Medical Forum / Diseases and Disorders / Prostate Cancer / January 2005
Plastic used in food container stimulates growth of certain prostate c
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c palmer - 04 Jan 2005 18:17 GMT Plastic used in food container stimulates growth of certain prostate cancer cells
Tuesday 4th January
04 Jan 2005
An estrogen-like chemical commonly used to synthesize plastic food containers has been shown to encourage the growth of a specific category of prostate cancer cell, potentially affecting the treatment efficacy for a subset of prostate cancers.
According to a study published in the January 1 issue of Cancer Research, such prostate cancer cells proved to be vulnerable to exposure to the chemical BPA (bisophenol A), an industrial chemical and nonsteroidal environmental estrogen used in the manufacture of food cans, milk container linings, food storage containers and water supply pipes. About 2.5 billion pounds of the chemical are produced each year.
In particular, the study showed that the affected class of prostate cancer cell, characterized by mutated receptors for androgens, the male hormone, can proliferate in response to BPA.
"The results may have implications for men who develop BPA-susceptible mutations in their androgen receptor genes during the course of prostate cancer treatment, although these concepts will need to be verified in animal systems," according to Karen Knudsen, Ph.D., an assistant professor in the University of Cincinnati's Department of Cell Biology and Center for Environmental Genetics. Scientists estimate that anywhere from eight to 25 percent of all prostate cancer patients may fall into this category.
In the United States alone this year, almost 220,000 men will be diagnosed with prostate cancer. The disease is the second most common type of cancer found in American men, and approximately 29,000 men will die from prostate cancer this year.
Many cases of prostate cancer depend on androgens like testosterone for tumor growth and cancer cell proliferation, said Dr. Knudsen, the study's senior author. A common treatment for prostate cancer includes limiting testosterone synthesis. Patients with mutated androgen receptors may not respond to this therapy and according to this new study, exposure to BPA among these patients could potentially put them at higher risk for increased cancer cell growth.
"The results we see in cell culture in response to BPA are ready to be moved to appropriate animal models next," said Dr. Knudsen. The effect of the environmental non-steroidal BPA on human prostate cancer tumor implants in laboratory animal models will shed additional light on whether the synthetic pseudo-estrogen encourages tumor growth in whole animal systems.
"We'll know more about the 'hormone sensitizing' ability of BPA in prostate cancer cells from studies on animals. It is also important to note that our study demonstrates that the actual dose of BPA exposure may change the biological response," Dr. Knudsen said.
The safety of BPA has been under intense debate for several years, with some arguing that exposure to the chemical among humans is safe, with others contending that it may promote the growth of human tumor cells and alter the growth and development of animals.
Also participating in the study were Yelena Wetherill, Ph.D., Nicola Fisher, B.S., and Ann Staubach, B.S., all with the University of Cincinnati; Mark Danielsen, Ph.D., Georgetown University, Washington, D.C.; and Ralph De Vere White, M.D., the University of California, Davis.
Founded in 1907, the American Association for Cancer Research is a professional society of more than 24,000 laboratory, translational, and clinical scientists engaged in all areas of cancer research in the United States and in more than 60 other countries. AACR's mission is to accelerate the prevention and cure of cancer through research, education, communication, and advocacy. Its principal activities include the publication of five major peer-reviewed scientific journals: Cancer Research; Clinical Cancer Research; Molecular Cancer Therapeutics; Molecular Cancer Research; and Cancer Epidemiology, Biomarkers & Prevention. AACR's Annual Meeting attracts more than 15,000 participants who share new and significant discoveries in the cancer field. Specialty meetings, held throughout the year, focus on the latest developments in all areas of cancer research. American Association for Cancer Research
knowledge is power - growing old is mandatory - growing wise is optional "Many more men die with prostate cancer than of it. Growing old is invariably fatal. Prostate cancer is only sometimes so." http://community.webtv.net/PALMER_ENT/doc
I.P. Freely - 05 Jan 2005 22:49 GMT Wunnerful, wunnerful. I stopped eating known harmful foods 20 years ago. Bacon, pizza, cheese, butter, margarine, pastries (that's right; not one donut or rib or stick of butter/marg in 20 years), white bread/rice/pasta, ribs, candy, pie, any snack "food" made in a factory, ice cream, whole milk, cream, and on and on -- cold turkey, plus or minus a pizza or sliced of pie without the crust (trans fats!!!) each year and plus a little home-cooked LEAN red meat now and then. I was gonna still be playing sports into my 80s, at least.
