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Medical Forum / Diseases and Disorders / Prostate Cancer / February 2005

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VERY interesting -A more accurate screening test for prostate    cancer?

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c palmer - 20 Feb 2005 09:34 GMT
19 Feb 2005

Men middle-aged and older routinely get blood tests for
prostate-specific antigen, or PSA, to screen for prostate cancer.

However, PSA testing has shortcomings: many men with elevated PSAs don't
have prostate cancer and undergo unnecessary biopsies, which can cause
infertility, incontinence, and impotence. Other men do have prostate
cancer, but have normal PSAs, allowing the cancer to spread undetected.

A preliminary study from Children's Hospital Boston, led by Dr. Bruce
Zetter, shows that a simple urine test may improve upon PSA screening.
Results appear in the Jan. 21 online edition of the journal Prostate.

Zetter, a researcher in the Vascular Biology Program at Children's, is
interested in the role of cell motility -- cells' ability to move and
travel -- in helping cancers to metastasize. He became especially
interested in thymosin ß15, a protein that stimulates cell migration
and promotes metastasis in prostate cancer. Unlike PSA, it is produced
almost exclusively by cancer cells, and is detectable in urine.
In this study, Zetter and colleagues compared thymosin ß15 levels in
urine samples from 121 men with prostate cancer, 15 men with other
genitourinary cancers (kidney or bladder cancer), 81 men with
non-malignant prostate disease (such as prostatitis), 73 men with other
non-malignant urologic diseases (such as urinary tract infection), and
52 healthy men who served as controls. Thymosin ß15 levels were
elevated in men with aggressive or untreated prostate cancer, but normal
or near-normal in healthy men and men with other genitourinary diseases.

Men with aggressive prostate cancer were 12 times more likely than the
healthy controls to have elevated thymosin ß15.
Notably, nearly half of cancer patients whose PSA levels were considered
normal tested positive for thymosin ß15.

Conversely, many men with other genitourinary diseases had elevated
PSAs, but normal thymosin ß15 values. When PSA and thymosin ß15 were
combined, the combination detected prostate cancer more often than PSA
testing alone, with far fewer false-positives.

Zetter, who is also Children's Chief Scientific Officer, is now
following the long-term outcomes of men with prostate cancer to
determine thymosin ß15's usefulness as a prognostic predictor in
combination with PSA testing.

The Vascular Biology Program at Children's is also actively studying
urinary markers for other cancers. In a small pilot study, Dr. Marsha
Moses and postdoctoral fellow Dr. Roopali Roy recently found that a
compound called ADAM 12, when detected in urine, is an early marker of
breast cancer. Another group of markers will soon enter formal clinical
trials in adults with prostate, breast, bladder, lung, and colon cancer.
------------------

knowledge is power - growing old is mandatory - growing wise is optional    
"Many more men die with prostate cancer than of it. Growing old is
invariably fatal. Prostate cancer is only sometimes so."
http://community.webtv.net/PALMER_ENT/doc
Leonard Evens - 20 Feb 2005 12:41 GMT
> 19 Feb 2005
>
[quoted text clipped - 4 lines]
> have prostate cancer and undergo unnecessary biopsies, which can cause
> infertility, incontinence, and impotence.

The only way a biopsy could cause such side effects is if cancer is
detected and is treated by surgery or radiation.   So this is not
talking about  unnecessary biopsies but rather "unnecessary" treatment.

> Other men do have prostate
> cancer, but have normal PSAs, allowing the cancer to spread undetected.
[quoted text clipped - 32 lines]
> determine thymosin ß15's usefulness as a prognostic predictor in
> combination with PSA testing.

It doesn't appear to me that this helps a lot in distinguishing cancers
which may metastasize somewhere down the line from those that never
will.   A test which did that could avoid unnecessary treatment.

> The Vascular Biology Program at Children's is also actively studying
> urinary markers for other cancers. In a small pilot study, Dr. Marsha
[quoted text clipped - 8 lines]
> invariably fatal. Prostate cancer is only sometimes so."
> http://community.webtv.net/PALMER_ENT/doc
Stephen Jordan - 20 Feb 2005 16:38 GMT
Quoting in pertinent part something posted by Curtis Palmer:

>> Men middle-aged and older routinely get blood tests for
>> prostate-specific antigen, or PSA, to screen for prostate cancer.
>> However, PSA testing has shortcomings: many men with elevated PSAs don't
>> have prostate cancer and undergo unnecessary biopsies, which can cause
>> infertility, incontinence, and impotence.

