Medical Forum / Diseases and Disorders / Prostate Cancer / August 2005
Soy
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Stavros Moschos - 04 Aug 2005 17:17 GMT I have received very mixed signals from my medical team about soy. I was told to eat lots of it and we are trying to do that quite systematically (along with vitamin D, selenium, green tea extract, lycopene--you name it), but yesterday a resident said that once you get PCa there is no point in eating soy, that it might prevent PCa from developing in the first place, but that there is no evidence that it does any good in preventing it from spreading. If it does no good I would be quite happy to go back to barbecued spare ribs.
David S. - 04 Aug 2005 18:09 GMT What you were told may or may not be true. When I was preparing for surgery they had me on a ground flax seed diet. The studies that they showed me indicated that in mice the cancer growth was slowed by whatever the active ingredient is in the flax seed. So, for some of these foods/supplements/drugs under study it may be true that their beneficial effect is only in preventing the cancer from happening in the first place, whereas with others it may have some beneficial effect on the proliferation of the cancer cells. I think we have to wait twenty years or so to find out for sure.
> I have received very mixed signals from my medical team about soy. I was > told to eat lots of it and we are trying to do that quite systematically [quoted text clipped - 4 lines] > spreading. If it does no good I would be quite happy to go back to > barbecued spare ribs. Stavros Moschos - 05 Aug 2005 16:29 GMT Thanks. I'm willing to wait.
> What you were told may or may not be true. When I was preparing for > surgery [quoted text clipped - 17 lines] >> spreading. If it does no good I would be quite happy to go back to >> barbecued spare ribs. Ken - 04 Aug 2005 19:21 GMT Stavros - It seems that there are so many variables involved with nutrition and PCa, it's just another crap shoot as to what to do... except for one... don't go back to the spare ribs. From everything I've read, it's about as close to unanimous as you can get in this arena, that there's increasingly strong evidence of a correlation between high animal fat consumption and increased probability of post treatment (surgery, et al) recurrance and spreading. For about a decade, the general consensus was that soy contributes to lowering testosterone, which "feeds" PCa. Lately, there seems to be some disagreement with that. In any case, soy is one of the best sources of non-animal derived protein, and (so far) I haven't read anything about negative side effects from it. (Also, soy and rice has been the primary nutrition of people in Japan, China and other parts of Asia for thousands of years. Seems to me they don't lack for testosterone.)
Stavros Moschos - 05 Aug 2005 16:30 GMT OK, spare ribs out, tofu in. Darn.
> Stavros - It seems that there are so many variables involved with > nutrition and PCa, it's just another crap shoot as to what to do... [quoted text clipped - 10 lines] > people in Japan, China and other parts of Asia for thousands of years. > Seems to me they don't lack for testosterone.) Tdub - 05 Aug 2005 02:10 GMT Soy is an excellent part of a balanced diet. It is also quite delicious, once you develop a taste for it. I now take it in my cereal, instead of milk. I no longer like the taste of plain milk, instead preferring the taste of Silk Very Vanilla soy milk. It is incredibly delicious. But the key is a lot of people don't get enough vegetable/legume products in their diet, and soy milk, once you get over the hump, is an easy way to get some daily. I used to have borderline blood pressure. I no longer do, and my best guess is because of the cereal and soy (I had neglected cereal for a long term, and have discovered it is quite a healthy part of a diet). A varied diet is the best for us homos (I mean, homo sapiens)! P.S. I have no financial investment in the soy industry.
Stavros Moschos - 05 Aug 2005 16:31 GMT OK, from now on we talk as one homo to another.
> Soy is an excellent part of a balanced diet. It is also quite > delicious, once you develop a taste for it. I now take it in my cereal, [quoted text clipped - 8 lines] > best for us homos (I mean, homo sapiens)! P.S. I have no financial > investment in the soy industry. Ed Friedman - 05 Aug 2005 18:24 GMT > I have received very mixed signals from my medical team about soy. I was > told to eat lots of it and we are trying to do that quite systematically [quoted text clipped - 4 lines] > spreading. If it does no good I would be quite happy to go back to > barbecued spare ribs. Stavros,
Actually, the science on this is extremely clear cut. It is all covered in my paper at http://www.tbiomed.com/content/2/1/10 and will be covered in more detail in my next paper.
To summarize the science involved:
1. If you don't have PCa, then lots of soy each meal will definitely prevent PCa by preventing telomere formation, which is the first step in PCa.
2. If you already have PCa, then soy will decrease the rate of apoptosis, resulting in a quicker doubling time for the overall population. This is because soy binds to estrogen receptor-beta, a receptor which ordinarily downregulates bcl-2, a protein that protects PCa from apoptosis.