But over those two decades, we've "discovered" dozens of foods or cooking techniques that are, if we're to believe the media or the labs, risky, dangerous, or downright deadly. Just since I was Dx'd with PC last August I've read about 4-5 ways I "brought my cancers on myself". First, grapefruit renders many common prescription meds harmful. Then it's cleared of that but promotes PC through some androgen receptor pathway or another. (I drink a jug a day of Diet Ruby Red because we gotta drink SOMETHING and I hate water if I'm not thirsty and I don't perceive thirst and most juices are full of sugar or HFCS and pop is bad for us and the sky is falling and most of us WILL die someday and the IRS MIGHT even stop taxing us a few years after that.) Next, low stomach acid contributes to colon cancer and inhibits anti-osteoporosis meds -- but I must suppress my stomach acid to prevent GERD and esophageal cancer and repeated dilation. Now the microwave-safe Crapperware I've nuked my cruciferous veggies (and half of the rest of my hot foods) in for 20 years is killing me?
Three lessons from all this: 1. Everything's poisonous, or at the very least costs us some freaking disease or another. 2. When my first cancer symptom appears, all bets are off. The sicker I get, the more CRAP (in deference to the 14-year-old daughters out there) I'm going to eat. My last months on this earth will be a conveyor belt of the very best/worst of the foods and manufactured crap the commercial "food" industry can crank out. I may even go into my first MacDonald's in >20 years as soon as my life insurance company pays off my widow-to-be. 3. I'm also going to buy another motorcycle, the fastest Japanese crotch rocket money can buy. I gave 'em up for safety's sake decades ago, but that won't matter at some point, any more than how I cook my broccoli, and I'd FAR rather die at 160 on a bike than eating broccoli.
My last meal will last months, not just an hour. And I'm nuking the whole damned thing in Crapperware. And then I'm going for a ride on that bike.
I.P.
> Plastic used in food container stimulates growth > of certain prostate cancer cells c palmer - 06 Jan 2005 07:04 GMT hi I.P. - i've been told to watch the movie "super size me". it's about McD's and the effect of eating their food for 30 days and the effects it had on the human body.
when i stop to think of that lovely charcoal grill......... steak juices dripping in to the fire and the flames that have been loaded with those transfats licking the bottom side of that meat - sealing in all that flavor......well, it's just makes my mouth water for that wonderful taste you get from grilling out. of course, you will have to wash it down with some of this cancer causing plastic that you are drinking out of. not to mention some of the other flavorings and foods that have been known to kill rats (but of course we are not rats and it doesn't apply - until we are big lab rats in the sky)
i guess my way of looking at it is like this. hell, something is going to kill me. i've already lived a lot longer than the average age of a man who lived at 1900. average age of death then was 49.
so, kick back enjoy life and good friends and live because we certainly don't know what tomorrow is going to bring.
~ curtis
knowledge is power - growing old is mandatory - growing wise is optional "Many more men die with prostate cancer than of it. Growing old is invariably fatal. Prostate cancer is only sometimes so." http://community.webtv.net/PALMER_ENT/doc
Alisson - 06 Jan 2005 17:38 GMT There's nothing that special about Super Size Me -- I'm not too sure why you've been told to watch it.
It might be worth a rental at best, but i wouldn't get upset if i missed it.
I.P. Freely - 07 Jan 2005 01:19 GMT SSM is an excellent movie. GIVEN HIS STATED PREMISES, it's set up, explained, and executed logically. It's also fun to watch, IMO.
I.P.
> hi I.P. - i've been told to watch the movie "super size me". it's about > McD's and the effect of eating their food for 30 days and the effects it > had on the human body. Alisson - 10 Jan 2005 21:30 GMT > SSM is an excellent movie. GIVEN HIS STATED PREMISES, it's set up, > explained, and executed logically. It's also fun to watch, IMO. [quoted text clipped - 4 lines] > > McD's and the effect of eating their food for 30 days and the effects it > > had on the human body. The thing is, I don't really think that I fully grasped his stated premise. Was he talking about general obesity trends in America, pointing fingers at the fast food industry or just arguing against overeating. There is a lot of information presented in this film (some of which, I'm not sure is 100% accurate based on some of the reviews/reports that I've read about the film), it just didn't seem to fit well together -- the weird music, his vomiting stints, the interviews with his doctors.
