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Medical Forum / Diseases and Disorders / Prostate Cancer / June 2005

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RP and rising BP?

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I. P. Freely - 18 Jun 2005 20:11 GMT
Makes no sense to me and my surgeon, but my BP has been consistently high
since my surgery. It ran about 120/70 or less for decades, right up through
last fall, but has consistently been 140-150/80-90 since winter.

Stress? (That ended with my ADT decision, as far as I can tell, but who
knows?).
Too much politics on TV/radio/internet? (I'm turning that crap off for a few
months to see if that helps.)
Physiological recovery issue from surgery?
Lingering effects of single Zoladex shot? (T recovery can take many months,
and it may never fully return; I'll get T tested again this fall).
Coincidence, with age (61)? (I doubt it; too big, too sudden, too
consistent.)
I attributed it to a winter with little exercise, but the past month has
included HUGE amounts of hard exercise and I "blew" a record 150/87
yesterday.

Any others experience this? Ideas?

BTW -- my surgeon was grinning from ear to ear at my 0.006 PSA yesterday @ >
seven months post-op, confirmed by two different labs. I presume that tells
him he got all that was existant at surgery.

I.P. Accidentally a Lot Less
James A Honeychuck - 18 Jun 2005 21:26 GMT
I have to defer to the doctors on the cause, but mine has also climbed
in the three years since surgery, much worse than yours.  It was also
high when I was in the service, then declined for a while after
retirement.  Now for the first time in my life I'm on medication for
high BP.

Since exercise has not lowered your BP, suggest you ask about
medication.  The doctors have many choices of BP medication, and it can
take a while to get it right, so be patient.

Congratulations on your PSA.  Don't drop off the group just cause you're
cured.

jimhoney
Standard RRP age 52, cured, no significant aftereffects

> Makes no sense to me and my surgeon, but my BP has been consistently high
> since my surgery. It ran about 120/70 or less for decades, right up through
[quoted text clipped - 20 lines]
>
> I.P. Accidentally a Lot Less
I. P. Freely - 19 Jun 2005 03:37 GMT
"James A Honeychuck"  wrote >
> Since exercise has not lowered your BP, suggest you ask about medication.
> The doctors have many choices of BP medication, and it can take a while to
> get it right, so be patient.
>
> Congratulations on your PSA.  Don't drop off the group just cause you're
> cured.

First action: cut the political media, go back to music.
Second: start cutting salt (never had a reason to before).
Third: see the doc on 12 July. I'd like to hold off on the BP meds until
absolutely necessary. Another month or three won't matter after a lifetime
of low BP.

"Cured"? Wish we thought so, but the charted odds of PSA returning within
five years still hit 80%. I'll expect biochemical recurrence by five and
claim a victory if it doesn't materialize. As for dropping off . . . still
way too much to learn. I asked my doc about some of the pertinent new
studies posted here in the past few months; none work for me. I'll post his
brief comments when I have more time. Speaking of which . . . time, rather
than being "cured", will cut into my presence here. There's just too much
not getting done, and I need to try to regain some of the months this beast
stole from me over the winter.

And there's another reason for me to back off somewhat: my memory of the
research I did is fading as though I were on Zoladex; I simply ain't got as
much to say as I did a few months ago. (I'd also guess the ripples haven't
all dissipated completely from the pond, either.)  '-)

The final reason? Surf's up!

I.P.
c palmer - 18 Jun 2005 21:35 GMT
hi i.p. - i never had high blood pressure for 55 years.  even when i
weighed 325, it was 125/82.

after i got the news of the pca, it skyrocketed.  i came over in a snow
storm and with the weather and the bad news of pca, it was 166/110.  

even when i went back to the VA clinic, it was 130/90, so they put me on
BP meds and for the two month wait for surgery, it stayed in the high
normal range.  

after surgery, they said my BP got down to 80/50 that night.

for 18 months, it's been in the low 120's/70's.

then, when i got the word that i might have a recurrence of pca, it has
been in the 140's and they shifted it to another BP med and it's dropped
a little bit.  

now, i have to go in for a stress test next thursday.  no telling what
that is going to say.  

yeah, been there, done that, got the T-shirt.

~ curtis

knowledge is power - growing old is mandatory - growing wise is optional    
"Many more men die with prostate cancer than of it. Growing old is
invariably fatal. Prostate cancer is only sometimes so."
http://community.webtv.net/PALMER_ENT/doc
I. P. Freely - 19 Jun 2005 03:41 GMT
> hi i.p. - i never had high blood pressure for 55 years.  even when i
> weighed 325, it was 125/82.
[quoted text clipped - 18 lines]
>
> yeah, been there, done that, got the T-shirt.

Sounds like I should add conscious relaxation to my BP regimen, too. I can't
imagine any physiological changes which could spike my BP this quickly, but
stress is certainly credible. The wife says I've gone from "intense" to
"cranky" over the past few months.

