Medical Forum / Diseases and Disorders / Prostate Cancer / March 2004
Is there a link between Vasectomy and Prostate Cancer?
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Rose - 29 Mar 2004 06:49 GMT Twenty years ago my doctor urged me to urge my husband to get a vasectomy in order for our family to avoid the risks associated with pregnancy in middle age. We weren't planning to have any more children; and according to the doctor, it was a much easier procedure to 'fix' my husband instead of me. My husband agreed to have the procedure without much fuss; however, after the procedure he seemed to have regrets. He complained of some pain for months, and he was somewhat unhappy with me for asking him to have the procedure in the first place. Well, then one day he heard some troubling information on the radio which seemed to link vasectomy to an increased risk for prostate cancer. This troubled him and me, but eventually our concerns were placed on the back burner and life went on. Of course, as soon as he was diagnosed with prostate cancer in June of 2003, he again mentioned the possibility of a link between the two. I felt like he was blaming me for causing his cancer. My friend consoled me and said, "You don't have that much power." However, I did some research on the internet, and I actually found that there have been some studies that found a link between vasectomy and prostate cancer. My husband even asked his urologist about it; the urologist's answer was somewhat vague, but he said he didn't think that it had really been proven. Well, I haven't given it too much more thought, and my husband didn't mentioned it again until yesterday.
During a discussion about our increasing despair over unrelenting erectile dysfunction since surgery four months ago, he mentioned that perhaps the vasectomy is responsible for his poor response to all ED medicines (including 6 injections in increasing doses up to 40 micrograms). Of course, he might as well have punched me in the gut. It can't be proven I suppose, but he sure has it in his head that there is some connection between that vasectomy and our current suffering.
Since our discussion I've been wondering if anyone else has similar concerns?
Alan Meyer - 29 Mar 2004 07:18 GMT Rose,
I don't know whether there is a correlation between vasectomy and prostate cancer. Even if there is, there is no way of knowing whether it was a factor in your husband's case.
Sometimes bad things happen to us. Sometimes it seems like we do the right things and bad things still happen. I never had a vasectomy. I always ate lots of vegetables, and other foods like green tea that are supposed to prevent cancer. I always exercised a lot. I had no cancer in my family. Yet I got cancer.
sh.t happens. You don't need a vasectomy to have it happen to you. He may very well have gotten cancer without having a vasectomy. I certainly did, and so did the vast majority of men who have had it.
Your husband is feeling sorry for himself. Who wouldn't when he's had cancer, had to go through this nasty treatment and had these nasty after effects.
I felt sorry for myself too. All of us did. But now is the time for the two of you to pull together. However bad he feels, he'll feel worse if he allows himself to turn against the most important person in his life. However bad you feel, you'll feel worse if you turn against him.
I strongly urge your husband to forget his recriminations. They are pointless and self-destructive. I strongly urge you to forget them too. They are coming from your husband's depression over the hard things that have happened to him. I urge both of you to offer each other love and support, and I promise that everything you give to each other will come back to you as well.
Marital counseling may help you to make this happen.
Best of luck to both of you.
