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Medical Forum / Diseases and Disorders / Prostate Cancer / April 2006

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free psa %

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devajayapal@gmail.com - 22 Apr 2006 01:39 GMT
i am 67 years old and for 6 years my psa was stable at around 6.7. i
had had biopsies 6 and 7 years ago and no cancer showed up. within the
last month my psa jumped to 8.5 and, on retesting 8.8 with a free psa
of 19.3%. i'm now scheduled for a biopsy in may. my urologist has
placed the odds at about 30% chance of cancer but dancing around the
internet it seems as if there are mixed messages about these free psa
readings. can anyone shed some light on the true meaning of this
combination of results?
many thanks
jay
ron - 22 Apr 2006 02:29 GMT
Jay...Do you know the approximate size of your prostate from past
biopsies?  Where abouts do you live?  If you're near a color-doppler
ultrasound expert, a targeted biopsy might be the way to go.  Do you
also suffer from BPH?

If your prostate were around 80-100cc in size, all of your PSA could be
produced from healthy tissue.  Free PSA>25% is often indicative of a
non-cancerous condition, while fPSA<15% is somewhat suggestive of
prostate cancer; the 15-25% range is a bit of a gray area, but there
are no hard and fast rules or numbers for this...Ron
devajayapal@gmail.com - 22 Apr 2006 17:44 GMT
ron
thanks so much for your reply. as my biopsy was 7 years ago i really
don't know the size of my prostate.  we live in the san francisco area
and use kaiser. that is where my next biopsy will take place.  they do
use ultrasound but i'm not sure about the color-doppler aspect. i do
know that the technology for biopsy has changed radically in the past 7
years and i think kaiser is pretty current. a good friend is going to
costa rica next week to have ultrasound treatment for his prostate
cancer.
cheers
jay
ron - 22 Apr 2006 18:26 GMT
Jay...There are 2 top-notch ultrasonographers in your neck of the
woods, one is in your backyard.  They are:

Duke K. Bahn MD
Medical Director, Department of Radiology
Prostate Institute of America
Community Memorial Hospital of San Buenaventura
168 N. Brent Street, Suite 402
Ventura, CA 93003
888-234-0004
805-585-3082
Fax: 805-641-3965
dkbahn@cmhhospital.org

Katsuto Shinohara MD
1600 Divisadero Street, 3rd floor
UCSF
San Francisco, CA 94115
Tel:415-476-1611
Fax:415-476-8849
kshinohara@urol.ucsf.edu
Assistant, Mary, at 415 353 9877

Bahn uses the color-doppler and Shinohara uses MRI (with a 3T magnet)
with spectroscopy.  Both techniques allow you to see the entire
prostate and even probe for extracapsular extension.  If they see
something, they do a targeted biopsy, otherwise they usually just give
you a clean bill of health and skip the biopsy.  With the standard
ultrasound-guided biopsy it is harder to visualize the prostate than
with color-doppler or MRI.  In fact, certain areas of the prostate that
can contain cancer are not normally targeted in the standard 12 core
ultrasound-guided biopsy.  So particularly if you have a large prostate
and have had previous negative biopsies, it might be an option woth
considering, to step up to these more sensitive methods.  Also if there
is any breast or prostate cancer in your family, this would be another
reason to have an expert involved at this time.  BTW, I'm assuming your
DREs have been negative...Best wishes and good health, Ron
devajayapal@gmail.com - 23 Apr 2006 02:01 GMT
ron
this is very helpful. however, i don't know what a dre is. i think i'll
try to track down shinohara on monday (we're far, far away from bahn
and ventura). i believe kaiser offers the standard 12 core. i don't
know what the cost of the mri might be but it is certainly worth
checking out. i'm a very healthy, athletic and sexually active guy of
67 so there is an awful lot at stake for me here.  i may have mentioned
that a good friend of  mine is headed to costa rica thursday for
ultrasound treatment of his pca. seems like a resonable alternative if
a low gleason cancer turns up.
j
juniper - 23 Apr 2006 07:33 GMT
> ron
> this is very helpful. however, i don't know what a dre is. i think i'll

A DRE is a digital rectal exam.  It is just the doctor sticking his
finger in your butt and feeling your prostate to see if it is normal.

