Medical Forum / Diseases and Disorders / Prostate Cancer / February 2006
Chances of nerve sparing w/high PSA
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juniper - 15 Feb 2006 21:30 GMT Hi, all. We saw a surgeon today, Kletscher, seemed very caring, competent, experienced. He said he does do nerve sparing surgery, but he was going to be honest and that he didn't think it likely in Steve's case. Apparently because the high PSA and fact that biopsy shows cancer on both sides. Although the MRI may give more info.
Does this sound right? Are all those nerve sparing surgeries on the guys with PSAs under 10 or 20? Any input will be appreciated.
Steve Jordan - 15 Feb 2006 22:01 GMT > Hi, all. We saw a surgeon today, Kletscher, seemed very caring, > competent, experienced. He said he does do nerve sparing surgery, but [quoted text clipped - 5 lines] > guys with PSAs under 10 or 20? Any input will be appreciated. > OK, I'll take a crack at it. I believe that the controlling criteria are the tumor burden and the likelihood of extra-capsular penetration. As I recall, both are rather high in Steve's case.
I do not believe that PSA is controlling, except to the extent that it provides some evidence of tumor burden.
But whether nerve sparing is possible often cannot be determined until the surgery is under way. See, Strum & Pogliano _A Primer on Prostate Cancer_ pages 75-77.
And, yes, the MRI (2/20?) should develop helpful info.
Sorry about the bleak outlook, but don't give up yet. And, if worse comes to worse, think sural nerve transplant.
Regards,
Steve J
juniper - 15 Feb 2006 22:39 GMT > OK, I'll take a crack at it. I believe that the controlling criteria are > the tumor burden and the likelihood of extra-capsular penetration. As I > recall, both are rather high in Steve's case. Yeah. Chance of ECP 46%, I don't know the tumor burden. I think it might be 7. Does that sound right?
> But whether nerve sparing is possible often cannot be determined until > the surgery is under way. See, Strum & Pogliano _A Primer on Prostate > Cancer_ pages 75-77. Well, I think that was his point but he wasn't going to be hopeful about it up front.
> Sorry about the bleak outlook, but don't give up yet. And, if worse > comes to worse, think sural nerve transplant. You know, we had talked about that between us but when we were at the doctor's we didn't ask. Argh. It's always something.
Although we figured on RP already, actually meeting the surgeon and setting up scheduling started another emotional shockwave. Should have been a surfer.
Steve Jordan - 16 Feb 2006 00:10 GMT On February 15, juniper replied to me, in pertinent part:
> >> OK, I'll take a crack at it. I believe that the controlling criteria are [quoted text clipped - 4 lines] > might be 7. Does that sound right? > I was using tumor burden as an equivalent of tumor *volume* but it turns out they are different though related. I think that what we should be considering is tumor volume. That is to say, the amount in cubic centimeters of PCa in the prostate.
I hope it's not 7 cc. That's a risky number.
See: http://www.prostate-cancer.org/education/staging/damico.html
>> But whether nerve sparing is possible often cannot be determined until >> the surgery is under way. See, Strum & Pogliano _A Primer on Prostate [quoted text clipped - 3 lines] > about it up front. > I think that that's known as CYA.
>> Sorry about the bleak outlook, but don't give up yet. And, if worse >> comes to worse, think sural nerve transplant. >> > You know, we had talked about that between us but when we were at the > doctor's we didn't ask. Argh. It's always something. > Ain't it though? Nothing is simple, nothing is certain.
> Although we figured on RP already, actually meeting the surgeon and > setting up scheduling started another emotional shockwave. Should have > been a surfer. > I hope that an RP has not yet been scheduled. There is much yet to be learned via the staging tests as to whether a local tx such as RP could be expected to be curative. I recommend that Steve should select his tx based upon the best available evidence of the state of his tumor. And I don't think that he has quite yet reached the stage at which an informed decision can be made.
