Medical Forum / Diseases and Disorders / Prostate Cancer / February 2005
Upgrading DRE Staging methods?
|
|
Thread rating:  |
Clarence Crow - 29 Jan 2005 22:13 GMT Hello again all,
My original DRE Staging by the Uro was T2A. in September 2004. My Biopsy report October 2004 showed that as well, with detailed info on the cores, 4 of which were G8 (4+4) and 2 @ G7 (3+4). A subsequent CT Scan revealed a Prostate Volume of 65cc, but no other significant info on the Tumour. I commenced a Clinical Trial Nov 01, 2004. I'm just over 3 months into ADT prior to entering RAD and HDR Temp Brachytherapy. When I had my 3 monthly review, the new Radio Oncologist told me my Staging was T2C. How can this be so if another DRE had not been done, I hadn't had Surgery for a post-op path report, nor had any mention been made of any empirical formula, whereby, due to the Original Biopsy report, the aggressiveness of the cores, had been Upgraded from T2A to T2C?
Go figger???
-- Reader to complete... -- Please reply to this ng as my email adress is fake:
-- Regards
-- CC
Stephen Jordan - 29 Jan 2005 23:33 GMT On January 29, Clarence Crow wrote, in pertinent part:
> My original DRE Staging by the Uro was T2A. in September 2004. (su-nip)
> I'm just over 3 months into ADT prior to entering RAD and HDR Temp > Brachytherapy. [quoted text clipped - 4 lines] > any empirical formula, whereby, due to the Original Biopsy report, the > aggressiveness of the cores, had been Upgraded from T2A to T2C? Helluva good question.
Apparently, if the medics are correct, Clarence progressed from T2a, the tumor involving half of a lobe or less, to T2c, the tumor involving both lobes, in just three months. I cannot make sense of this, even given the aggressiveGleason scores of 8 and 7. I'd be very surprised if the tumor progressed all that much in three months. But what were the percentages of tumor in the specimens?
On the other paw, there's a great deal of subjectivity in clinical staging. Some, probably most, medics just tell us to bend over and have at us. Others, Strum for example, will have the patient assume various positions and spend quite a while feeling around. He sez he uses plenty of K-Y.
But that leaves us -- and C -- with the open question: how did the new rad onc arrive at the T2c staging if no further examination had been performed???
I recommend that C demand a satisfactory answer from the medic.
Regards,
Steve J __ "Well, I've wrestled with reality for thirty-five years, Doctor, and I'm happy to state I finally won out over it." -- James Stewart as Elwood P. Dowd in "Harvey"
Clarence Crow - 30 Jan 2005 00:28 GMT >On January 29, Clarence Crow wrote, in pertinent part: > > >> My original DRE Staging by the Uro was T2A. in September 2004. <snip>
>> When I had my 3 monthly review, the new Radio Oncologist told me my >> Staging was T2C. <snip>
>Apparently, if the medics are correct, Clarence progressed from T2a, the >tumor involving half of a lobe or less, to T2c, the tumor involving both >lobes, in just three months. I cannot make sense of this, even given the >aggressiveGleason scores of 8 and 7. I'd be very surprised if the tumor >progressed all that much in three months. But what were the percentages >of tumor in the specimens? From A thru H, on the G8s, C=80%, D=50%, E=80%, H=40% The two G7s were 30% and 20% respectively 2 other cores no evidence of malignancy 2 cores not reported on? (misfires?) <snip>
>But that leaves us -- and C -- with the open question: how did the new >rad onc arrive at the T2c staging if no further examination had been >performed??? <snip> could it be Political, to ensure the HDR unit was available thru the Clinical Trials pre-qualification process? (shhh!)
>I recommend that C demand a satisfactory answer from the medic. It's at the top of my List when I go for the positioning CT scan in Feb (for the upcoming Rad).
-- Reader to complete... -- Please reply to this ng as my email adress is fake:
-- Regards
-- CC
Heather - 30 Jan 2005 00:08 GMT Not that this is particularly enlightening.....but when Ron was diagnosed as T2B (one lobe more than half tumour, IIRC).....but the rad onc told us that up to the year 2000, he would have been T2A. The reason being that they had changed the staging classifications, or some such.
Perhaps one of the group could explain this. Just one of those odd things that I remember from 18 months ago.
