The note below was reported in a recent issue of Nature.  I'm not sure
what it means, but it seems indirectly, at least, to question the
conventional theory that hormone resistant cells are there from the
beginning.

Cell 124, 615–629 (2006)

Prostate cancer responds at first to drugs that block the action of
androgens, such as testosterone, on which its growth depends. But
resistance to the drugs soon develops.

Now Michael Rosenfeld and David Rose of the University of California,
San Diego, and their colleagues report an unexpected mechanism that may
explain why the drugs stop working.

They traced the effect to a chemical produced by macrophages — immune
cells that infiltrate prostate tumours. The chemical produced, a
cytokine, triggers a chain of reactions that ultimately reactivate the
blocked androgen receptor.

The effect is mediated by a particular domain of the receptor. The same
domain is found in all sex steroid receptors, and may have evolved for
fine-tuning of hormone activity during sensitive events in mammalian
reproduction.