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Medical Forum / Diseases and Disorders / Prostate Cancer / April 2005Lupron & cholesterol
I am sure this topic has been discussed before bo please bear with me. My last shot of Lupron was supposed to have worn off in November but it seemed to take longer than that to recover some of the things I lost such a muscle mass, chest hair and energy. I just had my annual physical with my G.P. apparently not aware of what Lupron is much less what its side effects are. My cholesterol, which is usually in the 170 range is now 230+. Is this due in part to the lethargy, empathy and lack of exercise during treatment or does Lupron have a tendency to raise the cholesterol or is it both? I am just now being able to get back into exercising. Geez! Why don't they discuss this aspect of it with you before sticking you with the needle? "You'll be a little more tired...maybe...perhaps... kina' sorta'." Just like them saying the biopsy wouldn't hurt except for a 'slight discomfort'. Sorry for the ranting but I don't think they (the medical folks)fully know. Have a good day, Chuck McClellan Chuck...The following abstract indicates that ADT drives cholesterol levels up significantly. Unfortunately, the abstract doesn't say exactly how much...Best wishes and good health, Ron J Clin Endocrinol Metab. 2005 Feb;90(2):657-60. Epub 2004 Nov 23. Related Articles, Links The influence of androgen deprivation therapy on metabolism in patients with prostate cancer. Nishiyama T, Ishizaki F, Anraku T, Shimura H, Takahashi K. Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1-757, Niigata 951-8510, Japan. nisiyama@med.niigata-u.ac.jp The effects of androgen deprivation therapy (ADT) include not only suppression of tumor growth, but also adverse effects on various bodily functions. The aim of this study was to determine the metabolic effects of ADT in patients with nonmetastatic prostate cancer. Forty-nine men with prostate cancer were treated with ADT before beginning radical therapy for 6 months. Body weight, peripheral red blood cell counts, hemoglobin, hematocrit, fasting blood sugar, serum total cholesterol, blood urea nitrogen, uric acid, compensated calcium, inorganic phosphorus, bone-specific alkaline phosphatase, urinary deoxypyridinoline, and radial bone density determined using dual energy x-ray absorptiometry were examined before and 6 months after ADT treatment. Body weight (P = 0.037) and the levels of fasting blood sugar (P = 0.014), serum total cholesterol (P = 0.017), blood urea nitrogen (P = 0.030), compensated calcium (P < 0.001), inorganic phosphorus (P < 0.001), bone-specific alkaline phosphatase (P < 0.001), and compensated urinary deoxypyridinoline (P < 0.001) increased significantly. Peripheral red blood cell counts (P < 0.001), hemoglobin level (P < 0.001), hematocrit (P < 0.001), uric acid (P < 0.001), and radial bone density (P = 0.023) decreased significantly. These effects of ADT on various bodily functions warrant systematic study in clinical trials. We should be aware of the far-reaching consequences of ADT and incorporate strategies for preventing and managing adverse effects into routine practice. > The effects of androgen deprivation therapy (ADT) include not only > suppression of tumor growth, but also adverse effects on various bodily [quoted text clipped - 13 lines] > and compensated urinary deoxypyridinoline (P < 0.001) increased > significantly. "the levels of fasting blood sugar (P = 0.014) ... increased significantly. " What does (P = 0.014) mean? I had 2 four month Lupron shots and went from a fasting blood sugar of 130 (big whoop at 197 pounds, 5'7", and driving a desk) to a fasting 300 and I had lost 10 pounds! I'm 3 months past the day I was supposed to get the 3rd Lupron shot. I have a little more weight off. I'm maaaaybe at 180 and I just clocked a morning, not fasting, blood sugar of 138. So the sugar is trending right. I used to see 180 in the morning, then 160's, then 150's. I have more energy. I don't have the "diabetic buzz" and can write code again. I'd really like to find an authoritative report on Lupron or any ADT and blood sugar. My primary care doc doesn't think it's the Lupron. Neither does the Rad-doc. kh wrote...snip... > "the levels of fasting blood sugar (P = 0.014) ... increased > significantly. " > > What does (P = 0.014) mean? KH...It means that, statistically speaking, the result was significant at the (1.00 - 0.014 = 0.986) 98.6% confidence level. Said a bit differently, there is a 98.6% chance that the conclusion that ADT