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Medical Forum / Diseases and Disorders / Prostate Cancer / August 2005

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Soy

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Stavros Moschos - 04 Aug 2005 17:17 GMT
I have received very mixed signals from my medical team about soy.  I was
told to eat lots of it and we are trying to do that quite systematically
(along with vitamin D, selenium, green tea extract, lycopene--you name it),
but yesterday a resident said  that once you get PCa there is no point in
eating soy, that it might prevent PCa from developing in the first place,
but that there is no evidence that it does any good in preventing it from
spreading.  If it does no good I would be quite happy to go back to
barbecued spare ribs.
David S. - 04 Aug 2005 18:09 GMT
What you were told may or may not be true.  When I was preparing for surgery
they had me on a ground flax seed diet.  The studies that they showed me
indicated that in mice the cancer growth was slowed by whatever the active
ingredient is in the flax seed.  So, for some of these
foods/supplements/drugs under study it may be true that their beneficial
effect is only in preventing the cancer from happening in the first place,
whereas with others it may have some beneficial effect on the proliferation
of the cancer cells.   I think we have to wait twenty years or so to find
out for sure.

> I have received very mixed signals from my medical team about soy.  I was
> told to eat lots of it and we are trying to do that quite systematically
[quoted text clipped - 4 lines]
> spreading.  If it does no good I would be quite happy to go back to
> barbecued spare ribs.
Stavros Moschos - 05 Aug 2005 16:29 GMT
Thanks.  I'm willing to wait.

> What you were told may or may not be true.  When I was preparing for
> surgery
[quoted text clipped - 17 lines]
>> spreading.  If it does no good I would be quite happy to go back to
>> barbecued spare ribs.
Ken - 04 Aug 2005 19:21 GMT
Stavros - It seems that there are so many variables involved with
nutrition and PCa, it's just another crap shoot as to what to do...
except for one... don't go back to the spare ribs. From everything I've
read, it's about as close to unanimous as you can get in this arena,
that there's increasingly strong evidence of a correlation between high
animal fat consumption and increased probability of post treatment
(surgery, et al) recurrance and spreading. For about a decade, the
general consensus was that soy contributes to lowering testosterone,
which "feeds" PCa. Lately, there seems to be some disagreement with
that. In any case, soy is one of the best sources of non-animal derived
protein, and (so far) I haven't read anything about negative side
effects from it. (Also, soy and rice has been the primary nutrition of
people in Japan, China and other parts of Asia for thousands of years.
Seems to me they don't lack for testosterone.)
Stavros Moschos - 05 Aug 2005 16:30 GMT
OK, spare ribs out, tofu in.  Darn.

> Stavros - It seems that there are so many variables involved with
> nutrition and PCa, it's just another crap shoot as to what to do...
[quoted text clipped - 10 lines]
> people in Japan, China and other parts of Asia for thousands of years.
> Seems to me they don't lack for testosterone.)
Tdub - 05 Aug 2005 02:10 GMT
Soy is an excellent part of a balanced diet. It is also quite
delicious, once you develop a taste for it. I now take it in my cereal,
instead of milk. I no longer like the taste of plain milk, instead
preferring the taste of Silk Very Vanilla soy milk. It is incredibly
delicious. But the key is a lot of people don't get enough
vegetable/legume products in their diet, and soy milk, once you get
over the hump, is an easy way to get some daily. I used to have
borderline blood pressure. I no longer do, and my best guess is because
of the cereal and soy (I had neglected cereal for a long term, and have
discovered it is quite a healthy part of a diet). A varied diet is the
best for us homos (I mean, homo sapiens)! P.S. I have no financial
investment in the soy industry.
Stavros Moschos - 05 Aug 2005 16:31 GMT
OK, from now on we talk as one homo to another.

> Soy is an excellent part of a balanced diet. It is also quite
> delicious, once you develop a taste for it. I now take it in my cereal,
[quoted text clipped - 8 lines]
> best for us homos (I mean, homo sapiens)! P.S. I have no financial
> investment in the soy industry.
Ed Friedman - 05 Aug 2005 18:24 GMT
> I have received very mixed signals from my medical team about soy.  I was
> told to eat lots of it and we are trying to do that quite systematically
[quoted text clipped - 4 lines]
> spreading.  If it does no good I would be quite happy to go back to
> barbecued spare ribs.

Stavros,

Actually, the science on this is extremely clear cut.  It is all covered
in my paper at http://www.tbiomed.com/content/2/1/10 and will be covered
in more detail in my next paper.

To summarize the science involved:

1. If you don't have PCa, then lots of soy each meal will definitely
prevent PCa by preventing telomere formation, which is the first step in
PCa.

2. If you already have PCa, then soy will decrease the rate of
apoptosis, resulting in a quicker doubling time for the overall
population.  This is because soy binds to estrogen receptor-beta, a
receptor which ordinarily downregulates bcl-2, a protein that protects
PCa from apoptosis.

