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Medical Forum / Diseases and Disorders / Prostate Cancer / May 2006

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Reduction of Paclitaxel-induced Peripheral Neuropathy with Glutamine

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juniper - 06 May 2006 03:17 GMT
http://clincancerres.aacrjournals.org/cgi/content/full/7/5/1192

click on "Full Text" pdf on the right-hand menu
Alan Meyer - 06 May 2006 18:14 GMT
> http://clincancerres.aacrjournals.org/cgi/content/full/7/5/1192
>
> click on "Full Text" pdf on the right-hand menu

Being interested in this sort of thing, I did a few web searches
on glutamine.

It turns out that, although the body normally makes all the glutamine
it needs, when the body is under stress, it cannot always make
enough.   Weight lifters use glutamine as a supplement because
they appear to need more than can be produced after heavy
weight lifting.

It is very safe.  You can buy supplements over the counter.  It
is also found in the following foods: cabbage, beets, beef,
chicken, fish, beans, and dairy products.

According to one article I read, people have taken up to 10 grams
per day without ill effects, though it is possible to get too much of
it if it is directly injected into the body.
(http://www.whfoods.com/genpage.php?tname=nutrient&dbid=122)

I hope it helps Steve.

   Alan
juniper - 07 May 2006 01:17 GMT
> http://clincancerres.aacrjournals.org/cgi/content/full/7/5/1192
>
> click on "Full Text" pdf on the right-hand menu

In addition to preventing/minimizing neuropathy, it appears that
glutamine might increase the effectiveness of taxene chemotherapies.

Does anyone know if it matters if you take glutamine or l-glutamine?  I
read opinions both ways.
Alan Meyer - 07 May 2006 04:25 GMT
> Does anyone know if it matters if you take glutamine or l-glutamine?  I
> read opinions both ways.

The L (Leva, Greek for "left") and D (Dextro, Greek for "right")
forms of amino acids are isomers of each other.  They are
compounds with identical chemical formulas, but in one case
a particular functional group within the molecule is found on
the left side when viewed in a certain orientation and in the
other case the same functional group appears on the right
side when viewed in the same orientation.

According to my organic chemistry book, almost all of the
amino acids found in humans and other living organisms are
the L form.  So it's the L form that you want.

It may well be that when you buy something sold as just
"Glutamine", it's also the L form.  That's the form that's going
to be derived by processing beans or cabbage, or whatever
they process to get it.  It may actually be the only form you
can buy even if it's not labeled that way.

I imagine that most of the companies that sell supplements
don't really know what they're selling.  Some of them probably
buy chemicals in bulk and put them in pills.  Some probably
don't even do that, they just buy them in pills, maybe even in
bottles, with the contractor putting the label on that's provided
by the seller.

I think it's always a good idea to buy from some sort of name
brand organization that you have reason to believe stands
behind what they sell and actually knows what's inside.  However
I'm not sure what the best way to find such sellers is.

   Alan
juniper - 07 May 2006 06:12 GMT
> I think it's always a good idea to buy from some sort of name
> brand organization that you have reason to believe stands
> behind what they sell and actually knows what's inside.  However
> I'm not sure what the best way to find such sellers is.

In this case,
http://pfrc.med.nyu.edu/handouts/pdf/medic/pfrc02-000023.pdf recommends
Cambridge Nutraceuticals.  I haven't called them yet, it was Friday and
they were closed when I found this.
Alan Meyer - 07 May 2006 18:45 GMT
>> I think it's always a good idea to buy from some sort of name
>> brand organization that you have reason to believe stands
[quoted text clipped - 5 lines]
> Cambridge Nutraceuticals.  I haven't called them yet, it was Friday and
> they were closed when I found this.

I'll add them to my list of approved vendors.

I recall a posting from Vanilla Tooth in this newsgroup that I just located.
It was regarding purity of fish oil supplements.  He wrote:

> ConsumerLab.com regularly tests supplements off the shelf. They
> recently tested fish oil. Swanson and Puritan's Pride are two
> brands that always pass for potency and purity , and did so on
> the fish oil review.

I think he meant that Swanson's and Puritan's Pride pass tests for
all their supplements, not just fish oil.

   Alan
juniper - 07 May 2006 06:13 GMT
> According to my organic chemistry book, almost all of the
> amino acids found in humans and other living organisms are
[quoted text clipped - 5 lines]
> they process to get it.  It may actually be the only form you
> can buy even if it's not labeled that way.

Thanks for the information, Alan, particularly this part.
 
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