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Medical Forum / Diseases and Disorders / Prostate Cancer / April 2006Crowing! 1st PSA after RP
We got the bloodwork back that was done on 4/3, 4 weeks after surgery. PSA was .01, PAP was .7. Guess we'll never know how low it would have gone, since the Casodex was started 4/4 and the rest of the ADT will start next Thursday. Still, it is good news. Shouldn't take any time at all for PSA to go to zero. And the tumor load is obviously way, way down. Its making me feel more hopeful about a cure. FWIW. > We got the bloodwork back that was done on 4/3, 4 weeks after surgery. > PSA was .01, PAP was .7. Guess we'll never know how low it would have > gone, since the Casodex was started 4/4 and the rest of the ADT will > start next Thursday. Still, it is good news. Shouldn't take any time > at all for PSA to go to zero. And the tumor load is obviously way, way > down. Its making me feel more hopeful about a cure. FWIW. 0.01 is a fantastic PSA! ADT or not! CONGRATS!!! Great news!! MikeH :) > We got the bloodwork back that was done on 4/3, 4 weeks after surgery. > PSA was .01, PAP was .7. Guess we'll never know how low it would have > gone, since the Casodex was started 4/4 and the rest of the ADT will > start next Thursday. Still, it is good news. Shouldn't take any time > at all for PSA to go to zero. And the tumor load is obviously way, way > down. Its making me feel more hopeful about a cure. FWIW. > We got the bloodwork back that was done on 4/3, 4 weeks after surgery. > PSA was .01, PAP was .7. Guess we'll never know how low it would have > gone, since the Casodex was started 4/4 and the rest of the ADT will > start next Thursday. Still, it is good news. Shouldn't take any time > at all for PSA to go to zero. And the tumor load is obviously way, way > down. Its making me feel more hopeful about a cure. FWIW. You can ask about the sensitivity of the test that was used, but .01 might be as low as they report - meaning the same thing as "undetectable". I presume that he will eventually go off ADT. After that, you'll see what happens. It sounds like a wonderful start. Alan > I presume that he will eventually go off ADT. After that, you'll see what > happens. Yep, this morning I'm looking forward to 2 years. Maybe erections. No ADT. No chemo. NO CANCER. (crosses her fingers) >> I presume that he will eventually go off ADT. After that, you'll see >> what [quoted text clipped - 3 lines] > ADT. No chemo. NO CANCER. > (crosses her fingers) I think that's within reasonable bounds. I pray you get your wish.  SignaturePSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05, 2/06 PSA .07 .05 .06 .09 .08 .132 Non Illegitimi Carborundum > You can ask about the sensitivity of the test that was used, but > .01 might be as low as they report - meaning the same thing as > "undetectable". This was SonoraQwest labs. Does anyone know how they report undetectable? I know it was not ultra-sensitive. Quoting Alan Meyer: >> You can ask about the sensitivity of the test that was used, but >> .01 might be as low as they report - meaning the same thing as >> "undetectable". >> She replied: > This was SonoraQwest labs. Does anyone know how they report > undetectable? I know it was not ultra-sensitive. > I have had ultrasensitive PSAs performed monthly for ~14 months. They are done at Sonora Quest. The tests are "DPC, Third Generation, ICMA method." Generally, the results are reported as <0.01, which is considered undetectable; or more accurately, at the limit of the particular test's accuracy. I believe that that is as close as any lab comes to "undetectable." Unless, of course, they're using one of the procedures that go to the third or fourth decimal. And even then, they report a number and do not use the "U-word." DPC = Diagnostic Products Corporation. More info can be found on their website: www.dpcweb.com Regards, Steve J > I have had ultrasensitive PSAs performed monthly for ~14 months. They > are done at Sonora Quest. The tests are "DPC, Third Generation, ICMA > method." Generally, the results are reported as <0.01, which is > considered undetectable; or more accurately, at the limit of the > particular test's accuracy. Okay, looking at my results, it is Sonora Quest. "This test was performed using the DPC, ICMA method." So it doesn't say third generation. It definitely doesn't say "<" .1, it says "0.1". So it looks like they did find some. In other words, NOT undetectable. Still, very good for 4 weeks and pos margins & lymph nodes. > Okay, looking at my results, it is Sonora Quest. "This test was > performed using the DPC, ICMA method." So it doesn't say third > generation. It definitely doesn't say "<" .1, it says "0.1". So it > looks like they did find some. In other words, NOT undetectable. > Still, very good for 4 weeks and pos margins & lymph nodes. Now I'm confused. I thought you said .01 (as in 0.01). SignaturePSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05, 2/06 PSA .07 .05 .06 .09 .08 .132 Non Illegitimi