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Medical Forum / Diseases and Disorders / Prostate Cancer / December 2004

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An Heretofore Unrecognized Advantage with RP  :-)

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ron - 27 Dec 2004 19:51 GMT
Because of the "Testosterone after surgery" thread, I came across an
article by Dr. Walsh, et. al., entitled "Influence of Radical
Prostatectomy on Serum Hormone Levels" (J. Urol., 160, pp. 449-453,
1998).  The paper tracks the hormone levels in 63 men Walsh operated on
between 1994 - 1996.  The men had a seemingly normal distribution in
age and PCa characteristics, other than that no metastatic cases were
included.  Blood was collected, on average, 2 months before RP and then
again 1 year post-RP.  Interestingly, T was found to increase, on
average, by 28% (350 to 440 ng/dL) while DHT decreased 15% over this
time.  Both of these observations tested >99.9% significant.

Given the known correlation between male pattern baldness and DHT, does
this mean that men with PCa who select RP can anticipate a better head
of hair down the road than their non-RP counterparts
:-) ?..Best wishes and goood health, Ron
ronju99 - 27 Dec 2004 23:38 GMT
I wish that had happened to me. Three months after surgery my testosterone
was 375 and I had it taken a year later and it went down to 315. Either I
must be a rare case or  the studies that we all find may leave a lot to
desire. Maybe he's just trying to influence one's decision when it comes
to treatment choice.
Ron S
Claude - 28 Dec 2004 02:20 GMT
> Because of the "Testosterone after surgery" thread, I came across an
> article by Dr. Walsh, et. al., entitled "Influence of Radical
[quoted text clipped - 11 lines]
> of hair down the road than their non-RP counterparts
> :-) ?..Best wishes and goood health, Ron

Correct me if I'm wrong here, but isnt an increase in testosterone a
negative for someone with PCa (assuming that there may still be some cancer
cells left after the RP)?  Won't the testosterone stimulate these cells?
(And, as a side note---my hair continues to get thinner.)
I.P. Freely - 28 Dec 2004 02:37 GMT
Antiandrogens such as Casodex can (apparently) INCREASE T safely, because
they block the effects of T. They also increase bone density, rather than
lower it like the usual HT process. Some preliminary trial data say it works
pretty well by itself, but there's opposition.

And the beat goes on.

I.P.

> Correct me if I'm wrong here, but isnt an increase in testosterone a
> negative for someone with PCa (assuming that there may still be some cancer
> cells left after the RP)?  Won't the testosterone stimulate these cells?
chuck.mcclellan@juno.com - 28 Dec 2004 11:28 GMT
> Because of the "Testosterone after surgery" thread, I came across an
> article by Dr. Walsh, et. al., entitled "Influence of Radical
[quoted text clipped - 11 lines]
> of hair down the road than their non-RP counterparts
> :-) ?..Best wishes and goood health, Ron

That 'return-of-the-hair' benefit was one thing my wife noticed in the
weeks following the surgery (June of 2003).  I scoffed at the notion
until I noticed the thinning hair was actually allowing itself to be
parted again with something besides a washcloth.  We mentioned it to my
Uro on one of my follow up exams and all he could do was scratch his
chin and smile. Now the hairline on the forehead is still at the 'old
fart' height but the rest has thickened a bit though not to it's
original density.  Hats are still mandated on sunny days. I am going to
pass it this on to the doctor whom I see next month.

Chuck Mc
Bill - 28 Dec 2004 15:54 GMT
If you take finasteride for BPH or part of a total androgen blockade it
is called Proscar; if you take it for baldness it is called Propecia -
same drug (a 5-alpha reductase inhibitor)- just a smaller dose.
Bill Denton
RP 2/12/02
Memphis
Marshall Schuon - 29 Dec 2004 07:06 GMT
>Because of the "Testosterone after surgery" thread, I came across an
>article by Dr. Walsh, et. al., entitled "Influence of Radical
[quoted text clipped - 11 lines]
>of hair down the road than their non-RP counterparts
>:-) ?..Best wishes and goood health, Ron
______

It has seemed to me, after a year of hormone-deprivation, that my hair
is thicker.  Just the thing to attract the ladies, I have thought.
But I have realized, too, that my mane now promises more than I can
deliver.  :(

Marshall

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