Taxol (paclitaxel) versus Taxotere (docetaxel) for HRPC/AIPC

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PHD1993 - 29 Apr 2006 15:15 GMT

Just interested in finding references which compare and contrast treatment
with paclitaxel to treatment with docetaxel.

Would like to find research or overview articles that compare these two
taxanes with respect to response rate (PSA drops of more than 50%),
mean/median duration of response, and mean/median overall survival.

Comparisons between dosing every 4 weeks versus dosing at a lower level
every week for 3 weeks with 1 week off.

PCa went HRPC/AIPC with PSA doubling time of 59 days (from 0.2 ng/mL last
fall to 1.2 ng/mL at end of March - compared to PSA at initial diagnosis in
June 2000 of 0.5). Started low level paclitaxel (80 mg/m2) every week for 3
weeks with next Tuesday being my day of rest.

I can find several articles but nothing with direct comparisons - and the
articles I can find present results in differing manners. Recent articles
seem to point to docetaxel instead of paclitaxel - comments?

Thanks,

Sam Hutcheson (PHD1993)

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juniper - 29 Apr 2006 18:58 GMT

> Just interested in finding references which compare and contrast treatment
> with paclitaxel to treatment with docetaxel.

I found this. link to the pdf article:
http://theoncologist.alphamedpress.org/cgi/reprint/9/suppl_2/24. link
to index for article
http://theoncologist.alphamedpress.org/cgi/content/full/9/suppl_2/24.
It is a breast cancer study. Breast cancer and prostate cancer act
alike in many ways, so... since there's more breast cancer research, I
mine it for clues. That link is to a PDF file of the article, not just
the abstract.

I don't know if this vivisimo search is helpful or not, I haven't
looked at it.

> Would like to find research or overview articles that compare these two
> taxanes with respect to response rate (PSA drops of more than 50%),
> mean/median duration of response, and mean/median overall survival.
>
> Comparisons between dosing every 4 weeks versus dosing at a lower level
> every week for 3 weeks with 1 week off.

I'll look and see if I can find anything. I did find a study of
doxetaxel that the effectiveness of 21 day dosage was 2-3 times as
effective as the weekly. (I found another that said weekly dosing was
effective but gave no #s, studies, or backups, it was more a blurb for
the product.)

> I can find several articles but nothing with direct comparisons - and the
> articles I can find present results in differing manners. Recent articles
> seem to point to docetaxel instead of paclitaxel - comments?

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juniper - 29 Apr 2006 19:34 GMT

> I don't know if this vivisimo search is helpful or not, I haven't
> looked at it.

forgot the link

http://tinyurl.com/rvor5

http://vivisimo.com/search?query=paclitaxel+docetaxel+compare&v%3Aproject=vivisi
mo-com&v%3Asources=MSN%2CNetscape%2CLycos%2CLooksmart%2CFindWhat&x=59&y=10

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juniper - 29 Apr 2006 19:08 GMT

good site, sign up:
http://www.nice.org.uk/page.aspx?o=309509
http://www.nice.org.uk/page.aspx?o=280912

these are various cancers not PCa:
http://annonc.oxfordjournals.org/cgi/content/full/14/11/1640
http://jncicancerspectrum.oxfordjournals.org/cgi/content/full/jnci;96/22/1682
click the PDF link to get the full article

> Just interested in finding references which compare and contrast treatment
> with paclitaxel to treatment with docetaxel.
[quoted text clipped - 18 lines]
>
> Sam Hutcheson (PHD1993)

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