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Medical Forum / Diseases and Disorders / Prostate Cancer / February 2005

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Upgrading DRE Staging methods?

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Clarence Crow - 29 Jan 2005 22:13 GMT
Hello again all,

My original DRE Staging by the Uro was T2A. in September 2004.
My Biopsy report October 2004 showed that as well, with detailed info
on the cores, 4 of which were G8 (4+4) and 2 @ G7 (3+4).
A subsequent CT Scan revealed a Prostate Volume of 65cc, but no other
significant info on the Tumour.
I commenced a Clinical Trial Nov 01, 2004.
I'm just over 3 months into ADT prior to entering RAD and HDR Temp
Brachytherapy.
When I had my 3 monthly review, the new Radio Oncologist told me my
Staging was T2C.
How can this be so if another DRE had not been done, I hadn't had
Surgery for a post-op path report, nor had any mention been made of
any empirical formula, whereby, due to the Original Biopsy report, the
aggressiveness of the cores, had been Upgraded from T2A to T2C?

Go figger???

-- Reader to complete...
-- Please reply to this ng as my email adress is fake:

-- Regards

-- CC
Stephen Jordan - 29 Jan 2005 23:33 GMT
On January 29, Clarence Crow wrote, in pertinent part:

> My original DRE Staging by the Uro was T2A. in September 2004.
(su-nip)
> I'm just over 3 months into ADT prior to entering RAD and HDR Temp
> Brachytherapy.
[quoted text clipped - 4 lines]
> any empirical formula, whereby, due to the Original Biopsy report, the
> aggressiveness of the cores, had been Upgraded from T2A to T2C?

Helluva good question.

Apparently, if the medics are correct, Clarence progressed from T2a, the
tumor involving half of a lobe or less, to T2c, the tumor involving both
lobes, in just three months. I cannot make sense of this, even given the
aggressiveGleason scores of 8 and 7. I'd be very surprised if the tumor
progressed all that much in three months. But what were the percentages
of tumor in the specimens?

On the other paw, there's a great deal of subjectivity in clinical
staging. Some, probably most, medics just tell us to bend over and have
at us. Others, Strum for example, will have the patient assume various
positions and spend quite a while feeling around. He sez he uses plenty
of K-Y.

But that leaves us -- and C -- with the open question: how did the new
rad onc arrive at the T2c staging if no further examination had been
performed???

I recommend that C demand a satisfactory answer from the medic.

Regards,

Steve J
__
"Well, I've wrestled with reality for thirty-five years, Doctor, and I'm
happy to state I finally won out over it."
-- James Stewart as Elwood P. Dowd in "Harvey"
Clarence Crow - 30 Jan 2005 00:28 GMT
>On January 29, Clarence Crow wrote, in pertinent part:
> >
>> My original DRE Staging by the Uro was T2A. in September 2004.
<snip>
>> When I had my 3 monthly review, the new Radio Oncologist told me my
>> Staging was T2C.
<snip>
>Apparently, if the medics are correct, Clarence progressed from T2a, the
>tumor involving half of a lobe or less, to T2c, the tumor involving both
>lobes, in just three months. I cannot make sense of this, even given the
>aggressiveGleason scores of 8 and 7. I'd be very surprised if the tumor
>progressed all that much in three months. But what were the percentages
>of tumor in the specimens?

From A thru H, on the G8s, C=80%, D=50%, E=80%, H=40%
The two G7s were 30% and 20% respectively
2 other cores no evidence of malignancy
2 cores not reported on? (misfires?)
<snip>

>But that leaves us -- and C -- with the open question: how did the new
>rad onc arrive at the T2c staging if no further examination had been
>performed???

<snip> could it be Political, to ensure the HDR unit was available
thru the Clinical Trials pre-qualification process? (shhh!)

>I recommend that C demand a satisfactory answer from the medic.

It's at the top of my List when I go for the positioning CT scan in
Feb (for the upcoming Rad).

-- Reader to complete...
-- Please reply to this ng as my email adress is fake:

-- Regards

-- CC
Heather - 30 Jan 2005 00:08 GMT
Not that this is particularly enlightening.....but when Ron was diagnosed as
T2B (one lobe more than half tumour, IIRC).....but the rad onc told us that
up to the year 2000, he would have been T2A.  The reason being that they had
changed the staging classifications, or some such.

Perhaps one of the group could explain this.  Just one of those odd things
that I remember from 18 months ago.