3. If you already have PCa, and take a 5AR2 inhibitor as well as lots of soy, then you really, really increase your bcl-2 level, resulting in a greatly decreased rate of apoptosis and a much faster rate of population doubling (which in my opinion explains the greater number of high Gleason scores in the PCPT group taking finasteride). This applies not just to soy, but to any food that binds preferentially to ER-beta. For a list of such foods, check out http://www.prostatepointers.org/leibowitz/vitaminlist.10103.html and search for genistein.
Ed Friedman
Stavros Moschos - 05 Aug 2005 21:48 GMT I thank you for this and I certainly respect your intelligence and dedication to finding the truth, but right now I am utterly at a loss as to what to do, just when I thought I had it all sorted out and in place. I only hope that there will be discussion of this on the ng.But I am now more confused than ever.
>> I have received very mixed signals from my medical team about soy. I was >> told to eat lots of it and we are trying to do that quite systematically [quoted text clipped - 33 lines] > > Ed Friedman I. P. Freely - 05 Aug 2005 22:51 GMT > "Ed Friedman" wrote >> >> the science on this is extremely clear cut. 1. If you don't have PCa, >> then lots of soy each meal will definitely prevent PCa >> 2. If you already have PCa, then soy will . . . [result] in a quicker >> doubling time There's a problem here: many of us have PC for MANY years before we detect it; who's to say that soy consumed during silent PC doesn't CAUSE its emergence? It's like the sign on the doc's wall: "If you're preggers or may become preggers, don't take this or do that".
"Stavros Moschos" wrote >I am now more confused than ever.
It's just like virtually every other short cut, Stavros . . . virtually none of them are proven, and the ones that are "proven" are usually contradicted by counterproof followed by countercounterproof, etc.. This made it pretty easy for me to chose a mainstream treatment, pass on the adjuvant dice-roll, and take supplements pretty casually.
I.P.
Douwe - 06 Aug 2005 10:57 GMT "I. P. Freely" <fuhgheddaboutit@noway.nohow> wrote...
> There's a problem here: many of us have PC for MANY years before we detect > it; who's to say that soy consumed during silent PC doesn't CAUSE its > emergence? I do agree with you, IP. So many suggestions in food. We 'had to consume flaxseed oil, because of the omega 3 fats'. Later they found out that it's also a source of alpha-linolenic acid (ALA), a serious source of stimulating the growth of Pc. I used many bottles, in stead of good old cod liver oil.
I understand that there's no food that's able to avoid or stop devellopping prostate cancer, so please eat what you like and/or don't eat anything that 'might' help you. With every illness or sickness there are people, making use of the voulnerability. Spend the mony on your medicals or, like I do, to have some fun. Sorry for the errors in English.
Douwe
I. P. Freely - 06 Aug 2005 19:24 GMT > "I. P. Freely" <fuhgheddaboutit@noway.nohow> wrote... > [quoted text clipped - 15 lines] > medicals or, like I do, to have some fun. Sorry for the errors in > English. My overall diet has been exceptionally healthy for the past 20 years, and I have increased the food-borne lycopene consumption. What I've not been willing to do is spend minutes a day, let alone the hours a day some PC pts do, concocting/weighing/scheduling all sorts of potions based on rumors. WAY too often these rumors -- such as fiber and anti-radicals like Vit E -- just don't work out or even turn out to be harmful. I just don't have the time, short or long term, to bother with that. Fun is infinitely more valuable to me than bother, and may even be more curative. And flaxseed gave me WAY more bowel problems than my colon cancer has done.
Don't worry about your English; I don't know a word of Dutch.
I.P.
Ed Friedman - 08 Aug 2005 18:53 GMT >>"Ed Friedman" wrote >> >> [quoted text clipped - 18 lines] > > I.P. I.P.,
You are correct of course - I was a bit sloppy with my wording. What I should have said instead of "If you already have PCa" to instead be "If you already have any PCa cells". Of course, the latter is something that nobody can know for sure, so avoiding soy, flaxseed and any other foods that are shown to preferentially bind to ER-beta is the only rational course of action.
Ed Friedman
Glassman - 07 Aug 2005 03:29 GMT > I have received very mixed signals from my medical team about soy. I was > told to eat lots of it and we are trying to do that quite systematically [quoted text clipped - 4 lines] > spreading. If it does no good I would be quite happy to go back to > barbecued spare ribs. There is no evidence that diet has any effect on PCa. I'm an Atkins guy, and eat ribs, and bacon and eggs, and steak, all day and night. I've lost and kept off 50 lbs, and all my bloodwork, heart, and even colonoscopy are perfect after 7 years of this. I feel that suger and starch are the poison, not protein and fat. I may die tommorrow, but believe me this is a better life than eating tree bark, and living another 3 days! Quality of life is all that matters for me.