increased fasting blood sugar levels is correct (not caused by random chance) and a corresponding 1.4% chance that the conclusion is incorrect (the observation was caused by mere chance)...Best wishes and good health, Ron > kh wrote...snip... > > "the levels of fasting blood sugar (P = 0.014) ... increased [quoted text clipped - 9 lines] > incorrect (the observation was caused by mere chance)...Best wishes and > good health, Ron Thanks, That's a BIG help to me. I clocked a morning blood sugar of 138 yesterday. That's not great but the lowest I've seen in months. Six weeks ago, it was up around 180, then 160, week by week, it's been falling. This is on two glucophage's a day. I've also been feeling "clearer" and stronger. Did I mention that I managed a 75% firm erection with no Vitamin-V? This last week I did some lotusscript programming and patched some JSP's too. As the Lupron flushes out, I've been feeling better. Levels of fasting blood sugar (98.6% confidence level) increased significantly. I blame the Lupron.... reminds me, I got a piece of spam today that included the phrase Lupron-Depot in the subject line. What are the odds of that? But, hey thanks again for the stats-talk lesson. If Lupron does jack around with blood sugar, then they really should publicize it. I was in bad shape for about a half year, confused, thirsty, had the shakes, no energy, all classic diabetes symptoms. I really hope that my experience and misery will help someone avoid it. If you have to take Lupron, so be it but get your blood sugar monitored. > The effects of androgen deprivation therapy (ADT) include not only > suppression of tumor growth, but also adverse effects on various bodily [quoted text clipped - 13 lines] > and compensated urinary deoxypyridinoline (P < 0.001) increased > significantly. "the levels of fasting blood sugar (P = 0.014) ... increased significantly. " What does (P = 0.014) mean? I know it's some kind of statistical mumbo-jumbo but what? I had 2 four month Lupron shots and went from a fasting blood sugar of 130 (big whoop at 197 pounds, 5'7", and driving a desk) to a fasting 300 and I had lost 10 pounds! I'm 3 months past the day I was supposed to get the 3rd Lupron shot. I have a little more weight off. I'm maaaaybe at 180 and I just clocked a morning, not fasting, blood sugar of 138. So the sugar is trending right. I used to see 180 in the morning, then 160's, then 150's. I have more energy. I don't have the "diabetic buzz" and can write code again. I'd really like to find an authoritative report on Lupron or any ADT and blood sugar. My primary care doc doesn't think it's the Lupron. Neither does the Rad-doc. > I am sure this topic has been discussed before bo please bear with me. > My last shot of Lupron was supposed to have worn off in November but it [quoted text clipped - 10 lines] > biopsy wouldn't hurt except for a 'slight discomfort'. Sorry for the > ranting but I don't think they (the medical folks)fully know. Yes, Lupron and the other LHRH agonists tend to increase cholesterol levels. The reason that patients are often not informed about SE's is that the medics often are ignorant of them. One such is osteoporosis. Chuck should get himself a bone density test -- the QCT (Quantitative Computerized Tomography) test, *not* the DXA test. See: Prostate Cancer Research Institute at http://prostate-cancer.org/index.html Regards, Steve J __ "Never give in--never, never, never, never, in nothing great or small, large or petty, never give in except to convictions of honour and good sense. Never yield to force; never yield to the apparently overwhelming might of the enemy.'' --Sir Winston L. S. Churchill Yup. T deprivation => increased lipids (including cholesterol) => increased cardiovascular risk. And it takes some people many months to recover their T after stopping HT . . . not to mention the ones who never get their T back. This is one of the reasons I harp about SEs, and why I can't understand why some people whine when I harp about SEs. OTOH, I also tell folks biopsies don't hurt, because they normally don't. They're supposed to use a needle, not a sharp spoon, and our colons can't feel cuts, only pressure like with excess gas. I.P. > My last shot of Lupron was supposed to have worn off in November but it > seemed to take longer than that to recover some of the things I lost [quoted text clipped - 8 lines] > biopsy wouldn't hurt except for a 'slight discomfort'. Sorry for the > ranting but I don't think they (the medical folks)fully know.
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