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Medical Forum / Diseases and Disorders / Prostate Cancer / February 2006

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High Intensity Focused Ultrasound - opinions please

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From Bob - 04 Feb 2006 19:43 GMT
Recently diagnosed with pc, age 69, 10 core biopsy revealed 3 positive
cores, 2 on the right side, 1 on the left side, 5% of involved cores
showed adeno-carcinoma, with a gleason of 7. In process of exploring
treatment options, awaiting results of bone scan & cat scan, hopefully
it is localized. Not doing well emotionally with this news. Has anyone
had HIFU (high tensity focused ultrasound, as a treatment ???
~~~~~~~~~~~~~~~~~~~~~~~~~~~
High Intensity Focused Ultrasound (HIFU)
HIFU: is a medical device piloted by a computer designed to treat
localized prostate cancer using high intensity focused ultrasound
(HIFU). 
What is HIFU?
HIFU is a procedure where the temperature inside the prostate is raised
to 85° Celsius using a focused ultrasound beam
A probe is placed into the rectum after spinal or epidural anesthesia
has been administered
This probe emits a beam of high intensity focused ultrasound
At the point where the ultrasound is focused (focal point) the sudden
and intense absorption of the ultrasound beam quickly raises the
temperature which destroys targeted cells
The area destroyed by each beam is very small and precise
By repeating the process and moving the focal point it is possible to
destroy the prostate tissue
The treatment takes from 1 to 3 hours depending upon the size of the
prostate and is usually performed on an outpatient basis
What Do the Clinical Studies Show?
HIFU has been extensively used in Europe
One report of 137 patients showed that 93% of the patients had negative
prostate biopsies and 87% had PSA levels of less than 1.0 five years
after the treatment
Over 90% of patients undergoing HIFU therapy will not require further
treatment for their prostate cancer
HIFU treatment does not preclude other treatments. In those developing a
recurrence, they remain candidates for surgery, radiation or hormone
therapy
HIFU treatment has a similar success rate to radical prostatectomy but
has the major advantage of using non-invasive technology with many fewer
side effects
HIFU has proven to be an effective treatment for localized recurrent
prostate cancer
Published results indicate that 100 consecutive unsuccessful external
beam radiation patients shows 62% of patients had negative biopsies,
stable psa results and zero rectal fistulae
Is HIFU a Proven Therapy?
In 1989, three European research groups united in their efforts and
initiated a project to develop an efficient and non-surgical treatment
for localized prostate cancer
After ten years of development, HIFU was approved for treatment in
Europe. At present, HIFU is being used throughout Europe, Russia, Japan
and other Asian countries. In 2003, it received Canadian government
approval and patients are being treated in Toronto, Canada
To date, thousands of patients have been treated successfully in many
European centers and throughout the world
Advantages of HIFU
Destruction of the cancerous tissue with no risk of injury to the
surrounding organs
No chance of rectal injury
Patient does not undergo any radiation exposure
Usually no hospital stay is required
Treatment is performed under spinal or epidural anesthesia
Treatment can be repeated if necessary
Other therapeutic alternatives can be considered in case of incomplete
results
Nerve sparing procedure can be performed
HIFU can be used for the treatment of local recurrences (i.e. after
external beam radiotherapy)
Disadvantages of HIFU
No pathology (no tissue) to be examined following the procedure
A TUR-P may be required prior to treatment
Not yet available in the United States
Patients must travel to Canada for treatment
Not covered by many insurance plans, as treatment not available in the
U.S.
Steve Kramer - 04 Feb 2006 21:10 GMT
Sorry, Bob.  No one here, to my knowledge, has tried HIFU.  Canada Bob
researched it.  His last email address, that I know of, was or is
robert01942@hotmail.com

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05
PSA  .07 .05 .06 .05 .08
Non Illegitimi Carborundum

Recently diagnosed with pc, age 69, 10 core biopsy revealed 3 positive
cores, 2 on the right side, 1 on the left side, 5% of involved cores
showed adeno-carcinoma, with a gleason of 7. In process of exploring
treatment options, awaiting results of bone scan & cat scan, hopefully
it is localized. Not doing well emotionally with this news. Has anyone
had HIFU (high tensity focused ultrasound, as a treatment ???
~~~~~~~~~~~~~~~~~~~~~~~~~~~
High Intensity Focused Ultrasound (HIFU)
HIFU: is a medical device piloted by a computer designed to treat
localized prostate cancer using high intensity focused ultrasound
(HIFU).
What is HIFU?
HIFU is a procedure where the temperature inside the prostate is raised
to 85° Celsius using a focused ultrasound beam
A probe is placed into the rectum after spinal or epidural anesthesia
has been administered
This probe emits a beam of high intensity focused ultrasound
At the point where the ultrasound is focused (focal point) the sudden
and intense absorption of the ultrasound beam quickly raises the
temperature which destroys targeted cells
The area destroyed by each beam is very small and precise
By repeating the process and moving the focal point it is possible to
destroy the prostate tissue
The treatment takes from 1 to 3 hours depending upon the size of the
prostate and is usually performed on an outpatient basis
What Do the Clinical Studies Show?
HIFU has been extensively used in Europe
One report of 137 patients showed that 93% of the patients had negative
prostate biopsies and 87% had PSA levels of less than 1.0 five years
after the treatment
Over 90% of patients undergoing HIFU therapy will not require further
treatment for their prostate cancer
HIFU treatment does not preclude other treatments. In those developing a
recurrence, they remain candidates for surgery, radiation or hormone
therapy
HIFU treatment has a similar success rate to radical prostatectomy but
has the major advantage of using non-invasive technology with many fewer
side effects
HIFU has proven to be an effective treatment for localized recurrent
prostate cancer
Published results indicate that 100 consecutive unsuccessful external
beam radiation patients shows 62% of patients had negative biopsies,
stable psa results and zero rectal fistulae
Is HIFU a Proven Therapy?
In 1989, three European research groups united in their efforts and
initiated a project to develop an efficient and non-surgical treatment
for localized prostate cancer
After ten years of development, HIFU was approved for treatment in
Europe. At present, HIFU is being used throughout Europe, Russia, Japan
and other Asian countries. In 2003, it received Canadian government
approval and patients are being treated in Toronto, Canada
To date, thousands of patients have been treated successfully in many
European centers and throughout the world
Advantages of HIFU
Destruction of the cancerous tissue with no risk of injury to the
surrounding organs
No chance of rectal injury
Patient does not undergo any radiation exposure
Usually no hospital stay is required
Treatment is performed under spinal or epidural anesthesia
Treatment can be repeated if necessary
Other therapeutic alternatives can be considered in case of incomplete
results
Nerve sparing procedure can be performed
HIFU can be used for the treatment of local recurrences (i.e. after
external beam radiotherapy)
Disadvantages of HIFU
No pathology (no tissue) to be examined following the procedure
A TUR-P may be required prior to treatment
Not yet available in the United States
Patients must travel to Canada for treatment
Not covered by many insurance plans, as treatment not available in the
U.S.
ron - 04 Feb 2006 22:13 GMT
Bob...Go to PubMed
http://www.ncbi.nih.gov/entrez/query.fcgi
and search "HIFU, prostate cancer".  You'll get a lot of hits, the
available abstracts should be informative.  HIFU hasn't been practiced
all that long, so long term results (10 years or so) on disease
recurrence are not available.  Shorter term recurrence results do not
look impressive, they are generally higher than what surgery or RT
might produce at equivalent follow-up times.  Impotence and the need
for a TURP, post-HIFU, are also quite common.  On the positive side it
is a very well tolerated procedure and will probably improve further
with time...Ron
Clarence Crow - 04 Feb 2006 23:43 GMT
<snip>
> Has anyone
>had HIFU (high tensity focused ultrasound, as a treatment ???
<snip>
I haven't had it and wouldn't be keen to try it due to the possible
errors in focusing the 2 U/sound vector beams, working from a probe up
your rectum trying to pinpoint target areas in your prostate, each of
which moves independently of the other.