I do agree with you in the sense that its a lot of fun to watch -- Spurlock is, to say the least, very charismatic.
I.P. Freely - 10 Jan 2005 22:07 GMT It's been too long since I saw it to remember details. What I do recall is that as we left the movie, my wife pointed out several flaws in his facts, premises, logic, etc. When I reminded her of things said or shown in the movie which satisfied her objections, she concurred. We saw the movie for its entertainment value, and were surprised that it was also fairly well done as a pop documentary of sorts. Its basic claim that junk food is dismal fare from a health standpoint is pretty tough to refute, we enjoyed watching it, the medical consultation scenes added documentary credibility, and the movie flowed well, IMO. That's a Thumbs Up for me.
I don't recall -- or care -- whether all his information is precisely correct, as I didn't see the movie to learn facts. I don't recall any obvious factual errors, however. You ask, "Was he talking about general obesity trends in America, pointing fingers at the fast food industry, or just arguing against overeating?" You betcha! Whether he narrowed that down, I don't remember, but he surely got his point(s) across. For one, I consider the fast food industry to be about as devious, irresponsible, and hazardous as the tobacco industry. Unfortunately for weak-willed consumers, both are legal.
I.P.
"Alisson" <aleroona@yahoo.com> wrote >
> The thing is, I don't really think that I fully grasped his stated > premise. Was he talking about general obesity trends in America, [quoted text clipped - 7 lines] > I do agree with you in the sense that its a lot of fun to watch -- > Spurlock is, to say the least, very charismatic. helena - 13 Jan 2005 17:57 GMT >>We saw the movie for its entertainment value, and were surprised that it was also fairly well done as a pop documentary of sorts.
I'm glad that you and your wife looked at this film as more of entertainment value-I think a lot of people took the film way too seriously.
I.P. Freely - 13 Jan 2005 22:39 GMT Much like that OTHER recent mockumentary. '-) OTOH, more people SHOULD take "Supersize Me" seriously. It would save countless lives and insurance premiums.
I.P.
> >>We saw the movie for its entertainment value, and were surprised that > it was also fairly well done as a pop documentary of sorts. > > I'm glad that you and your wife looked at this film as more of > entertainment value-I think a lot of people took the film way too > seriously. Steve Kramer - 06 Jan 2005 07:27 GMT > I stopped eating known harmful foods 20 years ago.
> When my first cancer symptom appears, all bets are off. The sicker I get, > the more CRAP (in deference to the 14-year-old daughters out there) I'm > going to eat. My last months on this earth will be a conveyor belt of the > very best/worst of the foods and manufactured crap the commercial "food" > industry can crank out. I'm 20 years ahead of you (or 9 if you substract the difference in our ages). Long ago I figured out that I could live a couple years longer if I ate right, exercised often and generally made myself miserable my whole life. I decided the extra couple weren't worth it.
I.P. Freely - 07 Jan 2005 01:08 GMT > Long ago I figured out that I could live a couple years longer if I > ate right, exercised often and generally made myself miserable my whole > life. I decided the extra couple weren't worth it. Uh, oh . . . soapbox alert. I'm a strong advocate of plenty of the right kinds of exercise (i.e., hard play) and eating.
I'm your basic hedonist, so hard play and heavy eating aren't sacrifices to me. In fact, they are life's two greatest lasting pleasures. I walked away from my career when it got in the way of my play, and may risk my life by avoiding HT because it would halt my play. I still eat more and play longer and harder than 98% of the college-age kids I know, so not only has it already added decades of vigor to my life, I suspect it will allow a couple more vigorous decades if I can just beat Partin's statistics.