3. If you already have PCa, and take a 5AR2 inhibitor as well as lots of
soy, then you really, really increase your bcl-2 level, resulting in a
greatly decreased rate of apoptosis and a much faster rate of population
doubling (which in my opinion explains the greater number of high
Gleason scores in the PCPT group taking finasteride).  This applies not
just to soy, but to any food that binds preferentially to ER-beta.  For
a list of such foods, check out
http://www.prostatepointers.org/leibowitz/vitaminlist.10103.html and
search for genistein.

Ed Friedman
Stavros Moschos - 05 Aug 2005 21:48 GMT
I thank you for this and I certainly respect your intelligence and
dedication to finding the truth, but right now I am utterly at a loss as to
what to do, just when I thought I had it all sorted out and in place. I only
hope that there will be discussion of this on the ng.But I am now more
confused than ever.

>> I have received very mixed signals from my medical team about soy.  I was
>> told to eat lots of it and we are trying to do that quite systematically
[quoted text clipped - 33 lines]
>
> Ed Friedman
I. P. Freely - 05 Aug 2005 22:51 GMT
> "Ed Friedman"  wrote >>
>> the science on this is extremely clear cut. 1. If you don't have PCa,
>> then lots of soy each meal will definitely prevent PCa
>> 2. If you already have PCa, then soy will . . . [result] in a quicker
>> doubling time

There's a problem here: many of us have PC for MANY years before we detect
it; who's to say that soy consumed during silent PC doesn't CAUSE its
emergence?
It's like the sign on the doc's wall: "If you're preggers or may become
preggers, don't take this or do that".

"Stavros Moschos" wrote >I am now more confused than ever.

It's just like virtually every other short cut, Stavros . . . virtually none
of them are proven, and the ones that are "proven" are usually contradicted
by counterproof followed by countercounterproof, etc.. This made it pretty
easy for me to chose a mainstream treatment, pass on the adjuvant dice-roll,
and take supplements pretty casually.

I.P.
Douwe - 06 Aug 2005 10:57 GMT
"I. P. Freely" <fuhgheddaboutit@noway.nohow> wrote...

> There's a problem here: many of us have PC for MANY years before we detect
> it; who's to say that soy consumed during silent PC doesn't CAUSE its
> emergence?

I do agree with you, IP. So many suggestions in food. We 'had to consume
flaxseed oil, because of the omega 3 fats'. Later they found out that
it's also a source of alpha-linolenic acid (ALA), a serious source of
stimulating the growth of Pc. I used many bottles, in stead of good old
cod liver oil.

I understand that there's no food that's able to avoid or stop
devellopping prostate cancer, so please eat what you like and/or don't
eat anything that 'might' help you. With every illness or sickness there
are people, making use of the voulnerability. Spend the mony on your
medicals or, like I do, to have some fun. Sorry for the errors in
English.

Douwe
I. P. Freely - 06 Aug 2005 19:24 GMT
> "I. P. Freely" <fuhgheddaboutit@noway.nohow> wrote...
>
[quoted text clipped - 15 lines]
> medicals or, like I do, to have some fun. Sorry for the errors in
> English.

My overall diet has been exceptionally healthy for the past 20 years, and I
have increased the food-borne lycopene consumption. What I've not been
willing to do is spend minutes a day, let alone the hours a day some PC pts
do, concocting/weighing/scheduling all sorts of potions based on rumors. WAY
too often these rumors -- such as fiber and anti-radicals like Vit E -- just
don't work out or even turn out to be harmful. I just don't have the time,
short or long term, to bother with that. Fun is infinitely more valuable to
me than bother, and may even be more curative. And flaxseed gave me WAY more
bowel problems than my colon cancer has done.

Don't worry about your English; I don't know a word of Dutch.

I.P.
Ed Friedman - 08 Aug 2005 18:53 GMT
>>"Ed Friedman"  wrote >>
>>
[quoted text clipped - 18 lines]
>
> I.P.

I.P.,

You are correct of course - I was a bit sloppy with my wording.  What I
should have said instead of "If you already have PCa" to instead be "If
you already have any PCa cells".  Of course, the latter is something
that nobody can know for sure, so avoiding soy, flaxseed and any other
foods that are shown to preferentially bind to ER-beta is the only
rational course of action.

Ed Friedman
Glassman - 07 Aug 2005 03:29 GMT
> I have received very mixed signals from my medical team about soy.  I was
> told to eat lots of it and we are trying to do that quite systematically
[quoted text clipped - 4 lines]
> spreading.  If it does no good I would be quite happy to go back to
> barbecued spare ribs.

