Medical Forum / Diseases and Disorders / Prostate Cancer / February 2005
VERY interesting -A more accurate screening test for prostate cancer?
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c palmer - 20 Feb 2005 09:34 GMT 19 Feb 2005
Men middle-aged and older routinely get blood tests for prostate-specific antigen, or PSA, to screen for prostate cancer.
However, PSA testing has shortcomings: many men with elevated PSAs don't have prostate cancer and undergo unnecessary biopsies, which can cause infertility, incontinence, and impotence. Other men do have prostate cancer, but have normal PSAs, allowing the cancer to spread undetected.
A preliminary study from Children's Hospital Boston, led by Dr. Bruce Zetter, shows that a simple urine test may improve upon PSA screening. Results appear in the Jan. 21 online edition of the journal Prostate.
Zetter, a researcher in the Vascular Biology Program at Children's, is interested in the role of cell motility -- cells' ability to move and travel -- in helping cancers to metastasize. He became especially interested in thymosin ß15, a protein that stimulates cell migration and promotes metastasis in prostate cancer. Unlike PSA, it is produced almost exclusively by cancer cells, and is detectable in urine. In this study, Zetter and colleagues compared thymosin ß15 levels in urine samples from 121 men with prostate cancer, 15 men with other genitourinary cancers (kidney or bladder cancer), 81 men with non-malignant prostate disease (such as prostatitis), 73 men with other non-malignant urologic diseases (such as urinary tract infection), and 52 healthy men who served as controls. Thymosin ß15 levels were elevated in men with aggressive or untreated prostate cancer, but normal or near-normal in healthy men and men with other genitourinary diseases.
Men with aggressive prostate cancer were 12 times more likely than the healthy controls to have elevated thymosin ß15. Notably, nearly half of cancer patients whose PSA levels were considered normal tested positive for thymosin ß15.
Conversely, many men with other genitourinary diseases had elevated PSAs, but normal thymosin ß15 values. When PSA and thymosin ß15 were combined, the combination detected prostate cancer more often than PSA testing alone, with far fewer false-positives.
Zetter, who is also Children's Chief Scientific Officer, is now following the long-term outcomes of men with prostate cancer to determine thymosin ß15's usefulness as a prognostic predictor in combination with PSA testing.
The Vascular Biology Program at Children's is also actively studying urinary markers for other cancers. In a small pilot study, Dr. Marsha Moses and postdoctoral fellow Dr. Roopali Roy recently found that a compound called ADAM 12, when detected in urine, is an early marker of breast cancer. Another group of markers will soon enter formal clinical trials in adults with prostate, breast, bladder, lung, and colon cancer. ------------------
knowledge is power - growing old is mandatory - growing wise is optional "Many more men die with prostate cancer than of it. Growing old is invariably fatal. Prostate cancer is only sometimes so." http://community.webtv.net/PALMER_ENT/doc
Leonard Evens - 20 Feb 2005 12:41 GMT > 19 Feb 2005 > [quoted text clipped - 4 lines] > have prostate cancer and undergo unnecessary biopsies, which can cause > infertility, incontinence, and impotence. The only way a biopsy could cause such side effects is if cancer is detected and is treated by surgery or radiation. So this is not talking about unnecessary biopsies but rather "unnecessary" treatment.
> Other men do have prostate > cancer, but have normal PSAs, allowing the cancer to spread undetected. [quoted text clipped - 32 lines] > determine thymosin ß15's usefulness as a prognostic predictor in > combination with PSA testing. It doesn't appear to me that this helps a lot in distinguishing cancers which may metastasize somewhere down the line from those that never will. A test which did that could avoid unnecessary treatment.
