Medical Forum / Diseases and Disorders / Prostate Cancer / January 2005
link between Prostate Cancer and Finasteride... please help
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PWalker - 23 Jan 2005 08:21 GMT Hi,
I posted recently about my father (73 yrs old) recently diagnosed with prostate cancer.
As a result of this news I decided to get a blood test myself. I am 35 yrs old. My current PSA is 0.84. That sounds ok since I have been told the upper limit (before i should start worying) is around 1.4
But its not really ok since I have been taking finasteride for around 5 years (in the form of proscar to stop my hair from falling out). Given the fact that taking finasteride decreases your PSA by around 50% http://www.bchealthguide.org/kbase/topic/detail/drug/aa140863/detail.htm that would mean my PSA should be around 1.68 if i wasnt taking Finasteride. Should i be concerned, as this is above the 1.4 upper limit? The above webpage says the upper limit is 2.0. So is the upper limit 1.4 or 2.0?
Are there any articles, info about the relationship between PSA & Finasteride? There was a recent article about this:
Finasteride (Propecia) and the Promotion of High-grade Prostate Cancer W Reid Pitts Jr; Archives of Dermatology; Jul 2004; 140, 7; AMA Titles; pg. 885
In the article it was said that: It was found that "Finasteride prevents or delays the appearance of prostate cancer" by 24.6% (finasteride, 803/4368 [18.4%]; placebo, 1147/4692 [24.4%]) but "increased the risk of high-grade prostate cancer (Grade 7, 8, 9, 10)" by 67% (finasteride, 280/757 [37%]; placebo, 237/1068 [22.2%] [P<.001]) in men diagnosed as having prostate cancer.3
What can i do to possibly prevent the onset of prostate cancer? Any natural herbs/homeopathy/naturopathy etc?
Any help most appreciated!
Cheers, Peter
James A. Honeychuck - 23 Jan 2005 08:51 GMT Based on my reading, conventional medicine offers no definitive advice about preventing prostate cancer. Diet would appear to be a contributing factor, but no one has nailed down exactly how it works. Conventional medicine would probably just suggest a healthy diet and lifestyle.
Don't know anything useful about alternative medicine. Since it doesn't follow the scientific theory, it's hard to evaluate. My only caution is that if you are taking any herbs or potions, be sure to tell your conventional doctor.
With PSA readings as low as 1.4 or 2, doctors probably don't pay any attention to the actual number, they just watch for any rise (PSA velocity).
Sounds like you'd better quit that finasteride.
jimhoney
> Hi, > [quoted text clipped - 34 lines] > Cheers, > Peter Steve Kramer - 23 Jan 2005 13:02 GMT I have good news for you, Peter. No one currently on this NG, or who has been on this NG in the last three years, was dx'd with PCa before the age of 39. Only two were dx'd before the age of 42. The youngest I ever saw in back posts was 36.
However, 35 is a good time to start getting your PSA tested. That way you can have a baseline in case your PSA starts to climb. And THAT is the real indicator. If you are at .84 for five years, then go to 1.2, then to 2.5, you may have PCa.
Finally, if you're 35 and you are not a news anchor, quit worrying about your damned hair!
 Signature Prostate Cancer Survivor (so far), not a doctor PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3bN0M0 PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron (1 mo) 07/21/2003 @ 48 PSA .07 .05 .06 Lupron (4 mo) 8/03 (48), 12/03, 4/04 (49), 09/04 (50) non Illegitimi carborundum
> Hi, > [quoted text clipped - 34 lines] > Cheers, > Peter ron - 23 Jan 2005 17:37 GMT Hi Peter..."Ditto" to Steve's point on tracking your PSA over time, the trend is the key. As to the study you reference, PubMed does show an abstract, so I cant' be certain, but I suspect it is based on the paper on this subject from 2003 ("The influence of finasteride on the development of prostate cancer", Thompson IM, Goodman PJ, Tangen CM, Lucia MS, Miller GJ, Ford LG, Lieber MM, Cespedes RD, Atkins JN, Lippman SM, Carlin SM, Ryan A, Szczepanek CM, Crowley JJ, Coltman CA Jr., N Engl J Med. 2003 Jul 17;349(3):215-24). Finasteride is used for hair regrowth,and is also widely used in hormonal therapy treatment of prostate cancer (PCa). The good news from the study was that finasteride appears to significantly reduce or delay the occurrence of PCa in the general population. The disturbing sidebar, that when PCa does occur after finasteride use, it is more aggressive, has been called into question by several noted pathologists. They point out that any hormonal treatment will alter the appearance of PCa cells and make Gleason grading more difficult, if not impossible.
As to your question on PCa prevention, things that are part of a heart-healthy lifestyle (healthy eating, exercise, molecularly distilled omega-3s with a high DHA/EPA ratio, etc.) also appear to be good for cancer prevention. For PCa specifically, selenium and vitamin E, particularly the gamma isomer, are probably the most generally agreed upon supplements that appear to have some value...Best wishes and good health, Ron
P.S. Having mentioned PubMed, here is a link:
http://www.ncbi.nih.gov/entrez/query.fcgi
It is an amazing tool and it covers all medical areas, not just PCa. Type in search terms and it searches through all the journals it abstracts and shows you the hits, usually with links to the abstracts.
Leonard Evens - 23 Jan 2005 18:28 GMT > Hi Peter..."Ditto" to Steve's point on tracking your PSA over time, the > trend is the key. As to the study you reference, PubMed does show an [quoted text clipped - 28 lines] > Type in search terms and it searches through all the journals it > abstracts and shows you the hits, usually with links to the abstracts. I strongly endorse what ron has said. I would only add that since your father's cancer was diagnosed at age 73, you are not technically supposed to be at higher risk for prostate cancer than men in the general population. That wwould be the case if your father or other close male relative had been diagnosed at a somewhat younger age, say before age 65.
You should check with your doctor. Because of your father, it might be helpful to have a baseline measurement earlier as some have suggested. But is is possible your doctor will think you can wait until you are older before having regular PSA tests. For men not at special risk, that would be age 50. I believe that PSA testing for men in their 30s is at this point in time somewhat controversial.
I agree with Steve that you should stop owrrying about your hair, but then again I've been bald since I was 20. ;-)
Stephen Jordan - 23 Jan 2005 20:27 GMT On January 23, Leonard Evens wrote, in pertinent part:
> > I agree with Steve that you should stop owrrying about your hair, but > then again I've been bald since I was 20. ;-) OTOH, before going all to pieces over this, be aware that the finasteride dosage of Propecia (for hair) is just one mg qd. The dosage of Proscar for BPH and PCa usages is five times that: five mg qd.
As usual, do not think that medical info from us is authoritative. Before taking any action, check with the medics.
Regards,
Steve J
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