  There is no evidence that diet has any effect on PCa. I'm an Atkins guy,
and eat ribs, and bacon and eggs, and steak, all day and night. I've lost
and kept off 50 lbs, and all my bloodwork, heart, and even colonoscopy are
perfect after 7 years of this.  I feel that suger and starch are the poison,
not protein and fat. I may die tommorrow, but believe me this is a better
life than eating tree bark, and living another 3 days! Quality of life is
all that matters for me.

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I. P. Freely - 07 Aug 2005 08:06 GMT
I'm glad it's worked so well for you, but you're an exception to the Atkins
statistics, so I need to balance your success with some more general facts
lest Stavros blindly jump on the Atkins bandwagon.

QOL is so important to me that I chose it over the meds my oncologists
recommended to extend my life. I eat like a couple of pigs, in terms of
quantity and variety. Essentially all I avoid is sat fat, trans fats, white
bread in all its forms . . . plus tree bark, bean sprouts, and most forms of
"health food". I eat unlimited heaps of Mexican, Chinese, Italian, American
(whatever that means), Mediterranean, seafood, fruits, vegetables, whole
grains, etc. My diet has been proven over and over and over to be the
healthiest diet on the planet: the Mediterranean Diet. i.e., virtually the
opposite of Atkins. I give up very little for it except significant
quantities of the unhealthy fats (I haven't eaten a rib or a Big Mac or
slice of bacon in > 20 years, but don't consider that a sacrifice any more
than giving up cigarettes or Russsian roulette is a sacrifice -- especially
while I'm eating an entire wok full of marvelous shrimp stir fry, two pounds
of enchiladas, or half a loaf of walnut raisin whole wheat bread smothered
in seasoned olive oil.) To me, THAT'S QOL: gobs of great food that's going
to maximize my life and health. With Atkins going bankrupt because low-carb
diet and food popularity is plummeting by 75%, I think the public is
catching up with medical science.

I.P.

>> I have received very mixed signals from my medical team about soy.  I was
>> told to eat lots of it and we are trying to do that quite systematically
[quoted text clipped - 14 lines]
> life than eating tree bark, and living another 3 days! Quality of life is
> all that matters for me.
Stavros Moschos - 07 Aug 2005 17:27 GMT
IP, you make me laugh, truly.  No, I'm not going on any more bandwagons and
the "diet" you are on is just what we have decided to follow.  I'm with you
on this.  (Except for QOL I will make an exception once in a while.)

> I'm glad it's worked so well for you, but you're an exception to the
> Atkins statistics, so I need to balance your success with some more
[quoted text clipped - 45 lines]
>> life than eating tree bark, and living another 3 days! Quality of life is
>> all that matters for me.
I. P. Freely - 07 Aug 2005 23:20 GMT
I agree. I don't walk a tightrope with my diet. I'll eat a pizza (I don't
just "eat pizza"; I eat *A* pizza) once or twice a year, but I just found
cold turkey the easy solution to poison like bacon and ribs. When I go to a
buffet, I usually save some room for half a dozen desserts . . . after
plates of salad, veggies, and some very lean meat. There's plenty of room
for QOL in a healthy diet.

I.P.

> IP, you make me laugh, truly.  No, I'm not going on any more bandwagons
> and the "diet" you are on is just what we have decided to follow.  I'm
> with you on this.  (Except for QOL I will make an exception once in a
> while.)
Glassman - 09 Aug 2005 03:13 GMT
> I'm glad it's worked so well for you, but you're an exception to the Atkins
> statistics, so I need to balance your success with some more general facts
[quoted text clipped - 5 lines]
>
> I.P.

   We've been down this road before you and I, IP.  Your opinion is fine,
but very far from the facts. Let me just correct you a bit. Almost all of
the low carb lifestylers I know have equal or greater success and health
than low fat/high carb eaters. What does this mean? Probably nothing to you
if you're happy and successful eating tree bark, snake venom, or bear
excrement. LOL..... I speak to hundreds of folks weekly on the LC NG, who
swear by this way of eating,   many have lost and kept off upwards of 100
lbs in the 35 years since the book came out. This is not a fad. It's a way
of life for us. On the other hand I know of too many, including myself, that
gained weight eating high carb/low fat.
   As for the Atkins backruptcy here's the truth. True lowcarbers don't,
and never have, bought into the "frankenfoods" that were lining the shelves.
Lowcarb candy bars, cakes, and such have NEVER taken the place of eating
whole foods. This was simply a failed attempt at cashing in on the 30
million folks out there that live the LC lifestyle. Trust me no one has
stopped eating this way. Lack of interest was in these particular products
NOT the diet. These convenience foods aren't even mentioned in Atkins book.
   Remember the lowfat/nofat cakes that we were all eating years ago?  No
fat but loaded with sugar and starch. All gone from the shelves too.
  Again let me say that  we don't eat refined and fake junk food. No sugar,
and no starch. We get our carbs mostly from whole complex veggies, berries
and nuts.  If you're exercising regularly, you can pretty much eat any which
way you like and stay trim anyway.
   I'm not remotely trying to convince anyone to switch how they eat. I
never criticize anyones way of eating that works for them.  All I can do is
report the truth, which is my own success. I have never been healthier. How
do you account for this after 7 years, if my way of eating is bad for me?
All bloodwork, BP & Cholesterol down, heart and organ function fine, more
energy than ever, plus I eat as much as I want of great food. What else
could I want? Weight Watchers, Zone, Meditaranean, all will work, if you can
stick to it. Some are harder than others to follow as a lifestyle change.
  Lets all be healthy anyway we can and enjoy a great QOL as well. Of
course any study you can find can be countered with another that shows the
opposite, but you may enjoy reading the following:

