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Medical Forum / Diseases and Disorders / Prostate Cancer / May 2005Bi-Mix Failure.
The Caverject and tri-mix caused considerable discomfort, although they produced the desired result. The ED specialist changed me to the bi-mix and after two tries, the second using a 10% increase in the dosage, sorry to report that the injection resulted in a soft erection not stiff enough for penetration. I have a call in to the doctor to ask about taking an even higher dose, or ??? I am using an insulin syringe and started with 50 units. It is my understanding that this equals .5 ml. How much do others use? I wonder if using less tri-mix would still work and result in less discomfort? Ideas? Thank you. David S. David S, Sorry to hear of your travails. I started with Caverject day 13 post op. The erections and the sex were both excellent, but my penis hurt like hell afterwards. I swithched to bimix for several months. It was made up as (papaverine 30mg + phentolamine 1 mg) per ml. I was using 0.25 to 0.30 ml at a time with good results. The recommended dose was 0.25 to 0.75 ml. so depending on your mix, maybe you have room for an increase. Ask your doc. Several months later I tried left over Caverject, and it worked great with no post sex pain. My doc said he had not had anybody go back after initial bad experience. Good luck. Steve U > The Caverject and tri-mix caused considerable discomfort, although they > produced the desired result. The ED specialist changed me to the bi-mix and [quoted text clipped - 9 lines] > Thank you. > David S. The doctor's office nurse, a man, called back yesterday afternoon and told me to apply pressure to the injection site for five minutes and then stimulation for three minutes. He told me I could increase the dose to 60 units on the insulin needle scale (100 units = 1 ml, so that works out to .6 ml I think). If that does not work they told me to call back again. Has anyone using the injections ever heard of applying pressure to the injection site after giving the shot? That is a new one on me. > David S, > Sorry to hear of your travails. I started with Caverject day 13 post [quoted text clipped - 28 lines] > > Thank you. > > David S. David S, I always applied pressure after injection, but my doc told me it was to decrease the chances of bleeding (which I never have had a problem with). Steve U It's not just external bleeding. You want to minimize any bleeding internally.  SignaturePSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05 PSA .07 .05 .06 .05 non Illegitimi carborundum > David S, > I always applied pressure after injection, but my doc told me it was to > decrease the chances of bleeding (which I never have had a problem > with). > Steve U > It's not just external bleeding. You want to minimize any bleeding > internally. Bleeding internally can be very bad news. It may bring on peyronies disease. P.D. set in with me before my RRP and had cause shortening of my penis by about an inch and a half. Then when the uretha got stretched to replace the prostate I lost another inch. I am now 28 months post op and erections are returning, but that really just causes frustration, I'm too short to enter. :-(( Well at 72 YO, like an older friend said: "I remember how, I just can't always remember why!!" >> It's not just external bleeding. You want to minimize any bleeding >> internally. [quoted text clipped - 8 lines] > Well at 72 YO, like an older friend said: "I remember how, I just can't > always remember why!!" Wayne: Have you or has anyone here heard of, thought about or been aware of the use of DMSO for treating Peyronies Disease? It isn't FDA approved for that use and some consider DMSO to be a little wacky, but I have read reports of its use for Peyronie's (all anecdotal, to be sure) that has been very helpful in other countries where DMSO is used. It is simply swabbed on the penis and it is thought to reduce inflammation and aid in blood circulation as well as relax the muscle tissue in the penis. FWIW (and remember, you aren't paying a nickle for my thoughts)! OCL > Wayne: Have you or has anyone here heard of, thought about or been > aware of the use of DMSO for treating Peyronies Disease? http://www.peyroniesmd.com/treatmentdmso.html Hi, David... I was told to apply pressure for a couple of minutes... then massage the area to spread the bimix throughout the penis. The pressure was to be sort of like a pinch... to prevent the medication from exiting the penis immediately! MikeH > The doctor's office nurse, a man, called back yesterday afternoon and told > me to apply pressure to the injection site for five minutes and then [quoted text clipped - 5 lines] > injection > site after giving the shot? That is a new one on me. Hi Guys: I am still not clear on the pressure thing. Why did the tri-mix work without pressure and the bi-mix does not? What does applying pressure at the injection site have to do with the distribution of the drug in the penis? None of this makes sense to me, but I will try it, probably this weekend. Too damn tired to care when I get home from work. Thanks for the responses. David S. > Hi, David... > I was told to apply pressure for a couple of minutes... then massage the [quoted text clipped - 13 lines] > > injection > > site after giving the shot? That is a new one on me. |
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