Carborundum > Now I'm confused. I thought you said .01 (as in 0.01). I did, Steve. I'm sorry. Just switched that decimal around, I guess it was like a Freudian slip. Hope springs eternal. Quoting me: >> I have had ultrasensitive PSAs performed monthly for ~14 months. They >> are done at Sonora Quest. The tests are "DPC, Third Generation, ICMA >> method." Generally, the results are reported as <0.01, which is >> considered undetectable; or more accurately, at the limit of the >> particular test's accuracy. >> She replied: > Okay, looking at my results, it is Sonora Quest. "This test was > performed using the DPC, ICMA method." So it doesn't say third > generation. It definitely doesn't say "<" .1, it says "0.1". So it > looks like they did find some. In other words, NOT undetectable. > Still, very good for 4 weeks and pos margins & lymph nodes. > There are two PSA tests, and it appears that the ultrasensitive "third generation" test was not ordered. Was this test ordered by the uro? On the Sonora Quest report, there is one preprinted line that reads, "Requests.....Results......Out of Range Results......Reference Range......Units. The report, frex my last one, read, "PSA,POST-PROSTATECTOMY......<0.01......<0.10.....ng/mL=PAZ Take care not to confuse "Results" and "Reference Range." I would not worry unduly about the result. It was at the limit of accuracy of the particular test protocol, that's all. The result is excellent and I couldn't be more pleased if I had done it ;-) BTW, the code for the ultrasensitive test is 11061, and it is not found on the Sonora Quest form. It has to be filled in by hand. Regards, Steve J "He is the best physician who is the most ingenious inspirer of hope." -- Samuel Taylor Coleridge You crow, girl! Glad to hear it. -RonL > We got the bloodwork back that was done on 4/3, 4 weeks after surgery. > PSA was .01, PAP was .7. Guess we'll never know how low it would have > gone, since the Casodex was started 4/4 and the rest of the ADT will > start next Thursday. Still, it is good news. Shouldn't take any time > at all for PSA to go to zero. And the tumor load is obviously way, way > down. Its making me feel more hopeful about a cure. FWIW. Laurel, That is very good good news. It means that most (if not all) of Steve's tumor load is gone. If any tumor was left behind, it is not generating PSA or that level is undetectable. The combination of treatments to follow RP are designed to increase the possibility of total erradication. I am happy to see this PSA result. It is a good starting point. Congratulations to you both. RalphV > > We got the bloodwork back that was done on 4/3, 4 weeks after surgery. > > PSA was .01, PAP was .7. Guess we'll never know how low it would have To correct myself, it is 0.1 not .01. > Laurel, > That is very good good news. It means that most (if not all) of Steve's > tumor load is gone. If any tumor was left behind, it is not generating > PSA or that level is undetectable. I still think it is good news, even though I was off by a factor of ten. > The combination of treatments to follow RP are designed to increase the > possibility of total erradication. I am happy to see this PSA result. > It is a good starting point. Yes. As Dr. Barken wrote, In my opinion prostate cancer is systemic disease from day one. It is just that the systemic manifestation do not appear on our radar screen that we are using at a particular time. Dr Lange a famous prostate cancer researcher physician and patient found evidence of prostate cancer in bone marrow in patient who underwent radical prostatectomy. Those patients had classical localized disease. About 90% were found to have evidence for prostate cancer cells in the bone marrow. After surgery only about a third could be found to have bone marrow involvement. The fact that prostate cancer is systemic disease means that we have to deal with the prostate cancer locally and systemically according to the findings during staging and according to the probabilities of having systemic disease. > Congratulations to you both Crying again. (joy) > RalphV > To correct myself, it is 0.1 not .01. Disregard my last post. However, as you have said, 0.1 is still good considering what he had and the time that y'all have been working on it. SignaturePSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05, 2/06 PSA .07 .05 .06 .09 .08 .132 Non Illegitimi Carborundum THE PSA IS 0.1, not .01. Sorry! > We got the bloodwork back that was done on 4/3, 4 weeks after surgery. > PSA was .01, PAP was .7. Guess we'll never know how low it would have > gone, since the Casodex was started 4/4 and the rest of the ADT will > start next Thursday. Still, it is good news. Shouldn't take any time > at all for PSA to go to zero. And the tumor load is obviously way, way > down. Its making me feel more hopeful about a cure. FWIW. Laurel, What I said in my previous post still is valid! Remember it is 0.1 X 10(-9) Most of the tumor is gone RalphV |
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