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Medical Forum / Diseases and Disorders / Prostate Cancer / March 2004

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Is there a link between Vasectomy and Prostate Cancer?

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Rose - 29 Mar 2004 06:49 GMT
Twenty years ago my doctor urged me to urge my husband to get a
vasectomy in order for our family to avoid the risks associated with
pregnancy in middle age. We weren't planning to have any more
children; and according to the doctor, it was a much easier procedure
to 'fix' my husband instead of me. My husband agreed to have the
procedure without much fuss; however, after the procedure he seemed to
have regrets.  He complained of some pain for months, and he was
somewhat unhappy with me for asking him to have the procedure in the
first place.  Well, then one day he heard some troubling information
on the radio which seemed to link vasectomy to an increased risk for
prostate cancer. This troubled him and me, but eventually our concerns
were placed on the back burner and life went on.  Of course, as soon
as he was diagnosed with prostate cancer in June of 2003, he again
mentioned the possibility of a link between the two.  I felt like he
was blaming me for causing his cancer. My friend consoled me and said,
"You don't have that much power." However, I did some research on the
internet, and I actually found that there have been some studies that
found a link between vasectomy and prostate cancer.  My husband even
asked his urologist about it; the urologist's answer was somewhat
vague, but he said he didn't think that it had really been proven.
Well, I haven't given it too much more thought, and my husband didn't
mentioned it again until yesterday.

During a discussion about our increasing despair over unrelenting
erectile dysfunction since surgery four months ago, he mentioned that
perhaps the vasectomy is responsible for his poor response to all ED
medicines (including 6 injections in increasing doses up to 40
micrograms). Of course, he might as well have punched me in the gut.
It can't be proven I suppose, but he sure has it in his head that
there is some connection between that vasectomy and our current
suffering.

Since our discussion I've been wondering if anyone else has similar
concerns?
Alan Meyer - 29 Mar 2004 07:18 GMT
Rose,

I don't know whether there is a correlation between vasectomy
and prostate cancer.  Even if there is, there is no way of knowing
whether it was a factor in your husband's case.

Sometimes bad things happen to us.  Sometimes it seems like
we do the right things and bad things still happen.  I never had
a vasectomy.  I always ate lots of vegetables, and other foods
like green tea that are supposed to prevent cancer.  I always
exercised a lot.  I had no cancer in my family.  Yet I got cancer.

sh.t happens.  You don't need a vasectomy to have it happen to
you.  He may very well have gotten cancer without having a
vasectomy.  I certainly did, and so did the vast majority of men
who have had it.

Your husband is feeling sorry for himself.  Who wouldn't
when he's had cancer, had to go through this nasty treatment
and had these nasty after effects.

I felt sorry for myself too.  All of us did.  But now is the time
for the two of you to pull together.  However bad he feels, he'll
feel worse if he allows himself to turn against the most important
person in his life.  However bad you feel, you'll feel worse if you
turn against him.

I strongly urge your husband to forget his recriminations.  They
are pointless and self-destructive.  I strongly urge you to forget
them too.  They are coming from your husband's depression over
the hard things that have happened to him.  I urge both of you to
offer each other love and support, and I promise that everything
you give to each other will come back to you as well.

Marital counseling may help you to make this happen.

Best of luck to both of you.

   Alan

> Twenty years ago my doctor urged me to urge my husband to get a
> vasectomy in order for our family to avoid the risks associated with
[quoted text clipped - 30 lines]
> Since our discussion I've been wondering if anyone else has similar
> concerns?
c palmer - 29 Mar 2004 09:57 GMT
here's an article on the subject.  hope this helps ~ curtis