CERTAINLY my eating is "worth it": what's not to like about a few plate-sized blueberry pancakes swimming in syrup, a huge slab of salmon on the grille, a home-made enchilada casserole, a two-pound wok of fresh ginger chicken & veggie stir fry, two dinner plates of whole wheat spaghetti buried in a quart of sauce (lycopene!), a big double handful of raisin walnut cranberry whole wheat bread smothered in Italian seasoning olive oil, a six-egg omelet full of fresh bell peppers and low-fat cheese and buried in salsa and jalapenos and low-fat sour cream, and/or a quart-sized chunk of home made angel-food cake completely buried in fresh strawberries and buried again in Real Whip (actual whipped cream tastes like so much lard to me now)? No, not all in one sitting, or one day, but it makes a helluva 3-day weekend.)
All that and thousands of hours of hard play to add decades of vigor and maybe a few years of heartbeat, and all I had to give up was junk food? Not a big sacrifice, definitely "worth it" to me, and there will still be plenty of time to eat junk food when it doesn't matter any more.
Hard play probably really doesn't subtract from our time on earth, and great food may not, either, if it's the right stuff.
I.P.
Danny McCarty - 06 Jan 2005 19:28 GMT >Subject: Re: Plastic used in food container stimulates growth of >certainprostate c >From: "I.P. Freely" fuhgeddaboutit@noway.not >Date: 1/5/2005 4:49 PM Central Standard Time >Message-id: <if_Cd.23068$hW4.8930@fe07.lga> Yeah, I have NEVER given up any of that stuff. All nonsense. Sensible potions is the key, not abstinence.
>Wunnerful, wunnerful. >I stopped eating known harmful foods 20 years ago. Bacon, pizza, cheese, [quoted text clipped - 39 lines] > >I.P. I.P. Freely - 07 Jan 2005 00:07 GMT Apparently not true with trans fats. The medically acceptable amount of those is zero. And I found it far easier to cut back on the deadlier crap by just going cold turkey on it rather than deciding when and how much to eat. By simply eliminating the worst offenders from my life, I eliminated any desire for them almost immediately. Donuts, bacon, ribs, margarine . . . crap like that disgusts me enough that I simple haven't wanted any of it since I learned how harmful it is. That attitude lets me eat the occasional, rare dessert buffet or cheese dip guilt-free. I am aware of no redeeming ingredients in "foods" like those.
I.P.
"Danny McCarty" <roachable@aol.comneat> wrote > >
> Yeah, I have NEVER given up any of that stuff. All nonsense. Sensible potions > is the key, not abstinence. helena - 07 Jan 2005 01:03 GMT cpalmer-ssm doesn't teach you anything you don't know already. The key to any healthy lifestyle is watching your portions, which this lamo did not practice-to say the least.
Tom Cular - 07 Jan 2005 09:33 GMT IP, You constantly speak of QOL and then state that you've given up all of the tastey foods for the past two decades because some "health guru", somewhere along the line advised it. Unfortunately, you were still cursed with two types of cancer despite the the restricted diet. Something is wrong with this picture when someone believes that a wholesome diet alone will prevent serious disease. IMHO, I agree with Danny, moderation is probably the right route, i.e. a glass of red wine might be beneficial 5 glasses probably not. As far as the broccoli is concerned; some is OK as long as it's accompanied by a piece of charbroiled beef.
Tom
> >Subject: Re: Plastic used in food container stimulates growth of > >certainprostate c [quoted text clipped - 48 lines] > > > >I.P. helena - 07 Jan 2005 15:56 GMT > IP, > You constantly speak of QOL and then state that you've given up all of the [quoted text clipped - 72 lines] > > > > > >I.P. First off Tom, I don't mean to be critical-but it doesn't seem good natured to discuss why others may be dealt a rough hand with diseases. As we well know, diet is an important aspect to a healthy body-but it by no means is a precursor to whether or not you'll get cancer. Genetics has quite a bit to do with it as well. And as someone who's had two close family relatives who have done everything right (healthwise) and still were faced with these types of challenges, I had to say something.
As for the previous statements on ssm:
>>GIVEN HIS STATED PREMISES, it's set up, explained, and executed logically.
I have to disagree-what is logical about what this man did? And what was the profound premise that he was trying to gain. The film had me laughing in several scenes-but logical is not how I would describe this man's state.
I.P. Freely - 07 Jan 2005 18:42 GMT My aunt ranted loudly and often against smokers and smoking for most of her 70 years before dying of throat cancer. Caca pasa.