I.P.
ronju99 - 19 Jun 2005 12:08 GMT
IP
Don't worry about your blood pressure too much especially at the doctors
office. It will normally be high from anticipation of doom. Mine would get
up to 160/ 100 at the office and doc would want to send me for a stress
test. He also told me to monitor it at home especially in the mornings.
Before watching the news. I found mine would be in the normal range most
of the time. I attribute the highs to stress and not enough exercise. One
time when I went to the VA for a checkup the nurse told me my pressure was
high and that she would take it again. She told me to close my eyes and
think of being at the beach watching the sunset. She took it again in
about 5 mins. and it was 120/70. I would resist taking any meds. Try
focusing on more pleasent topics and keep up daily walks. Turn off the TV.
Don't worry too much about situational stress, especially at the doctors
office. I've followed a lot of your post and it would appear that you are
getting too heavily involved in the research aspect of prostate cancer.
Yours is probably cured like mine but like most of us we won't let it go.
I asked my GP Doc for a prescription for androderm and he said he wanted
another PSA first. The results came back 0.1 from Quest labs. He told me I
still had some PSA. I told him that both times Quest did my PSA it was 0.1
and that they for some reason don't use the caret in front of the results.
Four days later I went to AcuLab and had an ultrasensitive test done and it
came back <0.06. I called Quest but got nowhere with them. I was talking to
a foreigner and they didn't have a clue. The only two times I ever had a
result that wasn't <0.1 was when I went to Quest Lab. I'm now two years
post LRP and am 64.

Ron S.
James A Honeychuck - 19 Jun 2005 15:58 GMT
Ron has made an excellent point, and I kick myself for not making that
point in my earlier post.

My in-office BP readings are useless.  They soar due to "white coat
syndrome."  So I have a cuff-and-meter device which I use at home.  I
record those readings daily and make a copy for the doctor.

jimhoney

> IP
> Don't worry about your blood pressure too much especially at the doctors
[quoted text clipped - 23 lines]
>
> Ron S.
I. P. Freely - 20 Jun 2005 00:38 GMT
Thanks, Ron, for the thorough discussion. It brings up several valid points.
But my BP has been between 95/65 (just a few years ago, during months of
hard muscular and aerobic exercise 4-8 hours every day) and 125/70 (during
more sedentary periods), and that's in the presence of white coats. For the
last several months it's been > 140/80. I do consciously relax when having
my BP measured, but don't want to overdo it enough to artificially lower the
readings. Something's changed, and I need to find out what and correct it.
I'm sure you're right that I was stressed when researching my cancers last
winter, but once I made my treatment decisions I pretty much stopped reading
about it unless someone put an interesting article in front of my face.

I.P.

> IP
> Don't worry about your blood pressure too much especially at the doctors
[quoted text clipped - 25 lines]
>
> Ron S.
Leonard Evens - 19 Jun 2005 16:19 GMT
> Makes no sense to me and my surgeon, but my BP has been consistently high
> since my surgery. It ran about 120/70 or less for decades, right up through
[quoted text clipped - 12 lines]
> included HUGE amounts of hard exercise and I "blew" a record 150/87
> yesterday.

Do you have a home blood pressure meter?  There is a condition called
white coat hypertension where your bp is high when measured in the
doctor's office but normal at home.   If you do get such a device, make
sure the cuff is at heart level.   There can be a significant increase
in the systolic if your arm is below heart level, as high as 10 points
or more.

If your bp remains high, ask your doctor about medication.  He will
probably start off with a mild diuretic, which should have minimal side
effects.   But before that, you could try carefully monitoring the
amount of sodium in your diet.  I found I was taking in much more than I
had thought and when I reduced it to less than 1.5 grams a day, my blood
pressure went down to more like a normal range.

> Any others experience this? Ideas?
>
[quoted text clipped - 3 lines]
>
> I.P. Accidentally a Lot Less
I. P. Freely - 20 Jun 2005 00:50 GMT
My usual daily box of salt (?) has never been a problem before, but I will
cut it back as part of my shotgun approach to the problem to see if meds can
be avoided. Diuretics dehydrate us, introducing a whole 'nuther set of
medical threats. No, thanks. I work hard to deliberately keep my hydration
up as it is. And it's easy to get a gram or two of salt in one can of soup
or beans, which is but a small part of my daily diet. Something changed over
just a very few months to spike my BP, and I need to determine what that
was.

I will dig out our sphygmomanometer, but won't put much faith in it until I
can compare its readings side by side to what the nurses measure with their
"professional" units.

I.P

"Leonard Evens" <len@math.northwestern.edu> wrote >
> Do you have a home blood pressure meter?  There is a condition called
> white coat hypertension where your bp is high when measured in the
[quoted text clipped - 9 lines]
> thought and when I reduced it to less than 1.5 grams a day, my blood
> pressure went down to more like a normal range.
David S. - 20 Jun 2005 12:21 GMT
My surgery was in August 2003, and last year I ended up on two drugs for
high blood pressure.  Both had to be increased from the original dosage
before getting it down.  No one suggested a relationship between the RRP and
the rising BP, but I was having readings like 160/94.  So, who knows?

