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Medical Forum / Diseases and Disorders / Prostate Cancer / March 2005Change in PSA level
Just got off the phone with the results with my 3rd post-RRP PSA. Whereas the first two were <0.01, this latest test came back as 0.03. The doc's assistant said it's still too low to cause worry. However, I'm concerned about the rate of change. Next PSA isn't until early June. Would these numbers cause you to worry?? Thanks, Sandy K Age 48 RRP 6/17/04 No. Those readings are infinitessimally small. I do not get the results of my tests at all. The doctor would be obligated to tell me if they were >0.1 ng/ml, but other than that I don't care to know and he doesn't tell me. jimhoney > Just got off the phone with the results with my 3rd post-RRP PSA. Whereas > the first two were <0.01, this latest test came back as 0.03. The doc's [quoted text clipped - 7 lines] > Age 48 > RRP 6/17/04 In article <yKmXd.349713$w62.343114@bgtnsc05-news.ops.worldnet.att.net>, > No. Those readings are infinitessimally small. > [quoted text clipped - 3 lines] > > jimhoney This is me too. If my doc says good I'm good. The numbers would drive me up the wall. Dale j.  SignatureEmail: dalej2@mac.com > Just got off the phone with the results with my 3rd post-RRP PSA. Whereas > the first two were <0.01, this latest test came back as 0.03. The doc's > assistant said it's still too low to cause worry. However, I'm concerned > about the rate of change. Next PSA isn't until early June. > > Would these numbers cause you to worry?? Do you know the resolution and accuracy of the test? I thought I read somewhere on this newsgroup that the most sensitive tests can't really distinguish anything below .04. If that's so, then .01 and .03 may simply be test artifacts, not real, distinguishable numbers. But I don't know that for sure. Maybe someone else has some information about this. Alan Hi Alan...The analytical detection limit with the DPC Immulite ultrasensitive assay is 0.002 ng/ml and the functional sensitivity is 0.005 ng/ml. 0.055 ng/ml might come back as 0.05 ng/ml one day and 0.06 ng/ml the next, but < 0.01 is different from 0.03 ng/ml assuming the lab equipment is properly calibrated and the same lab is used...Best wishes and good health, Ron I'm wondering if Sandy got the numbers right. Usually the results are <.1 and not <.01. It's possible that the lab result of .03 was an ultra sesitive test result as compared to the earliar standard test. Ron S > I'm wondering if Sandy got the numbers right. Usually the results are <.1 > and not <.01. It's possible that the lab result of .03 was an ultra > sesitive test result as compared to the earliar standard test. > Ron S Ron - Yes, I got the numbers right, as I asked to revierify them. The prior test result of <.01 was actually reported to me as 0.00 and the.03 was reported as .03. Sandy Sandy, Check out my last PSAs. And I'm ecstatic. You are still way below that magical, mystical < 0.1. Open up the bubbly and celebrate. SignaturePSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3bN0M0 Seminal Vesicle involvement, Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05 PSA .07 .05 .06 .05 non Illegitimi carborundum > Just got off the phone with the results with my 3rd post-RRP PSA. Whereas > the first two were <0.01, this latest test came back as 0.03. The doc's [quoted text clipped - 7 lines] > Age 48 > RRP 6/17/04 > Just got off the phone with the results with my 3rd post-RRP PSA. Whereas > the first two were <0.01, this latest test came back as 0.03. The doc's [quoted text clipped - 7 lines] > Age 48 > RRP 6/17/04 Sandy, at this point I think I would not sweat the results very much. I did not have RRP but was treated with ADT3, chemotherapy and IMRT. All my PSA tests are done to the DPC Immulite 2000 technology which is ultrasensitive. My medical oncologist is someone fairly well known in the PCa treatment community and whose practice is limited to treating men with PCa. For your reference I am including below two e-mails to him about some PSA results. To the one listed just below he responded: "The results are fine." 08-2004___0.06 05-2004___0.06 02-2004___0.05 11-2003___0.03 07-2003___0.003 04-2003___0.004 Hormone Deprivation Therapy discontinued at this time. 12-2002___0.004 Three weeks after completing IMRT/Bat 09-2002___0.025 Started IMRT/Bat Another message included the following results and questions: He responded: "The PSA is still very low and it is not surprising it has risen a little as you have testosterone in your system." 11.26.2004......0.07 08.26.2004......0.06 05.25.2004......0.06 02.04.2004......0.05 10.31.2003......0.03 It has slightly more than doubled in the past 13 months albeit PSA remains at a low level. What is your observation based on these results? Of course, Sandy you had RRP. I did not. But the medical & radiation oncologists who are treating me consider these numbers very low and that they are nothing from which to draw any definite conclusions. They are taken so as to develope over an extended period of time a trend line from which to then draw some conclusion. Harold on 3/10/2005 6:00 PM Harold said the following: >>Just got off the phone with the results with my 3rd post-RRP PSA. > [quoted text clipped - 23 lines] > the PCa treatment community and whose practice is limited to treating > men with PCa. Like Harold sez: Don't worry about it. I had a positive margin and went to watchful waiting before commencing radiation of the prostate bed. First two PSA's for me were <0.01 also then the third at 8 months came back 0.07. Talk about sending a shockwave through me. Called my surgeon, Dr. Catalona, in near hysteria. His advice was "that's what I don't like about the hyper-sensitive assays. They can come up with these weird results. Relax. You don't need to do anything until we see an upwards trend and I would not recommend any further treatment unless we see a PSA of 1.0. I calmed down, relaxed and, as I approach the fifth anniversary of my RRP my PSA has remained undetectable. Watch it carefully but don't go nuts. If you keep monitoring it at 90 day intervals or 180 day intervals, you'll be fine. Bob |
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