Alan
> Twenty years ago my doctor urged me to urge my husband to get a > vasectomy in order for our family to avoid the risks associated with [quoted text clipped - 30 lines] > Since our discussion I've been wondering if anyone else has similar > concerns? c palmer - 29 Mar 2004 09:57 GMT here's an article on the subject. hope this helps ~ curtis
Vasectomy & Prostate Cancer
Many studies have looked for possible long-term health problems associated with vasectomy. Almost without fail, concerns that have arisen in one study have been disproved in others. The one question that has remained throughout many years is whether prostate cancer risk increases after vasectomy. In the space below, I'll give you the representative data, and let you see why nobody is sure. If there is an increased risk, it is very small. Until 1993, there were about an equal number of studies that claimed vasectomy was not associated with increase risk for prostate cancer as said it was. At least one study even found it protective against prostate cancer. Then, two large studies by the same principal author were published in the February 1993 issue of the Journal of the American Medical Association (JAMA). The first was a 'prospective' study, meaning that the data was collected as the study was done, with this specific question in mind. Approximately 10,000 men who had had vasectomies, and about 38,000 who did not (but appeared to have the same characteristics in every other regard), were sent questionnaires every six months. These questionnaires collected data on any significant change in health over the preceding six months. Over the four-year course of the study, approximately 300 new prostate cancers were detected. The men who had had vasectomy were just over 1.5 times as likely as those that did not have vasectomy to develop prostate cancer. The second study was 'retrospective', meaning the study pulled data from medical charts that already existed (these are generally considered slightly less reliable than prospective studies). This study had approximately 15,000 men who had had vasectomy compared with 15,000 men that had not. The results were virtually the same as in the first study. If these large studies are accurate, it means the risk of developing prostate cancer after vasectomy goes from 7 per 1000 men per year to 11 per 1000 men per year, or just over a 60% increase. But there are reasons to question numbers even from these large studies, which I'll go into later. Other researchers have turned the question around - If a man already has prostate cancer, what are the odds he has had a vasectomy sometime before? The reasoning is that if there were an association between the two, certainly more people with prostate cancer would have had a vasectomy than those in the general population. One such study was published in June of 1999, and overall demonstrated no difference. Sixteen percent of men with prostate cancer had had a vasectomy, while fifteen percent who were healthy had had a vasectomy. In this study, though, men who had prostate cancer under the age of 55 were almost twice as likely to have had a vasectomy. Another such study was published in October of 1999. Enrolled were 753 men with prostate cancer and 703 who were healthy. The odds of having had a vasectomy were almost identical - 39% of the prostate cancer group compared with 37% of the healthy control group. Interestingly, the tumours in the group with vasectomy tended to be less aggressive. The difference between the two studies in the percent of men having vasectomy at all is a quirk of the Unites States - it has been previously demonstrated that men in the East (the first study) are much less likely to get a vasectomy than men in the West (the second study)! Why don't people accept these numbers at face value? Because every study has biases, or unseen influences that are hard to account for. What if the men who had vasectomies on average had more unprotected sex with more partners (not everyone, but just a few of them!)? Theories have been put forward that prostate cancer may have a link with previous venereal disease. That would mean it wasn't the vasectomy that caused the problem, but rather what the man did with it. We have no data on this. What if some of the men who had vasectomies said to their doctors, "While you are down there can you check something else for me - I haven't been urinating as well as I used to"? These men would be more likely to have an earlier pick-up of a prostate cancer. Already, in separate studies, it has been demonstrated that men who have vasectomies are more health conscious than others, so would on average have more routine health checks, and so have more chance of picking up an early prostate cancer. These factors are called detection biases, in this case potentially making it look like vasectomy was associated with prostate cancer, when in fact it was not. Finally, there is one factor that cannot be overlooked. There is a small but measurable increase in serum testosterone after a vasectomy. Testosterone is known as a promoter of already established prostate cancers. This may be the missing link as to why there is seen to be a small increase in prostate cancer after vasectomy in some studies. But again there is missing information. Would men who have not had a vasectomy have developed the same tumours but at a later date? Are the tumours that arise in vasectomized men qualitatively different, e.g. less aggressive as suggested in one study, than those in men without a vasectomy are? We do not have answers to these questions yet. So, the final answer is not in. The worst case scenario is a very weak link. You have to decide if that uncertainty is acceptable to you. Remember though, even if this reported weak link is accurate, vasectomy still has the lowest risk of causing illness or death compared with the birth control pill, tubal ligation, or having another baby. Women have accepted those risks for a long time!
knowledge is power - growing old is mandatory - growing wise is optional
trifold - 29 Mar 2004 21:00 GMT PALMER ENT@webtv.net (c palmer) wrote in message news:
This is a very nice summary, although I am inclined to view studies that account for detection bias as the most convincing--and these, I think, agree that there is no association. Do you have a source for the article below? It might be useful at a website I know about (which links to numerous medical articles as well as general info. about vasectomy procedures, complications, etc, and stories submitted by men who have been through vasectomy), and we would like to include citation inforamtion if possible.
trifold www.vasectomy-information.com
<11603-4067E4E5-232@storefull-3197.bay.webtv.net>...
