Uncertainty about the need for prostate cancer

Medical Study NewsPublished: Wednesday, 16-Mar-2005  

 Initial results from an ongoing study evaluating the benefit of
prostate cancer screening practices demonstrate that the combined use of
both standard tests - the prostate-specific antigen (PSA) blood test and
the digital rectal exam (DRE) - is optimal for detecting cancer.
The initial results also confirm that the design of the massive study,
which will continue until 2019, will indeed allow researchers to
determine whether current screening practices reduce death from prostate
cancer, according to the authors. They present their analyses in two
papers, one in the March 16 issue of the Journal of the National Cancer
Institute and the other in the March issue of the Journal of Urology.
The study is part of the Prostate, Lung, Colorectal and Ovarian (PLCO)
Cancer Screening Trial being conducted by researchers at Washington
University School of Medicine in St. Louis and several other
institutions.
Uncertainty about the need for prostate cancer screens stems from
several factors. PSA and DRE tests can be inaccurate, giving both false
negatives and false positives. In addition, neither test indicates how
aggressive a man's cancer is. Furthermore, because prostate cancers grow
slowly in many cases and treatments can have unpleasant side effects,
treating the cancer may be less desirable than leaving it alone,
especially in older men.
"But the main thing is we don't know whether screening saves lives,"
says Gerald L. Andriole Jr., M.D., head of the Division of Urologic
Surgery at Washington University and Barnes-Jewish Hospital. "Our study
follows about 75,000 men, half of whom we are screening, and half of
whom are getting conventional care. By comparing groups over the long
term, we will see what difference screening makes in survival rates."
Begun in 1993, the PLCO study has screened 34,244 men across the United
States, aged 55 to 74, for prostate cancer and followed their subsequent
medical history. The PLCO protocol advises men to consult their own
physician if either the PSA or DRE tests given by PLCO are suggestive of
cancerous growth.
The outcome of the study should aid patients and doctors in making
decisions about diagnosis and treatment of prostate cancer. "It's a
complex decision," Andriole explains. "Say your father had an abnormal
PSA test, and he's 76 and has a bad heart, diabetes, or recently had a
stroke. Frankly, the patient and doctor have to base their decision on
the probability that one of those factors may cause death before
prostate cancer."
Of the men screened by PLCO, about 14 percent had positive screening
results, indicative of possible cancer. Approximately 8 percent screened
positive by PSA test, and about 7 percent screened positive by DRE test.
Only about 1 percent of these results overlapped, demonstrating the
importance of using both screening methods.
"We were hopeful some years ago that men could just have the PSA blood
test, because men hate the rectal exam," Andriole says. "We've found
that if you omit the DRE, you'll miss a certain percentage of cancers."
Three-fourths of the men with positive PLCO screens went in for further
diagnostic evaluation with their personal physician. The physicians
would decide whether to conduct their own screenings and whether to
subsequently perform a biopsy, which is needed to confirm the presence
of cancer before treatment.
About a third of men with abnormal tests had a prostatic biopsy within a
year of the initial screen. Of men with PSA readings higher than normal,
64 percent underwent biopsy within three years. The higher the PSA
readings, the higher the biopsy rates. The biopsy rate in men with
positive DRE alone was 28 percent.
The initial data indicate that younger men, men with a family history of
prostate cancer and African American men are more likely to have a
biopsy after an abnormal screening result. "These statistics parallel
many medical recommendations and reassure us that good judgment is being
applied to the evaluation of the initial screen," Andriole says. "We are
confident that when the study is ultimately completed, it will truly
measure the effect of current medical practices."
In men with suspicious PSA readings, regardless of DRE findings, biopsy
revealed cancer almost half the time, while in men with suspicious DRE
tests, regardless of PSA levels, biopsy found cancer about a third of
the time.
The majority of men with cancer had localized cancers. About ten percent
had more serious advanced forms. These advanced cancers were linked to
higher PSA numbers and suspicious DRE results.
Overall, 1.4 percent of the approximately 34,000 men screened were
subsequently diagnosed with prostate cancer by tissue biopsy. This rate
of detection is lower than in two previous studies of prostate cancer
screening, which found cancer in 4.2 and 3.2 percent of patients,
respectively.
This lower rate of detection more accurately reflects the contemporary
standards of practice, because biopsy and diagnosis took place outside
of the PLCO study, according to the authors.
http://medinfo.wustl.edu/
 

knowledge is power - growing old is mandatory - growing wise is optional    
"Many more men die with prostate cancer than of it. Growing old is
invariably fatal. Prostate cancer is only sometimes so."
http://community.webtv.net/PALMER_ENT/doc