Vasectomy & Prostate Cancer

           Many studies have looked for possible
long-term health problems associated with vasectomy. Almost without
fail, concerns that have arisen in one study have been disproved in
others. The one question that has remained throughout many years is
whether prostate cancer risk increases after vasectomy. In the space
below, I'll give you the representative data, and let you see why nobody
is sure. If there is an increased risk, it is very small.
           Until 1993, there were about an equal
number of studies that claimed vasectomy was not associated with
increase risk for prostate cancer as said it was. At least one study
even found it protective against prostate cancer. Then, two large
studies by the same principal author were published in the February 1993
issue of the Journal of the American Medical Association (JAMA).
          The first was a 'prospective' study, meaning
that the data was collected as the study was done, with this specific
question in mind. Approximately 10,000 men who had had vasectomies, and
about 38,000 who did not (but appeared to have the same characteristics
in every other regard), were sent questionnaires every six months. These
questionnaires collected data on any significant change in health over
the preceding six months. Over the four-year course of the study,
approximately 300 new prostate cancers were detected. The men who had
had vasectomy were just over 1.5 times as likely as those that did not
have vasectomy to develop prostate cancer.
          The second study was 'retrospective',
meaning the study pulled data from medical charts that already existed
(these are generally considered slightly less reliable than prospective
studies). This study had approximately 15,000 men who had had vasectomy
compared with 15,000 men that had not. The results were virtually the
same as in the first study. If these large studies are accurate, it
means the risk of developing prostate cancer after vasectomy goes from 7
per 1000 men per year to 11 per 1000 men per year, or just over a 60%
increase. But there are reasons to question numbers even from these
large studies, which I'll go into later.
          Other researchers have turned the question
around - If a man already has prostate cancer, what are the odds he has
had a vasectomy sometime before? The reasoning is that if there were an
association between the two, certainly more people with prostate cancer
would have had a vasectomy than those in the general population.
          One such study was published in June of
1999, and overall demonstrated no difference. Sixteen percent of men
with prostate cancer had had a vasectomy, while fifteen percent who were
healthy had had a vasectomy. In this study, though, men who had prostate
cancer under the age of 55 were almost twice as likely to have had a
vasectomy. Another such study was published in October of 1999. Enrolled
were 753 men with prostate cancer and 703 who were healthy. The odds of
having had a vasectomy were almost identical - 39% of the prostate
cancer group compared with 37% of the healthy control group.
Interestingly, the tumours in the group with vasectomy tended to be less
aggressive. The difference between the two studies in the percent of men
having vasectomy at all is a quirk of the Unites States - it has been
previously demonstrated that men in the East (the first study) are much
less likely to get a vasectomy than men in the West (the second study)!
          Why don't people accept these numbers at
face value? Because every study has biases, or unseen influences that
are hard to account for. What if the men who had vasectomies on average
had more unprotected sex with more partners (not everyone, but just a
few of them!)? Theories have been put forward that prostate cancer may
have a link with previous venereal disease. That would mean it wasn't
the vasectomy that caused the problem, but rather what the man did with
it. We have no data on this.
          What if some of the men who had vasectomies
said to their doctors, "While you are down there can you check something
else for me - I haven't been urinating as well as I used to"? These men
would be more likely to have an earlier pick-up of a prostate cancer.
Already, in separate studies, it has been demonstrated that men who have
vasectomies are more health conscious than others, so would on average
have more routine health checks, and so have more chance of picking up
an early prostate cancer. These factors are called detection biases, in
this case potentially making it look like vasectomy was associated with
prostate cancer, when in fact it was not.
          Finally, there is one factor that cannot be
overlooked. There is a small but measurable increase in serum
testosterone after a vasectomy. Testosterone is known as a promoter of
already established prostate cancers. This may be the missing link as to
why there is seen to be a small increase in prostate cancer after
vasectomy in some studies. But again there is missing information. Would
men who have not had a vasectomy have developed the same tumours but at
a later date? Are the tumours that arise in vasectomized men
qualitatively different, e.g. less aggressive as suggested in one study,
than those in men without a vasectomy are? We do not have answers to
these questions yet.
          So, the final answer is not in. The worst
case scenario is a very weak link. You have to decide if that
uncertainty is acceptable to you. Remember though, even if this reported
weak link is accurate, vasectomy still has the lowest risk of causing
illness or death compared with the birth control pill, tubal ligation,
or having another baby. Women have accepted those risks for a long time!
 

knowledge is power - growing old is mandatory - growing wise is optional
trifold - 29 Mar 2004 21:00 GMT
PALMER ENT@webtv.net (c palmer) wrote in message news:

This is a very nice summary, although I am inclined to view studies
that account for detection bias as the most convincing--and these, I
think, agree that there is no association.  Do you have a source for
the article below?  It might be useful at a website I know about
(which links to numerous medical articles as well as general info.
about vasectomy procedures, complications, etc, and stories submitted
by men who have been through vasectomy), and we would like to include
citation inforamtion if possible.

trifold
www.vasectomy-information.com

<11603-4067E4E5-232@storefull-3197.bay.webtv.net>...
> here's an article on the subject.  hope this helps ~ curtis
>
[quoted text clipped - 90 lines]
>
> knowledge is power - growing old is mandatory - growing wise is optional
trifold - 29 Mar 2004 21:13 GMT
> here's an article on the subject.  hope this helps ~ curtis