He replied:

> The only way a biopsy could cause such side effects is if cancer is
> detected and is treated by surgery or radiation.   So this is not
> talking about  unnecessary biopsies but rather "unnecessary" treatment.

True, and the quote is also stunning in its ignorance. It has the
potential to mislead a man who is uncertain about having a biopsy to
decide against it for the wrong reasons. So it's dangerous, too.

I'd love to see the original citation. This has the look of some
reporter's interpretation.

Curtis?

Regards,

Steve J
c palmer - 20 Feb 2005 21:42 GMT
From: mycroftscj@earthlink.net (Stephen Jordan)
On February 20, Leonard Evens wrote:
Quoting in pertinent part something posted by Curtis Palmer:

Men middle-aged and older routinely get blood tests for
prostate-specific antigen, or PSA, to screen for prostate cancer.
However, PSA testing has shortcomings: many men with elevated PSAs don't
have prostate cancer and undergo unnecessary biopsies, which can cause
infertility, incontinence, and impotence.

He replied:

The only way a biopsy could cause such side effects is if cancer is
detected and is treated by surgery or radiation.   So this is not
talking about unnecessary biopsies but rather "unnecessary" treatment.
True, and the quote is also stunning in its ignorance. It has the
potential to mislead a man who is uncertain about having a biopsy to
decide against it for the wrong reasons. So it's dangerous, too.
I'd love to see the original citation. This has the look of some
reporter's interpretation.
Curtis?
Regards,
Steve J
===============

hi steve - i want to point out that i just report the articles, not
write them.  people need to know what is being said and by whom, which
is why i try to leave the tags on the article in case there is any
doubt.

sometimes, i will get people who want to kill the messager instead of
looking at the article.  but you ask me what i thought of this article,
so here is my thoughts.

the information about a biopsy causing these problems could happen.
everything has a risk.  but years ago, they didn't have the modern tools
to focus where to stick the needles, and let's face it, shooting a
needle into an organ could definitely cause problems.  for example - the
erectile nerves are on the bottom side of the prostate - the same side
that the biopsy needles has to pass through to reach the prostate.

my mother died from a routine heart cath. procedure and to this day,
they don't know why.  everything was checked and rechecked, but that
doesn't alter the fact that she's dead.  it is a very real, cold hard
fact of life.  everything has a risk.  she was told up front that there
was less than a 1% chance of anything could go wrong, and the doctor
said that i've done thousands of them and never lost a patient yet.  but
this time he lost one - my mother.

so, in response to the article, that statement could be true.  that
little tiny per cent that something could go wrong.  where the needle
missed it's mark and hit something that shouldn't have been growing
there - a nerve - for example.

but this is also where they skew the facts.  the writer has not done the
homework needed to point out a clear picture of what the article was
saying.

my reason for posting this article for not for what i'm discussing, but
for this reason.............thymosin ß15, a protein that stimulates
cell migration and promotes metastasis in prostate cancer. Unlike PSA,
it is produced almost exclusively by cancer cells, and is detectable in
urine.  When PSA and thymosin ß15 were combined, the combination
detected prostate cancer more often than PSA testing alone, with far
fewer false-positives.

now to me, that is a direction we ought to be looking into.

while each one of us opt for the treatment they think is best for them,
i chose mine.  but when i posted my concerns about the very possibility
of having a failed RP when i had no positive margins or S.V.
involvement, and a .01 of psa rise, some think that i'm being overly
concerned.

and i believe in respecting each and everyone's right to their opinion.
but make no mistake,  when your surgeon is telling you that he has
concern for your .01 rise and spends ten minutes explaining why, i
listened.  

i understand that the path i'm taking is a virgin one here.  to boldly
go where no man is going.  to take such an active approach and getting
the jump on the possibility of a failed RP.  but at what point do you
get worried?  there are four people in the same boat as myself and one
of them is a doctor and he's getting the same type answers that i am.  