> The Vascular Biology Program at Children's is also actively studying > urinary markers for other cancers. In a small pilot study, Dr. Marsha [quoted text clipped - 8 lines] > invariably fatal. Prostate cancer is only sometimes so." > http://community.webtv.net/PALMER_ENT/doc Stephen Jordan - 20 Feb 2005 16:38 GMT Quoting in pertinent part something posted by Curtis Palmer:
>> Men middle-aged and older routinely get blood tests for >> prostate-specific antigen, or PSA, to screen for prostate cancer. >> However, PSA testing has shortcomings: many men with elevated PSAs don't >> have prostate cancer and undergo unnecessary biopsies, which can cause >> infertility, incontinence, and impotence. He replied:
> The only way a biopsy could cause such side effects is if cancer is > detected and is treated by surgery or radiation. So this is not > talking about unnecessary biopsies but rather "unnecessary" treatment. True, and the quote is also stunning in its ignorance. It has the potential to mislead a man who is uncertain about having a biopsy to decide against it for the wrong reasons. So it's dangerous, too.
I'd love to see the original citation. This has the look of some reporter's interpretation.
Curtis?
Regards,
Steve J
c palmer - 20 Feb 2005 21:42 GMT From: mycroftscj@earthlink.net (Stephen Jordan) On February 20, Leonard Evens wrote: Quoting in pertinent part something posted by Curtis Palmer:
Men middle-aged and older routinely get blood tests for prostate-specific antigen, or PSA, to screen for prostate cancer. However, PSA testing has shortcomings: many men with elevated PSAs don't have prostate cancer and undergo unnecessary biopsies, which can cause infertility, incontinence, and impotence.
He replied:
The only way a biopsy could cause such side effects is if cancer is detected and is treated by surgery or radiation. So this is not talking about unnecessary biopsies but rather "unnecessary" treatment. True, and the quote is also stunning in its ignorance. It has the potential to mislead a man who is uncertain about having a biopsy to decide against it for the wrong reasons. So it's dangerous, too. I'd love to see the original citation. This has the look of some reporter's interpretation. Curtis? Regards, Steve J ===============
hi steve - i want to point out that i just report the articles, not write them. people need to know what is being said and by whom, which is why i try to leave the tags on the article in case there is any doubt.
sometimes, i will get people who want to kill the messager instead of looking at the article. but you ask me what i thought of this article, so here is my thoughts.
the information about a biopsy causing these problems could happen. everything has a risk. but years ago, they didn't have the modern tools to focus where to stick the needles, and let's face it, shooting a needle into an organ could definitely cause problems. for example - the erectile nerves are on the bottom side of the prostate - the same side that the biopsy needles has to pass through to reach the prostate.
my mother died from a routine heart cath. procedure and to this day, they don't know why. everything was checked and rechecked, but that doesn't alter the fact that she's dead. it is a very real, cold hard fact of life. everything has a risk. she was told up front that there was less than a 1% chance of anything could go wrong, and the doctor said that i've done thousands of them and never lost a patient yet. but this time he lost one - my mother.
so, in response to the article, that statement could be true. that little tiny per cent that something could go wrong. where the needle missed it's mark and hit something that shouldn't have been growing there - a nerve - for example.
but this is also where they skew the facts. the writer has not done the homework needed to point out a clear picture of what the article was saying.
my reason for posting this article for not for what i'm discussing, but for this reason.............thymosin ß15, a protein that stimulates cell migration and promotes metastasis in prostate cancer. Unlike PSA, it is produced almost exclusively by cancer cells, and is detectable in urine. When PSA and thymosin ß15 were combined, the combination detected prostate cancer more often than PSA testing alone, with far fewer false-positives.
now to me, that is a direction we ought to be looking into.
while each one of us opt for the treatment they think is best for them, i chose mine. but when i posted my concerns about the very possibility of having a failed RP when i had no positive margins or S.V. involvement, and a .01 of psa rise, some think that i'm being overly concerned.
and i believe in respecting each and everyone's right to their opinion. but make no mistake, when your surgeon is telling you that he has concern for your .01 rise and spends ten minutes explaining why, i listened.