I should have mentioned the website I referenced (url below) includes
a link to a summary review of the vasectomy literature published in
2000 (Schwigle and Guess, "Safety and Effectiveness of Vasectomy,"
Journal of Fertility and Sterility, 2000).  One point it makes re:
detection bias is that up until relatively recently, the American
Urological Association recommended that vasectomised men be screened
for prostate cancer ealier and more regularly than non-vasectomised
men.  I believe this recommendation derived from the reports of higher
serum T in vasecotmised men, as you noted.  In any case, the practice
of earlier screening would naturally have led to earlier detection,
giving the impression of an association.   Subsequent research that
cast doubt on an association has since led the American Urological
Assocation to revise its former recommendation.  (BTW, I have seen at
least one medical article suggesting that the observations of higher T
levels in vasectomised men later into life may be unreliable:  the
author makes the point that men with higher T levels may choose
vasectomy more often than others:  so rather than vasectomy causing
higher T levels, higher T levels might cause vasectomy!)

trifold
www.vasectomy-information.com
trifold - 29 Mar 2004 21:16 GMT
For what it is worth, the American Urological Assocation's take on the
issue (c. 2002):

Vasectomy and Prostate Cancer (AUA 11/02)
(http://www.auanet.org/aboutaua/policy_statements/services.cfm#vasectomy)

The American Urological Association Inc. (AUA) is aware of the recent
controversy surrounding prostate cancer risk following vasectomy.
However, the association feels that vasectomy is a safe method of
surgical sterilization and men need not worry about an increased risk
of developing prostate cancer after the procedure. Clinicians should
be confident in advising their patients about the benefits and risks
of surgical sterilization.

Two papers in the Journal of the American Medical Association (JAMA)
in 1993 raised the
possibility that vasectomy resulted in the increased incidence of
prostate cancer. The AUA
immediately formed a committee composed of Drs. John Grayhack, Patrick
Walsh, Donald
Coffey, Bert Peterson and Stuart Howards. This committee reviewed all
the available data,
and then formulated a position paper for the AUA, which stated that
evidence was not
convincing and that it was unlikely there was a relationship between
vasectomy and prostate
cancer. This opinion was based on the fact that the relationship was
extremely weak
although statistically significant in that there was no biologic
rationale. The committee did
recommend that clinicians advise patients who requested a vasectomy of
the fact that some
investigators felt there might be a relationship between vasectomy and
prostate cancer.
Soon after the AUA position paper, the National Institutes of Health
(NIH) convened a
conference involving Dr. Howards and many epidemiologists. The
consensus statement of
the NIH conference was that there was no convincing evidence of a
relationship been
vasectomy and prostate cancer and the NIH did not even recommend
informing patients of
the previous publications.

Since that time a large number of papers have been published which
include more patients
at risk for many more patient years than did the first two
manuscripts. None of these papers
have documented a relationship between vasectomy and prostate cancer.
In 1998
Bernal-Delgado and Associates reviewed 14 existing papers on this
subject including five
cohort and nine case-control studies. Relative risk shown in these
studies ranged between
.44 and 6.75. The overall relative risk was not significant. They
concluded that there was no
casual relationship between vasectomy and prostate cancer. They also
concluded that
individuals who had undergone vasectomy are not at higher risk for
developing prostate
cancer. These authors did a population-based control study of 923 new
cases of prostate
cancer from the New Zealand Cancer Registry. They found there was no
association between prostate cancer and vasectomy.

A June 2002 JAMA article provided reassuring data that indicated no
correlation between
prostate cancer risk and vasectomy. More than 1,000 men with prostate
cancer and 1,800
men without the disease were contacted in a large retrospective study
in New Zealand. Men
were asked about various health data, including a history of having
undergone a vasectomy;
9 percent of cancer patients and 10 percent of controls had undergone
the procedure. The
relative risk of prostate cancer was not increased in patients who had
undergone vasectomy
in the past.

In summary, papers published over the last nine years have
conclusively documented that
there is no increased risk of prostate cancer after vasectomy.
Therefore, it is no longer
imperative to inform patients of a possible risk and it is very safe
to use vasectomy as a
form of male sterilization.

1.Fertility and Sterility, 1998: Vol. 70, Page 191-200)
2.Cox et al, JAMA 287, page 3110-3115, 2002

Board of Directors, November 2002
Ray Walsh - 29 Mar 2004 11:06 GMT
Rose

In 1972 at the age of 32 I had a vasectomy. Not long after, I read a study
that said all men who had had a vasectomy was at greater risk of a heart
attack. Seeing that the operation was past history and I have a philosophy
of "Don't worry about things I can't control", I put the study out of my
mind and forgot about it until I read your post today.

