Dr. Elias Zerhouni, director of the National Institutes of Health, said
yesterday on the Diane Rehm program, "It's pretty clear ...there is a
consensus... that surgery after the age of 65 does not make a lot of
sense. There is a general consensus there." For younger ages there is a
different story, but the main criterion (for example for a 45 year old
man) is to identify whether the cancer is likely to be aggressive and
deadly.
He didn't expand on what treatments should be given for an older
prostate cancer patient (or for a younger one, either), but he was
quite clear about surgery for the older patient.
If you want to hear the entire interview. it can be found at:
http://www.wamu.org/programs/dr/06/03/15.php#10705
Transcripts are also available. Visit the www.wamu.org.
Does anyone know of a recent expert committee or other definitive
source for his statement? As someone over 69 who had an RRP at a
well-known research hospital 2 years ago, I'm wondering how long this
recommendation has been a consensus view.
In any case, anyone considering treatment who is at or near that age
should definitely discuss this matter with his urologist.
Doug Taylor - 16 Mar 2006 16:49 GMT
>Does anyone know of a recent expert committee or other definitive
>source for his statement? As someone over 69 who had an RRP at a
>well-known research hospital 2 years ago, I'm wondering how long this
>recommendation has been a consensus view.
Is there really any "consensus view" for PCa treatment?
But it makes sense to my layman brain. If the average life expectancy
for a US male is 75 +/- years, and the treatment cure prognoses for
surgery, EBRT and seeds are equal for 10 years, then surgery would be
the last choice for patients 65 years and above, given the physical
demands of surgery and the greater potential for incontinence and
impotence vs. lesser side effects for radiation.
ron - 16 Mar 2006 19:03 GMT
"that surgery after the age of 65 does not make a lot of sense"
Well Fred, then there appears to be a significant portion of the PCa RP
community that has "Stopped Making Sense"! A recent demographic study
(WHO IS THE AVERAGE PATIENT PRESENTING WITH PROSTATE CANCER?; UROLOGY
66 (Suppl 5A): 76-82, 2005; KIRSTEN L. GREENE, JANET E. COWAN,
MATTHEW R. COOPERBERG, MAXWELL V. MENG, JANEEN DUCHANE, AND PETER R.
CARROLL) of RP patients found the following
Demographic 1997-1999, n (%)
2000-2003, n (%)
Age at diagnosis
<60 76 (23)
590 (28)
60-70 149 (46)
893 (42)
>70 102 (31) 659 (31)
...Ron
Steve Kramer - 16 Mar 2006 19:37 GMT
I've done some NG research. Of those who have posted here in the last 4
years:
108 have reported themselves to have been 65 or older at the time of initial
treatment and 92 of those informed us of their initial treatment.
Of those 92:
42 had surgery (RRP, RLRP)
21 had radiation (Brachy, IMRT, EBRT)
11 had hormone therapy (Lupron, Zoladex, Casodex or combinations)
7 had a combination of therapies, usually RT and HT
7 had cryo
3 watched and waited
1 had HIFU
The oldest to have surgery? Four 72-year-olds.

Signature
PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA .1 .1 .1 .27 .37 .75
EBRT 05-07/2002 @ 47
PSA .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06
PSA .07 .05 .06 .09 .08 .132
Non Illegitimi Carborundum
> "that surgery after the age of 65 does not make a lot of sense"
>
[quoted text clipped - 17 lines]
>
> ...Ron
Steve Kramer - 17 Mar 2006 18:42 GMT
This just in.....
> I've done some NG research. Of those who have posted here in the last 4
> years:
I have since received private email from a lurker. Please add 1 to the
following numbers: 108, 92 and 42.
Also, add and "LRP" to the examples parenthetically mentioned after
"surgery".
Finally, add 2½ to the oldest man to have had surgery. He had an LRP during
2005 at 74½ years of age.
> 108 have reported themselves to have been 65 or older at the time of
> initial treatment and 92 of those informed us of their initial treatment.
[quoted text clipped - 10 lines]
>
> The oldest to have surgery? Four 72-year-olds.
Doug Taylor - 17 Mar 2006 23:19 GMT
>Finally, add 2½ to the oldest man to have had surgery. He had an LRP during
>2005 at 74½ years of age.
At the other end of the spectrum, anybody younger than me (52 at the
time) opt for EBRT?
Steve Kramer - 18 Mar 2006 08:11 GMT
>>Finally, add 2½ to the oldest man to have had surgery. He had an LRP
>>during
>>2005 at 74½ years of age.
>
> At the other end of the spectrum, anybody younger than me (52 at the
> time) opt for EBRT?