http://www.ravnskov.nu/cholesterol.htm

http://www.second-opinions.co.uk/cholesterol_myth_2.html

http://www.lowcarb.ca/articlesa/article217.html

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Ken - 11 Aug 2005 03:58 GMT
           "There is no evidence that diet has any effect on PCa."

Here's an article about a study published in the Journal of Urology,
August 10, 2005...

BY JOHN FAUBER
Milwaukee Journal Sentinel

MILWAUKEE - (KRT) - A provocative new study suggests that men with
early-stage prostate cancer who elect not to undergo conventional
treatment may be able to halt the progression of their disease by
making substantial lifestyle changes such as adopting a very low-fat,
vegan diet, exercising and meditating.

The authors of the study, published Thursday in the Journal of Urology,
say it is the first randomized clinical trial showing that lifestyle
changes can halt the progression of prostate cancer.

However, urologists not associated with the research said the length of
the study was too short, the number of men too few and the outcome
measures too imprecise to make definitive conclusions about the
benefits of the intervention.

In addition, maintaining the strict diet used in the study would be
very difficult for many men, they said.

"I don't know if Draconian is the word," said William See, chairman of
the urology department at the Medical College of Wisconsin. "(But) the
ability of the average Midwesterner to tolerate that kind of diet is
questionable."

The study comes at a time when there is growing controversy about the
best way to treat early-stage, localized prostate cancer. The study and
additional research that may stem from it could have implications for
some of the more than 230,000 men who are diagnosed with prostate
cancer each year. African-American men have a 60 percent higher risk of
developing prostate cancer than whites, and are twice as likely to die
of the disease.

Lead author Dean Ornish, director of the Preventive Medicine Research
Institute in Sausalito, Calif., and a longtime crusader of ultra
low-fat diets, said the study shows that adopting various lifestyle
changes can be beneficial to men with prostate cancer in addition to
whatever other conventional measures they take.

"(Improved) diet and lifestyle play a role in the progression of
prostate cancer and the only side effects are good ones," said Ornish,
a controversial author and clinical professor of medicine at the
University of California, San Francisco.

Other study authors included researchers from UCSF and the Memorial
Sloan-Kettering Cancer Center in New York.

"This is the first in a series of trials attempting to better identify
the exact role of diet and lifestyle in the prevention and treatment of
prostate cancer," senior author Peter Carroll, chairman of the urology
department at UCSF, said in a statement.

Earlier epidemiological studies have linked various lifestyle measures
such as a high-fat diet, especially animal fat, obesity and a lack of
physical activity with an increased risk of developing prostate cancer.

There is hope that various dietary measures, such as eating fruits and
vegetables or taking supplements such as lycopene, selenium and vitamin
E, can lower risk, but that evidence still is insufficient, according
to the National Cancer Institute.

The study involved 93 men with an average age of about 66 who were
diagnosed by biopsies with low-grade prostate cancer. All of the men
had decided to undergo so-called watchful waiting, which meant their
cancer would be monitored but they would not immediately undergo
conventional treatment such as surgery or radiation.

Forty-four of the men were put into an intensive intervention program
that included a low-fat, vegan diet, and daily tofu and soy
supplements, as well as 400 international units of vitamin E, three
grams of fish oil, 200 micrograms of selenium, two grams of vitamin C,
30 minutes of moderate exercise six days a week, and an hour a day of
stress management with techniques such as meditation and yoga.

The other 49 men did not undergo intensive lifestyle changes.

Researchers used the prostate-specific antigen, or PSA, test as a way
to monitor the disease progression in the men.

After one year, the men in the intervention program had an average 4
percent decline in their PSA test scores, compared with a 6 percent
increase in the scores of the control group.

In another measure, six of the men in the control group went on to have
surgery or some other treatment due to a progression of their disease,
compared with none of the men in the intervention group.

In addition, blood samples were taken from the men to see if the serum
could inhibit prostate cancer tumor growth in a laboratory dish. There
was a 70 percent inhibition of tumor cell growth from the blood from
the men in the intervention group, compared with 9 percent from the
control group.