I had RRP in December 2000.

Between 1972 and 2000 (and now) I have had no heart problems, so at least
for me, that blew the heart attack report out of the water. Apart from a
cardiac arrest while having the op (hypersensitivity to the aneasthetic) I
had no problems. I had the op on Tuesday, took 2 days off work and on
Saturday played in an all-day lawn bowls competition. For me, the physical
and emotional effects of the vasectomy were minimal. However, I know many
who reacted in a similar way to your husband.

From 1972 until the RRP I had never had a problem with ED. Erections were
strong, lasted at least as long as they needed to, and appeared as and when
required. Therefore, I'm happy to declare that in this regard, the vasectomy
had no effect -- again with the proviso that this relate only to me.

After the RRP with no nerve sparing total and complete ED. I was expecting
it but it still came as a bit of a shock. I went to an impotence clinic for
a consultation. When I told the doc my history, plus being a diabetic, plus
having high blood pressure and being on medication for it, plus being 61
when I saw him, he just smiled and suggested that any solution was wishful
thinking.

When I commented that I'd had absolutely no problem prior to the RRP he just
smiled condescendingly and gave the impression he thought I was deluding
myself. Anyway, he gave me an injection of the magic potion and told me to
wait for 20 minutes. On his return he asked how things were. I replied that
things were pretty good, and again he replied with a dismissive smile and
said "don't tell me, show me." I did. His eyes opened wider and he just
commented "I'm impressed!"

I've related this in detail because in my case, I think this gives some
evidence that the vasectomy had no effect on ED. What it does for others I
couldn't say.

Unfortunately the injections were too successful. They were not painful or
unpleasant but I seemed to be hypersensitive to the ingredients. No matter
how diluted thay made the prescription, I always ended with an erection that
lasted for at least 4 hours and was very, very painful. So my wife and I
just found alternative ways of maintaining that aspect of our relationship.
Signature

Ray Walsh
Armadale WA 6992 Australia

> Twenty years ago my doctor urged me to urge my husband to get a
> vasectomy in order for our family to avoid the risks associated with
[quoted text clipped - 30 lines]
> Since our discussion I've been wondering if anyone else has similar
> concerns?
MrBill - 29 Mar 2004 15:52 GMT
Rose,
I also had a Vasectomy 25 years ago and I ask my URO the same
question.  He said from the studies they have not been able to make
the connection.  I think like Alan said, sh.t happens.
My Robitic RP was 12/15/2003 and I have been optimestic looking for
the erection to return but am also being a realist to not expect it
until atleast 8 months out if not further.  I am looking forward to
the celebration for when it does, and I am sure my wife is too.  But
until then, just wrap your arms around each other and consider it many
months of renewing your courtship or foreplay.  It can be nice
focusing on each other instead of satisfying "Mr. Long John".  And
this is coming from a 48 year old that could still be considered in my
prime.

Bill
PSA 1.4
Gleason 6 (3+3)
T2a
age 48

> Twenty years ago my doctor urged me to urge my husband to get a
> vasectomy in order for our family to avoid the risks associated with
[quoted text clipped - 30 lines]
> Since our discussion I've been wondering if anyone else has similar
> concerns?
Dave Perry - 29 Mar 2004 21:02 GMT
I had a vasectomy over 30 years ago and of course started to hear all
the gloom and doom related stuff right after.  First, there was
supposed to be a connection between vasectomy and heart disease.
Turned out to be no connection.  Then more recently I heard about a
connection between vasectomy and prostate cancer.  Read about a year
ago, I cannot remember where, that the connection had been disproven.
Like others have said, bad things can happen no matter what you do or
do not do.  I thought for many years that using a selenium based
shampoo daily all my adult life would protect me from prostate cancer.
No such luck.  The shampoo was re-formulated a couple of years ago
because of fear of overdose.  Maybe I overdosed on selenium.  Anyway,
there is nothing anyone can do about stuff in the past.  We all can
make the best of the future though.
Dave Perry
Leonard Evens - 29 Mar 2004 18:06 GMT
> Twenty years ago my doctor urged me to urge my husband to get a
> vasectomy in order for our family to avoid the risks associated with
[quoted text clipped - 30 lines]
> Since our discussion I've been wondering if anyone else has similar
> concerns?

