 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / Diseases and Disorders / Prostate Cancer / August 2006Omega-6: fuel for prostate cancer cells?
"Omega-6: fuel for prostate cancer cells?", Reuters UK, February 10, 2006, Link: http://today.reuters.co.uk/news/newsArticle.aspx?type=healthNews&storyID=2006-02 -10T172708Z_01_COL062760_RTRIDST_0_HEALTH-OMEGA-CANCER-DC.XML&archived=False Adding arachidonic acid, a common omega-6 polyunsaturated fatty acid, to culture media causes prostate cancer cells to grow twice as fast as usual, according to a report in the February 1st issue of Cancer Research. "Investigating the reasons for this rapid growth, we discovered that the omega-6 was turning on a dozen inflammatory genes that are known to be important in cancer," lead author Dr. Millie Hughes-Fulford, from the San Francisco VA Medical Center, said in a statement. Further analysis indicated that arachidonic acid was activating these genes through the "PI3-kinase" pathway, which is known to play a key role in the pathogenesis of cancer. Adding a nonsteroidal anti-inflammatory drug or a PI3-kinase inhibitor to the culture media blocked the arachidonic acid-induced growth of prostate cancer cells. In light of the current findings, Dr. Hughes-Fulford said she now avoids cooking with corn oil, which is known to be high in omega-6 fatty acids. "I'm not a physician, and do not tell people how to eat, but I can tell you what I do in my own home. I use only canola oil and olive oil." SOURCE: Cancer Research, February 1, 2006. Hard to believe that prostrate cancer is made worse by essential fatty acids. More propaganda from the drug firm and media shill? It is essential that fatty acids be consumed as a whole, 3 - 6 - 9 and in the proper ratio. This study proves that and nothing more. Why spin it into the evil it isn't. Shall we start a war on omega 6? > Hard to believe that prostrate cancer is made worse by essential fatty > acids. More propaganda from the drug firm and media shill? It is > essential that fatty acids be consumed as a whole, 3 - 6 - 9 and in the > proper ratio. This study proves that and nothing more. Why spin it into > the evil it isn't. Shall we start a war on omega 6? Actually Omega 6, although being great, especially for women, is usually way more than required for men. This is ONLY when considered in relation to Omega 3. The point for us is to be sure to get a balance. Our typical eating habits are either too high in 6 or too low in 3 (same difference for this discussion). Most people need more 3 not less 6. > Hard to believe that prostrate cancer is made worse by essential fatty > acids. More propaganda from the drug firm and media shill? It is > essential that fatty acids be consumed as a whole, 3 - 6 - 9 and in the > proper ratio. This study proves that and nothing more. Why spin it into > the evil it isn't. Shall we start a war on omega 6? Considering how heavily the U.S. "food" manufacturers have swung towards corn oil, maybe we should. Our government has bolstered corn too heavily for decades now, with the latest negative impact being high fructose corn syrup in place of good 'ol sugar as sweeteners in everything. I.P. >Hard to believe that prostrate cancer is made worse by essential fatty >acids. More propaganda from the drug firm and media shill? It is >essential that fatty acids be consumed as a whole, 3 - 6 - 9 and in the >proper ratio. This study proves that and nothing more. Why spin it into >the evil it isn't. Shall we start a war on omega 6? This is not the first study to show that omega-6 fatty acids increase prostate cancer growth rate. The worst omega-6 fatty acid for prostate cancer is arachidonic acid (AA), which is found mostly in red meat, farm-raised fatty fish (not in wild fish or othe wild seafood) and in eggs. Besides trying to reduce dietary AA, the harmful effect of AA can be reduced or blocked by inhibiting the enzyme 5-lipoxygenase (5-LOX), which is required to convert AA to its harmful metabolites, mainly 5-HETE. Inhibition of 5-LOX can be done by drugs or by dietary means, because there many natural 5-LOX inhibitors. Inhibition of the enzymes 12-lipoxygenas (12-LOX) and COX-2 could also be useful