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I. P. Freely - 07 Aug 2005 08:06 GMT I'm glad it's worked so well for you, but you're an exception to the Atkins statistics, so I need to balance your success with some more general facts lest Stavros blindly jump on the Atkins bandwagon.
QOL is so important to me that I chose it over the meds my oncologists recommended to extend my life. I eat like a couple of pigs, in terms of quantity and variety. Essentially all I avoid is sat fat, trans fats, white bread in all its forms . . . plus tree bark, bean sprouts, and most forms of "health food". I eat unlimited heaps of Mexican, Chinese, Italian, American (whatever that means), Mediterranean, seafood, fruits, vegetables, whole grains, etc. My diet has been proven over and over and over to be the healthiest diet on the planet: the Mediterranean Diet. i.e., virtually the opposite of Atkins. I give up very little for it except significant quantities of the unhealthy fats (I haven't eaten a rib or a Big Mac or slice of bacon in > 20 years, but don't consider that a sacrifice any more than giving up cigarettes or Russsian roulette is a sacrifice -- especially while I'm eating an entire wok full of marvelous shrimp stir fry, two pounds of enchiladas, or half a loaf of walnut raisin whole wheat bread smothered in seasoned olive oil.) To me, THAT'S QOL: gobs of great food that's going to maximize my life and health. With Atkins going bankrupt because low-carb diet and food popularity is plummeting by 75%, I think the public is catching up with medical science.
I.P.
>> I have received very mixed signals from my medical team about soy. I was >> told to eat lots of it and we are trying to do that quite systematically [quoted text clipped - 14 lines] > life than eating tree bark, and living another 3 days! Quality of life is > all that matters for me. Stavros Moschos - 07 Aug 2005 17:27 GMT IP, you make me laugh, truly. No, I'm not going on any more bandwagons and the "diet" you are on is just what we have decided to follow. I'm with you on this. (Except for QOL I will make an exception once in a while.)
> I'm glad it's worked so well for you, but you're an exception to the > Atkins statistics, so I need to balance your success with some more [quoted text clipped - 45 lines] >> life than eating tree bark, and living another 3 days! Quality of life is >> all that matters for me. I. P. Freely - 07 Aug 2005 23:20 GMT I agree. I don't walk a tightrope with my diet. I'll eat a pizza (I don't just "eat pizza"; I eat *A* pizza) once or twice a year, but I just found cold turkey the easy solution to poison like bacon and ribs. When I go to a buffet, I usually save some room for half a dozen desserts . . . after plates of salad, veggies, and some very lean meat. There's plenty of room for QOL in a healthy diet.
I.P.
> IP, you make me laugh, truly. No, I'm not going on any more bandwagons > and the "diet" you are on is just what we have decided to follow. I'm > with you on this. (Except for QOL I will make an exception once in a > while.) Glassman - 09 Aug 2005 03:13 GMT > I'm glad it's worked so well for you, but you're an exception to the Atkins > statistics, so I need to balance your success with some more general facts [quoted text clipped - 5 lines] > > I.P. We've been down this road before you and I, IP. Your opinion is fine, but very far from the facts. Let me just correct you a bit. Almost all of the low carb lifestylers I know have equal or greater success and health than low fat/high carb eaters. What does this mean? Probably nothing to you if you're happy and successful eating tree bark, snake venom, or bear excrement. LOL..... I speak to hundreds of folks weekly on the LC NG, who swear by this way of eating, many have lost and kept off upwards of 100 lbs in the 35 years since the book came out. This is not a fad. It's a way of life for us. On the other hand I know of too many, including myself, that gained weight eating high carb/low fat. As for the Atkins backruptcy here's the truth. True lowcarbers don't, and never have, bought into the "frankenfoods" that were lining the shelves. Lowcarb candy bars, cakes, and such have NEVER taken the place of eating whole foods. This was simply a failed attempt at cashing in on the 30 million folks out there that live the LC lifestyle. Trust me no one has stopped eating this way. Lack of interest was in these particular products NOT the diet. These convenience foods aren't even mentioned in Atkins book. Remember the lowfat/nofat cakes that we were all eating years ago? No fat but loaded with sugar and starch. All gone from the shelves too. Again let me say that we don't eat refined and fake junk food. No sugar, and no starch. We get our carbs mostly from whole complex veggies, berries and nuts. If you're exercising regularly, you can pretty much eat any which way you like and stay trim anyway. I'm not remotely trying to convince anyone to switch how they eat. I never criticize anyones way of eating that works for them. All I can do is report the truth, which is my own success. I have never been healthier. How do you account for this after 7 years, if my way of eating is bad for me? All bloodwork, BP & Cholesterol down, heart and organ function fine, more energy than ever, plus I eat as much as I want of great food. What else could I want? Weight Watchers, Zone, Meditaranean, all will work, if you can stick to it. Some are harder than others to follow as a lifestyle change. Lets all be healthy anyway we can and enjoy a great QOL as well. Of course any study you can find can be countered with another that shows the opposite, but you may enjoy reading the following:
http://www.ravnskov.nu/cholesterol.htm
http://www.second-opinions.co.uk/cholesterol_myth_2.html
http://www.lowcarb.ca/articlesa/article217.html
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Ken - 11 Aug 2005 03:58 GMT "There is no evidence that diet has any effect on PCa."
