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Medical Forum / Diseases and Disorders / Prostate Cancer / December 2005PSA and Saw Palmetto
I had read, some time back, on web sites that PSA is masked by use of Saw Palmetto, something I definitely use. The pains and other things that I get have me worried. Eg, if I need to pee and crap at the same time, the pain is like a knife in me and even in the street this can happen and I cant move. It lasts only 30 seconds and goes away completely until next time. So, I have decided to get a PSA done and have gone completely off my Saw Palmetto, much to my upset as the pains have increased markedly since then and I have become very sick at the same time and absolutely worn out. My question is - how long do I have to be off Saw Palmetto completely before the masking effect is gone? Does anyone know, please? This is a serious question, not a frivolous one. Thanks. From: No@address.given (Slightly Unsure) I had read, some time back, on web sites that PSA is masked by use of Saw Palmetto, something I definitely use. The pains and other things that I get have me worried. Eg, if I need to pee and crap at the same time, the pain is like a knife in me and even in the street this can happen and I cant move. It lasts only 30 seconds and goes away completely until next time. So, I have decided to get a PSA done and have gone completely off my Saw Palmetto, much to my upset as the pains have increased markedly since then and I have become very sick at the same time and absolutely worn out. My question is - how long do I have to be off Saw Palmetto completely before the masking effect is gone? Does anyone know, please? This is a serious question, not a frivolous one. Thanks. ========== call the place that you are going to have the psa test done and explain what you have been taking and ask them how long it will take to be out of your system. i'm sure you are not the first person to ask them that question or they may have a set of rules as a guideline to be able to help you. ~ curtis knowledge is power - growing old is mandatory - growing wise is optional "Many more men die with prostate cancer than of it. Growing old is invariably fatal. Prostate cancer is only sometimes so." http://community.webtv.net/PALMER_ENT/doc > knowledge is power - growing old is mandatory - growing wise is optional > "Many more men die with prostate cancer than of it. Growing old is > invariably fatal. Prostate cancer is only sometimes so." Just saw that at the end of your letter. In fact in this country at least, many more men die of prostate cancer than women do of breast cancer. Don't ask for an URL. That was on the news about a month ago. >I had read, some time back, on web sites that PSA is masked by use of Saw Palmetto, >something I definitely use. The pains and other things that I get have me worried. Eg, if [quoted text clipped - 9 lines] > effect is gone? Does anyone know, please? This is a serious question, not a frivolous > one. Thanks. It is widely believed that saw palmetto reduces PSA, but I'm not at all convinced that it's true. I did a search on Pubmed for "saw palmetto" "psa". The first three hits I looked at measured PSA before and after taking saw palmetto and all three reported no difference in PSA measurements. Here are the studies: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra ct&list_uids=12092634&query_hl=3 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra ct&list_uids=11725694&query_hl=3 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra ct&list_uids=11601567&query_hl=3 So I'm wondering if the supposed suppressive influence of saw palmetto on PSA is a myth. It very often happens that someone surmises that "it makes sense that ..." and soon this surmise becomes accepted wisdom. I also tried to find out the "half-life" of saw palmetto in the body, but the only definitive statement I found was in Davis' Drug Guide for Nurses, which said the half-life is unknown. However, please don't take my word for any of this. I'm no expert and I really don't know what you should do. But you might want to read the above three hyperlinked abstracts for yourself, do whatever other searching seems reasonable, and draw your own conclusions. Good luck. Alan Alan Meyer wrote...snip... > It is widely believed that saw palmetto reduces PSA, but I'm not > at all convinced that it's true. [quoted text clipped - 13 lines] > So I'm wondering if the supposed suppressive influence of saw palmetto > on PSA is a myth. Alan...This is my understanding too. Current thinking seems to be that SP does not affect PSA. Like 5AR inhibitors (Finasteride, Dutasteride), SP blocks the T - DHT conversion. Unlike them, SP does not bind to the androgen receptor and block binding of the PSA expression gene...Ron > However, please don't take my word for any of this. I'm no expert and I > really don't know what you should do. But you might want to read the > above > three hyperlinked abstracts for yourself, do whatever other searching > seems > reasonable, and draw your own conclusions. Thanks for all that info and yes I will read them! > I had read, some time back, on web sites that PSA is masked by use of Saw > Palmetto, something I definitely use. The pains and other things that I get [quoted text clipped - 9 lines] > the masking effect is gone? Does anyone know, please? This is a serious > question, not a frivolous one. Thanks. Have you seen a uro about your pain, or are you self treated? I would run if I were you. Herbal treatments work well for imagined problems, but for CANCER you need to get into the real world of modern medicine. Sorry to be so blunt, but pain is not a good indicator of good health.  