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Medical Forum / Diseases and Disorders / Prostate Cancer / April 2006Casodex only & testosterone up
Is this a spike? Started Casodex 50 mg once a day exactly a week ago. His T has been in the 500s. Had a T today and it was 943. Not quite doubled. He starts Trelstar on Thursday. P.S. his PSA was "< .04" (confirmed not my typo). Does Casodex alone drop PSA? And raise T? TIA, laurel Casodex is supposed to prevent spiking. Since it blocks the binding of T to the androgen receptors (located throughout the body), I would expect T levels in blood to be somewhat increased (don't know if it would be a lot or a little). Also, there is a strong diurnal variation in T levels; changing up to 30-some percent between night (lower) and morning (higher). Endocrinologists that want to accurately track your T will collect the blood sample at the same time of day on each visit...Ron > Casodex is supposed to prevent spiking. Since it blocks the binding of > T to the androgen receptors (located throughout the body), I would [quoted text clipped - 4 lines] > will collect the blood sample at the same time of day on each > visit...Ron The last test was about 4 pm and today's was about 8 am. That fits. > Casodex is supposed to prevent spiking. Since it blocks the binding of > T to the androgen receptors (located throughout the body), I would [quoted text clipped - 4 lines] > will collect the blood sample at the same time of day on each > visit...Ron Ron, I guess the idea here is that if the receptor sites are blocked by Casodex, there will be more free testosterone in the blood stream because it can't bind to the cell receptors. Is that what you figure is going on? Maybe too, whatever signals the release of T will also increase in level if feedback from the body indicates that more T is needed (because not enough is binding). The body is certainly an extraordinary biochemical machine. Alan Alan wrote... Maybe too, whatever signals the release of T will also increase in level if feedback from the body indicates that more T is needed (because not enough is binding). ------------------------------------------------------------------------------------------------------------------------ Good point Alan. Bottom line is that there can't be a large T spike when Casodex usage is initiated. After all, spiking is what the Casodex is supposed to prevent (when LHRH therapy is started). But I would suspect that ther might be some kind of T increase when Casodex therapy is initiated (all that T with no where to go). Then, the mechanisms that control T production would sense this and react accordingly...Ron |
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