"We are learning more and more about compounds that may prevent, if not
have therapeutic potential in prostate cancer," said Jason Gee, a
urologic oncologist at the University of Wisconsin Hospital in Madison.
"In a select group of patients who are appropriate for watchful
waiting, some dietary changes may be helpful as suggested by this
study."

However, Gee said it was too early to make overall recommendations
based on the study, which needs to be validated by further research.

Howard Parnes, a physician with the National Cancer Institute, said the
study's results appear to support the hypothesis that dietary and
lifestyle measures can affect prostate cancer progression, "but there
are a lot of caveats."

One problem, he said, is that the PSA score, the primary measure in the
study, is only a surrogate for disease progression. It is not a
clinical outcome, such as mortality.

The PSA score could have been affected by the soy, which has a weak
hormonal affect, he said.

In addition, there were so many variables in the study that it was
impossible to sort out which ones may have caused the beneficial
effects, he said.

"To say to patients, `You've got to do all these things' puts a large
burden on them and creates a lot of guilt and stress," said Parnes,
chief of the prostate and urologic cancer research group in the
division of cancer prevention at the cancer institute.

"I don't think we should tell people you should do this." However, he
said the study was a step in the right direction. "This kind of work
does stimulate the research field to look at dietary and lifestyle
measures," he said.

In addition to lower PSA scores, the men in the intervention group lost
an average of about 10 pounds and had significant improvements in their
cholesterol levels.

In earlier research, Ornish has showed that similar intensive
intervention programs can reverse heart disease.

Here is the regimen researchers used on the men whose prostate cancer
appeared to improve:

A low-fat, vegan diet, and daily tofu and soy supplements
400 international units of vitamin E
Three grams of fish oil
200 micrograms of selenium
Two grams of vitamin C
30 minutes of moderate exercise six days a week
An hour a day of stress management with techniques such as meditation
and yoga
Glassman - 11 Aug 2005 05:52 GMT
>             "There is no evidence that diet has any effect on PCa."
>
[quoted text clipped - 9 lines]
> making substantial lifestyle changes such as adopting a very low-fat,
> vegan diet, exercising and meditating.

 All I have to point to is the late great Martin Howard. Lifelong vegan,
yoga, hiker, meditator, biker, urine drinker, herbal believer, and generally
marched to a different drummer. PSA in the neighborhood of 1000 while he
cathedered himself daily. I repeat..... diet has no effect on this disease.

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ron - 11 Aug 2005 15:15 GMT
Isn't there a middle ground where, depending upon your genetic makeup,
contraction and / or progression of diseases may or may not be
influenced by factors such as diet, supplements, exercise, etc.?..Best
wishes and good health, Ron
Glassman - 12 Aug 2005 04:39 GMT
> Isn't there a middle ground where, depending upon your genetic makeup,
> contraction and / or progression of diseases may or may not be
> influenced by factors such as diet, supplements, exercise, etc.?..Best
> wishes and good health, Ron

  I agree that genetic makeup is a huge factor, but until I see proof of
the others, I'm a non believer. Too many world class athletes, health nuts,
and assorted saintly folks all get cancer. I say QOL is the most important
thing. Keeping yourself from the joys of eating good food will only make
your days that much less fun. If I knew for a fact that eating treebark
would extend my life another 3 months, then I'm going fo rthe steak! Get
yourself treated, then eat, exercise, and have a blast!

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Ben - 17 Aug 2005 14:40 GMT
Earlier epidemiological studies have linked various lifestyle measures
such as a high-fat diet, especially animal fat, obesity and a lack of
physical activity with an increased risk of developing prostate cancer.

When they say animal fat are they talking about red meat only or does
that include all animals like  fish and poultry?
Peter Headland - 17 Aug 2005 15:52 GMT
Fish = Good
All else = Bad

There is far more fat in an intensively reared chicken breast than a
pork chop these days (to the benefit of neither)...

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Glassman - 20 Aug 2005 05:44 GMT
> Earlier epidemiological studies have linked various lifestyle measures
> such as a high-fat diet, especially animal fat, obesity and a lack of
> physical activity with an increased risk of developing prostate cancer.

 I've never seen such studies, that didn't also account for high
carbohydrate intake as well.

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I. P. Freely - 13 Aug 2005 06:53 GMT
Medical research trumps anecdotal stories and commercially-sponsored
literature in my book.

I.P.

>> I'm glad it's worked so well for you, but you're an exception to the
> Atkins
[quoted text clipped - 58 lines]
>
> http://www.lowcarb.ca/articlesa/article217.html
Glassman - 13 Aug 2005 07:32 GMT
> Medical research trumps anecdotal stories and commercially-sponsored
> literature in my book.
>
> I.P.

