Celebrex versus Lupron-Side effects

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Chuck McClellan - 31 Jul 2004 00:48 GMT

I have been on Celebrex 200 mg daily for about a year before my DX and
the resulting RRP. The Celebrex really helped me and continued to do
so until I got started with the Lupron treatment in conjucntion with
EBRT. I have been noticing that the old 'stiff joints' feeling is
coming back as though the Celebrex has been negated by the Lupron.
When I asked the pharmacist or my doctor they respond they hadn't
heard of this sort of conflict. If I sit, stand, kneel, squat or
anything static for too long it is as though I never took Celebrex at
all. I'm almost afraid to skip a dose of the Celebrex to see if it's
my imagination or not. It could simply be the side effects of Lupron
and the Celelbrex can't overcome it. Has anyone else faced this? I am
going to continue the Celebrex, I was just wondering if the Lupron
fights the Celebrex or not.

Oh well, gotta' see the humor in it all.
Chuck McClellan

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Alan Meyer - 31 Jul 2004 02:14 GMT

> I have been on Celebrex 200 mg daily for about a year before my DX and
> the resulting RRP. The Celebrex really helped me and continued to do
[quoted text clipped - 12 lines]
> Oh well, gotta' see the humor in it all.
> Chuck McClellan

Chuck,

I got some arthritic like problems in my hands recently that
seemed to have begun shortly after I finished with Lupron,
so I did some research.

See: http://www.lupron.com/prostate/PackageInsert.asp

The package inserts are reproduced there. Among other
side effects, one that I saw for patients who have had a four
month dose (I had a 1 month, then a 3 month) is:

Joint Disorder - 8 patients, 16.3% of patients in the study.

I then called TAP pharmaceuticals and asked if anyone had
developed rheumatoid arthritis after taking Lupron, because my
symptoms were like that. The nurse I spoke to said that some
women taking it had developed that. I asked if she had any
more information or advice and she didn't.

So there you have it. Is the pain and swelling in my hands
caused by the Lupron? Is your stiff joint problem cause by
Lupron. It could be.

My own doctor prescribed NSAIDs (ibuprofen and naproxen)
but they didn't do anything. The only thing that helped me was
lots of exercise. I still have the symptoms but I seem to
be able to control them with exercise.

If you get any more information, or a doctor tells you something
of value, or you figure anything out, please let us know.

Alan

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Chuck McClellan - 31 Jul 2004 14:08 GMT

> > I have been on Celebrex 200 mg daily for about a year before my DX
> and
[quoted text clipped - 53 lines]
>
> Alan

Thanks Alan. Exercise seems to work for me also but it is soemtimes
so hard to get started. Sitting in a car for any length of time
requires I walk about half a mile to work off the stiffness. Working
itout and Tylenol are the only comforts so far. Oh well, only three
and half more months of it and I can't complain anyway; I got to see
the sun rise.

Chuck M

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Alan Meyer - 01 Aug 2004 21:19 GMT

> ... Exercise seems to work for me also but it is soemtimes
> so hard to get started. Sitting in a car for any length of time
> requires I walk about half a mile to work off the stiffness. Working
> itout and Tylenol are the only comforts so far. Oh well, only three
> and half more months of it and I can't complain anyway; I got to see
> the sun rise.

An excellent point of view.

When I got the symptoms in my hands I went to the library
and checked out some books on arthritis. It appears that
arthritis is many different conditions, not one or two, but that
most of them benefit from exercise. Some of the books have
specific exercises to try. Different ones emphasize
flexibility, mobility, or strength. You might find something
useful there. For example, a mixture of strength exercises
done once or twice a day to build up muscle around the
joint, plus motion exercises to overcome stiffness might
make a world of difference.

I was trying to rest my hands - which was the worst possible
thing to do. The stiffness and pain interfered with my typing -
which was a problem for a computer programmer like me.
Then I started exercising and I can now type with no pain
at all.

Another thing to try is heat or ice. Paradoxically, both work
the same for me. When I wake up in the morning my hands
are stiff. I run them under either cold or hot water and flex
them at the same time and within a few minutes they feel
pretty good.

Alan

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