Here's an article about a study published in the Journal of Urology, August 10, 2005...
BY JOHN FAUBER Milwaukee Journal Sentinel
MILWAUKEE - (KRT) - A provocative new study suggests that men with early-stage prostate cancer who elect not to undergo conventional treatment may be able to halt the progression of their disease by making substantial lifestyle changes such as adopting a very low-fat, vegan diet, exercising and meditating.
The authors of the study, published Thursday in the Journal of Urology, say it is the first randomized clinical trial showing that lifestyle changes can halt the progression of prostate cancer.
However, urologists not associated with the research said the length of the study was too short, the number of men too few and the outcome measures too imprecise to make definitive conclusions about the benefits of the intervention.
In addition, maintaining the strict diet used in the study would be very difficult for many men, they said.
"I don't know if Draconian is the word," said William See, chairman of the urology department at the Medical College of Wisconsin. "(But) the ability of the average Midwesterner to tolerate that kind of diet is questionable."
The study comes at a time when there is growing controversy about the best way to treat early-stage, localized prostate cancer. The study and additional research that may stem from it could have implications for some of the more than 230,000 men who are diagnosed with prostate cancer each year. African-American men have a 60 percent higher risk of developing prostate cancer than whites, and are twice as likely to die of the disease.
Lead author Dean Ornish, director of the Preventive Medicine Research Institute in Sausalito, Calif., and a longtime crusader of ultra low-fat diets, said the study shows that adopting various lifestyle changes can be beneficial to men with prostate cancer in addition to whatever other conventional measures they take.
"(Improved) diet and lifestyle play a role in the progression of prostate cancer and the only side effects are good ones," said Ornish, a controversial author and clinical professor of medicine at the University of California, San Francisco.
Other study authors included researchers from UCSF and the Memorial Sloan-Kettering Cancer Center in New York.
"This is the first in a series of trials attempting to better identify the exact role of diet and lifestyle in the prevention and treatment of prostate cancer," senior author Peter Carroll, chairman of the urology department at UCSF, said in a statement.
Earlier epidemiological studies have linked various lifestyle measures such as a high-fat diet, especially animal fat, obesity and a lack of physical activity with an increased risk of developing prostate cancer.
There is hope that various dietary measures, such as eating fruits and vegetables or taking supplements such as lycopene, selenium and vitamin E, can lower risk, but that evidence still is insufficient, according to the National Cancer Institute.
The study involved 93 men with an average age of about 66 who were diagnosed by biopsies with low-grade prostate cancer. All of the men had decided to undergo so-called watchful waiting, which meant their cancer would be monitored but they would not immediately undergo conventional treatment such as surgery or radiation.
Forty-four of the men were put into an intensive intervention program that included a low-fat, vegan diet, and daily tofu and soy supplements, as well as 400 international units of vitamin E, three grams of fish oil, 200 micrograms of selenium, two grams of vitamin C, 30 minutes of moderate exercise six days a week, and an hour a day of stress management with techniques such as meditation and yoga.
The other 49 men did not undergo intensive lifestyle changes.
Researchers used the prostate-specific antigen, or PSA, test as a way to monitor the disease progression in the men.
After one year, the men in the intervention program had an average 4 percent decline in their PSA test scores, compared with a 6 percent increase in the scores of the control group.
In another measure, six of the men in the control group went on to have surgery or some other treatment due to a progression of their disease, compared with none of the men in the intervention group.
In addition, blood samples were taken from the men to see if the serum could inhibit prostate cancer tumor growth in a laboratory dish. There was a 70 percent inhibition of tumor cell growth from the blood from the men in the intervention group, compared with 9 percent from the control group.