> checking out. i'm a very healthy, athletic and sexually active guy of
> 67 so there is an awful lot at stake for me here.  i may have mentioned
> that a good friend of  mine is headed to costa rica thursday for
> ultrasound treatment of his pca. seems like a resonable alternative if
> a low gleason cancer turns up.

There is a lot at stake.  You should be getting all your medical
reports as they are created, and keeping them.  So that, for instance,
if you want to know the size of your prostate, you can look at the
ultrasound from that earlier biopsy.  You might need to know if your
prostate is larger now, for instance.  Saves a lot of time at the next
doctor, also.
Steve Kramer - 23 Apr 2006 12:17 GMT
> ron
> this is very helpful. however, i don't know what a dre is. i think i'll
[quoted text clipped - 7 lines]
> a low gleason cancer turns up.
> j

Unless you have done a lot of research on the topic, Jay, you should not yet
be considering one treatment over another.  There are many treatments and
several side effects for each.  At your age and condition, all of the
treatments are in play.  Some have a track record on which you may rely;
some do not.  Please be careful in how you choose.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06
PSA  .07 .05 .06 .09 .08 .132
Non Illegitimi Carborundum

ugghle - 23 Apr 2006 21:12 GMT
> Jay...There are 2 top-notch ultrasonographers in your neck of the
> woods, one is in your backyard.  They are:
[quoted text clipped - 33 lines]
> reason to have an expert involved at this time.  BTW, I'm assuming your
> DREs have been negative...Best wishes and good health, Ron

The MRSI is best done before any biopsies
devajayapal@gmail.com - 25 Apr 2006 01:20 GMT
Spoke to my urologist today to ask if a mri with spectroscopy would be
advisable prior to a decision on a biopsy (I had called dr.
shinohara's office at ucsf, an expert in this area, but have not
received a callback yet). My guy at kaiser said the mri is only used
for people already diagnosed with cancer and would not be a sibstitute
for a biopsy. Does this ring true?
devajayapal@gmail.com - 25 Apr 2006 01:21 GMT
ron
Spoke to my urologist today to ask if a mri with spectroscopy would be
advisable prior to a decision on a biopsy (I had called dr.
shinohara's office at ucsf, an expert in this area, but have not
received a callback yet). My guy at kaiser said the mri is only used
for people already diagnosed with cancer and would not be a sibstitute
for a biopsy. Does this ring true?
jay
ron - 25 Apr 2006 01:33 GMT
Jay...Your uro's view does ring true in the following sense.  An MRI or
color-doppler ultrasound, will reveal any areas suspicious for PCa
within the prostate.  If suspicious areas are identified than a
targeted (rather than random) biopsy can be performed as a next step.
If no suspicious areas are seen, then a biopsy is not recommended.  At
least that's how Dr. Fred Lee plays it out.

So the MRI or cdus can be viewed as another information gathering step
prior to a biopsy.  This information would allow you and your doc to
make a more informed decision on the need for a biopsy, and, if you
decide to proceed with a biopsy, increase the odds that it will be
meaningful...Ron
devajayapal@gmail.com - 25 Apr 2006 15:55 GMT
ron
i can't tell you how much i appreciate your input. this is using the
internet tool at its best. friday off to new york for some r and r and
will carry on when i return.
cheers
jay
Steve Kramer - 22 Apr 2006 12:23 GMT
That's a fairly high PSA, Jay, but if your normal PSA is 6 to 7, it just
might be that that is what  your prostate produces.  The freePSA was a good
choice, but unfortunately put you right in no man's land.  If it had been
over 25% you're good.  Under 15%, not good.  But 19.3%?  Nobody knows.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06
PSA  .07 .05 .06 .09 .08 .132
Non Illegitimi Carborundum

>i am 67 years old and for 6 years my psa was stable at around 6.7. i
> had had biopsies 6 and 7 years ago and no cancer showed up. within the
[quoted text clipped - 6 lines]
> many thanks
> jay
 
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