> here's an article on the subject. hope this helps ~ curtis > [quoted text clipped - 90 lines] > > knowledge is power - growing old is mandatory - growing wise is optional trifold - 29 Mar 2004 21:13 GMT > here's an article on the subject. hope this helps ~ curtis I should have mentioned the website I referenced (url below) includes a link to a summary review of the vasectomy literature published in 2000 (Schwigle and Guess, "Safety and Effectiveness of Vasectomy," Journal of Fertility and Sterility, 2000). One point it makes re: detection bias is that up until relatively recently, the American Urological Association recommended that vasectomised men be screened for prostate cancer ealier and more regularly than non-vasectomised men. I believe this recommendation derived from the reports of higher serum T in vasecotmised men, as you noted. In any case, the practice of earlier screening would naturally have led to earlier detection, giving the impression of an association. Subsequent research that cast doubt on an association has since led the American Urological Assocation to revise its former recommendation. (BTW, I have seen at least one medical article suggesting that the observations of higher T levels in vasectomised men later into life may be unreliable: the author makes the point that men with higher T levels may choose vasectomy more often than others: so rather than vasectomy causing higher T levels, higher T levels might cause vasectomy!)
trifold www.vasectomy-information.com
trifold - 29 Mar 2004 21:16 GMT For what it is worth, the American Urological Assocation's take on the issue (c. 2002):
Vasectomy and Prostate Cancer (AUA 11/02) (http://www.auanet.org/aboutaua/policy_statements/services.cfm#vasectomy)
The American Urological Association Inc. (AUA) is aware of the recent controversy surrounding prostate cancer risk following vasectomy. However, the association feels that vasectomy is a safe method of surgical sterilization and men need not worry about an increased risk of developing prostate cancer after the procedure. Clinicians should be confident in advising their patients about the benefits and risks of surgical sterilization.
Two papers in the Journal of the American Medical Association (JAMA) in 1993 raised the possibility that vasectomy resulted in the increased incidence of prostate cancer. The AUA immediately formed a committee composed of Drs. John Grayhack, Patrick Walsh, Donald Coffey, Bert Peterson and Stuart Howards. This committee reviewed all the available data, and then formulated a position paper for the AUA, which stated that evidence was not convincing and that it was unlikely there was a relationship between vasectomy and prostate cancer. This opinion was based on the fact that the relationship was extremely weak although statistically significant in that there was no biologic rationale. The committee did recommend that clinicians advise patients who requested a vasectomy of the fact that some investigators felt there might be a relationship between vasectomy and prostate cancer. Soon after the AUA position paper, the National Institutes of Health (NIH) convened a conference involving Dr. Howards and many epidemiologists. The consensus statement of the NIH conference was that there was no convincing evidence of a relationship been vasectomy and prostate cancer and the NIH did not even recommend informing patients of the previous publications.
Since that time a large number of papers have been published which include more patients at risk for many more patient years than did the first two manuscripts. None of these papers have documented a relationship between vasectomy and prostate cancer. In 1998 Bernal-Delgado and Associates reviewed 14 existing papers on this subject including five cohort and nine case-control studies. Relative risk shown in these studies ranged between .44 and 6.75. The overall relative risk was not significant. They concluded that there was no casual relationship between vasectomy and prostate cancer. They also concluded that individuals who had undergone vasectomy are not at higher risk for developing prostate cancer. These authors did a population-based control study of 923 new cases of prostate cancer from the New Zealand Cancer Registry. They found there was no association between prostate cancer and vasectomy.
A June 2002 JAMA article provided reassuring data that indicated no correlation between prostate cancer risk and vasectomy. More than 1,000 men with prostate cancer and 1,800 men without the disease were contacted in a large retrospective study in New Zealand. Men were asked about various health data, including a history of having undergone a vasectomy; 9 percent of cancer patients and 10 percent of controls had undergone the procedure. The relative risk of prostate cancer was not increased in patients who had undergone vasectomy in the past.
In summary, papers published over the last nine years have conclusively documented that there is no increased risk of prostate cancer after vasectomy. Therefore, it is no longer imperative to inform patients of a possible risk and it is very safe to use vasectomy as a form of male sterilization.