"We are learning more and more about compounds that may prevent, if not have therapeutic potential in prostate cancer," said Jason Gee, a urologic oncologist at the University of Wisconsin Hospital in Madison. "In a select group of patients who are appropriate for watchful waiting, some dietary changes may be helpful as suggested by this study."
However, Gee said it was too early to make overall recommendations based on the study, which needs to be validated by further research.
Howard Parnes, a physician with the National Cancer Institute, said the study's results appear to support the hypothesis that dietary and lifestyle measures can affect prostate cancer progression, "but there are a lot of caveats."
One problem, he said, is that the PSA score, the primary measure in the study, is only a surrogate for disease progression. It is not a clinical outcome, such as mortality.
The PSA score could have been affected by the soy, which has a weak hormonal affect, he said.
In addition, there were so many variables in the study that it was impossible to sort out which ones may have caused the beneficial effects, he said.
"To say to patients, `You've got to do all these things' puts a large burden on them and creates a lot of guilt and stress," said Parnes, chief of the prostate and urologic cancer research group in the division of cancer prevention at the cancer institute.
"I don't think we should tell people you should do this." However, he said the study was a step in the right direction. "This kind of work does stimulate the research field to look at dietary and lifestyle measures," he said.
In addition to lower PSA scores, the men in the intervention group lost an average of about 10 pounds and had significant improvements in their cholesterol levels.
In earlier research, Ornish has showed that similar intensive intervention programs can reverse heart disease.
Here is the regimen researchers used on the men whose prostate cancer appeared to improve:
A low-fat, vegan diet, and daily tofu and soy supplements 400 international units of vitamin E Three grams of fish oil 200 micrograms of selenium Two grams of vitamin C 30 minutes of moderate exercise six days a week An hour a day of stress management with techniques such as meditation and yoga
Glassman - 11 Aug 2005 05:52 GMT > "There is no evidence that diet has any effect on PCa." > [quoted text clipped - 9 lines] > making substantial lifestyle changes such as adopting a very low-fat, > vegan diet, exercising and meditating. All I have to point to is the late great Martin Howard. Lifelong vegan, yoga, hiker, meditator, biker, urine drinker, herbal believer, and generally marched to a different drummer. PSA in the neighborhood of 1000 while he cathedered himself daily. I repeat..... diet has no effect on this disease.
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ron - 11 Aug 2005 15:15 GMT Isn't there a middle ground where, depending upon your genetic makeup, contraction and / or progression of diseases may or may not be influenced by factors such as diet, supplements, exercise, etc.?..Best wishes and good health, Ron
Glassman - 12 Aug 2005 04:39 GMT > Isn't there a middle ground where, depending upon your genetic makeup, > contraction and / or progression of diseases may or may not be > influenced by factors such as diet, supplements, exercise, etc.?..Best > wishes and good health, Ron I agree that genetic makeup is a huge factor, but until I see proof of the others, I'm a non believer. Too many world class athletes, health nuts, and assorted saintly folks all get cancer. I say QOL is the most important thing. Keeping yourself from the joys of eating good food will only make your days that much less fun. If I knew for a fact that eating treebark would extend my life another 3 months, then I'm going fo rthe steak! Get yourself treated, then eat, exercise, and have a blast!
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Ben - 17 Aug 2005 14:40 GMT Earlier epidemiological studies have linked various lifestyle measures such as a high-fat diet, especially animal fat, obesity and a lack of physical activity with an increased risk of developing prostate cancer.
When they say animal fat are they talking about red meat only or does that include all animals like fish and poultry?
Peter Headland - 17 Aug 2005 15:52 GMT Fish = Good All else = Bad
There is far more fat in an intensively reared chicken breast than a pork chop these days (to the benefit of neither)...
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Glassman - 20 Aug 2005 05:44 GMT > Earlier epidemiological studies have linked various lifestyle measures > such as a high-fat diet, especially animal fat, obesity and a lack of > physical activity with an increased risk of developing prostate cancer. I've never seen such studies, that didn't also account for high carbohydrate intake as well.
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I. P. Freely - 13 Aug 2005 06:53 GMT Medical research trumps anecdotal stories and commercially-sponsored literature in my book.
I.P.