   All diet chat and kidding aside for a moment IP..... I'm kind of crabby
lately about how people are so intent on extending their lives at any cost.
Of course since we have all had a closer brush than most, it hits closer to
home. I do understand the fight for survival, but every now and again a new
poster makes me crazy asking if it's true that eating bees knees with
curried yak toenails is the cure? At some point we need to "unfocus" on
disease and live our remaining years to their fullest. Sure we want to be
healthy and trim, and hard bodied, and gorgeous. Let's not forget that as
far as we know this life is going to end someday. Don't deprive yourselves
of it's joys. Make that read ALL it's joys. Or as many as you can physically
engage in. That means chocolate, steak, whipped cream, luxury,  loud music,
big screen TV, and silly laughter.

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Aussie Ron - 13 Aug 2005 09:02 GMT
>    All diet chat and kidding aside for a moment IP..... I'm kind of crabby
> lately about how people are so intent on extending their lives at any
[quoted text clipped - 13 lines]
> music,
> big screen TV, and silly laughter.

Hear, Hear!!  I'll second those comments.
Larry - 13 Aug 2005 15:08 GMT
I'll pass on that steak - that I used to enjoy so much - and still do very
occasionally - if it means a few more years of watching my grandkids grow
up.
I plan to go down fighting, thank you very much . . . .

> > Medical research trumps anecdotal stories and commercially-sponsored
> > literature in my book.
[quoted text clipped - 13 lines]
> engage in. That means chocolate, steak, whipped cream, luxury,  loud music,
> big screen TV, and silly laughter.
Stavros Moschos - 13 Aug 2005 15:56 GMT
I just bought a big screen HDTV, which I had been postponing as being down
the road.  Am I ever enjoying my DVD collection.

>> Medical research trumps anecdotal stories and commercially-sponsored
>> literature in my book.
[quoted text clipped - 18 lines]
> music,
> big screen TV, and silly laughter.
Steve Kramer - 13 Aug 2005 16:56 GMT
I planned my family room and party room around plazma TVs when I built this
condo.  And I've never pulled the trigger on making the purchase.  It's been
two years.  Maybe I oughta reconsider.

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05
PSA  .07 .05 .06 .05
non Illegitimi carborundum

> I just bought a big screen HDTV, which I had been postponing as being down
> the road.  Am I ever enjoying my DVD collection.
[quoted text clipped - 21 lines]
> > music,
> > big screen TV, and silly laughter.
Glassman - 14 Aug 2005 05:26 GMT
I just bought a big screen HDTV, which I had been postponing as being down
the road.  Am I ever enjoying my DVD collection.

> I planned my family room and party room around plazma TVs when I built this
> condo.  And I've never pulled the trigger on making the purchase.  It's been
> two years.  Maybe I oughta reconsider.

 Geez I never thought PCa would change the market for big screen TV's? Get
this.... my son has a 9' screen with a LCD projector featuring an HDTV
quality picture. He cranks up the surround sound and plays his video games
as well as TV on it. If you have the space, I would check into it instead of
a plasma.

Signature

JK Sinrod
Sinrod Stained Glass Studios
www.sinrodstudios.com
Coney Island Memories
www.sinrodstudios.com/coneymemories

Stavros Moschos - 13 Aug 2005 15:59 GMT
"curried yak toenails"?  Do you know where I can get some?

>> Medical research trumps anecdotal stories and commercially-sponsored
>> literature in my book.
[quoted text clipped - 18 lines]
> music,
> big screen TV, and silly laughter.
I. P. Freely - 14 Aug 2005 02:53 GMT
"Glassman" wrote>
>    All diet chat and kidding aside for a moment IP..... I'm kind of crabby
> lately about how people are so intent on extending their lives at any
[quoted text clipped - 13 lines]
> music,
> big screen TV, and silly laughter.

This is long, but if it motivates one or two people to get off their duffs
and enjoy what's left, be it a year or 30 years, it may be worth their time
and mine.

I fully agree with you on the non-NECESSITY of living austere lives to
(maybe) gain a few months, but I do respect well-considered decisions to do
so, at least to the extent that for some, their QOL is founded on hope for
the future, rather than living to the fullest right now. They are
goal-oriented people, whereas you sound like me -- a myopic hedonist. But
just as I don't see a conflict between creationism and evolution, I also
don't see a conflict between 1) a full lifestyle with lavish eating and 2) a
healthy, longevity-promoting regimen. Not to tell you how to eat or live,
but lest others here think one must eat bark or live in a bubble to be
healthy and have fun . . .