1.Fertility and Sterility, 1998: Vol. 70, Page 191-200) 2.Cox et al, JAMA 287, page 3110-3115, 2002
Board of Directors, November 2002
Ray Walsh - 29 Mar 2004 11:06 GMT Rose
In 1972 at the age of 32 I had a vasectomy. Not long after, I read a study that said all men who had had a vasectomy was at greater risk of a heart attack. Seeing that the operation was past history and I have a philosophy of "Don't worry about things I can't control", I put the study out of my mind and forgot about it until I read your post today.
I had RRP in December 2000.
Between 1972 and 2000 (and now) I have had no heart problems, so at least for me, that blew the heart attack report out of the water. Apart from a cardiac arrest while having the op (hypersensitivity to the aneasthetic) I had no problems. I had the op on Tuesday, took 2 days off work and on Saturday played in an all-day lawn bowls competition. For me, the physical and emotional effects of the vasectomy were minimal. However, I know many who reacted in a similar way to your husband.
From 1972 until the RRP I had never had a problem with ED. Erections were strong, lasted at least as long as they needed to, and appeared as and when required. Therefore, I'm happy to declare that in this regard, the vasectomy had no effect -- again with the proviso that this relate only to me.
After the RRP with no nerve sparing total and complete ED. I was expecting it but it still came as a bit of a shock. I went to an impotence clinic for a consultation. When I told the doc my history, plus being a diabetic, plus having high blood pressure and being on medication for it, plus being 61 when I saw him, he just smiled and suggested that any solution was wishful thinking.
When I commented that I'd had absolutely no problem prior to the RRP he just smiled condescendingly and gave the impression he thought I was deluding myself. Anyway, he gave me an injection of the magic potion and told me to wait for 20 minutes. On his return he asked how things were. I replied that things were pretty good, and again he replied with a dismissive smile and said "don't tell me, show me." I did. His eyes opened wider and he just commented "I'm impressed!"
I've related this in detail because in my case, I think this gives some evidence that the vasectomy had no effect on ED. What it does for others I couldn't say.
Unfortunately the injections were too successful. They were not painful or unpleasant but I seemed to be hypersensitive to the ingredients. No matter how diluted thay made the prescription, I always ended with an erection that lasted for at least 4 hours and was very, very painful. So my wife and I just found alternative ways of maintaining that aspect of our relationship.
 Signature Ray Walsh Armadale WA 6992 Australia
> Twenty years ago my doctor urged me to urge my husband to get a > vasectomy in order for our family to avoid the risks associated with [quoted text clipped - 30 lines] > Since our discussion I've been wondering if anyone else has similar > concerns? MrBill - 29 Mar 2004 15:52 GMT Rose, I also had a Vasectomy 25 years ago and I ask my URO the same question. He said from the studies they have not been able to make the connection. I think like Alan said, sh.t happens. My Robitic RP was 12/15/2003 and I have been optimestic looking for the erection to return but am also being a realist to not expect it until atleast 8 months out if not further. I am looking forward to the celebration for when it does, and I am sure my wife is too. But until then, just wrap your arms around each other and consider it many months of renewing your courtship or foreplay. It can be nice focusing on each other instead of satisfying "Mr. Long John". And this is coming from a 48 year old that could still be considered in my prime.
Bill PSA 1.4 Gleason 6 (3+3) T2a age 48
> Twenty years ago my doctor urged me to urge my husband to get a > vasectomy in order for our family to avoid the risks associated with [quoted text clipped - 30 lines] > Since our discussion I've been wondering if anyone else has similar > concerns? Dave Perry - 29 Mar 2004 21:02 GMT I had a vasectomy over 30 years ago and of course started to hear all the gloom and doom related stuff right after. First, there was supposed to be a connection between vasectomy and heart disease. Turned out to be no connection. Then more recently I heard about a connection between vasectomy and prostate cancer. Read about a year ago, I cannot remember where, that the connection had been disproven. Like others have said, bad things can happen no matter what you do or do not do. I thought for many years that using a selenium based shampoo daily all my adult life would protect me from prostate cancer. No such luck. The shampoo was re-formulated a couple of years ago because of fear of overdose. Maybe I overdosed on selenium. Anyway, there is nothing anyone can do about stuff in the past. We all can make the best of the future though. Dave Perry
Leonard Evens - 29 Mar 2004 18:06 GMT > Twenty years ago my doctor urged me to urge my husband to get a > vasectomy in order for our family to avoid the risks associated with [quoted text clipped - 30 lines] > Since our discussion I've been wondering if anyone else has similar > concerns? Rose,
Four months is still early days for return of erections. I don't know if the Vasectomy increased the risk of prostate cancer, but it seems higly unlikely that it had any effect on post surgical impotence. Your husband is clearly having a hard time adusting to his situation. Your best strategy is to be as supportive as possible. trying not to take it personally.
