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Medical Forum / Diseases and Disorders / Prostate Cancer / March 2005

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Woody thanks you

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woody - 18 Feb 2005 18:05 GMT
I attended a two hour bracytherapy lecture at my HMO yesterday where
they explained the advantages and disadvantages of permanent seeding,
external radiation and surgery.  (They don't do HDR temporary
bracytherapy.)  Since they do all three procedures, I figured there
should be no bias involved.

The main advantages of permanent seeds are one day treatment, greater
chance of preserving potency and easier recovery.  But the main
disadvantage is urinary frequency, urgency and burning for a longer
time compared to other treatments.

What surprised me was data that showed similar survival rates at 5 and
10 years, reguardless of which proceedure was used. (Blasko study)

Luckly my HMO includes a Kaiser Permanente hospital near Sacramento, CA
that I heard is second in the U S in the number of seeding procedures
done.  (6 to 9 a week, over 1300 total)  What convinsed me to schedule
a seeding procedure, was that after 6 years 100% of their patients were
alive and 95% were cancer free.

Everyone must make their own choise, but I would urge anyone consider
permanent seeding if you can find an experienced doctor and you are in
the low risk catagory.

I wish to thank all who answered my post and helped me with my
decision.

P.S.  My real name is Woody, I wasn't bragging.
ron - 18 Feb 2005 18:55 GMT
woody wrote...snip...
> What surprised me was data that showed similar survival rates at 5 and
> 10 years, reguardless of which proceedure was used. (Blasko study)

Woody...Imagine person A saying, "the temperature where I am at is 35C"
and person B saying, "the temperature where I am at is 50F."  From this
am I to conclude that person B is in the warmer location?  Just as the
definition of temperature is important in comparing temperatures, so is
the definition of failure (DOF) important in comparing treatment
efficacy.

Since few newly diagnosed, "low-risk" men will die within 10 years of
diagnosis, saying that various treatments have similar survival rates
at 10 years doesn't tell us much.  It's not a very meaningful
comparison since one of these men who does nothing will probably also
survive for 10 years.  On the other hand, a comparison of biochemical
recurrence rates (bNED) may be more telling since many men do recur
biochemically within 10 years.

If they were speaking to a bNED comparison of surgery, seeds and XBRT
they probably used a different definition of failure for surgery versus
what was used for the two RT treatments.  A number of papers have been
published on this point.  These various papers show that the ASTRO
method confers somewhere between an 8% and 35% advantage to the RT
methods that use this DOF, as compared to the PSA>0.2 ng/ml failure DOF
generally used for RP.  So if the two groups (RP and RT) had "equal"
bNEDs with the different DOFs, then subtracting this "correction" from
the RT numbers leaves the two groups no longer equal.

I don't claim to "know" which methods are better or worse, I merely
point out the conundrum...Best wishes and good health, Ron
carriertech - 19 Feb 2005 02:17 GMT
"ron" <oitbso@yahoo.com> wrote in message <Snip>
> If they were speaking to a bNED comparison of surgery, seeds and XBRT
> they probably used a different definition of failure for surgery versus
[quoted text clipped - 8 lines]
> I don't claim to "know" which methods are better or worse, I merely
> point out the conundrum...Best wishes and good health, Ron

Ron, the Center where I was treated fully believes in comparing "apples to
apples" by using the PSA>0.2ng/ml DOF used by the best surgeons.  They have
treated almost 8000 men at this Center.  Their data speaks well for their
program.  Top quality work with RP or RT pays off down the road. Just my
ramblin' thoughts!
Doug Taylor - 18 Feb 2005 20:25 GMT
>Everyone must make their own choise

This is indeed true.  When it comes to matters of subjective judgment,
dispute, or choice, I never listen to anybody who insists that THEIR
way is the "best" or , worse, the "only" way.  In a word, who try to
equate matters of relative truth with absolute.  Including medical
procedures, politics and religion.  This is fallacious reasoning, and
True Believers, I am becoming increasingly convinced, are suffering
from a form of mental illness.  The degree of emotional conviction of
the universality of the so-called truth is directly proportional to
the degree of its lack of credibility.