in prostate cancer. Prostate cancer patients should also avoid large amounts of omega-3 fatty acid alpha-linolenic acid (ALA), which in several epidemiological studies has been statistically associated with an increased risk of prostate cancer. Watch for example the oils you use, some of them have a fair amount of ALA. Estra virgin olive oil is the safest, it contains mostly monounsaturated omega-9 oleic acid, less omega-6 linoleic acid that most other oils, and practically no ALA. Long chain omega-3 fatty acids EPA and DHA found in fish are not harmful in prostate cancer and could be beneficial. Prostate cancer cells need arachidonic acid/ 5-lipoxygenase metabolite, 5-HETE (5-hydroxyeicosatetraenoic acid) to survive and inhibition of the enzyme 5-lipoxygenase completely blocks 5-HETE production and induces massive apoptosis in both hormone-responsive (LNCaP) and -nonresponsive (PC3) human prostate cancer cells. See the following Medline references: Ghosh J, Myers CE. Arachidonic acid stimulates prostate cancer cell growth: critical role of 5-lipoxygenase. Biochem Biophys Res Commun. 1997 Jun 18;235(2):418-23. PMID: 9199209 [PubMed - indexed for MEDLINE] <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra ctPlus&list_uids=9199209> Ghosh J, Myers CE. Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13182-7. PMID: 9789062 [PubMed - indexed for MEDLINE] <http://www.pnas.org/cgi/content/full/95/22/13182> Anderson KM, Seed T, Vos M, Mulshine J, Meng J, Alrefai W, Ou D, Harris JE. 5-Lipoxygenase inhibitors reduce PC-3 cell proliferation and initiate nonnecrotic cell death. Prostate. 1998 Nov 1;37(3):161-73. PMID: 9792133 [PubMed - indexed for MEDLINE] <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra ctPlus&list_uids=9792133> <http://www3.interscience.wiley.com/cgi-bin/abstract/5005796/ABSTRACT?CRETRY=1&SR ETRY=0> (link to full text PDF provided) Myers CE, Ghosh J Lipoxygenase inhibition in prostate cancer. Eur Urol. 1999;35(5-6):395-8. Review. PMID: 10325495 [PubMed - indexed for MEDLINE] <http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=eur35395> Nie D, Hillman GG, Geddes T, Tang K, Pierson C, Grignon DJ, Honn KV. Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth. Cancer Res. 1998 Sep 15;58(18):4047-51. PMID: 9751607 [PubMed - indexed for MEDLINE] <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9 751607&dopt=Abstract> Shureiqi I, Lippman SM. Lipoxygenase modulation to reverse carcinogenesis. Cancer Res. 2001 Sep 1;61(17):6307-12. Review. PMID: 11522616 [PubMed - indexed for MEDLINE] <http://cancerres.aacrjournals.org/cgi/content/full/61/17/6307> Nie D, Che M, Grignon D, Tang K, Honn KV. Role of eicosanoids in prostate cancer progression. Cancer Metastasis Rev. 2001;20(3-4):195-206. Review. PMID: 12085962 [PubMed - indexed for MEDLINE] <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra ctPlus&list_uids=12085962> <http://www.springerlink.com/(mafdkr55bvntlnekvg3r1i55)/app/home/contribution.asp ?referrer=parent&backto=issue,5,16;journal,15,85;linkingpublicationresults,1:102 861,1> (link to full text PDF provided) Matsuyama M, Yoshimura R, Mitsuhashi M, Hase T, Tsuchida K, Takemoto Y, Kawahito Y, Sano H, Nakatani T. Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors. Int J Oncol. 2004 Apr;24(4):821-7. PMID: 15010818 [PubMed - indexed for MEDLINE] <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra ctPlus&list_uids=15010818> Matsuyama M, Yoshimura R, Tsuchida K, Takemoto Y, Segawa Y, Shinnka T, Kawahito Y, Sano H, Nakatani T. Lipoxygenase inhibitors prevent urological cancer cell growth. Int J Mol Med. 2004 May;13(5):665-8. PMID: 15067367 [PubMed - indexed for MEDLINE] <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra ctPlus&list_uids=15067367> Is I mentioned earlier, natural inhibitors of 5-lipoxygenase exist, the best is probably Boswellia serrata a.k.a.frankincense (Boswellic acid). There also natural COX-2 ihibitors. Selenium's and vitamin E's anticancer effects against prostate cancer may at least partly be caused by the fact, that they at least to some extent inhibit 5-lipoxygenase. Other natural 5-lipoxygenase inhibitors include cocoa, GLA (from evening primrose oil for example; GLA