Nope! One at 53, but none other at 52 or less.
Steve Kramer - 16 Mar 2006 19:04 GMT
> Dr. Elias Zerhouni, director of the National Institutes of Health, said
> yesterday on the Diane Rehm program, "It's pretty clear ...there is a
[quoted text clipped - 3 lines]
> man) is to identify whether the cancer is likely to be aggressive and
> deadly.
I think there might be a general consensus that the older you are, the
lesser able you will be to tolerate major surgery. In all due defference to
Dr. Zerhouni (who quite possibly has little more remaining medical
qualifications than a 3M CEO), I know 50-year-olds who should not risk major
surgery and some 75-year-olds who could.
I'm not saying the surgery is always the preferred treatment, but you should
not second-guess your decision nor use 65 as a delimiter.

Signature
PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA .1 .1 .1 .27 .37 .75
EBRT 05-07/2002 @ 47
PSA .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06
PSA .07 .05 .06 .09 .08 .132
Non Illegitimi Carborundum
I.P. Freely - 16 Mar 2006 21:29 GMT
Fred quoted:
> Dr. Elias Zerhouni, director of the National Institutes of Health, said
> yesterday on the Diane Rehm program, "It's pretty clear ...there is a
> consensus... that surgery after the age of 65 does not make a lot of
> sense. There is a general consensus there."
If the good doctor can make blanket statements, so can we: Untreated PC
kills in 15 years and the AVERAGE 65-year-old man is expected to live
15-16 years. Then tell it to the millions of men over 80, thousands of
whom are athletes and HALF of whom are expected to live past 88. At the
limit, tell it to Jack Lalanne.
Case by case, guys. If you are athletic, have old parents, and are
otherwise in good health, it's a pretty good guess that you're among the
half of 65-YOs likely to benefit from treatment, including surgery.
I.P.
Alan Meyer - 16 Mar 2006 22:19 GMT
> Dr. Elias Zerhouni, director of the National Institutes of Health, said
> yesterday on the Diane Rehm program, "It's pretty clear ...there is a
[quoted text clipped - 3 lines]
> man) is to identify whether the cancer is likely to be aggressive and
> deadly.
...
Dr. Zerhouni is a very well respected former professor and researcher
with some 157 peer reviews scientific publications to his credit. He's
a very, very, bright and knowledgeable guy.
Also (surprise!) he's a radiologist - though his specialty was
diagnostic
radiology rather than treatment.
It seems to me that flat statements about what is best for patients
should be treated only as general guidelines. There are extremely
fit 65 year olds and very decrepit 50 years old. So age is not a
perfect criterion for determining what treatment is best in many
cases.
Whatever the age consensus is, there is at least a general consensus
that, at some age, a patient is better off with radiation than surgery,
at some age he's better off with hormone therapy than radiation, and
at some age he's better off with no treatment at all. However the age
cutoffs should probably be established by a doctor who examines
an individual patient rather than by reading an age chart.
Alan
Leonard Evens - 16 Mar 2006 23:16 GMT
> Dr. Elias Zerhouni, director of the National Institutes of Health, said
> yesterday on the Diane Rehm program, "It's pretty clear ...there is a
[quoted text clipped - 7 lines]
> prostate cancer patient (or for a younger one, either), but he was
> quite clear about surgery for the older patient.
Dr. Zerhouni should be very careful about what he says in public. It is
not age per se that is important but the health and expected lifetime of
the patient. Some men at 75 still have a good 20 years ahead of them
and others at 60 would be lucky to last another 10 years. The general
guideline that urologists have been using for years to decide whether or
not to treat early prostate cancer aggressively is an expected lifetime
of 10 or more years. One other factor in deciding between surgery and
radiation is that it is very difficult for even the best surgeons to
prevent impotence in men over 70. But again, this can depend quite a
lot on the specific man. No urologist worth his salt makes decisions of
this kind based purely on the patient's age.
At age 66, my urologist recommended either surgery or radiation. I
chose surgery, and I've come through okay, at least so far. I have had
undetectable PSAs for 5 years, and after about 18 months I regained
erections. Had I been 5 years older at the time, I probably would have
chosen radiation because of the somewhat lower risk of impotence and a
lower expected lifetime in which the cancer could recur.
> If you want to hear the entire interview. it can be found at:
> http://www.wamu.org/programs/dr/06/03/15.php#10705
[quoted text clipped - 8 lines]
> In any case, anyone considering treatment who is at or near that age
> should definitely discuss this matter with his urologist.
Certainly, anyone considering treatment should discuss all his options
with his urologist and understand all the odds as they apply to him in
particular. I would hope that is standard practice. It certainly was
in my case.