Alan,

Dr. Leibowitz has treated patients at all stages, as well as patients
who had all sorts of previous treatment before seeing him.  His
published work was just on early stage, but on his website you will see
references to other types of patients.

F alone will have some benefit, but only if a sufficiently high
threshold of T is present.  The article I referenced in my previous post
showed that F alone with no T had no real benefit, whereas F with the
amount of T that they used was ~5 times more effective compared to
continual ADT.  This research is all very new, and nobody has yet
determined (when you are using F) the minimum amount of T necessary to
achieve apoptosis is, what the optimal amount of T is, or what the
maximum amount of T is, above which no further apoptosis occurs.

However, just as pure guesswork, I would say that men with a level of T
of at least 500 should definitely benefit from F alone, at least to slow
down the rate at which the PCa population doubles.  However, you also
have to watch your diet to avoid foods like soy and flaxseed (see my
paper for why this is necessary). The higher the level of  T, the longer
it should take to double, until you reach the minimum level of T at
which apoptosis occurs at a faster rate than growth does.

According to my model, the hormone therapy applies to all stages of PCa,
no matter what the prior treatment.  The only problems to watch out for
are when rare mutations occur, which can make this particular therapy
harmful, instead of beneficial.  If one could only know the exact
genetic makeup of the PCa within someone, then you could tailor the
hormone treatment to be optimal for that particular PCa.  However, in
the case of high T plus F, problems would arise if you have a mutated
iAR that binds T as tightly as it does DHT, or any mutations that impair
the ability of mAR to produce apoptotic proteins, but not bcl-2.

In terms of talking to doctors, they might be more receptive to the idea
of high T with F plus casodex, instead of just F.  Since most doctors
have no idea that mAR exists, they will assume that the T does nothing
since the only androgen receptor that they are aware of will be blocked
by the casodex and further be protected by the lack of DHT caused by
taking F.  However, for quality of life, high T plus F should be
superior, and showing your doctors that article I referred to in my
previous post might convince one of them to try it.

Ed Friedman