Signature"Don't get me wrong... I'm SNARKY" JK Sinrod Sinrod Stained Glass Studios www.sinrodstudios.com Coney Island Memories www.sinrodstudios.com/coneymemories > Have you seen a uro about your pain, or are you self treated? I would run > if I were you. Herbal treatments work well for imagined problems, but for > CANCER you need to get into the real world of modern medicine. Sorry to be > so blunt, but pain is not a good indicator of good health. Last time I saw a Uro was late 1998 and that is how I was diagnosed with Chronic Bacterial Prostatitis and at that time was put under an ultrasound and told all clear for cancer. They warned me to come back every 6 months for testing as they said I was a prime candidate for prostate cancer but I never did. I had been given the all clear and I just don't like to play the hypochondriac. However, a friend of my wife has a husband who recently was diagnosed with it around the nerves after the GP gave him the all clear with only a small rider - that the PSA was ever so slightly elevated. This guy is apparently a "if it isn't normal, check it out" type of person and he insisted on all the necessary tests at which point the cancer was discovered. That made me jump from the "she'll be right" side of the track to "sh.t, better check this out I suppose" side thus the question about how long Saw Palmetto affects PSAs. Anyway, will be getting it done early in the new year or, if things keep going the way they are right now, really soon. I have no idea why me stopping Saw Palmetto has made me feel weak and sick but it has and I am actually getting other symptoms non prostate related that knock me weak as a kitten for near a week now. I cant effectively work this way and that costs money so I need to fix THAT problem soon. Thanks for taking the time to reply. I really appreciate all who did. > > Have you seen a uro about your pain, or are you self treated? I would run > > if I were you. Herbal treatments work well for imagined problems, but for [quoted text clipped - 7 lines] > never did. I had been given the all clear and I just don't like to play the > hypochondriac. Sorry but ultrasound is not a definitive test for cancer. It will pick up something really remarkable, but PCa is often very tiny. The ONLY way to know you have it is biopsy. There's quite alot of room between being a hypochondriac and getting a recommended test when told to. Signature"Don't get me wrong... I'm SNARKY" JK Sinrod Sinrod Stained Glass Studios www.sinrodstudios.com Coney Island Memories www.sinrodstudios.com/coneymemories >> > Have you seen a uro about your pain, or are you self treated? I would > run [quoted text clipped - 19 lines] > know you have it is biopsy. There's quite alot of room between being a > hypochondriac and getting a recommended test when told to. Not in this country there isn't. If you go to the doctor you are immediately a hypochondriac and that usually labelled by the doctor! > Not in this country there isn't. If you go to the doctor you are > immediately a hypochondriac and that usually labelled by the doctor! I'm sorry, Unsure. I missed what country that is? SignaturePSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05 PSA .07 .05 .06 .05 .08 Non Illegitimi Carborundum >> Not in this country there isn't. If you go to the doctor you are >> immediately a hypochondriac and that usually labelled by the doctor! > > I'm sorry, Unsure. I missed what country that is? .au here. Ah, yes. AU.... where you're expected to drink a pint of 200 proof an dig out your own prostate with a butter knife. SignaturePSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05 PSA .07 .05 .06 .05 .08 Non Illegitimi Carborundum >>> Not in this country there isn't. If you go to the doctor you are >>> immediately a hypochondriac and that usually labelled by the doctor! >> >> I'm sorry, Unsure. I missed what country that is? > > .au here. Steve, It's not that bad, a sharp knife is allowed. Tom > Ah, yes. AU.... where you're expected to drink a pint of 200 proof an > dig out your own prostate with a butter knife. [quoted text clipped - 5 lines] >> >> .au here. > Ah, yes. AU.... where you're expected to drink a pint of 200 proof an > dig out your own prostate with a butter knife. You whingers have a knife for BUTTER - or is that a knife MADE of butter? :)
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