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Medical Forum / Diseases and Disorders / Prostate Cancer / November 2004Enhanced MRI can find tumors far better than conventional MRI
An enhanced type of MRI can detect much smaller tumors than ever before - some tinier than a pea - in an advance that could open a new age in diagnosing cancer without surgery, researchers say. The experimental technique examines the lymph nodes for signs of spreading cancer. The enhanced technique proved superior to conventional MRI's when tested with cancer that had spread from the prostate. The leader of the research, Dr. Mukesh Harisinghani and his team has done a prostate study in which the technique found 63 cancerous lymph nodes in 33 patients. Conventional MRI would have missed 71% of the nodes, and the spreading cancer would have gone undetected in nine patients. "Even is it only works this well for prostate cancer, it's a significant advance," said Dr. Jeffrey Brown, a radiologist at Washington University in St. Louis. Earlier detection of spreading prostate cancer would allow more aggressive treatment sooner, help doctors track the response and spare some patients unnecessary removal of the prostate gland or lymph nodes. The Food and Drug Administration is considering whether to approve the new technique. It is unclear when the FDA might decide. Imaging systems have never reliably shown tumors this small before anywhere in the body. Up to now, the smallest tumors detectable by MRI have been about the size of a fingernail. knowledge is power - growing old is mandatory - growing wise is optional "Many more men die with prostate cancer than of it. Growing old is invariably fatal. Prostate cancer is only sometimes so." http://community.webtv.net/PALMER_ENT/doc On November 24, Curtis Palmer wrote: > An enhanced type of MRI can detect much smaller tumors than ever before > - some tinier than a pea - in an advance that could open a new age in [quoted text clipped - 5 lines] > The enhanced technique proved superior to conventional MRI's when tested > with cancer that had spread from the prostate. (su-nip interesting news) I'd be grateful if Curtis would post his source for this. I'd like to refer my rad onc to it. My next meeting with him -- for 30-day post-IMRT status review -- is Monday, November 29. Will also receive Lupron injection. Thanks! Steve J __ "Never give in--never, never, never, never, in nothing great or small, large or petty, never give in except to convictions of honour and good sense. Never yield to force; never yield to the apparently overwhelming might of the enemy.'' --Sir Winston L. S. Churchill I'd be grateful if Curtis would post his source for this. I'd like to refer my rad onc to it. ============ hi steve - i would love to give you the source, but all i can tell you on this particular story is i had read it in the local newspaper about 5 to 6 months ago set the paper aside. i never did see anymore on this type of article since then. as i was cleaning up for thanksgiving, i saw the paper and was wondering why i had kept it, then read the article again. what i posted is what was in the article. since it is in a clinical study, your doctor may know of somewhere to lay his hands on the results. the article did list those people and it's possible to maybe on contact them. normally, i do list the sources, but this is one that didn't give a whole lot of info. i felt i should pass this information on, because the technology is improving all the time and if would be great if folks knew that there was a better mousetrap being built. i just don't know how soon the new MRI is going to pressed into service. hope this answers your questions. ~ curtis knowledge is power - growing old is mandatory - growing wise is optional "Many more men die with prostate cancer than of it. Growing old is invariably fatal. Prostate cancer is only sometimes so." http://community.webtv.net/PALMER_ENT/doc > On November 24, Curtis Palmer wrote: > > [quoted text clipped - 15 lines] > My next meeting with him -- for 30-day post-IMRT status review -- is > Monday, November 29. Will also receive Lupron injection. http://wuphysicians.wustl.edu/newsArchive.asp?navID=1&category=home&ID=342 According to that it's in the NEJM The study findings appear in today's New England Journal of Medicine. Copyright 2003 St. Louis Post-Dispatch http://tinyurl.com/68efb American Cancer Society Webpage ew Imaging Techniques Better at Detecting Cancer Spread May Reduce Futile Surgeries Article date: 2003/06/20 Two reports in the New England Journal of Medicine (Vol. 348, No. 25:2491-2499 and 2500-2507) describe new ways to spot cancer that has spread from its original site. (see the rest) Without biopsy, how do they know there isn't two different cancers? and/or doesn't removing the prostate slow it down somewhat? In other words, I think there's some flaws in these high-tech imaging... J > On November 24, Curtis Palmer wrote: > > [quoted text clipped - 12 lines] > I'd be grateful if Curtis would post his source for this. I'd like to > refer my rad onc to it. Hi Steve...Here are two links (they both need to be reforged into a single line) that provide abstracts of Dr. Harisinghani's work with MRI plus magnetic nanoparticles to detect occult lymph node mets. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1 2815134&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1 2815134&dopt=Abstract In the ProstatePointers discussion group, Dr. Strum has noted that, "Mass General, under the aegis of Dr. Mukesh Harisinghani has a limited number of openings to do the USPIO-Sinerem/Combidex study. In the USA, it will be called Combidex. In Europe, Sinerem."...Good health and best wishes, Ron Curtis, "J" and ron wrote reples to my request for further info on the new MRI technique. Thanks to all! Regards, Steve J __ "Research is what I'm doing when I don't know what I'm doing." -- Wernher von Braun > An enhanced type of MRI can detect much smaller tumors than ever before > - some tinier than a pea - in an advance that could open a new age in [quoted text clipped - 6 lines] > with cancer that had spread from the prostate. > ... The clinical trial I was in was testing MRI in cancer treatment. They stuck an antenna onto a kind of balloon attached to a kind of pole. They shoved the pole up my rectum (I swear the guy twisted it around a few times), positioned it against the prostate, and then inflated the balloon - pushing the antenna squarely into the prostate area. Then they went through about an hour and a half of scanning. Later this whole procedure was repeated during treatment - using real-time imaging to place the HDR brachytherapy treatment catheters - needles through which the radioactive wires were inserted for treatment. They showed me the images they got from the dry run. They were remarkably clear - giving very detailed black and white views of the prostate, lymph nodes, seminal vesicles, and other structures. The tumor - a big ugly black thing with little branches in various directions - showed up very clearly. They were also able to determine, as near as could be done without taking biopsies, that the lymph nodes and seminal vesicles were clear. I imagine the process was pretty expensive. There were about six people doing the work and they had some very impressive looking equipment. And it took a couple of hours from beginning to end. But it looked to me like a great diagnostic technique. Some day, 10 or 20 years from now. The equipment to do this kind of work may be cheap enough to put in every urologist's office, and automation may be such that a doctor and nurse can handle the whole job in 20 minutes. Alan My brother in law is currently undergoing chemo for lymphoma. His most recent MRI showed additional abnormal nodes but "are not yet cancerous". I wonder how they know that.  SignatureProstate Cancer Survivor (so far), not a doctor PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3bN0M0 PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron (1 mo) 07/21/2003 @ 48 PSA .07 .05 .06 Lupron (3 mo) 8/03 (48), 12/03, 4/04 (49), 09/04 (50) non illegitimi carborundum > An enhanced type of MRI can detect much smaller tumors than ever before > - some tinier than a pea - in an advance that could open a new age in [quoted text clipped - 31 lines] > invariably fatal. Prostate cancer is only sometimes so." > http://community.webtv.net/PALMER_ENT/doc >Subject: Re: Enhanced MRI can find tumors far better than conventional MRI >From: "Steve Kramer" skramer@cinci.rr.com [quoted text clipped - 5 lines] > >I wonder how they know that. Cancerous tumors have irregular boundaries and invasiive extensions into surrounding tissue. The cells might be cancerous- definitions. I haven't heard that MRI can examine the structure of individual cells yet. |
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