could cause accumulation of AA in serum, so it should alwasy be taken with EPA or fish oil which prevents this), quercetin, dried or semi-dried qinger powder, curcumin, propolis, milk thistle extract silymarin and its ingredient silibinin (silybin), resveratrol (from red wine), New Zealand green-lipped mussel (Perna Canaliculus) extracts (Lyprinol for example), garlic, onions and saw palmetto berry extracts More information about these on the web page Reducing Inflammation with Diet and Supplements: The Story of Eicosanoid Inhibition <http://www.itmonline.org/arts/lox.htm> There is even a natural 12-lipoxygenase inhibitor: Chinese scullcap (Scutellaria baicalensis): The Golden Root: Clinical Applications of Scutellaria baicalensis GEORGI flavonoids as Modulators of the Inflammatory Response <http://www.thorne.com/altmedrev/fulltext/scutellaria2-6.html> Easy-to-read web sites about natural 5-lipoxygenase and COX-2 inhibitors: Natural Anti-Inflammatory Supplements: Research Status and Clinical Applications <http://www.massagetoday.com/archives/2001/12/12.html> Natural Remedies for Inflammation <http://www.thenutritionreporter.com/remedies_for_inflammation.html> Herbal Anti-Inflammatories <http://www.chiroweb.com/archives/17/13/06.html> Beyond Aspirin: The COX-2 Medical Revolution. Healthy & Natural Journal, Oct, 2000, by Thomas M. Newmark, Paul Schulick <http://www.findarticles.com/cf_dls/m0HKL/5_7/66918309/p1/article.jhtml> Cancer Fighters in Your Spice Rack <http://www.wholehealthmd.org/news/viewarticle/1,1513,844,00.html> <http://www.chifountain.com/studies_Folder/Cancer%20Fighters%20in%20Your%20Spice% 20Rack.pdf> Medline references about herbal LOX-inhibitors: Schneider I, Bucar F. Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5-lipoxygenase and 5-lipoxygenase[sol ]cyclooxygenase. Phytother Res. 2005 Feb;19(2):81-102. Review. PMID: 15852496 [PubMed - indexed for MEDLINE] <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra ctPlus&list_uids=15852496> <http://www3.interscience.wiley.com/cgi-bin/abstract/110477935/ABSTRACT?CRETRY=1& SRETRY=0> <http://www3.interscience.wiley.com/cgi-bin/fulltext/110477935/PDFSTART> Schneider I, Bucar F. Lipoxygenase inhibitors from natural plant sources. Part 2: medicinal plants with inhibitory activity on arachidonate 12-lipoxygenase, 15-lipoxygenase and leukotriene receptor antagonists. Phytother Res. 2005 Apr;19(4):263-72. Review. PMID: 16041764 [PubMed - indexed for MEDLINE] <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=R etrieve&dopt=abstractplus&list_uids=16041764> <http://www3.interscience.wiley.com/cgi-bin/fulltext/110477935/PDFSTART>  SignatureMatti Narkia Yikes, science overload! :-) Matti, who are you? Bill Denton RP 2/12/02 PSA .93 Memphis >Yikes, science overload! :-) Well, isn't this a science group? ;-). >Matti, who are you? I'm a nutritional and medical information freak and internet poster since 1994 ;-). I was diagnosed with Ca in 1988, not PCa, though. I basically like to gather information and discuss about it with same minded people. These bits were best pieces from a recent thread in sci.med.nutrition and some other groups. I was asked to post it to prostate cancer groups, so I did. Hope you didn't mind. SignatureMatti Narkia >>Yikes, science overload! :-) >> >Well, isn't this a science group? ;-). Oops, I replied in the sci.med.prostate.cancer and forgot for a moment, that this thread was posted to other groups, too. SignatureMatti Narkia >>Yikes, science overload! :-) >> [quoted text clipped - 8 lines] > sci.med.nutrition and some other groups. I was asked to post it to > prostate cancer groups, so I did. Hope you didn't mind. Matti, keep that kind of information coming! Any well-researched information about cancer is a real contribution to this group. Alex > "Omega-6: fuel for prostate cancer cells?", Reuters UK, February 10, > 2006, > Link: > http://today.reuters.co.uk/news/newsArticle.aspx?type=healthNews&storyID=2006-02 -10T172708Z_01_COL062760_RTRIDST_0_HEALTH-OMEGA-CANCER-DC.XML&archived=False New confirmation: Source: University of California - Los Angeles Altering Fatty Acid Levels In Diet May Reduce Prostate Cancer Growth Rate August 1, 2006 UCLA