The logic was in the movie's well-defined premises, objectives and constraints, making it a technically well-done documentary as entertaining movies go. I've forgotten much since seeing it a year or so ago, but examples include his choosing MacD because it is the top dog, his supersizing everything IF ASKED TO DO SO because studies say most people do, and his eating to the stuffed point because most people do. Who can eat just one MacFry? My wife mentioned several flaws in his presumptions and logic as we left the movie, but closer examination of the narration revealed explanations for every apparent logic gap. After all, a lot of people, especially latchkey kids, get most of their calories from MacD and its clones. That's a major cause of the recent INCREDIBLE increase in obesity and obesity-related disease in the US, and we KNOW what that does to us. Example: our expected lifespan is DECREASING for the first time in recorded history.
I.P.
> First off Tom, I don't mean to be critical-but it doesn't seem good > natured to discuss why others may be dealt a rough hand with diseases. [quoted text clipped - 14 lines] > laughing in several scenes-but logical is not how I would describe this > man's state. helena - 07 Jan 2005 21:22 GMT >>After all, a lot of people, especially latchkey kids, get most of their calories from MacD and its clones. That's a major cause of the recent INCREDIBLE increase in obesity and obesity-related disease in the US, and we KNOW what that does to us.
But who's responsibility is that? I'd argue that much of it has to do with the parents' role.
I.P. Freely - 07 Jan 2005 22:01 GMT Of course. And the parents aren't doing much better themselves.
I.P.
> >>After all, a lot of people, > especially latchkey kids, get most of their calories from MacD and its [quoted text clipped - 5 lines] > But who's responsibility is that? I'd argue that much of it has to do > with the parents' role. I.P. Freely - 07 Jan 2005 18:21 GMT > IP, > You constantly speak of QOL and then state that you've given up all of the [quoted text clipped - 7 lines] > broccoli is concerned; some is OK as long as it's accompanied by a piece of > charbroiled beef. Folks, this rant may seem self-centered at first glance, but its real message is that even at our age we can change our habits to improve our QOL, and often our life span, significantly. For example, guess what age group responds most quickly and dramatically to increased exercise. Yup . . . OLD people. Like 80s and 90s. So here goes.
Sorry, Tom, but I've researched and written about health issues for many years. It's not just some "health guru"; just about every major university and hospital medical center and research study on the planet agrees that exercise and something like the Mediterranean diet -- including that wine in moderation -- make a significant difference in our physical and mental QOL and lifespan. Athletes in their 20s ask me often how they might match my muscles and endurance, and I've never "worked out" in my life except for occasional Bowflex sessions when my play time is hampered by weather and I'm not building some dang yard thing or another. Stress EKG? "Jeez, guy, these charts say you could play college football."
The other thing people comment on VERY often is the variety and quantity of food I eat. When they're eating a dinky little bowl of cereal or frying up some greasy breakfast stuff, I'm scarfing down a dinner plate heaped high with layers of chicken enchiladas, beans, low-fat cheeses, salsa, peppers, and low fat sour cream. Then we go out and play, and I outlast them literally 3 to 1 . . . and many of them are 1/2 to 1/3 my age. Lunch? They're eating bags of greasy manufactured crap from the 7-11 plus some fried chicken WITH THE DAMN SKIN ON IT, while I'm eating barbecued jalapeno beans, peanut butter on whole grain bread, fruit, a skinless chicken breast slathered with raspberry chipotle sauce, and a big homemade lemon blueberry walnut raisin muffin. Then they are exhausted by 5-6 PM -- usually HOURS sooner -- and start grilling a slab of red meat with which to line their arteries. I keep playing until it's too dark to play any more, often 5-6 hours past their endurance wall, then dive into that pile of blueberry pancakes I mentioned and polish it off with a double-fisted chocolate bran walnut raisin honey muffin. God, I'm starving just thinking about it . . . and I don't even miss those 32-oz steaks I ate for decades before wising up. Now I eat red meat maybe once a week, but only the leanest cuts and with a pound or more of brightly colored vegetables.
Now . . . what are these tasty foods I've "given up"? OK, pizza, but only because when I do eat one, I literally eat one. A whole, medium to large one, with thick cheese-filled crust and ham and pineapple and chicken and sweet peppers all over it. Damn; it's been months now. It's time.