Re (a), people have dropped their jaws for 50 years, right up through
yesterday, at the way I live my life. It's been balls to the wall play 5-7
days a week for the past 55 years with a huge variety of sports, many of
them rather vigorous and some perceived as risky (e.g., racing dirt bikes in
terrain horses couldn't negotiate, windsurfing in 50 mph winds, flying
snowmobiles off cornices). Our neighbors used to make book on how many
sports my wife and I would engage in on any given weekend . . . and whether
I'd get a nap between snowmobiling all Wednesday night and returning to the
office Thursday morning. I walked away from my engineering career in 1988 at
age 45 to play full time, and still easily outlast virtually every 40- or
20-year-old kid with whom I carve up the waves. Most of them are whimpering
jelly after 2-4 hours of heavy sports, whereas I have no problem with 8-10
hours in a day (think playing football, offense and defense, from breakfast
until supper). It's the highest priority in my life, and has received my
full, exclusive attention for decades now. I deprive myself of absolutely
nothing that interests me. I chose my lifestyle over hormone therapy, if you
recall, because it is more important to me than a few extra months of
heartbeat. As a result of 5+ decades of hard play, my physicians and peers
say I'm fitter than many athletes half my age, and that's WITH dual cancers.

As for (b), I've been accused of having bulemia, a ten-pound tapeworm,
secret pouches in my clothes (by buffet managers, two of whom refused me
further food, another who CHANGED HIS BUFFET TO PAY-AS-YOU-EAT CAFETERIA
because of the trays of food I ate for a couple of bucks), the metabolism of
a whole colony of shrews, etc. I have always and still do eat like two pigs,
with one simple concession to healthy diet science: I keep sat- and
trans-fats to bare minimums 360 days a year. Bees' knees'n'yak backs, my
muscular a.s. How about fajitas, lasagne, mixing bowls full of strawberry
angel food shortcake hidden by mounds of whipped cream, enchiladas, 3-4
loaves a week of something like raisin walnut cranberry honey whole wheat
bread smothered in Italian-seasoned olive oil, green chile chicken stew,
6-egg shrimp'n'peppers omelettes with sides of hash browns and blueberry
whole wheat pancakes swimming in marionberry syrup, plates of whole wheat
spaghetti buried in pints of chicken'n'sausage marinara sauce, wild or
farmed salmon flank steaks hot off the grille and smothered with any of
several sauces plus a couple pounds of grilled vegetables dripping in sweet
onion vinegarette, two pounds of peppers'n'shrimp or chicken stir fry, Home
Town Buffet from breakfast right through lunch, a half-gallon of
boulliabase, heaps of candied yams any day of the year, skewers of shish
kebab grilled over fresh mesquite picked up off the desert floor outside my
RV . . . yeah, I deprive myself of great food, all right, but only because I
can eat only several pounds a day any more. My days of an 18" Chicago pizza
with a chocolate malt for lunch before five plates of buffet for supper
ended in my 30s, but two full IHOP breakfasts is still a piece of cake . . .
as long as they don't feature bacon, sausage, etc. . . . and my whipped
cream, cheese, rare sausage, etc. are low-sat-fat varieties.

And, oh yeah . . . we have 9 TVs in our home. I watch -- more like listen
to -- way too much of it, especially while bombing down the highway at 95
mph in my motor home.

I get more hedonistic play and more varieties of food in most years than
many people get in a lifetime, and for the last 20 years, since we learned
what sat- and trans-fats do to us and my body stopped healing overnight,
both have been exceedingly healthy. If bees knees and yak toenails will help
me, I'll try 'em . . . as long as they don't diminish my QOL in the process.
Last Wednesday was one of my best days in the waves in years; I'm not giving
that up for some hypothetical seven months in a hospital bed at the end of
the line.

I.P.
Ken - 07 Aug 2005 19:03 GMT
                       "There is no evidence that diet has any effect
on PCa."

There have been dozens of major research papers published on diet and
PCa. Some of them disagree with each other, but I have never seen
disagreement about negative effects of a high fat diet on PCa. Here are
short excerpts from two reports I happen to have:

Dr. Steven Strum, 3/10/2005, Page 6 of
http://www.lef.org/LEFCMS/aspx/PrintVersionMagic.aspx?CmsID=77474