> Makes no sense to me and my surgeon, but my BP has been consistently high
> since my surgery. It ran about 120/70 or less for decades, right up through
[quoted text clipped - 21 lines]
>
> I.P. Accidentally a Lot Less
Ed Friedman - 21 Jun 2005 19:13 GMT
> Makes no sense to me and my surgeon, but my BP has been consistently high
> since my surgery. It ran about 120/70 or less for decades, right up through
[quoted text clipped - 20 lines]
>
> I.P. Accidentally a Lot Less

I.P.,

There is no question that low endogenous levels of T are associated with
high blood pressure in men.  If you check "Testosterone and Other
Anabolic Steroids as Cardiovascular Drugs" in American Journal of
Therapeutics, 1999, 6:167-174, you will see that virtually all
cardiovascular risk factors, including blood pressure, are linked to low
T.  To quote from the paper: "In men, testosterone has been shown to
have antianginal effects, and endogenous levels have an inverse
relationship to systolic blood pressure."

Ed Friedman
I. P. Freely - 21 Jun 2005 19:33 GMT
Makes me wonder how thoroughly my T level rebounded from my one-month
experiment with Zoladex. in February. We plan to check my T in December.
Maybe if my BP drops back to normal I can resume watching the news and
reading the Op Ed page.

I.P.

"Ed Friedman" <ed@math.uchicago.edu> wrote >
> There is no question that low endogenous levels of T are associated with
> high blood pressure in men.  If you check "Testosterone and Other Anabolic
[quoted text clipped - 6 lines]
>
> Ed Friedman
ron - 21 Jun 2005 21:27 GMT
Ed...How do you square that refernce with the work of Zmuda, et. al..
who's right?..Ron

Am J Epidemiol. 1997 Oct 15;146(8):609-17; Longitudinal relation
between endogenous testosterone and cardiovascular disease risk factors
in middle-aged men. A 13-year follow-up of former Multiple Risk Factor
Intervention Trial participants; Zmuda JM, Cauley JA, Kriska A, Glynn
NW, Gutai JP, Kuller LH
"There was little relation between change in testosterone and change in
total and low density lipoprotein cholesterol or blood pressure. This
longitudinal study confirms a gradual decline in total testosterone
levels with advancing age in older men and provides evidence that
lifestyle and psychosocial factors are related to this decline.
Decreases in endogenous testosterone levels with age in men are
associated with potentially unfavorable changes in triglycerides and
high density lipoprotein cholesterol."
Ed Friedman - 21 Jun 2005 21:55 GMT
> Ed...How do you square that refernce with the work of Zmuda, et. al..
> who's right?..Ron

Ron,

The paper I was referring to was reviewing the entire literature, and
making conlcusions based on the preponderance of studies.  E.g., they
say: "The majority of studies evaluating the effects of exogenous
androgens on plasma lipids and lipoproteins have shown reductions in LDL
cholesterol."  Note that they are saying the majority, not every study.

Personally, I think that all past studies evaluating the effects of
exogenous T are flawed, because no efforts were made to prevent the
conversion of T to DHT and to E2.

Ed Friedman
ronju99 - 22 Jun 2005 00:43 GMT
I don't know if any of us really knows what happens to us after removal of
the prostate. I believe it's a more important organ than many believe.
Especially how it affects our hormones. Three months after my surgery I
had my testosterone checked and it was 375. A year later I had it tested
and it dropped to 315. Eight months later it was 382. I checked it again
one week later at my own expense and it came back at 452. The test were
done around noon each time. Now my HDL is an other issue. Total was 209 a
year ago and HDL was 40. This spring total was 192 and HDL was 28. Not so
good. My VA GP put me on 250mg. niacin. Haven't had a test since to
determine if it helped.
I had first thought that removal of the prostate might be the cause of my
falling testosterone. Now I'm wondering if it wasn't do to the extended
time I spent in surgery that shut down my system and has taken a long time
for my (Nuts) to get back to normal. I have no other explanation for the
rise in testosterone.
As for IP Freely and others recently out of surgery, I suspect it's too
soon to come to any conclusions about much of anything for the first
couple of years. I'm now reaching the point where I realize how much
emotions drive our decision making, not only before treatment but for some
time after treatment. By being two years post-op, I'm now becomeing more
relaxed about the whole experience and not fretting about the future
especially recurrence. I believe the statistics on recurrence is greatly
flawed by including pre psa era patients. I believe if your numbers are
right for surgery and your post pathology report is clean, it's unlikely
you will have recurrence in your lifetime.

And that's my opinion.
Ron S.
 
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