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Medical Forum / Diseases and Disorders / Prostate Cancer / June 2004

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Radiation After Surgery Helps Prostate Cancer Patients Live    Longer

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c palmer - 22 Jun 2004 04:03 GMT
ALEXANDRIA, VA -- June 21, 2004 -- Prostate cancer patients who receive
radiation therapy within six months after surgery live longer than
patients who do not receive radiation afterwards, according to a new
study in the July 1, 2004, issue of the International Journal of
Radiation Oncology*Biology*Physics, the official journal of ASTRO, the
American Society for Therapeutic Radiology and Oncology.
Between 1986 and 1999, 415 patients underwent surgery to remove their
prostate and surrounding lymph nodes. The patients were then split into
two groups - those who were scheduled for external beam radiation
therapy within six months of surgery and those who would be followed
over time and possibly undergo radiation therapy later if the cancer
showed signs of returning. None of the patients showed any evidence of
metastatic disease.
Within eight years, prostate specific antigen tests on the patients
revealed that 69 percent of patients who received radiation therapy
within six months of surgery showed no signs of the prostate cancer
returning while 31 percent of patients who did not have radiation at all
or had radiation after the cancer recurred. Researchers also found that
the disease remained localized in the prostate for 93 percent of the
patients in the radiation therapy group compared with 63 percent in the
other. The risk of death from localized prostate cancer was also
significantly lower in the radiation therapy group.
"To my knowledge, this is the largest study of its kind completed at a
single institution," said Cesare Cozzarini, M.D., a radiation oncologist
at San Raffaele H. Scientific Institute in Milan, Italy. "The results
show that radiation therapy after surgery helps limit the chances that
the cancer will recur allowing prostate patients to live longer."

knowledge is power - growing old is mandatory - growing wise is optional    
"Many more men die with prostate cancer than of it. Growing old is
invariably fatal. Prostate cancer is only sometimes so."
ronju99 - 22 Jun 2004 12:47 GMT
Curtis,
Not much of a study. They didn't report the numbers on the patients going
into the study and what was really interesting was they didn't state what
kind of surgery they had. It couldn't have been RRP as they report that
93% of patients with radiation treatment compared to 63% of the ones
without treatment still had the disease localized in the (prostate). How
dod that happen?

Ron
c palmer - 22 Jun 2004 18:22 GMT
From: res0rbp6@nospam.verizon.net (ronju99)
Curtis,
Not much of a study. They didn't report the numbers on the patients
going into the study and what was really interesting was they didn't
state what kind of surgery they had. It couldn't have been RRP as they
report that 93% of patients with radiation treatment compared to 63% of
the ones without treatment still had the disease localized in the
(prostate). How dod that happen?
Ron
==========
don't kill the messager - i just find the different studies and bring
them to light.  as leonard and others will point out, when one is doing
studies, you have to look at the base.  from the base, you can produce
the results you want.  for example, if they had patients that were T1c,
the results would be different yet.  if all patients were T3c, again
different results.  and if there were a study that has various staging
in it, different results, all with the same type of treatment.

somebody is funding these studies and are making decisions.  big
decisions.  and these decisions are relayed to the doctors who treat
patients that are dx'ed with pca.  biased??  you betchya, but that is
the trouble with some of this testing and this is just one of many that
proves it.  by bringing it to light just makes us aware of what is going
on and commenting of it makes us even more aware of what these studies
are doing to the society to shape the thoughts in the treatment process.
not all studies are going to be big hits and accepted by the public.

for example, i was tempted to post a spam ad that was in another
newsgroup.......why???   because it was basically a bracelet that you
wear, but the ad gave a big long scientific explanation about how
electricity cures this problem and at the very end of the spam was a
disclaimer.  why post this spam ad when it sounds like something we've
all heard before?  because it was posted in an impotent newsgroup,
claiming for cure impotence, and then the same ad was used, but the
first paragraph changed, only this time, the spam ad claimed to cure
prostate cancer.  how many people will respond to that ad?  and to the
tune of 90 dollars for that bracelet i might add.  

i had my eyes pried open early in life that everything was not always as
they seem.  that if we want to see the world through rose colored
glasses, that's fine.  society will allow this to happened.  but i grew
up in a city and came back to that same city many years later.  i had
seen it through the eyes of a child.  i had seen things that adults
never saw.  they would look straight through the events without ever
registering at the brain.  i came back and worked as a counselor, and i
saw this same city through the eyes of the homeless, the drug users, the
gays, the people down on their luck.  i saw things that were always
there, but failed to actually the event myself.  now, i readily see
them.  having had two different types of businesses in the very same
city, i see and talk with people who on one end, never see or hear of
these events i've described in one business and in the other business, i
would meet people who lived in the hallways and under tables.  in fact,
i was given a handout (2 pages) of places that would give you handouts -
where they were, their phone numbers, what they were looking for to
prove in order to get the handout and for how long you could get the
handout, and it was not just for this city, but cities within 40 miles
around.

one world - no.  one trial study - no.  but when you look at all the
studies that they are doing, it makes you sometimes - rethink.  and
sometimes, you come up with the same answer, and sometimes you don't'.
that is why i posted this particular study.  just an explanation this
time.

~ curtis

knowledge is power - growing old is mandatory - growing wise is optional    
"Many more men die with prostate cancer than of it. Growing old is
invariably fatal. Prostate cancer is only sometimes so."
Glenn Enoch - 23 Jun 2004 03:49 GMT
Two questions:  From the article..."69 percent of patients who
received radiation therapy within six months of surgery showed no
signs of the prostate cancer returning while 31 percent of patients
who did not have radiation at all or had radiation after the cancer
recurred."

That last bit is not a complete sentence.  31 percent of patients who
did not have radiation or had radiation after the cancer recurred
WHAT?

Also: "The risk of death from localized prostate cancer was also
significantly lower in the radiation therapy group."  How do you die
from localized prostate cancer?

I went to the ASTRO website for more information, and could not find
anything on this study.  The last press release I could find was on a
similar, but different, study.

> From: res0rbp6@nospam.verizon.net (ronju99)
> Curtis,
[quoted text clipped - 65 lines]
> "Many more men die with prostate cancer than of it. Growing old is
> invariably fatal. Prostate cancer is only sometimes so."
ronju99 - 22 Jun 2004 12:59 GMT
In further studing the article, I assume they examined the prostates after
surgery and found that one group had 93% localized cancer and the other
group had 63% localized cancer. My question is how could a random
selection process have such a disparity. It seems that the untreated group
didn't have much of a chance for success if 37% of them had cancer that
wasn't localized. The study seems quite bias.
Ron
ronju99 - 22 Jun 2004 14:14 GMT
The article is a study of patients with adverse pathologic findings ie;
Stage t2b toT4, extracapsular extension, positive resection margins,
gleason score equal>7, and or positive lymph nodes. The conclusion states
that ERT within 6 months after surgery improves survival rates for the
advance cases. The only problem I see is that they still try to label
these cases as localized by the pre-op numbers. When in fact they state
that the study is on cases of advanced cancer,(outside the prostate). Many
seem to miss the point in that your pre-op numbers don't guarentee organ
confined cancer yet the studies like to use the word localized for
comparison purposes when in fact the cancer is not localized.
Ron  
 
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