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Medical Forum / Diseases and Disorders / Prostate Cancer / May 2004

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Selenium and advanced PCa

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Alan Meyer - 06 May 2004 03:49 GMT
There is some new evidence that selenium may help
prevent advanced forms of prostate cancer.  See

http://www.reutershealth.com/archive/2004/05/04/eline/links/20040504elin017.html

or

http://story.news.yahoo.com/news?tmpl=story&cid=97&ncid=751&e=11&u=/hsn/20040505
/hl_hsn/antioxidantmaypreventprostatecancer


There is a clinical trial going on testing selenium
and vitamin E.  See: http://www.crab.org/select/
and http://www.cancer.gov/clinicaltrials/digestpage/SELECT/

  Alan
Leonard Evens - 06 May 2004 13:11 GMT
> There is some new evidence that selenium may help
> prevent advanced forms of prostate cancer.

My experience so far is at least not inconsistent with that.  I started
taking 200 micrograms of selenium daily in the middle 90s on the
recommendation of my primary care physician.  Later I began to worry
about the possible side effects of too much selenium, so I stopped for a
while.   The problem is that it is easy to overdose on selenium since it
is also a normal part of a healthy diet.  But when my PSA started
increasing, I went back to using it.  My PSA actually decreased from a
high of 4.5 to 3.8, but that may have been normal statistical variation.
 Also, although my biopsy showed a Gleason 7=3+4, the post surgical
biopsy showed no change in the Gleason and the cancer was confined to
the prostate.  Of course, it is impossible to know if the selenium had
any effect in slowing down the development of my cancer.

More recently, I've looked at the details of the study currently
underway comparing selenium + vitamin E with a placebo, and I concluded
that 200 micrograms daily is safe.   But since the upper limit is
something like 400 micrograms daily, one has to be careful about
multivitamins containing selenium and the rest of one's diet.

I plan to continue with selenium + Vitamin E in the hopes that it will
lower the risk of recurrence, unless of course future studies show no
effect for prostate cancer or other cancers.

>  See
>
[quoted text clipped - 9 lines]
>
>    Alan
Steve Kramer - 07 May 2004 04:16 GMT
I started taking Selenium and Vitamin E at the direction of my uro when I
started HT.  My PSA is down to 0.05.  Was it the Selenium?  Vitamin E?
Lupron?  Hmmmmmmmmmmm

Signature

Prostate Cancer Survivor (so far), not a doctor
PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000
PSA  .1  .1  .1  .27  .37  .75
EBRT 05-07/2002 @ 47
PSA  .34 .22 .15 .21 .32
Erection 05/12/2003 @ 48
HTbegins 07/21/2003 @ 48
PSA  .07 .05
Lupron 7/03, 8/03, 12/03, 4/04

> > There is some new evidence that selenium may help
> > prevent advanced forms of prostate cancer.
[quoted text clipped - 23 lines]
>
> >  See

http://www.reutershealth.com/archive/2004/05/04/eline/links/20040504elin017.html

> > or

http://story.news.yahoo.com/news?tmpl=story&cid=97&ncid=751&e=11&u=/hsn/20040505
/hl_hsn/antioxidantmaypreventprostatecancer


> > There is a clinical trial going on testing selenium
> > and vitamin E.  See: http://www.crab.org/select/
> > and http://www.cancer.gov/clinicaltrials/digestpage/SELECT/
> >
> >    Alan
 
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