Heather

> Hello again all,
>
[quoted text clipped - 21 lines]
>
> -- CC
Steve Kramer - 30 Jan 2005 00:49 GMT
P150 in Walsh's book:

"The first TNM classification for prostate cancer was developed in 1992;
it's a good system , and the one we use in this book.  However, in 1997, it
was meddled with by the American Joint Commission on Cancer.  For mystifying
reasons, the 1997 modification streamlined three distinct stages of
localized cancer -- T2a, T2b, and T2c -- into two.  We feel strongly that
this is a mistake...."

The only differences are that T2b in 1992 became T2a in 1997 and T2c became
T2b.  Since there is no T2c in the 1997 staging, I suspect it's kind of
fallen by the wayside, because lots of us were staged at T2c.

Signature

Prostate Cancer Survivor (so far), not a doctor
PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), Tic
RRP 12/15/2000 G7 (3+4), T3bN0M0
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron (1 mo) 07/21/2003 @ 48
PSA  .07 .05 .06
Lupron (4 mo) 8/03 (48), 12/03, 4/04 (49), 09/04 (50)
non Illegitimi carborundum

> Not that this is particularly enlightening.....but when Ron was diagnosed as
> T2B (one lobe more than half tumour, IIRC).....but the rad onc told us that
[quoted text clipped - 31 lines]
> >
> > -- CC
Heather - 30 Jan 2005 01:26 GMT
Thanks, Steve.  I wasn't sure if my memory was exactly right......but the
rad onc thought it was rather ridiculous.....the change in the labelling, I
mean.  2000 stuck in my mind.....but it could have been earlier.  Unless
they didn't change it up here till then.

Matters naught now......Heather

> P150 in Walsh's book:
>
[quoted text clipped - 47 lines]
> > >
> > > -- CC
Steve Kramer - 30 Jan 2005 01:25 GMT
I guess it is possible that, by 2000, they went back to the 1992 staging.
That would explain why he said T2b woudl have been T2a.

Signature

Prostate Cancer Survivor (so far), not a doctor
PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3bN0M0
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Lupron (1 mo) 07/21/2003 @ 48
PSA  .07 .05 .06
Lupron (4 mo) 8/03 (48), 12/03, 4/04 (49), 09/04 (50)
non Illegitimi carborundum

> Thanks, Steve.  I wasn't sure if my memory was exactly right......but the
> rad onc thought it was rather ridiculous.....the change in the labelling, I
[quoted text clipped - 59 lines]
> > > >
> > > > -- CC
Clarence Crow - 30 Jan 2005 03:47 GMT
For all other than Steve Jordan:

Regardless of PAST statistics on changes to Staging Measurement
methods. they don't address the time frame to which I  referred.

In fact they seem to "Fray the Thread" around the edges, similar to
"poor differentiation" mentioned in Biopsy Reports on G4 & G5 cores.

If we have an A 3 months ago and a C now without any Valid
substantiation by further Examination , it wouldn't matter what Scale
of Measurement was employed, provided it was the same in both
instances.

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-- CC
JerryW - 30 Jan 2005 15:31 GMT
I agree with Clarence here. IIRC, T2 means it's palpable by DRE and "a"
means it's in one lobe, left or right. T2c would indicate palpable by DRE
and present in both lobes. Correct? How does staging change from "a" to "c"
without some intervening examination? Unless this information was gained
from his intervening CT scan.

Mine did the same thing before and after pathological examination, for
example.
Signature

JerryW
jweindel at flash dot net

2/11/04 PSA 2.6, Suspicious DRE (age 62)
2/23/04 Biopsy: Gleason 3+4=7, T2a, left lobe
5/18/04 RRP, Path: Gleason 4+3=7, T2c, both lobes
7/13/04 PSA <0.1
10/12/04 PSA <0.1
1/18/05 PSA <0.1

> For all other than Steve Jordan:
>
[quoted text clipped - 15 lines]
>
> -- CC
Clarence Crow - 30 Jan 2005 20:54 GMT
>I agree with Clarence here. IIRC, T2 means it's palpable by DRE and "a"
>means it's in one lobe, left or right. T2c would indicate palpable by DRE
[quoted text clipped - 4 lines]
>Mine did the same thing before and after pathological examination, for
>example.

Thanks for the attentive reply Jerry.

My CT Scan prior to entry into the Clinical Trial only gave dimensions
of the Prostate, confirmed no pathologically enlarged lymph nodes were
seen and excluded evidence of solid visceral metastasis.