Heather
> Hello again all, > [quoted text clipped - 21 lines] > > -- CC Steve Kramer - 30 Jan 2005 00:49 GMT P150 in Walsh's book:
"The first TNM classification for prostate cancer was developed in 1992; it's a good system , and the one we use in this book. However, in 1997, it was meddled with by the American Joint Commission on Cancer. For mystifying reasons, the 1997 modification streamlined three distinct stages of localized cancer -- T2a, T2b, and T2c -- into two. We feel strongly that this is a mistake...."
The only differences are that T2b in 1992 became T2a in 1997 and T2c became T2b. Since there is no T2c in the 1997 staging, I suspect it's kind of fallen by the wayside, because lots of us were staged at T2c.
 Signature Prostate Cancer Survivor (so far), not a doctor PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), Tic RRP 12/15/2000 G7 (3+4), T3bN0M0 PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron (1 mo) 07/21/2003 @ 48 PSA .07 .05 .06 Lupron (4 mo) 8/03 (48), 12/03, 4/04 (49), 09/04 (50) non Illegitimi carborundum
> Not that this is particularly enlightening.....but when Ron was diagnosed as > T2B (one lobe more than half tumour, IIRC).....but the rad onc told us that [quoted text clipped - 31 lines] > > > > -- CC Heather - 30 Jan 2005 01:26 GMT Thanks, Steve. I wasn't sure if my memory was exactly right......but the rad onc thought it was rather ridiculous.....the change in the labelling, I mean. 2000 stuck in my mind.....but it could have been earlier. Unless they didn't change it up here till then.
Matters naught now......Heather
> P150 in Walsh's book: > [quoted text clipped - 47 lines] > > > > > > -- CC Steve Kramer - 30 Jan 2005 01:25 GMT I guess it is possible that, by 2000, they went back to the 1992 staging. That would explain why he said T2b woudl have been T2a.
 Signature Prostate Cancer Survivor (so far), not a doctor PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3bN0M0 PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron (1 mo) 07/21/2003 @ 48 PSA .07 .05 .06 Lupron (4 mo) 8/03 (48), 12/03, 4/04 (49), 09/04 (50) non Illegitimi carborundum
> Thanks, Steve. I wasn't sure if my memory was exactly right......but the > rad onc thought it was rather ridiculous.....the change in the labelling, I [quoted text clipped - 59 lines] > > > > > > > > -- CC Clarence Crow - 30 Jan 2005 03:47 GMT For all other than Steve Jordan:
Regardless of PAST statistics on changes to Staging Measurement methods. they don't address the time frame to which I referred.
In fact they seem to "Fray the Thread" around the edges, similar to "poor differentiation" mentioned in Biopsy Reports on G4 & G5 cores.
If we have an A 3 months ago and a C now without any Valid substantiation by further Examination , it wouldn't matter what Scale of Measurement was employed, provided it was the same in both instances.
-- Reader to complete... -- Please reply to this ng as my email adress is fake:
-- Regards
-- CC
JerryW - 30 Jan 2005 15:31 GMT I agree with Clarence here. IIRC, T2 means it's palpable by DRE and "a" means it's in one lobe, left or right. T2c would indicate palpable by DRE and present in both lobes. Correct? How does staging change from "a" to "c" without some intervening examination? Unless this information was gained from his intervening CT scan.
Mine did the same thing before and after pathological examination, for example.
 Signature JerryW jweindel at flash dot net
2/11/04 PSA 2.6, Suspicious DRE (age 62) 2/23/04 Biopsy: Gleason 3+4=7, T2a, left lobe 5/18/04 RRP, Path: Gleason 4+3=7, T2c, both lobes 7/13/04 PSA <0.1 10/12/04 PSA <0.1 1/18/05 PSA <0.1
> For all other than Steve Jordan: > [quoted text clipped - 15 lines] > > -- CC Clarence Crow - 30 Jan 2005 20:54 GMT >I agree with Clarence here. IIRC, T2 means it's palpable by DRE and "a" >means it's in one lobe, left or right. T2c would indicate palpable by DRE [quoted text clipped - 4 lines] >Mine did the same thing before and after pathological examination, for >example. Thanks for the attentive reply Jerry.
My CT Scan prior to entry into the Clinical Trial only gave dimensions of the Prostate, confirmed no pathologically enlarged lymph nodes were seen and excluded evidence of solid visceral metastasis.
In your case your Staging was changed by path post-surgery (as many are).
