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Medical Forum / Diseases and Disorders / Prostate Cancer / February 2006

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Provenge

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Stavros - 19 Feb 2006 02:50 GMT
http://paktribune.com/news/index.php?id=134647
Steve Kramer - 19 Feb 2006 12:04 GMT
I just can't get excited about, "Overall, Provenge prolonged life by as much
as 4.5 months over those patients given the placebo vaccine."

Sounds like a step in the right direction.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05
PSA  .07 .05 .06 .05 .08
Non Illegitimi Carborundum

> http://paktribune.com/news/index.php?id=134647
Steve Jordan - 19 Feb 2006 17:30 GMT
On February 19, Steve Kramer replied to Stavros:
> I just can't get excited about, "Overall, Provenge prolonged life by as much
> as 4.5 months over those patients given the placebo vaccine."
>
> Sounds like a step in the right direction.
>  
As in so many such studies, the medication is given to a cohort of
patients who are, as my med onc puts it, on their last legs, in
desperate condition.

Such appears to the case here: "The research involved 127 men, aged 47
to 85, with metastatic prostate cancer. None of the men had symptoms
from the cancer, such as pain. The men no longer were responding to
traditional hormone treatment for prostate cancer."

Another instance is that of the trials of docetaxel (Taxotere), in which
the cohort under study was much the same as this one.

To me, what this means is that until/unless I am in a condition like
that of the study cohorts, I should be able to anticipate a much better
outcome.

Regards,

Steve J

"Do not go where the path may lead, go instead where there is no path
and leave a trail."
-- Ralph Waldo Emerson

Which is what the brave and selfless men in such cohorts have done for
the rest of us. They must not be forgotten.
Alex - 19 Feb 2006 17:40 GMT
>I just can't get excited about, "Overall, Provenge prolonged life by as
>much as 4.5 months over those patients given the placebo vaccine."
>
> Sounds like a step in the right direction.

Yes, but these guys all had metastatic cancer, and "Perhaps more significant
were the results seen three years after the vaccine was given. At that
point, 34% of vaccine patients were still alive compared with 11% of men
that received the placebo vaccine." Tripling the survival rate three years
out seems like exciting news to me.

Alex
Stavros - 19 Feb 2006 18:57 GMT
>>I just can't get excited about, "Overall, Provenge prolonged life by as
>>much as 4.5 months over those patients given the placebo vaccine."
[quoted text clipped - 8 lines]
>
> Alex

I thought so, too.  And it suggests more to come.  After all,  with PCa
advanced "all" we are doing is extending our time and it's good to know that
the treatments are constantans improving.  I think so, anyway.
Steve Kramer - 20 Feb 2006 11:29 GMT
I agree that 3 years would be something to get excited about.  However, the
drug failed in that regard, with those studied, 66% of the time.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05
PSA  .07 .05 .06 .05 .08
Non Illegitimi Carborundum

>>I just can't get excited about, "Overall, Provenge prolonged life by as
>>much as 4.5 months over those patients given the placebo vaccine."
[quoted text clipped - 8 lines]
>
> Alex
Bill - 20 Feb 2006 15:15 GMT
What pisses me off is that virtually all of the new treatments are
tested on men w/ hormone refractory PCa and, when the Tx is finally
approved, that's who it will be approved for. Who knows, if taken after
biological failure it might delay the need for HT for a really
significant time.

Bill Denton
RP 2/12/02
PSA .67
Memphis
Steve Kramer - 20 Feb 2006 23:28 GMT
> What pisses me off is that virtually all of the new treatments are
> tested on men w/ hormone refractory PCa and, when the Tx is finally
> approved, that's who it will be approved for. Who knows, if taken after
> biological failure it might delay the need for HT for a really
> significant time.

Aha!  I knew you were a post-HT-refractive bigot!

                     ... you make a good point though.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05
PSA  .07 .05 .06 .09 .08
Non Illegitimi Carborundum

Steve Kramer - 20 Feb 2006 23:30 GMT
Dammit!  Forgot that smiley thingy

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05
PSA  .07 .05 .06 .09 .08
Non Illegitimi Carborundum

>> What pisses me off is that virtually all of the new treatments are
>> tested on men w/ hormone refractory PCa and, when the Tx is finally
[quoted text clipped - 5 lines]
>
>                      ... you make a good point though.
 
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