i understand that the path i'm taking is a virgin one here. to boldly go where no man is going. to take such an active approach and getting the jump on the possibility of a failed RP. but at what point do you get worried? there are four people in the same boat as myself and one of them is a doctor and he's getting the same type answers that i am.
here' one for you. if a psa test has been proven and verified to be true because that is the sole reason we had learned to trust a test - ANY TEST. it has to check what it is suppose to check for - the validity, and it has to do it each and every time - to be dependable. doesn't make any difference if you have having a sugar test ran, T check, liver levels, or a psa. we should be able to trust those findings. yet, there has been many a post and lots of ink spend on whether or not psa tests are any good at finding prostate cancer. the doctor had his blood sent to one lab who can do the psa test into the thousandths and he sent it to the other lab that has been doing his psa work. there was quite a difference between the numbers and when he ask how, he was told that he should stick with one lab.
do you know how stupid this is??? can you possibly imagine that you being told when you bought a car to stick with shell gas only? or that you had to buy your gas at X gas station because they sell you their measure of one gallon, or you have to buy your meat at one particular store because they sell the meat by their measure of a pound. so, why do we accept this type of variable in a psa test?
and the knowledge after the RP and psa levels is just as bad. my own provider nurse told me that a .05 reading was great because i could go all the way up to 4.0 before it was consider a problem........and she knew i had the RP!!!!
but getting back to your comment steve - This has the look of some reporter's interpretation. i agree. the person who writes the article is usually not the person who is doing the research.
~ curtis
knowledge is power - growing old is mandatory - growing wise is optional "Many more men die with prostate cancer than of it. Growing old is invariably fatal. Prostate cancer is only sometimes so." http://community.webtv.net/PALMER_ENT/doc
Stephen Jordan - 20 Feb 2005 23:49 GMT On Februry 20, Curtis palmer responded to me: (snip)
> ..............i want to point out that i just report the articles, not > write them. people need to know what is being said and by whom, which > is why i try to leave the tags on the article in case there is any > doubt. I never had the slightest idea that Curtis wrote the article. But I couldn't see anything in his post that told me its source. Thus my post. I'd still like to know its source.
As for a prostate biopsy *causing* "infertility, incontinence, and impotence" as the article clearly stated, I know of no evidence of such occurring. But I'm willing to learn, if someone will cite such evidence.
Now, I'm not referring to speculation, rumor, or what someone's friend's uncle claims, I want to see reliable *evidence*.
The following is not directed at Curtis, but at his source: PPOR.
BTW, this same thing was posted on PHML. The source was challenged, as has not yet responded.
Regards,
Steve J __ "Think what tedious years of study, thought, practice, experience went to the equipment of that peerless old master who was able to impose upon the whole world the lofty and sounding maxim that 'truth is mighty and will prevail' -- the most majestic compound fracture of fact which any of woman born has yet achieved. For the history of our race and each individual's experience are sown thick with evidence that a truth is not hard to kill, and a lie told well is immortal." -- Mark Twain
c palmer - 21 Feb 2005 07:22 GMT hi steve - i went back as far as could and i can't find the article at the moment. webtv has a limited memory backspace. i usually put the tag line of who wrote it or a contact number because some of these are clinical trials and this may be the information that the person needs to get in contact with them.
i don't know what happen to the tag line i put in it. i'm lost for an answer, and the only thing i can say is this webtv does funny things at times and lately it's been acting up. i need to go ahead and break out the laptop and get the internet provider installed but am waiting for that disk to come in. still like webtv because it can't be screwed up that much as far as viruses, worms, etc. and i don't have to deal with it. the down side is that it has it's quirks and it's s-s-l-l-l-o-o-o-o-o-o-ow-o-wo-ow-ow.... oh, did i mention it's slow??? :)
i don't want you to think i was thinking the comments were at me directly. i was merely pointing out that in the past, some posters get angry at the post and it seems like they are taking potshots at the messenger because they don't know who to direct the comments to.
now, i'm taking an educated guess on the incontinence, erection problems and infertility. i can see where it is possible that the needle sticks could pass through say, the erectile nerve - ripping it into two pieces or nicking it. same for possible bladder nerves. the infertility factor at best would have to be excessive scarring from the needle sticking of where the S. V. come in. remember, i'm reaching for a logical explanation, but how is the risk factor that this could have happen is another story. i think this part of the story they printed should have been deleted because it had absolutely nothing to do with the news of what they were trying to say.