researchers found that altering the fatty acid ratio found in the typical Western diet to include more omega-3 fatty acids and decrease the amount of omega-6 fatty acids may reduce prostate cancer tumor growth rates and PSA levels. Published in the Aug. 1 issue of the journal Clinical Cancer Research, this initial animal-model study is one of the first to show the impact of diet on lowering an inflammatory response known to promote prostate cancer tumor progression and could lead to new treatment approaches. The omega-6 fatty acids contained in corn, safflower oils and red meats are the predominant polyunsaturated fatty acids in the Western diet. The healthier marine omega-3 fatty acids are found in cold-water fish like salmon, tuna and sardines. "Corn oil is the backbone of the American diet. We consume up to 20 times more omega-6 fatty acids in our diet compared to omega-3 acids," said principal investigator Dr. William Aronson, a professor in the department of urology at the David Geffen School of Medicine at UCLA and a researcher with UCLA's Jonsson Cancer Center. "This study strongly suggests that eating a healthier ratio of these two types of fatty acids may make a difference in reducing prostate cancer growth, but studies need to be conducted in humans before any clinical recommendations can be made." Scientists used a special mouse model for hormone-sensitive prostate cancer that closely mirrors the disease in humans. Researchers fed one group of mice a diet comprised of 20 percent fat with a healthy one-to-one ratio of omega-6 to omega-3 fatty acids. A second group of mice were fed the same diet but with the fat derived from mostly omega-6 fatty acids. The study showed that tumor cell growth rates decreased by 22 percent and PSA levels were 77 percent lower in the group receiving a healthier balance of fatty acids compared with the group that received predominantly omega-6 fatty acids. The most likely mechanism for the tumor reductions, according to researchers, was due to an increase of the prostate tumor omega-3 fatty acids DHA and EPA and a lowering of the omega-6 acid known as arachidonic acid. These three fatty acids compete to be converted by cyclooxgenase enzymes (COX-1 and COX-2) into prostaglandins, which can become either pro-inflammatory and increase tumor growth, or anti-inflammatory and reduce growth. Researchers found that pro-inflammatory prostaglandin (PGE-2) levels were 83 percent lower in tumors in the omega-3 group than in mice on the predominantly omega-6 fatty acid diet, demonstrating that higher levels of DHA and EPA may lead to development of more anti-inflammatory prostaglandins. "This is one of the first studies showing changes in diet can impact the inflammatory response that may play a role in prostate cancer tumor growth," Aronson said. "We may be able to use EPA and DHA supplements while also reducing omega-6 fatty acids in the diet as a cancer prevention tool or possibly to reduce progression in men with prostate cancer." Currently, the research team is conducting a clinical trial with men who are undergoing prostate removal due to cancer to compare the effects of a low-fat diet using omega-3 supplements and a balanced Western diet. Aronson said that positive findings from this study may lead to larger clinical trials. In addition, Aronson said that further study might show that COX-2 inhibitors or non-steroidal anti-inflammatories (NSAIDS) combined with omega-3 supplements also may lower the inflammatory response in prostate cancer development. ==== The study was funded by the Department of Veterans Affairs, the National Institute of Health Grants: Specialized Programs of Research Excellence and UCLA's Jonsson Cancer Center. Other study authors include: Naoko Kobayashi, R. James Barnard, Susanne M. Henning, David Elashoff, Srinivasa T. Reddy, Pinchas Cohen, Pak Leung, Jenny Hong-Gonzalez, Stephen J. Freedland, Jonathan Said, Dorina Gui, Navindra P. Seerum, Laura M. Popoviciu, Dilprit Bagga, David Heber, and John A. Glaspy. http://www.sciencedaily.com/releases/2006/08/060801132100.htm |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2008 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.