Moderation is highly advisable in most aspects of our lives, but it doesn't satisfy me. I pick activities and foods I really like and go whole hog, which raises my QOL graph off the chart much of the time -- with risks. I get away with it because I like burning off those calories even more than I do putting them down. "Restricted diet"? I don't think sat fat and trans fat, or unburned calories in general, are much to give up, not when it helps avert a list of deadly diseases that would fill a paragraph. Type II diabetes? Usually self-inflicted, voluntary, and reversible. Scores of thousands of heart attacks and strokes? Self-inflicted and voluntary. Many cancers? Promoted by bad diet and enabled by bad genes. Crushed knees and ankles and hips due to obesity? Self-inflicted and to some degree reversible. 10-20-30 years of crappy health and low QOL -- very often self-inflicted and often reversible.
But when genes fail us, plus in my case 40 years of quantities you would not believe of high-fat foods (example: a large thick-crust pizza with several toppings plus two chocolate malts . . . for lunch, between normal breakfast and supper), we get diseases. This PC brewed in my groin for a decade or two, my doc says. He also says -- and his colleagues and he perform clinical trials full time -- that so far there's no proven dietary link to PC's cause or cures.
People here often comment on how important it is that we PC patients take charge of our own PC care. Well, that also goes for the other aspects of our health and vitality. Lots of exercise and a DELICIOUS, filling, wholesome diet WILL add significantly to our lifespan and DRAMATICALLY to our QOL, unless statistics and genes bite us in the a.s . . . or the crotch.
Rant off.
I.P.
Tom Cular - 08 Jan 2005 12:56 GMT IP, I wasn't scoffing at a healthy diet or your choices, but merely pointing out that the best diet in the world will not prevent ( it may reduce the possibility) us from contracting cancer. Sensible diets and lifestyles certainly have a positive effect on diabetic, coronary and many other health issues, I don't think many would disagree with that. In the past few years I've made some dietary changes that should have been made years ago, I have no doubt that being physically active all my life has been beneficial. I'm 63 and weigh about 10 lbs. more than I did in high school, my sugar is fine, cholesterol under control without medication and BP under control. I still enjoy bacon & eggs or a steak, even an occasional cigar, but in moderation, these things also are a part of QOL.
Tom *Snipped for brevity*
>> diet WILL add significantly to our lifespan and DRAMATICALLY to our QOL, > unless statistics and genes bite us in the a.s . . . or the crotch. > > Rant off. > > I.P. helena - 10 Jan 2005 19:49 GMT >>Of course. And the parents aren't doing much better themselves. Tell me about it-it's a very sad situation when kids are learning by example from their folks.
But how do you think that SSM teaches us about the importance of exercise and moderation when Spurlock does none of that?
I.P. Freely - 10 Jan 2005 22:29 GMT His demonstration of the impacts of LACK of moderation make a pretty good appeal for moderation, to me. And exercise or no exercise, overweight or skinny as a board, no one should regularly consume the crap he ate in that movie. Even scrawny marathoners can acquire major cardiovascular disease. The list of "foods" I will put back into my diet when I can see the Grim Reaper looming STILL doesn't include Big Macs. MacFries, maybe, and supersized, but not Big Macs or their awful, plastic shakes. There's man-made crap and there's decadence, and they're at opposite ends of the Last Meal spectrum I want on my lips when *I* pull the plug. ;-) When I eat my way to the grave, it's going to be on Marie Calendar's French Silk pie and pumpkin cinnamon malts made from Haagen Dasz.
I.P.
"helena" <helenasand_2@hotmail.com> asked>
> But how do you think that SSM teaches us about the importance of > exercise and moderation when Spurlock does none of that? helena - 13 Jan 2005 18:17 GMT >>make a pretty good appeal for moderation, to me. And exercise or no exercise, overweight or skinny as a board, no one should regularly consume the crap he ate in that movie.
I agree-the fact that he did was rather silly-I don't think though that he educated us on the importance of learning about moderation though and especially exercise. Some people can eat fast food more than others-look at the Big Mac guy in the film-his cholesterol level was normal. Everyone's bodies react differently to what we eat, and he was no exception.
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