~ curtis
knowledge is power - growing old is mandatory - growing wise is optional "Many more men die with prostate cancer than of it. Growing old is invariably fatal. Prostate cancer is only sometimes so." http://community.webtv.net/PALMER_ENT/doc
Tom Cular - 21 Feb 2005 10:45 GMT Curt and Steve, Here's the source, most of the article has been snipped for brevity.
Tom
February 16, 2005
For Further Information: Bess Andrews 617-355-6420 elizabeth.andrews@childrens.harvard.edu At AAAS conference (Feb. 16-21): Please page Susan Craig at 617-339-4518
A More Accurate Screening Test for Prostate Cancer?
New marker in urine may improve on PSA testing, reduce unnecessary biopsies [BIG SNIP]
Children's also is the primary pediatric teaching affiliate of Harvard Medical School. For more information about the hospital visit: http://www.childrenshospital.org/research/.
Questions regarding the Press Room should be sent to pubaff@tch.harvard.edu
> hi steve - i went back as far as could and i can't find the article at > the moment. webtv has a limited memory backspace. i usually put the tag [quoted text clipped - 34 lines] > invariably fatal. Prostate cancer is only sometimes so." > http://community.webtv.net/PALMER_ENT/doc c palmer - 21 Feb 2005 12:09 GMT thanks tom.....
~ curtis
knowledge is power - growing old is mandatory - growing wise is optional "Many more men die with prostate cancer than of it. Growing old is invariably fatal. Prostate cancer is only sometimes so." http://community.webtv.net/PALMER_ENT/doc
Stephen Jordan - 21 Feb 2005 16:38 GMT > Curt and Steve, > Here's the source, most of the article has been snipped for [quoted text clipped - 12 lines] > > A More Accurate Screening Test for Prostate Cancer? (snip)
My thanks.
That source was cited on the other NG I mentioned. Another poster wrote that she had sent a message to the source regarding the nonsense. That was nearly a week ago. No response.
Regards,
Steve J
Stephen Jordan - 21 Feb 2005 16:52 GMT On February 21, Curtis wrote, in pertinent part:
> i don't know what happen to the tag line i put in it. i'm lost for an > answer, and the only thing i can say is this webtv does funny things at [quoted text clipped - 5 lines] > s-s-l-l-l-o-o-o-o-o-o-ow-o-wo-ow-ow.... > oh, did i mention it's slow??? :) I started my online experience with what later became known as "WebTV Classic." Took about a year to become sick of it, throw it away, and buy a Mac.
If virii, etc. are a concern, the Apple product line is the way to go, IMO. Macs can be and are targeted, but to a very much lesser extent than PC's. I have the Norton antivirus program installed, plus Earthlink's whizbang, and have never had a problem. From time to time, I get a message from Earthlink advising me that they've intercepted a virus, worm, trojan horse, whatever.
Also: I never, ever, open an e-mail -- or any attachment, for that matter -- from an unknown sender. My morning ritual includes deleting any such garbage.
Also, "phishing" is a popular diversion among certain scumbags who try to obtain financial info by pretending to be a bank, PayPal, Earthlink, etc. and asking for confirmation of account details. After reporting these to the real folks, I just throw them away. It pays to be a suspicious old crank.
Regards,
Steve J
c palmer - 21 Feb 2005 21:29 GMT thanks steve - i appreciate the good info.
~ curtis
knowledge is power - growing old is mandatory - growing wise is optional "Many more men die with prostate cancer than of it. Growing old is invariably fatal. Prostate cancer is only sometimes so." http://community.webtv.net/PALMER_ENT/doc
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