here' one for you.  if a psa test has been proven and verified to be
true because that is the sole reason we had learned to trust a test -
ANY TEST.  it has to check what it is suppose to check for - the
validity,  and it has to do it each and every time - to be dependable.
doesn't make any difference if you have having a sugar test ran, T
check, liver levels, or a psa.  we should be able to trust those
findings.  yet, there has been many a post and lots of ink spend on
whether or not psa tests are any good at finding prostate cancer.  
the doctor had his blood sent to one lab who can do the psa test into
the thousandths and he sent it to the other lab that has been doing his
psa work.  there was quite a difference between the numbers and when he
ask how, he was told that he should stick with one lab.  

do you know how stupid this is???  can you possibly imagine that you
being told when you bought a car to stick with shell gas only?  or that
you had to buy your gas at X gas station because they sell you their
measure of one gallon,  or you have to buy your meat at one particular
store because they sell the meat by their measure of a pound.  so, why
do we accept this type of variable in a psa test?

and the knowledge after the RP and psa levels is just as bad.  my own
provider nurse told me that a .05 reading was great because i could go
all the way up to 4.0 before it was consider a problem........and she
knew i had the RP!!!!  

but getting back to your comment steve - This has the look of some
reporter's interpretation.   i agree.  the person who writes the article
is usually not the person who is doing the research.

~ curtis

knowledge is power - growing old is mandatory - growing wise is optional    
"Many more men die with prostate cancer than of it. Growing old is
invariably fatal. Prostate cancer is only sometimes so."
http://community.webtv.net/PALMER_ENT/doc
Stephen Jordan - 20 Feb 2005 23:49 GMT
On Februry 20, Curtis palmer responded to me:
(snip)

> ..............i want to point out that i just report the articles, not
> write them.  people need to know what is being said and by whom, which
> is why i try to leave the tags on the article in case there is any
> doubt.

I never had the slightest idea that Curtis wrote the article. But I
couldn't see anything in his post that told me its source. Thus my post.
I'd still like to know its source.

As for a prostate biopsy *causing* "infertility, incontinence, and
impotence" as the article clearly stated, I know of no evidence of such
occurring. But I'm willing to learn, if someone will cite such evidence.

Now, I'm not referring to speculation, rumor, or what someone's friend's
uncle claims, I want to see reliable *evidence*.

The following is not directed at Curtis, but at his source: PPOR.

BTW, this same thing was posted on PHML. The source was challenged, as
has not yet responded.

Regards,

Steve J
__
"Think what tedious years of study, thought, practice, experience went
to the equipment of that peerless old master who was able to impose upon
the whole world the lofty and sounding maxim that 'truth is mighty and
will prevail' -- the most majestic compound fracture of fact which any
of woman born has yet achieved. For the history of our race and each
individual's experience are sown thick with evidence that a truth is not
hard to kill, and a lie told well is immortal."
-- Mark Twain
c palmer - 21 Feb 2005 07:22 GMT
hi steve - i went back as far as could and i can't find the article at
the moment.  webtv has a limited memory backspace. i usually put the tag
line of who wrote it or a contact number because some of these are
clinical trials and this may be the information that the person needs to
get in contact with them.

i don't know what happen to the tag line i put in it.  i'm lost for an
answer, and the only thing i can say is this webtv does funny things at
times and lately it's been acting up.  i need to go ahead and break out
the laptop and get the internet provider installed but am waiting for
that disk to come in.  still like webtv because it can't be screwed up
that much as far as viruses, worms, etc.  and i don't have to deal with
it.  the down side is that it has it's quirks and it's
s-s-l-l-l-o-o-o-o-o-o-ow-o-wo-ow-ow....
oh, did i mention it's slow???  :)

i don't want you to think i was thinking  the comments were at me
directly.  i was merely pointing out that in the past, some posters get
angry at the post and it seems like they are taking potshots at the
messenger because they don't know who to direct the comments to.

now, i'm taking an educated guess on the incontinence, erection problems
and infertility.   i can see where it is possible that the needle sticks
could pass through say, the erectile nerve - ripping it into two pieces
or nicking it.  same for possible bladder nerves.  the infertility
factor at best would have to be excessive scarring from the needle
sticking of where the S. V. come in.  remember, i'm reaching for a
logical explanation, but how is the risk factor that this could have
happen is another story.  i think this part of the story they printed
should have been deleted because it had absolutely nothing to do with
the news of what they were trying to say.