"Dietary Fat Increases PC Growth Rates.
   There are studies that show that dietary fat increases tumor growth
rates in an animal model of human PC. In a mouse model of PC involving
androgen-sensitive human prostatic adenocarcinoma cells (LNCaP cells),
mice fed a 40.5% fat diet had mean tumor weights more than 2 times
greater than mice fed a 21% fat diet. The 40.5% fat diet approximates
that found in the average American male diet, which has been determined
to be 36%.30.
   The slower tumor growth associated with the low-fat diet occurred
even after the formation of measurable tumors when the diets were
changed from 40% fat to 21% fat. Serum PSA levels also were highest in
the 40.5 kcal% fat group and lowest in another group fed only 2.3 kcal%
fat.30
Reduction of Total Calorie Consumption Decreases Tumor Size by
Decreasing VEGF, Angiogenesis, and IGF-1 and by Increasing Apoptosis.
  The emphasis on dietary fat, per se, has lessened our focus on the
importance of caloric over-consumption. Fat excess, however, is linked
to excessive calorie consumption, since fat contains twice as many
calories, gram for gram, as protein or carbohydrate.
  An important study demonstrated that energy intake (caloric intake)
modulates the growth of prostate tumors in two animal models: the
androgen-dependent Dunning R3327-H adenocarcinoma in rats and the
androgen-sensitive LNCaP human adenocarcinoma in severe combined
immunodeficiency (SCID) mice.31 Specifically, decreasing calorie
consumption (energy restriction) by 20-40% from the control animals fed
ad libitum resulted in:
        Increased PC cell apoptosis (programmed cell death)
        A two- to threefold reduction in PC angiogenesis as
measured by microvessel density
        A decrease in vascular endothelial growth factor (VEGF)
expression
        A decrease in circulating levels of IGF-1
        A significant decrease in tumor size
  Therefore, all of these findings were benefits observed in the
calorie-restricted group. This study showed that the nutritional status
directly or indirectly influenced interaction between tumor cells and
local blood vessels by changing the expression of angiogenic growth
factors."
..........................................................

>From a paper by Dr. William Catalona, et al, 4/18/2005:

  "....when Asian men migrate to the West, their risk increases.
Dietary fat is believed to be the culprit. "Cholesterol is the building
block of the male hormone testosterone," said Dr. William J. Catalona,
director of the Clinical Prostate Cancer Program of Northwestern
University's Robert H. Lurie Comprehensive Cancer Center. Since statins
lower blood levels of this fatty substance, there may be less of it
available to synthesize testosterone and dihydrotestostrone, he
explained. And that may reduce male hormones that stimulate prostate
cancer."
I. P. Freely - 07 Aug 2005 23:31 GMT
"Ken" < wrote (I have no idea why the >'s don't appear in my quotes this
time)
"The emphasis on dietary fat, per se, has lessened our focus on the
importance of caloric over-consumption."

I've been trying to resolve that dilemma (i.e.,  define "caloric
over-consumption") for 45 years. Is eating 2-4 times the quantity of
calories and/or volume others eat "caloric over-consumption" if we burn it
off and maintain a lean body? Would a person like that live much longer if
s/he cut calories WAY back to become downright skinny? Lab rats do, but a)
would we, b) how's it feel being hungry alla time, and c) I'll bet these
starving rats cut their wheel time back dramatically.

I.P.
Tdub - 08 Aug 2005 03:26 GMT
I agree with I.P. on the diet issue. I'm 55 and relatively fit, and I
eat whatever I feel like, except I never eat deep fried food, and avoid
manufactured food (e.g., trans foods), because what is best for us is
what our ancestors ate, (including meat, etc.), because that is the
kind of diet our bodies were designed for (as a result of
successive-generation gene variations). So go for organic foods, avoid
pesticides, chemicals and additives in your food, eat a healthy balance
of all the good foods in the world, and don't eat stuff that your
grandparents, and their ancestors, probably didn't eat. Eating deep
fried foods, IMO, is about as healthy as smoking cigarettes - the "deep
fat" often is never changed, and has been held at 600+ degrees for a
long time, which makes any health elements in it vanish, and god only
knows the negative health effects of the chemicals created by the
extended heating of the fat - if vegetable oil is used in this way, it
quickly becomes rancid because of the prolonged high heat exposure.
Douwe - 08 Aug 2005 08:27 GMT
"Tdub" <gripshift5@email.com> wrote...
> I agree with I.P. on the diet issue. I'm 55 and relatively fit, and I
> eat whatever I feel like, except I never eat deep fried food, and avoid
> manufactured food (e.g., trans foods), because what is best for us is
> what our ancestors ate, (including meat, etc.), because that is the
> kind of diet our bodies were designed for (as a result of
> successive-generation gene variations).

I'm sorry to disagree with this. Our ancestors worked 12 to 16 hours a
day, so a plate full of potato's with bacon and a lot of fat was
neccesary to keep the engine running. Their expected life-span was about
53 years.
I do not turn this around. Our average life should be 73 years. For
those 20 years difference we should have taken precousion, but did we?

A life span for a car is about 50 years, when and if you don't start
racing from day 1

I believe this subject (Soy and food) is OT in this group. There is no
food that heals us. There is some food we should have avoided and there
might be some food (pumpkin-pits and tomato ketchup) that could help to
keep the prostate a healthy pink peace of meat a little while longer,
but it takes at least two generations to prove this is true. Eating like
our ancestors did is not a cause for cancer.

Douwe
Douwe - 08 Aug 2005 09:23 GMT
"Douwe" <Douwe_in_nl@yahoo.com> wrote...

> A life span for a car is about 50 years,
                                         ^^^^

20 years, sorry
 
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