Rose,

Four months is still early days for return of erections.  I don't know
if the Vasectomy increased the risk of prostate cancer,  but it seems
higly unlikely that it had any effect on post surgical impotence.   Your
husband is clearly having a hard time adusting to his situation.  Your
best strategy is to be as supportive as possible. trying not to take it
personally.

Note also that even if the risk of prostate cancer is increased by
vasectomy, it is not by a large amount.  Biostatisticians don't get too
excited by a 50 percent increase, particularly if there could be
confounders, i.e. other factors explaining both the increased risk of pc
and the decision to have a vasectomy in the first place.
jk - 29 Mar 2004 19:49 GMT
 If he insists on making you feel guilty and miserable, I say trade him in!
LOL.... As for ED probs... it's only a few months for him. Give the nerves
and system a chance to heal up and reconnect. I'm sexually active and at 18
months post RP, and still feel like it's improving.

Signature

JK Sinrod
Sinrod Stained Glass Studios
www.sinrodstudios.com
Coney Island Memories
www.sinrodstudios.com/coneymemories

Steve Kramer - 29 Mar 2004 22:52 GMT
Rose,

I'm sorry you are having these thoughts.  I suggest you discuss them with
him.  At the very least, he can tell you whether he honestly believes the
Big V caused his PCa and, more importantly, if he believes you are
responsible for his PCa.  I suspect it is more in your mind than in his.

As to vasectomy-caused PCa, I'm sure in every bit of research you saw not
one 'finding' that it causes PCa.  There are so many things that might cause
or could cause or maybe is associated with PCa and yet nothing has been
shown to actually cause it or be associated with it except that 100% of the
patients are male and if your father had it at an early age (mid-40s) you
have a slightly increased chance of getting it.

As to vasectomy and ED, that's just so much nonsense.  You need to study
anatomy.  All they do is cut the vas to stop the microscopic sperm from
getting to the rest of the glands and organs.  The prostate is literally the
second last stop for sperm and by then it is surrounded by so much fluid it
is hardly noticed by the prostate.  That's why when we get a prostatectomy,
our 'ejaculant' is bone-dry, or very nearly so.

Signature

Prostate Cancer Survivor (so far), not a doctor
PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000
PSA  .1  .1  .1  .3  .4  .8
EBRT 05-07/2002 @ 47
PSA  .3 .2  .2  .2 .3
Erection 05/12/2003 @ 48
HTbegins 07/21/2003 @ 48
PSA  .1
Lupron 7/03, 8/03, 12/03

> Twenty years ago my doctor urged me to urge my husband to get a
> vasectomy in order for our family to avoid the risks associated with
[quoted text clipped - 30 lines]
> Since our discussion I've been wondering if anyone else has similar
> concerns?
Rebecca Ford - 30 Mar 2004 01:56 GMT
Sorry you have to be here. My husband's vasectomy saved his life. He had one
Oct '02 at age 42 and ended up with an infection. The doc decided to do a
psa which was elevated. Three more psas and one biopsy later my hubby had an
RRP June '03 at 43. He has had no incontinence or ED. His 45 year old
brother was diagnosed and had an RRP Aug '03 and is still having ED,
although he need a nerve graft due to loss of one of the nerve bundles. He
never had a vasectomy.

There is no blame in prostate cancer. It's the luck of the draw. Trust me. I
never thought I'd be faced with these issues at only 35 with two small kids
in tow. I hope life improves for both of you. Don't look back, just live for
now.

Signature

Rebecca Ford

> Twenty years ago my doctor urged me to urge my husband to get a
> vasectomy in order for our family to avoid the risks associated with
[quoted text clipped - 30 lines]
> Since our discussion I've been wondering if anyone else has similar
> concerns?
Rose - 30 Mar 2004 14:39 GMT
> Sorry you have to be here. My husband's vasectomy saved his life. He had one
> Oct '02 at age 42 and ended up with an infection. The doc decided to do a
[quoted text clipped - 8 lines]
> in tow. I hope life improves for both of you. Don't look back, just live for
> now.

Yes, I guess it is just the luck of the draw.  Still it is natural to
wonder Why? when your life has changed so dramatically. Years ago I
asked the same thing. I had surgery when I was 20 years old; and it
didn't go well, so I have had to take medication and be under a
doctor's care for 30 something years.  About 25 years ago I asked my
doctor Why?  He said, "Well, I guess it was because I need a new
Cadillac."  I suppose it was his way of telling me that there is no
way to answer that question, but I never went back to him.  At the
time I really wanted to know Why?  Thirty-three years later I don't
wonder about it anymore; it is just my reality.
 
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