Regards,
Steve J
"The thing is to expect nothing in particular, but be aware of the lack of enforceable guarantees or enforceable contracts with nature/god/entropy as to the condition or durability of our bodies." -- Brian Brunner, PCa survivor, December 12, 2005 on The Prostate Problems Mailing List Thank you, Brian.
c palmer - 16 Feb 2006 00:48 GMT We saw a surgeon today, Kletscher, seemed very caring, competent, experienced. He said he does do nerve sparing surgery, but he was going to be honest and that he didn't think it likely in Steve's case. Apparently because the high PSA and fact that biopsy shows cancer on both sides. Although the MRI may give more info. Does this sound right? Are all those nerve sparing surgeries on the guys with PSAs under 10 or 20? Any input will be appreciated. ========== here's something that i've picked up along the way. all the tests and reports are best indicators but the true situation is not known until they open everything up and take a look.
i've seen operations go both ways and for different, but solid reasons.
i had a psa of 6.35 and had my nerves spared, while another man, who had a psa of 6.25 was operated on by the same surgeon at the same hospital and the couldn't save his nerves.
i have a friend who had a psa of 10 the year before and the doctor never told him that something was wrong, then when he got his psa ran the following year, it was 16 and then they decided to the biopsy, and they were able to save one side of nerves.
the bottom line is this. this is what my surgeon told me. he said that when he gets in there and gets to the erectile nerves. if the prostate tissue slides off the nerve like the meat does on a piece of chicken, then the prostate cancer has not attacked the nerve. but the cancer is sticky and will stick to the nerve as it attacks it. if it isn't too bad, there will be "flakes" of cancer and he can strip that off of the nerve, but if the prostate tissue to stuck solid to the nerve bundle, then there is nothing left to do but cut the nerve bundle and remove it with the prostate.
on the flip side, it is possible to do nerve grafting and you need to discuss that as an option with your surgeon.
hope this information helps.
~ curtis
knowledge is power - growing old is mandatory - growing wise is optional "Many more men die with prostate cancer than of it. Growing old is invariably fatal. Prostate cancer is only sometimes so." http://community.webtv.net/PALMER_ENT/doc
juniper - 16 Feb 2006 01:35 GMT ALL of this reply is very helpful, Curtis. Thank you.
> We saw a surgeon today, Kletscher, seemed very caring, competent, > experienced. He said he does do nerve sparing surgery, but he was going [quoted text clipped - 40 lines] > invariably fatal. Prostate cancer is only sometimes so." > http://community.webtv.net/PALMER_ENT/doc I.P. Freely - 16 Feb 2006 02:14 GMT > on the flip side, it is possible to do nerve grafting and you need to > discuss that as an option with your surgeon. But, of course, nerve grafting has its own set of prognosis statistics. As the situation goes from both nerves spared to one nerve spared to no nerves spared to this or that or the other, the likelihood of nerve grafting helping drops off rapidly. Once my surgeon saw real time that I had to lose one of the two nerve bundles, and knew that I already had mild ED, and knew this and that about my case and my priorities, he decided not to do the sural graft, as its odds of helping were too low to justify the process. i.e., it's not merely "an option", but a whole 'nuther decision based on statistics, priorities, scenario, real-time pathology assessment, etc.
I.P.
juniper - 16 Feb 2006 02:50 GMT I.C., I.P. Thanks for your input.
(I generally avoid writing "I agree" or "thanks for the answer"-type notes, but f-it. I appreciate all this.)
> > on the flip side, it is possible to do nerve grafting and you need to > > discuss that as an option with your surgeon. [quoted text clipped - 10 lines] > > I.P. Bill - 16 Feb 2006 16:41 GMT "the bottom line is this. this is what my surgeon told me. he said that when he gets in there and gets to the erectile nerves. if the prostate tissue slides off the nerve like the meat does on a piece of chicken, then the prostate cancer has not attacked the nerve. but the
cancer is sticky and will stick to the nerve as it attacks it. if it isn't too bad, there will be "flakes" of cancer and he can strip that off of the nerve, but if the prostate tissue to stuck solid to the nerve bundle, then there is nothing left to do but cut the nerve bundle and remove it with the prostate."
That is the way I understand it too. The surgeon makes a judgement call based on how the prostate looks and feels; I don't think they even wait for the frozen section. My PSA was 33+ at time of surgery and the first thing the surgeon told me when I woke up was that the margins looked clear and he saved both nerves. That was good news. Later I got the pathology and I had positive margins and seminal vesicle inolvement. That was not good news. Later I had biological failure. That was not good news. So, is the recurrence due to the nerves? In my case I think not, but that is the danger of leaving them in high risk cases.
Juniper, depending on your age, importance of erectile function, etc., you and your surgeon should have a discussion about how much discretion he has and how "aggressive" you want to be. As I recall, I told mine that he if got in and PCa was much in evidence, just close me up; if it looks good then save what you can. Many surgeons just decide on the front end not to take any chances in high risk cases, and he will decide for you unless you speak up.