>P.S.  My real name is Woody, I wasn't bragging.

Well,  a year after, whatever procedure you choose, you won't have so
much to brag about.  I am emotionally convinced this is an absolute
truth, so take it with a grain of salt ;-)
--dt
Leonard Evens - 18 Feb 2005 21:55 GMT
> I attended a two hour bracytherapy lecture at my HMO yesterday where
> they explained the advantages and disadvantages of permanent seeding,
[quoted text clipped - 4 lines]
> The main advantages of permanent seeds are one day treatment, greater
> chance of preserving potency

I think this can depend on other factors such as the age of the patient.
 Avoiding impotence can be quite difficult for even the best surgeons
for men over 70.   But skilled surgeons can do quite well in that
department for younger men.  Impotence rates following radiation of any
kind doesn't seem to fall off quite as rapidly with age.

> and easier recovery.  But the main
> disadvantage is urinary frequency, urgency and burning for a longer
> time compared to other treatments.
>
> What surprised me was data that showed similar survival rates at 5 and
> 10 years, reguardless of which proceedure was used. (Blasko study)

I agree with ron that survival at 5 and 10 years is pretty meaningless
for prostate cancer discovered by PSA testing, as is commonly the case
in the US.   In other countries where they don't routinely test, such as
Sweden, prostate cancer tends to be diagnosed five or more years later,
survival rates can be a significant criterion.

> Luckly my HMO includes a Kaiser Permanente hospital near Sacramento, CA
> that I heard is second in the U S in the number of seeding procedures
[quoted text clipped - 10 lines]
>
> P.S.  My real name is Woody, I wasn't bragging.
ed - 19 Feb 2005 21:41 GMT
my own personal experience, to date, doesn't really reflect a big
increase in frequency of urination,  but I do experience some
discomfort....not huge but noticeable.  The main difference for me in
urinating is it takes longer.  I had permanent seeding about 2 1/2
months ago.  I am happy to report that I generally do not have to get
up to urinate at night..  I worry a bit about the temp seeding at
higher doses...I wonder if that could contribute to radiation damage
but I suppose they have taken that into consideration.  I also had some
lethargy for a few weeks but that went away.  I am no longer napping
and exercising regularly....It is not the end of the quality of your
life, at least it is not for me as yet!....Ed
Steve Kramer - 21 Feb 2005 01:20 GMT
Excellent!  You've made your decision.  This may be the hardest part of your
experience.

What's the date?

Signature

PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3bN0M0
Seminal Vesicle involvement, Neg margins
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05
PSA  .07 .05 .06 .05

non Illegitimi carborundum

> I attended a two hour bracytherapy lecture at my HMO yesterday where
> they explained the advantages and disadvantages of permanent seeding,
[quoted text clipped - 24 lines]
>
> P.S.  My real name is Woody, I wasn't bragging.
D M R Taplin - 25 Feb 2005 16:09 GMT
Dear Woody,

I explored California/Oakland --- as well as Seattle, Florida and MSK in New
York ----- but went to Atlanta at  rcog.com which was good for me and worth
checking thier website.

Decatur

> I attended a two hour bracytherapy lecture at my HMO yesterday where
> they explained the advantages and disadvantages of permanent seeding,
[quoted text clipped - 24 lines]
>
> P.S.  My real name is Woody, I wasn't bragging.
Chris Ness - 26 Mar 2005 20:29 GMT
> Dear Woody,
>
[quoted text clipped - 4 lines]
>
> Decatur

They practically invented seeding. I am kind of embarrassed to say that I go
there for throat cancer treatment. It seems that prostate is the specialty
of the house.  But be glad, at least for prostate you don't have to do
Amifostine.
 
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