 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / Diseases and Disorders / Prostate Cancer / April 2006Basic questions about clinical trials
Hello All, I've been asked to partake in a Phase III clinical trial. Would I be able to see the results of the Phase I and II portions of the trial before I signed up? I understand that the trial looks at results for as long as 10 years and the trial is only 6 years old from the Phase I part and would have only 'so called' partial data. Still I'd love to see what Phase I and II have shown so far. Thanks, WhiteSoxFan You should ask the provider about the results for the phase I and II studies. If you have the Trial identifier you MIGHT be able to find some additional info on-line. DanR So called, shmocalled....it's BS. Yes, do not parcipitate if they cannot provide at the very least some information. Not too much to ask if you are indeed "parcipitating". B.A. > So called, shmocalled....it's BS. > Yes, do not parcipitate if they cannot provide at the very least some > information. Not too much to ask if you are indeed "parcipitating". And if you're really really upset, don't participate, either. ;-) Regards, Steve J Oops, damn spell checker again!! Thanks for pointing that out. Participate, participate, participate, participate, participate.... I think I've got it! Thanks Steve. B.A. On April Fools Day, Bob Anthony responded to me: > Oops, damn spell checker again!! Thanks for pointing that out. Just having a little innocent fun. Also, in some circles it's known as a spill chucker. (snip) Regards, Steve J > Hello All, > [quoted text clipped - 8 lines] > > WhiteSoxFan As I understand it, a clinical trial will normally result in at least one publication that presents the results of the trial. I would expect that any Phase I trial that is followed by a Phase II, and any Phase II trial that is followed by a Phase III, would have produced such publications. Ask the doctors for information about them and see if they can get you reprints. If you know the NCI or other ID of the Phase III trial, you can look it up in cancer.gov or clinicaltrials.gov (the former may have more complete information if it's listed there.) You may find citations to the results of earlier trials. If not, you will at least find the names of the principal investigators. Use those name to look for their publications in PubMed and you should find anything they have published in the past. Scientific publishing is a slow process, so some of the publications might not be out yet. The article is written, then sent in for publication to a journal. It might go to multiple journals, one after another. The journals will send the drafts out for a review. If the reviewers recommend publication, they might also point out weaknesses in the article to the author, who will then revise the article for another review. Finally, when all is ready, the journal puts it in their publication pipeline - which might already be full for many months. So it takes a while. If the articles have not been published yet, it may be hard to get solid information. The journals don't like authors circulating pre-prints of articles that haven't appeared yet. You'll have to be a little persistent to get all the information you want, but I think you should be able to get some. If you need help finding things, email me and I'll see if I can help. Good luck. Alan All trials result in a publication. Before a next stage trial commences, a previous stage trial has been published. Your Doctor will have that publication. Mike > Hello All, > [quoted text clipped - 8 lines] > > WhiteSoxFan As a Clinical Pharmacokineticist (how the drug acts in the body) I have been involved in numerous Phase I, II, III, and IV clinical trials. They do not always result in publications. However, it is common for results to be presented in some form somewhere. Use the internet to search for the drug name (even the code name assigned by the drug manufacturer) and see if you can find any entries. The Principle Investigator (the doctor) must have received a document called an "Investigators Brochure" which will contain all known information about the drug. There still may be studies that have been completed in the clinic that have yet to have an internal drug company report written - but the span of time between the completion of the study and the drug company internal Clinical Study Report (CSR) should not be over 6-12 months. The previously mentioned web sites from National Cancer Institute and Clinical Trials are good places to start looking. If all else fails send me the drug name and I can see if I can find anything - even a small chance I might have been involved with some other study on the drug (OK, very, very, very small chance...) Good luck, Sam H. > All trials result in a publication. > [quoted text clipped - 14 lines] >> >> WhiteSoxFan |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2008 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.