>> I'm glad it's worked so well for you, but you're an exception to the > Atkins [quoted text clipped - 58 lines] > > http://www.lowcarb.ca/articlesa/article217.html Glassman - 13 Aug 2005 07:32 GMT > Medical research trumps anecdotal stories and commercially-sponsored > literature in my book. > > I.P. All diet chat and kidding aside for a moment IP..... I'm kind of crabby lately about how people are so intent on extending their lives at any cost. Of course since we have all had a closer brush than most, it hits closer to home. I do understand the fight for survival, but every now and again a new poster makes me crazy asking if it's true that eating bees knees with curried yak toenails is the cure? At some point we need to "unfocus" on disease and live our remaining years to their fullest. Sure we want to be healthy and trim, and hard bodied, and gorgeous. Let's not forget that as far as we know this life is going to end someday. Don't deprive yourselves of it's joys. Make that read ALL it's joys. Or as many as you can physically engage in. That means chocolate, steak, whipped cream, luxury, loud music, big screen TV, and silly laughter.
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Aussie Ron - 13 Aug 2005 09:02 GMT > All diet chat and kidding aside for a moment IP..... I'm kind of crabby > lately about how people are so intent on extending their lives at any [quoted text clipped - 13 lines] > music, > big screen TV, and silly laughter. Hear, Hear!! I'll second those comments.
Larry - 13 Aug 2005 15:08 GMT I'll pass on that steak - that I used to enjoy so much - and still do very occasionally - if it means a few more years of watching my grandkids grow up. I plan to go down fighting, thank you very much . . . .
> > Medical research trumps anecdotal stories and commercially-sponsored > > literature in my book. [quoted text clipped - 13 lines] > engage in. That means chocolate, steak, whipped cream, luxury, loud music, > big screen TV, and silly laughter. Stavros Moschos - 13 Aug 2005 15:56 GMT I just bought a big screen HDTV, which I had been postponing as being down the road. Am I ever enjoying my DVD collection.
>> Medical research trumps anecdotal stories and commercially-sponsored >> literature in my book. [quoted text clipped - 18 lines] > music, > big screen TV, and silly laughter. Steve Kramer - 13 Aug 2005 16:56 GMT I planned my family room and party room around plazma TVs when I built this condo. And I've never pulled the trigger on making the purchase. It's been two years. Maybe I oughta reconsider.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05 PSA .07 .05 .06 .05 non Illegitimi carborundum
> I just bought a big screen HDTV, which I had been postponing as being down > the road. Am I ever enjoying my DVD collection. [quoted text clipped - 21 lines] > > music, > > big screen TV, and silly laughter. Glassman - 14 Aug 2005 05:26 GMT I just bought a big screen HDTV, which I had been postponing as being down the road. Am I ever enjoying my DVD collection.
> I planned my family room and party room around plazma TVs when I built this > condo. And I've never pulled the trigger on making the purchase. It's been > two years. Maybe I oughta reconsider. Geez I never thought PCa would change the market for big screen TV's? Get this.... my son has a 9' screen with a LCD projector featuring an HDTV quality picture. He cranks up the surround sound and plays his video games as well as TV on it. If you have the space, I would check into it instead of a plasma.
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Stavros Moschos - 13 Aug 2005 15:59 GMT "curried yak toenails"? Do you know where I can get some?
>> Medical research trumps anecdotal stories and commercially-sponsored >> literature in my book. [quoted text clipped - 18 lines] > music, > big screen TV, and silly laughter. I. P. Freely - 14 Aug 2005 02:53 GMT "Glassman" wrote>
> All diet chat and kidding aside for a moment IP..... I'm kind of crabby > lately about how people are so intent on extending their lives at any [quoted text clipped - 13 lines] > music, > big screen TV, and silly laughter. This is long, but if it motivates one or two people to get off their duffs and enjoy what's left, be it a year or 30 years, it may be worth their time and mine.
I fully agree with you on the non-NECESSITY of living austere lives to (maybe) gain a few months, but I do respect well-considered decisions to do so, at least to the extent that for some, their QOL is founded on hope for the future, rather than living to the fullest right now. They are goal-oriented people, whereas you sound like me -- a myopic hedonist. But just as I don't see a conflict between creationism and evolution, I also don't see a conflict between 1) a full lifestyle with lavish eating and 2) a healthy, longevity-promoting regimen. Not to tell you how to eat or live, but lest others here think one must eat bark or live in a bubble to be healthy and have fun . . .
