCa.
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