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Medical Forum / Diseases and Disorders / Prostate Cancer / May 2004

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Effect of chondroitin on PCa

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John Brockhouse - 28 May 2004 21:06 GMT
I have been taking a combination of Glucosomine/Chondroitin for a long
time called TripleFlex. Upon reading concerns about this subject on the
NG about  Dr. Charles Myers stating  chondroitin may cause the PCa to
mestasize, I decided to email the author of "The Arthritis Cure", the
New York Times #1 bestseller in which he loudly praises TripleFlex and
other brands he names to prevent and control pain in joints and to
preserve cartilage from erosion.  
   If you will goto Drtheo.com, you will see that he is not a con
artist or pushing snake oil.  Better yet, you can buy the paperback in
most bookstores.
   I emailed him a copy of Dr. Myers article and this was the reply I
received this morning:
 "His reasoning is totally flawed. The chondroitin could be in response
to the cancer, not the cause. This occurs with calculation supplements
causing breast cancer!"
   By the way, I started my father on chondroitin after he was
diagnosed and treated for aggressive PCa, and 4 years later, his PSA is
still zero.  Shows you how concerned I am about this.
               Dr. Theo
    In my  earlier research, one doctor said if Myers was correct about
chondroitin, the same would be true of calcium in the formation of
plaque, etc in the arteries. To follow this line, you would need to stop
drinking milk, taking Calcium supplements, etc.
   As Steve would say, "I'm not a doctor, but I am going to keep on
taking chondroitin and save my joints and cartilage."
                   John in OR
Leonard Evens - 29 May 2004 20:52 GMT
> I have been taking a combination of Glucosomine/Chondroitin for a long
> time called TripleFlex. Upon reading concerns about this subject on the
[quoted text clipped - 22 lines]
> taking chondroitin and save my joints and cartilage."
>                     John in OR

There is an association between too much calcium in the diet and the
development of prostate cancer.   Also, there is an association with
more aggressive prostate cancers.   Several nutritional studies seem to
have shown that. From what I've seen, the association is air tight, but
I think anyone who has or has had prostate cancer would be prudent not
to take calcium supplements or to include too much calcium in his diet.
  On the other hand, too little calcium can also lead to health
problems,  so it is a matter of balance.   In addition, those on hormone
suppressing therapy may end up with osteoporosis and may need calcium
supplements for that.   That would be the greater risk to that of
encouraging the cancer from the calcium, which as I said is uncertain at
best.   According the Walsh's book, calcium may interfere with Vitamin D
metabolism and that may be what the problem is.   He suggests that one
may be able to counteract the effect by eating plenty of fruit.   That
is probably a good idea anyway, so even if it doesn't help the cancer,
it can't hurt.

I thought that glucosamine had been shown to help with arthritis and has
few side effects, but that the helpful effect of condroitin was
questionable and it does have side effects.   It might be prudent to
switch to just using glucosamine.  I've tried to get my wife to use it
for her arthritis, and she says it does help, but it also upsets her
digestion, so she hasn't been using it.   If anyone knows some way to
deal with that side effect of glucosamine,  let me know.
John Brockhouse - 30 May 2004 03:39 GMT
Leonard,
 Please furnish website or literature stating too much calcium causes
prostate cancer.  
  I have been taking a supplement consisting of 500mg Calcium + Vitamin
D, a combination of both.  A lack of calcium in the diet of elderly
folks can cause  bone and joint deterioration.  It would be a serious
mistake to stop taking calcium supplement thinking it will cause PCa.
                  John in OR
Leonard Evens - 30 May 2004 04:27 GMT
> Leonard,
>   Please furnish website or literature stating too much calcium causes
> prostate cancer.

Walsh mentions it in Guide to Surviving Prostate Cancer.  He says that
high calcium levels in the blood may interfere with Vitamin D
accessibility.   Vitamin D tends to protect against cancer, but if it
can't get where it needs to go, you have a problem.  He goes on to say
that fructose may prevent the calcium from doing that, so a diet high in
fruit may help.  At least that is the theory.

I'm afraid I don't have the exact references handy, but I've seen
references on the web to two studies.   One I managed to find some
detail on.  It was done by some nutritionists at Harvard, I think, who
looked at a large group of physicians in the Boston area.   They found
that men who had the equivalent of four or more glasses of milk a day in
their diets were more likely to have been diagnosed with prostate cancer
than men who had little calcium in their diets.  But the problem with
studies of this kind is that there may be confounding factors.

You can probably find such studies by doing a medline/pubmed search on
prostate cancer and calcium.   Medline is available at
www.ncbi.nlm.nih.gov/pubmed
If you can't find anything, let me know and I will try a search.

>    I have been taking a supplement consisting of 500mg Calcium + Vitamin
> D, a combination of both.  A lack of calcium in the diet of elderly
> folks can cause  bone and joint deterioration.  It would be a serious
> mistake to stop taking calcium supplement thinking it will cause PCa.

I agree that cutting out calcium entirely would be a serious mistake.
The question is just how much one should have in one's diet.   Myself, I
limit myself to the equivalent of something like two to three glasses of
milk a day and I eat fruit and drink fruit juice.

>                    John in OR
John Brockhouse - 31 May 2004 01:59 GMT
Leonard,
 Thanks for your post.  As for calcium, all of the articles I have read
the majority of doctors recommend calcium supplements for the elderly,
up to a 1000mg/da, depending on if you drink milk and take a
multivitamin.  Also, chondoitin sulfate for back and knees.
                       John
Leonard Evens - 30 May 2004 04:11 GMT
>> I have been taking a combination of Glucosomine/Chondroitin for a long
>> time called TripleFlex. Upon reading concerns about this subject on the
[quoted text clipped - 27 lines]
> more aggressive prostate cancers.   Several nutritional studies seem to
> have shown that. From what I've seen, the association is air tight,

Oops!  I meant to say it is NOT airtight!

> but
> I think anyone who has or has had prostate cancer would be prudent not
[quoted text clipped - 17 lines]
> digestion, so she hasn't been using it.   If anyone knows some way to
> deal with that side effect of glucosamine,  let me know.
 
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