Re (a), people have dropped their jaws for 50 years, right up through yesterday, at the way I live my life. It's been balls to the wall play 5-7 days a week for the past 55 years with a huge variety of sports, many of them rather vigorous and some perceived as risky (e.g., racing dirt bikes in terrain horses couldn't negotiate, windsurfing in 50 mph winds, flying snowmobiles off cornices). Our neighbors used to make book on how many sports my wife and I would engage in on any given weekend . . . and whether I'd get a nap between snowmobiling all Wednesday night and returning to the office Thursday morning. I walked away from my engineering career in 1988 at age 45 to play full time, and still easily outlast virtually every 40- or 20-year-old kid with whom I carve up the waves. Most of them are whimpering jelly after 2-4 hours of heavy sports, whereas I have no problem with 8-10 hours in a day (think playing football, offense and defense, from breakfast until supper). It's the highest priority in my life, and has received my full, exclusive attention for decades now. I deprive myself of absolutely nothing that interests me. I chose my lifestyle over hormone therapy, if you recall, because it is more important to me than a few extra months of heartbeat. As a result of 5+ decades of hard play, my physicians and peers say I'm fitter than many athletes half my age, and that's WITH dual cancers.
As for (b), I've been accused of having bulemia, a ten-pound tapeworm, secret pouches in my clothes (by buffet managers, two of whom refused me further food, another who CHANGED HIS BUFFET TO PAY-AS-YOU-EAT CAFETERIA because of the trays of food I ate for a couple of bucks), the metabolism of a whole colony of shrews, etc. I have always and still do eat like two pigs, with one simple concession to healthy diet science: I keep sat- and trans-fats to bare minimums 360 days a year. Bees' knees'n'yak backs, my muscular a.s. How about fajitas, lasagne, mixing bowls full of strawberry angel food shortcake hidden by mounds of whipped cream, enchiladas, 3-4 loaves a week of something like raisin walnut cranberry honey whole wheat bread smothered in Italian-seasoned olive oil, green chile chicken stew, 6-egg shrimp'n'peppers omelettes with sides of hash browns and blueberry whole wheat pancakes swimming in marionberry syrup, plates of whole wheat spaghetti buried in pints of chicken'n'sausage marinara sauce, wild or farmed salmon flank steaks hot off the grille and smothered with any of several sauces plus a couple pounds of grilled vegetables dripping in sweet onion vinegarette, two pounds of peppers'n'shrimp or chicken stir fry, Home Town Buffet from breakfast right through lunch, a half-gallon of boulliabase, heaps of candied yams any day of the year, skewers of shish kebab grilled over fresh mesquite picked up off the desert floor outside my RV . . . yeah, I deprive myself of great food, all right, but only because I can eat only several pounds a day any more. My days of an 18" Chicago pizza with a chocolate malt for lunch before five plates of buffet for supper ended in my 30s, but two full IHOP breakfasts is still a piece of cake . . . as long as they don't feature bacon, sausage, etc. . . . and my whipped cream, cheese, rare sausage, etc. are low-sat-fat varieties.
And, oh yeah . . . we have 9 TVs in our home. I watch -- more like listen to -- way too much of it, especially while bombing down the highway at 95 mph in my motor home.
I get more hedonistic play and more varieties of food in most years than many people get in a lifetime, and for the last 20 years, since we learned what sat- and trans-fats do to us and my body stopped healing overnight, both have been exceedingly healthy. If bees knees and yak toenails will help me, I'll try 'em . . . as long as they don't diminish my QOL in the process. Last Wednesday was one of my best days in the waves in years; I'm not giving that up for some hypothetical seven months in a hospital bed at the end of the line.
I.P.
Ken - 07 Aug 2005 19:03 GMT "There is no evidence that diet has any effect on PCa."
There have been dozens of major research papers published on diet and PCa. Some of them disagree with each other, but I have never seen disagreement about negative effects of a high fat diet on PCa. Here are short excerpts from two reports I happen to have:
Dr. Steven Strum, 3/10/2005, Page 6 of http://www.lef.org/LEFCMS/aspx/PrintVersionMagic.aspx?CmsID=77474
"Dietary Fat Increases PC Growth Rates. There are studies that show that dietary fat increases tumor growth rates in an animal model of human PC. In a mouse model of PC involving androgen-sensitive human prostatic adenocarcinoma cells (LNCaP cells), mice fed a 40.5% fat diet had mean tumor weights more than 2 times greater than mice fed a 21% fat diet. The 40.5% fat diet approximates that found in the average American male diet, which has been determined to be 36%.30. The slower tumor growth associated with the low-fat diet occurred even after the formation of measurable tumors when the diets were changed from 40% fat to 21% fat. Serum PSA levels also were highest in the 40.5 kcal% fat group and lowest in another group fed only 2.3 kcal% fat.30 Reduction of Total Calorie Consumption Decreases Tumor Size by Decreasing VEGF, Angiogenesis, and IGF-1 and by Increasing Apoptosis. The emphasis on dietary fat, per se, has lessened our focus on the importance of caloric over-consumption. Fat excess, however, is linked to excessive calorie consumption, since fat contains twice as many calories, gram for gram, as protein or carbohydrate. An important study demonstrated that energy intake (caloric intake) modulates the growth of prostate tumors in two animal models: the androgen-dependent Dunning R3327-H adenocarcinoma in rats and the androgen-sensitive LNCaP human adenocarcinoma in severe combined immunodeficiency (SCID) mice.31 Specifically, decreasing calorie consumption (energy restriction) by 20-40% from the control animals fed ad libitum resulted in: Increased PC cell apoptosis (programmed cell death) A two- to threefold reduction in PC angiogenesis as measured by microvessel density A decrease in vascular endothelial growth factor (VEGF) expression A decrease in circulating levels of IGF-1 A significant decrease in tumor size Therefore, all of these findings were benefits observed in the calorie-restricted group. This study showed that the nutritional status directly or indirectly influenced interaction between tumor cells and local blood vessels by changing the expression of angiogenic growth factors." ..........................................................