I had HDR Brachytherapy, which I consider to be more accurate in
"mapping" the target areas within the prostate. More CT scans are
taken after the template placement and the catheter positions are
checked and adjusted against the model at each session.

The object of BOTH treatments is to boil your prostate into one HUGE
blister, killing every cell inside the capsule with excessive heat.

The very fact that HIFU Spin Doctors offer a free TURP with each
treatment, smacks of "blind shooting".

If you want to be one of the Pioneers in HIFU, you can get it done on
the cheap in Mexico.

 
-- Reader to complete...
-- Please reply to this ng as my email adress is fake:

-- Regards

-- CC
Steve Jordan - 05 Feb 2006 00:39 GMT
On February 4 (US) Clarence Crow wrote, in pertinent part:
> If you want to be one of the Pioneers in HIFU, you can get it done on
> the cheap in Mexico.
>  
Well, I dunno about cheap.

A friend of mine had the procedure (done by a well-known uro from
southern California) in Cabo San Lucas, Baja California, Mexico. He had
elected to try to have his cake and eat it too by having only a partial
"ablation" performed. Cost him US$22,000, none of which was covered by
any sort of insurance.

BTW, it didn't work very well. He had a large surge in PSA and had to
undergo chemotherapy (Taxotere) + ADT. At the moment, he's dong well,
though.

Regards,

Steve J

"The thing is to expect nothing in particular, but be aware of the lack
of enforceable guarantees or enforceable contracts with
nature/god/entropy as to the condition or durability of our bodies."
-- Brian Brunner, PCa survivor, December 12, 2005 on The Prostate
Problems Mailing List
Thank you, Brian.
>  
> -- Reader to complete...
[quoted text clipped - 4 lines]
> -- CC
>  
c palmer - 05 Feb 2006 00:41 GMT
hi bob - Hifi was developed in 1999 and had 7 years to develop.  so far,
i've not seen much from it as far as actual results.  i'm starting to
see more along the lines of pushing it in advertising than i'm seeing in
lab reports and lab results.

please be advised that you are playing with a treatment that doesn't
have a long history as compared to the other two forms of treatment
(surgery or radiation)
both of those have proven track records.

given your age (69),  you would have to ask yourself, 'how's your
health?"

this may limit the type of treatment you seek.  

for example,  maybe your health won't allow surgery as an option.

you didn't say what your psa was.

your biopsy revealed that you are a stage 'c' whether it is in stage 1
or 2.

also, another point to consider is your gleason of 7.  was it (4 + 3) or
(3 + 4)?

you will find that it isn't a one answer fits all when it comes to
prostate cancer, but to research the options and look at your facts,
then opt for the best treatment in your particular case.

as to the mental part of not taking it well.  that goes with the
program.  the best way to look at it is that you will go through the
different phases as if you experience a death of a loved one.  

the disbelief, the anger, the let's make a deal stage, the
depression........ etc, etc.

it's normal to cry too.

keep asking questions and researching.  

prostate cancer is not a death sentence.  you can beat it.  

~ curtis

knowledge is power - growing old is mandatory - growing wise is optional    
"Many more men die with prostate cancer than of it. Growing old is
invariably fatal. Prostate cancer is only sometimes so."
http://community.webtv.net/PALMER_ENT/doc
 
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