~ curtis

knowledge is power - growing old is mandatory - growing wise is optional    
"Many more men die with prostate cancer than of it. Growing old is
invariably fatal. Prostate cancer is only sometimes so."
http://community.webtv.net/PALMER_ENT/doc
Tom Cular - 21 Feb 2005 10:45 GMT
           Curt and Steve,
           Here's the source, most of the article has been snipped for
brevity.

           Tom

           February 16, 2005

           For Further Information:
           Bess Andrews
           617-355-6420
           elizabeth.andrews@childrens.harvard.edu
           At AAAS conference (Feb. 16-21):
           Please page Susan Craig at 617-339-4518

           A More Accurate Screening Test for Prostate Cancer?

           New marker in urine may improve on PSA testing, reduce
unnecessary biopsies
           [BIG SNIP]

           Children's also is the primary pediatric teaching affiliate of
Harvard Medical School. For more information about the hospital visit:
http://www.childrenshospital.org/research/.

     Questions regarding the Press Room should be sent to
pubaff@tch.harvard.edu

> hi steve - i went back as far as could and i can't find the article at
> the moment.  webtv has a limited memory backspace. i usually put the tag
[quoted text clipped - 34 lines]
> invariably fatal. Prostate cancer is only sometimes so."
> http://community.webtv.net/PALMER_ENT/doc
c palmer - 21 Feb 2005 12:09 GMT
thanks tom.....

~ curtis

knowledge is power - growing old is mandatory - growing wise is optional    
"Many more men die with prostate cancer than of it. Growing old is
invariably fatal. Prostate cancer is only sometimes so."
http://community.webtv.net/PALMER_ENT/doc
Stephen Jordan - 21 Feb 2005 16:38 GMT
> Curt and Steve,
> Here's the source, most of the article has been snipped for
[quoted text clipped - 12 lines]
>
> A More Accurate Screening Test for Prostate Cancer?

(snip)

My thanks.

That source was cited on the other NG I mentioned. Another poster wrote
that she had sent a message to the source regarding the nonsense. That
was nearly a week ago. No response.

Regards,

Steve J
Stephen Jordan - 21 Feb 2005 16:52 GMT
On February 21, Curtis wrote, in pertinent part:

> i don't know what happen to the tag line i put in it.  i'm lost for an
> answer, and the only thing i can say is this webtv does funny things at
[quoted text clipped - 5 lines]
> s-s-l-l-l-o-o-o-o-o-o-ow-o-wo-ow-ow....
> oh, did i mention it's slow???  :)

I started my online experience with what later became known as "WebTV
Classic." Took about a year to become sick of it, throw it away, and buy
a Mac.

If virii, etc. are a concern, the Apple product line is the way to go,
IMO. Macs can be and are targeted, but to a very much lesser extent than
PC's. I have the Norton antivirus program installed, plus Earthlink's
whizbang, and have never had a problem. From time to time, I get a
message from Earthlink advising me that they've intercepted a virus,
worm, trojan horse, whatever.

Also: I never, ever, open an e-mail  -- or any attachment, for that
matter -- from an unknown sender. My morning ritual includes deleting
any such garbage.

Also, "phishing" is a popular diversion among certain scumbags who try
to obtain financial info by pretending to be a bank, PayPal, Earthlink,
etc. and asking for confirmation of account details. After reporting
these to the real folks, I just throw them away. It pays to be a
suspicious old crank.

Regards,

Steve J
c palmer - 21 Feb 2005 21:29 GMT
thanks steve - i appreciate the good info.

~ curtis

knowledge is power - growing old is mandatory - growing wise is optional    
"Many more men die with prostate cancer than of it. Growing old is
invariably fatal. Prostate cancer is only sometimes so."
http://community.webtv.net/PALMER_ENT/doc
 
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