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Medical Forum / Diseases and Disorders / Prostate Cancer / September 2005

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New diagnostic test

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btollefson@kos.net - 22 Sep 2005 11:59 GMT
Check it out
http://abcnews.go.com/WNT/MedicineCuttingEdge/story?id=1147031&page=1
Pops - 22 Sep 2005 13:00 GMT
I had steam coming out of my ears as they reported "In fact, 80 percent
of PSA results are false alarms."

This new test is up ten years away from being approved, as reported in
the same segment.

Now they've told a bunch of guys who thought they had to have regular
PSA tests that there's an 80% chance they're wrong anyways. PCa is
still a nightmare to consider and so a whole bunch of those guys are
gonna think this is a reason not to have tests. They'll be at their
oncologist a few years later with bone pain and incurable PCa. I hope
these idiots from ABC News can sleep well considering that they've
probably killed lots of men who would have been cured had they followed
their Uros instructions and reacted to PSA and DRE results.

The MD's who reported these results are obviously energetic about this
new detection scenario. So am I, but it ain' there yet and there's no
reason to put down PSA testing in order to promote their agenda.

Does anybody know where these stats have come from? Is it that AMA
article? It didn't take me,a layman, long to shoot holes in that
analysis. It wasn't "wrong", just tunnel visioned, and I don't remember
that 80% figure. Does this mean that 80% of PSA driven biopsies are
negative? So what are the percentages of PSA driven biopsies that don't
detect real PCa? What a way to twist statistics.

I'll bet that this statistic includes real negatives as well as false
positives. In other words the test report a low PSA and no need to do a
biopsy. Of course they don't talk aout DREs.

I'll wait a bit before firing off a scathing email to the ABC News
team. In my opinion somebody ought to sue them for reporting such
statistics without validating them. If someone can substantiate this
data let me know.
Buttercup's Dad - 22 Sep 2005 14:25 GMT
My primary care doctor spend fifteen minutes explaining the PSA test to me,
and the problem with the false positives.  The PSA Free was not available at
that time.  He left it to me to decide whether to have the PSA test or not,
realizing that the biopsy was the result of a PSA above 4.0.  I decided not
because all the men in my family died of heart attacks and strokes before
age 60, so I did not feel at risk.  Also, my doctor did the DRE, so the
prostate was being checked, or so I thought at the time.  It was an
insurance physical a few years later that came back with a PSA of 5 that
prompted a PSA Free test that came back at 6% (which I understand is bad).
If not for that I could still be totally ignorant of Depends' products,
vacuum pumps, and the fact that sticking a needle in my penis really does
not hurt.  Of course, then I would not know all of you people, I would not
be aware of Kramer's great dry sense of humor, Curtis' many faceted talents,
met Mike H live and in person, my wife would not be jealous of my special
relationship with Heather, and the cancer cells would be merrily
proliferating in my body.

As to ABC news, I learned long ago not to believe anything I see on tv.   My
suggestion is to send the letter while you are still hot Pops.  Be sure to
tell the men there to not get those nasy PSA tests.  They should wait for
the new test in ten years.

> I had steam coming out of my ears as they reported "In fact, 80 percent
> of PSA results are false alarms."
[quoted text clipped - 30 lines]
> statistics without validating them. If someone can substantiate this
> data let me know.
Dan Dubosky - 22 Sep 2005 15:04 GMT
I believe that the news release by ABC is referring to a recent article in
the New England Journal of Medicine.

http://content.nejm.org/cgi/content/short/353/12/1224?query=TOC

Dan

>I had steam coming out of my ears as they reported "In fact, 80 percent
> of PSA results are false alarms."
[quoted text clipped - 30 lines]
> statistics without validating them. If someone can substantiate this
> data let me know.
 
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