>From a paper by Dr. William Catalona, et al, 4/18/2005: "....when Asian men migrate to the West, their risk increases. Dietary fat is believed to be the culprit. "Cholesterol is the building block of the male hormone testosterone," said Dr. William J. Catalona, director of the Clinical Prostate Cancer Program of Northwestern University's Robert H. Lurie Comprehensive Cancer Center. Since statins lower blood levels of this fatty substance, there may be less of it available to synthesize testosterone and dihydrotestostrone, he explained. And that may reduce male hormones that stimulate prostate cancer."
I. P. Freely - 07 Aug 2005 23:31 GMT "Ken" < wrote (I have no idea why the >'s don't appear in my quotes this time) "The emphasis on dietary fat, per se, has lessened our focus on the importance of caloric over-consumption."
I've been trying to resolve that dilemma (i.e., define "caloric over-consumption") for 45 years. Is eating 2-4 times the quantity of calories and/or volume others eat "caloric over-consumption" if we burn it off and maintain a lean body? Would a person like that live much longer if s/he cut calories WAY back to become downright skinny? Lab rats do, but a) would we, b) how's it feel being hungry alla time, and c) I'll bet these starving rats cut their wheel time back dramatically.
I.P.
Tdub - 08 Aug 2005 03:26 GMT I agree with I.P. on the diet issue. I'm 55 and relatively fit, and I eat whatever I feel like, except I never eat deep fried food, and avoid manufactured food (e.g., trans foods), because what is best for us is what our ancestors ate, (including meat, etc.), because that is the kind of diet our bodies were designed for (as a result of successive-generation gene variations). So go for organic foods, avoid pesticides, chemicals and additives in your food, eat a healthy balance of all the good foods in the world, and don't eat stuff that your grandparents, and their ancestors, probably didn't eat. Eating deep fried foods, IMO, is about as healthy as smoking cigarettes - the "deep fat" often is never changed, and has been held at 600+ degrees for a long time, which makes any health elements in it vanish, and god only knows the negative health effects of the chemicals created by the extended heating of the fat - if vegetable oil is used in this way, it quickly becomes rancid because of the prolonged high heat exposure.
Douwe - 08 Aug 2005 08:27 GMT "Tdub" <gripshift5@email.com> wrote...
> I agree with I.P. on the diet issue. I'm 55 and relatively fit, and I > eat whatever I feel like, except I never eat deep fried food, and avoid > manufactured food (e.g., trans foods), because what is best for us is > what our ancestors ate, (including meat, etc.), because that is the > kind of diet our bodies were designed for (as a result of > successive-generation gene variations). I'm sorry to disagree with this. Our ancestors worked 12 to 16 hours a day, so a plate full of potato's with bacon and a lot of fat was neccesary to keep the engine running. Their expected life-span was about 53 years. I do not turn this around. Our average life should be 73 years. For those 20 years difference we should have taken precousion, but did we?
A life span for a car is about 50 years, when and if you don't start racing from day 1
I believe this subject (Soy and food) is OT in this group. There is no food that heals us. There is some food we should have avoided and there might be some food (pumpkin-pits and tomato ketchup) that could help to keep the prostate a healthy pink peace of meat a little while longer, but it takes at least two generations to prove this is true. Eating like our ancestors did is not a cause for cancer.
Douwe
Douwe - 08 Aug 2005 09:23 GMT "Douwe" <Douwe_in_nl@yahoo.com> wrote...
> A life span for a car is about 50 years, ^^^^
20 years, sorry
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