-- Reader to complete... -- Please reply to this ng as my email adress is fake:
-- Regards
-- CC
No Spam - 01 Feb 2005 02:13 GMT > Hello again all, ...
> aggressiveness of the cores, had been Upgraded from T2A to T2C? > > Go figger??? My story.
2002, I clock a PSA 9+ and my primary care doc says, "I can't feel anything, go see this guy, he's a top urologist."
The uro-doc can't feel anything either but does a 6 core biopsy which comes back negative. He's not sure but says that some guys just have numbers like that.
2004, I clock a PSA 10+. My primary care doc says, go back to the the urologist, "you are outside/beyond my area of expertise."
I'm thinking that it's not a big deal.
Again, the uro can't DRE anything but says, "Let's do another biopsy."
dang.
This time he does 12 cores and finds the cancer in 1 core. 5% sticks in my mind. "aggressive though", he says.
So I go to a rad-oncologist, get imaged up the wazoo, so to speak.
The rad doc says, "You're an unusual case, most tumors form to the back, yours is toward the front." That's why it can't be felt.
So the Uro-doc's calling T1, could not feel a thing, detected by PSA and biopsy.
The rad-doc's high-tech imaging shows "something" toward the front and on the left side. Is that a T2a?
The Rad doc calls it T3. Aggressive, near the front, very close to the capsule, possible penetration.
Both docs hit it with everything they have, Lupron, IMRT, Palladium-103.
PSA 10+ PSA 1.3 after 3 months of Lupron PSA 0.8 after 4 months of Lupron and half the IMRT. PSA <0.1 2 months after seeding, 7 months Lupron.
T1, T2, or T3? It's subjective.
What matters is the PSA <0.1, That's the first reading post treatment. The next one will be late March.
We'll see.
Clarence Crow - 01 Feb 2005 11:23 GMT <snip>
>T1, T2, or T3? It's subjective. > >What matters is the PSA <0.1, That's the first reading post >treatment. The next one will be late March. > >We'll see. Just yesterday, I was discussing all of this with my new Chinese G.P. (primary care medic).
He confirmed any DRE can not feel any palpable lumps on the "Dark Side of the Moon" and also said I was extremely lucky to get a TRUS Biopsy report on 6 out of 10 cores as they don't get super Imaging of the gland from the Ultrasound probe. (actually I had 2 cores that were not reported on, which he said were probably "misfires" into tissue outside the gland).
He also suggested that the Rad Oncologist would have up-staged the Tumour to T2C, because of the aggressive Gleason Scores,4 x G8 (4+4), with 2 of those showing 80%, the Entry PSA of 21.0, the large Tumour volume of 72cc and the PSA acceleration over the run-up period of 3 months from 15.0 to 21.0.
From ADT at 12 wks my PSA is 0.45 and Testosterone <0.8 m/mol/litre.(multiply by 28.4 to get to your "money").
I'm headed up for a positioning CT Scan in a couple of weeks in prep for EBRT.
I'll be asking a few questions then.
-- Reader to complete... -- Please reply to this ng as my email adress is fake:
-- Regards
-- CC
No Spam - 01 Feb 2005 12:39 GMT > From ADT at 12 wks my PSA is 0.45 and Testosterone <0.8 > m/mol/litre.(multiply by 28.4 to get to your "money"). > > I'm headed up for a positioning CT Scan in a couple of weeks in prep > for EBRT. PSA .45 is good news. My docs said, "it's responding well to treatment." to my dropping PSA. The falling numbers really encouraged them. Keep hammering it.
I know some docs stop at the EBRT but doing 3 phases, Hormones, external radiation, and then seeds, makes sense to me.
Clarence Crow - 02 Feb 2005 09:53 GMT >PSA .45 is good news. My docs said, "it's responding well to >treatment." to my dropping PSA. The falling numbers really >encouraged them. Keep hammering it. > >I know some docs stop at the EBRT but doing 3 phases, Hormones, >external radiation, and then seeds, makes sense to me. Sorry, forgot to mention, EBRT for 5 wks, then a rest for a few wks, then HDR Temporary Brachytherapy, 3 fractions over a 48hr period, then still on the Hormones up to 18 mths (reduced dosage intervals from 3 mths to 6 mths), some DREs along the way with continual PSA monitoring in line with the Hormone shots.
-- Reader to complete... -- Please reply to this ng as my email adress is fake:
-- Regards
-- CC
|
|
|