In your case your Staging was changed by path post-surgery (as many
are).

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-- CC
No Spam - 01 Feb 2005 02:13 GMT
> Hello again all,

...

> aggressiveness of the cores, had been Upgraded from T2A to T2C?
>
> Go figger???

My story.  

2002, I clock a PSA 9+ and my primary care doc says, "I can't feel
anything, go see this guy, he's a top urologist."

The uro-doc can't feel anything either but does a 6 core biopsy
which comes back negative.   He's not sure but says that some
guys just have numbers like that.

2004, I clock a PSA 10+.  My primary care doc says, go back to the
the urologist, "you are outside/beyond my area of expertise."

I'm thinking that it's not a big deal.

Again, the uro can't DRE anything but says, "Let's do another
biopsy."

dang.

This time he does 12 cores and finds the cancer in 1 core. 5% sticks
in my mind.  "aggressive though", he says.

So I go to a rad-oncologist, get imaged up the wazoo, so to speak.

The rad doc says, "You're an unusual case, most tumors form to the
back, yours is toward the front."  That's why it can't be felt.

So the Uro-doc's calling T1, could not feel a thing, detected by
PSA and biopsy.

The rad-doc's high-tech imaging shows "something" toward the front
and on the left side.  Is that a T2a?  

The Rad doc calls it T3.  Aggressive, near the front, very
close to the capsule, possible penetration.  

Both docs hit it with everything they have, Lupron, IMRT,
Palladium-103.    

PSA 10+
PSA 1.3  after 3 months of Lupron
PSA 0.8  after 4 months of Lupron and half the IMRT.
PSA <0.1 2 months after seeding, 7 months Lupron.

T1, T2, or T3?  It's subjective.  

What matters is the PSA <0.1,  That's the first reading post
treatment.  The next one will be late March.  

We'll see.  
Clarence Crow - 01 Feb 2005 11:23 GMT
<snip>

>T1, T2, or T3?  It's subjective.  
>
>What matters is the PSA <0.1,  That's the first reading post
>treatment.  The next one will be late March.  
>
>We'll see.  

Just yesterday, I was discussing all of this with my new Chinese G.P.
(primary care medic).

He confirmed any DRE can not feel any palpable lumps on the "Dark Side
of the Moon" and also said I was extremely lucky to get a TRUS Biopsy
report on 6 out of 10 cores as they don't get super Imaging of the
gland from the Ultrasound probe. (actually I had 2 cores that were not
reported on, which he said were probably "misfires" into tissue
outside the gland).

He also suggested that the Rad Oncologist would have up-staged the
Tumour to T2C, because of the aggressive Gleason Scores,4 x G8 (4+4),
with 2 of those showing 80%, the Entry PSA of 21.0, the large Tumour
volume of 72cc and the PSA acceleration over the run-up period of 3
months from 15.0 to 21.0.

From ADT at 12 wks my PSA is 0.45 and Testosterone <0.8
m/mol/litre.(multiply by 28.4 to get to your "money").

I'm headed up for a positioning CT Scan in a couple of weeks in prep
for EBRT.

I'll be asking a few questions then.

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-- Regards

-- CC
No Spam - 01 Feb 2005 12:39 GMT
> From ADT at 12 wks my PSA is 0.45 and Testosterone <0.8
> m/mol/litre.(multiply by 28.4 to get to your "money").
>
> I'm headed up for a positioning CT Scan in a couple of weeks in prep
> for EBRT.

PSA .45 is good news.  My docs said, "it's responding well to
treatment." to my dropping PSA.  The falling numbers really
encouraged them. Keep hammering it.

I know some docs stop at the EBRT but doing 3 phases, Hormones,
external radiation, and then seeds, makes sense to me.
Clarence Crow - 02 Feb 2005 09:53 GMT
>PSA .45 is good news.  My docs said, "it's responding well to
>treatment." to my dropping PSA.  The falling numbers really
>encouraged them. Keep hammering it.
>
>I know some docs stop at the EBRT but doing 3 phases, Hormones,
>external radiation, and then seeds, makes sense to me.

Sorry, forgot to mention, EBRT for 5 wks, then a rest for a few wks,
then HDR Temporary Brachytherapy, 3 fractions over a 48hr period, then
still on the Hormones up to 18 mths (reduced dosage intervals from 3
mths to 6 mths), some DREs along the way with continual PSA monitoring
in line with the Hormone shots.

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-- CC
 
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