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Medical Forum / Diseases and Disorders / Prostate Cancer / March 2006

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HIFU?

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rosbif - 08 Mar 2006 19:04 GMT
I met with a surgeon last week to discuss options for treatment
(gl(3+4), PSA 7, t1c, 61 years).  He tells me he's also treating using
HIFU - though it's too early to have useful data on its efficacy.
Any thoughts here on this method?  
ron - 08 Mar 2006 19:35 GMT
> I met with a surgeon last week to discuss options for treatment
> (gl(3+4), PSA 7, t1c, 61 years).  He tells me he's also treating using
> HIFU - though it's too early to have useful data on its efficacy.
> Any thoughts here on this method?

Gelet and Uchida are two of the HIFU pioneers and 5-year results from
their studies are emerging.  Even though they use very favorable
methods to measure treatment success, their success rates are far below
what can be obtained at similar post-treatment intervals with more
traditional forms of RT and surgery.  Making matters worse, their poor
recurrence rates appear to be accompanied by high rates of ED and a
high percentage of their treated men require a TURP.  On the other
hand, the method is repeatable and easily tolerated.  Those who want to
debulk their primary tumor load, treat recurrence or have various
comorbitities that preclude more traditional treatments may find HIFU
of value...Ron

Hinyokika Kiyo. 2005 Oct;51(10):651-8; Transrectal high-intensity
focused ultrasound in the treatment of localized prostate cancer: a
multicenter study; Uchida T, Baba S, Irie A, Soh S, Masumori N,
Tsukamoto T, Nakatsu H, Fujimoto H, Kakizoe T, Ueda T, Ichikawa T, Ohta
N, Kitamura T, Sumitomo M, Hayakawa M, Aoyagi T, Tachibana M, Ikeda R,
Suzuki K, Tsuru N, Suzuki K, Ozono S, Fujimoto K, Hirao Y, Monden K,
Nasu Y, Kumon H, Nishi K, Ueda S, Koga H, Naitoh S.

Nippon Rinsho. 2005 Feb;63(2):345-9; High-intensity focused ultrasound
for localized prostate cancer; Uchida T.

Urology. 2004 Feb;63(2):297-300; High-intensity focused ultrasound for
the treatment of localized prostate cancer: 5-year experience; Blana A,
Walter B, Rogenhofer S, Wieland WF.

American Urological Association Annual Meeting, May 8-13, 2004, San
Francisco, California, USA; Program#/Poster#: 830; Presentation Title:
PROSTATE CANCER CONTROL WITH TRANSRECTAL HIFU IN 242 CONSECUTIVE
PATIENTS: 5-YEAR RESULTS; Albert Gelet, Jean Yves Chapelon, Laura
Poissonnier, Raymonde Bouvier, Olivier Rouviere, Ibrahim Bah-Clozel,
Denis Lyonnet, Jean Michel Dubernard. Edouard Herriot Hospital, Lyon,
France, INSERM Unit 556, Lyon, France, Edouard Herriot Hospital, Lyon,
France
rosbif - 11 Mar 2006 14:17 GMT
>> I met with a surgeon last week to discuss options for treatment
>> (gl(3+4), PSA 7, t1c, 61 years).  He tells me he's also treating using
[quoted text clipped - 12 lines]
>comorbitities that preclude more traditional treatments may find HIFU
>of value...Ron

many thanks - and for the refs below.

>Hinyokika Kiyo. 2005 Oct;51(10):651-8; Transrectal high-intensity
>focused ultrasound in the treatment of localized prostate cancer: a
[quoted text clipped - 19 lines]
>France, INSERM Unit 556, Lyon, France, Edouard Herriot Hospital, Lyon,
>France
Clarence Crow - 08 Mar 2006 22:28 GMT
>I met with a surgeon last week to discuss options for treatment
>(gl(3+4), PSA 7, t1c, 61 years).  He tells me he's also treating using
>HIFU - though it's too early to have useful data on its efficacy.
>Any thoughts here on this method?  

Give it a big MISS!

Just think about the degree of Accuracy that can be achieved, by
Mapping the HIFU Convergence Points from one MOVING organ to another.

That's why the Mexicans offer a Complementary TURP with each
procedure, plus they acknowledge the HIFU may need to be repeated.

If you're a Go-Lightly Addict, knock yourself out LOL.

BTW: I had HDRB in July 2004, and was extremely impressed by the 3D
Mapping and individual Session Adjustment of the Catheters. The Dosage
was heavy, but then, there was a reason for this (some G8s), and I'll
need another TURP in a few mths time, as I also have BPH (72cc).
The Outcome is still pending until the Hormones,
(Lucrin = Lupron)entirely leave my body in, say, 6 mths time.

-- Reader to complete...
-- Please reply to this ng as my email adress is fake:

-- Regards

-- CC
rosbif - 11 Mar 2006 14:18 GMT
>>I met with a surgeon last week to discuss options for treatment
>>(gl(3+4), PSA 7, t1c, 61 years).  He tells me he's also treating using
[quoted text clipped - 5 lines]
>Just think about the degree of Accuracy that can be achieved, by
>Mapping the HIFU Convergence Points from one MOVING organ to another.

Isn't the problem of mapping precision inherent also with RT?

>That's why the Mexicans offer a Complementary TURP with each
>procedure, plus they acknowledge the HIFU may need to be repeated.

Scardino's short section on HIFU suggests that the TURP is a wise
accompaniment because of the problem of sloughing through the dead
tissue which would otherwise cause urinary retention.  HIFU's
proponents seem to represent repeatability as a 'benefit' as/when/if
it's deemed wise.... but I fully appreciate your negativity about it.

>If you're a Go-Lightly Addict, knock yourself out LOL.
>
[quoted text clipped - 4 lines]
>The Outcome is still pending until the Hormones,
>(Lucrin = Lupron)entirely leave my body in, say, 6 mths time.

all the best for your treatment.

>-- Reader to complete...
>-- Please reply to this ng as my email adress is fake:
>
>-- Regards
>
>-- CC
Steve Kramer - 08 Mar 2006 23:57 GMT
>I met with a surgeon last week to discuss options for treatment
> (gl(3+4), PSA 7, t1c, 61 years).  He tells me he's also treating using
> HIFU - though it's too early to have useful data on its efficacy.
> Any thoughts here on this method?

I don't think anyone here has used HIFU.  Canada Bob robert01942@hotmail.com
almost did, but was turned down at the last minute.

He doesn't associate with us anymore, but might entertain an inquiry.

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
2/06
PSA  .07 .05 .06 .09 .08 .132
Non Illegitimi Carborundum
rosbif - 11 Mar 2006 14:18 GMT
>>I met with a surgeon last week to discuss options for treatment
>> (gl(3+4), PSA 7, t1c, 61 years).  He tells me he's also treating using
[quoted text clipped - 5 lines]
>
>He doesn't associate with us anymore, but might entertain an inquiry.

thanks for the ref.

>PSA 16 10/17/2000 @ 46
>Biopsy 11/01/2000 G7 (3+4), T2c
[quoted text clipped - 6 lines]
>PSA  .07 .05 .06 .09 .08 .132
>Non Illegitimi Carborundum
 
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