Bill Denton RP 2/12/02 PSA /67 Memphis
I.P. Freely - 16 Feb 2006 18:32 GMT >, I told mine > that he if got in and PCa was much in evidence, just close me up; if it > looks good then save what you can. Many surgeons just decide on the > front end not to take any chances in high risk cases, and he will > decide for you unless you speak up. I made it clear to my surgeon that my life's in my head, not my pants, so if in doubt (about a nerve bundle), cut it out. He preserved one side.
I.P.
Leonard Evens - 16 Feb 2006 15:01 GMT > Hi, all. We saw a surgeon today, Kletscher, seemed very caring, > competent, experienced. He said he does do nerve sparing surgery, but [quoted text clipped - 4 lines] > Does this sound right? Are all those nerve sparing surgeries on the > guys with PSAs under 10 or 20? Any input will be appreciated. I think the others have more or less confirmed what your doctor told you, and they also gave you some other useful information. But one thing to keep in mind is that even if the nerves aren't spared, you can still have a relatively normal sex life. I was impotent for 18 months following surgery. During that time, I used a pump (VED) with reasonable success and my wife and I maintained an active sex life---about the same as before surgery. Other men have used injections successfully. Finally, if all else fails, there is the possibility of penile implants. It is a rather drastic solution, but apparently men who do have it done are generally satisfied with the results.
Alan Meyer - 19 Feb 2006 20:10 GMT >> Hi, all. We saw a surgeon today, Kletscher, seemed very caring, >> competent, experienced. He said he does do nerve sparing surgery, but [quoted text clipped - 13 lines] > fails, there is the possibility of penile implants. It is a rather drastic solution, > but apparently men who do have it done are generally satisfied with the results. I agree strongly with Leonard's point.
If it turns out that your husband is rendered impotent by the treatment, you do not need to give up on sex. Sex is still possible either with aids like a vacuum pump or chemical injections, or even with a limp penis. The nerves that are damaged are only the nerves involved in erections. The nerves involved in sexual stimulation are still active, and the primary sexual organ (the brain) is completely untouched by the surgery.
I advise you to be as supportive as you can be to your husband, both before and after the surgery. Let him know that you're still interested in him and won't find him any the less of a man because of this. Be prepared to explore new ways to have sex and be prepared to see it as what it can be - still exciting, still satisfying.
Alan
juniper - 19 Feb 2006 20:56 GMT Thank you all for your input. I imagine we'll find out what you mean. I printed this thread earlier, and think it was valuable to my husband. He told me later that he 'got it'-- that he was okay with the PCa and whatever happens. "I realized that no matter what, I'll still be chasing your tail for years to come..." ; ) He said another time, "I'll deal with what comes, and hope that during surgery, my prostate slides off like chicken off a bone." He couldn't say that one with a straight face. So we've reached an accomodation with reality. I am sure that it will be up and down--there is nothing about this disease that is smooth, is there?-- but it feels like an important step has been taken. Thank you all very, very much.
> I agree strongly with Leonard's point. > [quoted text clipped - 13 lines] > > Alan dale.j. - 17 Feb 2006 00:47 GMT > Hi, all. We saw a surgeon today, Kletscher, seemed very caring, > competent, experienced. He said he does do nerve sparing surgery, but [quoted text clipped - 4 lines] > Does this sound right? Are all those nerve sparing surgeries on the > guys with PSAs under 10 or 20? Any input will be appreciated. I think your doc is being very honest with you. You may have picked a very good surgeon.
Good luck
Dale j.
 Signature Email: dalej2@mac.com
Steve Kramer - 18 Feb 2006 01:28 GMT My PSA was 16. My doc didn't think nerve-sparing was a good idea in my case. The post-op biopsy proved him correct.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05 PSA .07 .05 .06 .05 .08 Non Illegitimi Carborundum
> Hi, all. We saw a surgeon today, Kletscher, seemed very caring, > competent, experienced. He said he does do nerve sparing surgery, but [quoted text clipped - 4 lines] > Does this sound right? Are all those nerve sparing surgeries on the > guys with PSAs under 10 or 20? Any input will be appreciated. Justin Case - 18 Feb 2006 20:19 GMT : My PSA was 16. My doc didn't think nerve-sparing was a good idea in my : case. The post-op biopsy proved him correct. <Remainder snipped>
My PSA was considerably higher than yours, Steve, and the doctor tactfully asked my wife and me together if we were "sexually active," the implication clearly being: "Surgery is going to virtually guarantee an end to that part of your lives." I did inquire, however, about retropubic prostatectomy, to which my surgeon said that wasn't really an option for me.
Ken Bland
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