Note also that even if the risk of prostate cancer is increased by vasectomy, it is not by a large amount. Biostatisticians don't get too excited by a 50 percent increase, particularly if there could be confounders, i.e. other factors explaining both the increased risk of pc and the decision to have a vasectomy in the first place.
jk - 29 Mar 2004 19:49 GMT If he insists on making you feel guilty and miserable, I say trade him in! LOL.... As for ED probs... it's only a few months for him. Give the nerves and system a chance to heal up and reconnect. I'm sexually active and at 18 months post RP, and still feel like it's improving.
 Signature JK Sinrod Sinrod Stained Glass Studios www.sinrodstudios.com Coney Island Memories www.sinrodstudios.com/coneymemories
Steve Kramer - 29 Mar 2004 22:52 GMT Rose,
I'm sorry you are having these thoughts. I suggest you discuss them with him. At the very least, he can tell you whether he honestly believes the Big V caused his PCa and, more importantly, if he believes you are responsible for his PCa. I suspect it is more in your mind than in his.
As to vasectomy-caused PCa, I'm sure in every bit of research you saw not one 'finding' that it causes PCa. There are so many things that might cause or could cause or maybe is associated with PCa and yet nothing has been shown to actually cause it or be associated with it except that 100% of the patients are male and if your father had it at an early age (mid-40s) you have a slightly increased chance of getting it.
As to vasectomy and ED, that's just so much nonsense. You need to study anatomy. All they do is cut the vas to stop the microscopic sperm from getting to the rest of the glands and organs. The prostate is literally the second last stop for sperm and by then it is surrounded by so much fluid it is hardly noticed by the prostate. That's why when we get a prostatectomy, our 'ejaculant' is bone-dry, or very nearly so.
 Signature Prostate Cancer Survivor (so far), not a doctor PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 PSA .1 .1 .1 .3 .4 .8 EBRT 05-07/2002 @ 47 PSA .3 .2 .2 .2 .3 Erection 05/12/2003 @ 48 HTbegins 07/21/2003 @ 48 PSA .1 Lupron 7/03, 8/03, 12/03
> Twenty years ago my doctor urged me to urge my husband to get a > vasectomy in order for our family to avoid the risks associated with [quoted text clipped - 30 lines] > Since our discussion I've been wondering if anyone else has similar > concerns? Rebecca Ford - 30 Mar 2004 01:56 GMT Sorry you have to be here. My husband's vasectomy saved his life. He had one Oct '02 at age 42 and ended up with an infection. The doc decided to do a psa which was elevated. Three more psas and one biopsy later my hubby had an RRP June '03 at 43. He has had no incontinence or ED. His 45 year old brother was diagnosed and had an RRP Aug '03 and is still having ED, although he need a nerve graft due to loss of one of the nerve bundles. He never had a vasectomy.
There is no blame in prostate cancer. It's the luck of the draw. Trust me. I never thought I'd be faced with these issues at only 35 with two small kids in tow. I hope life improves for both of you. Don't look back, just live for now.
 Signature Rebecca Ford
> Twenty years ago my doctor urged me to urge my husband to get a > vasectomy in order for our family to avoid the risks associated with [quoted text clipped - 30 lines] > Since our discussion I've been wondering if anyone else has similar > concerns? Rose - 30 Mar 2004 14:39 GMT > Sorry you have to be here. My husband's vasectomy saved his life. He had one > Oct '02 at age 42 and ended up with an infection. The doc decided to do a [quoted text clipped - 8 lines] > in tow. I hope life improves for both of you. Don't look back, just live for > now. Yes, I guess it is just the luck of the draw. Still it is natural to wonder Why? when your life has changed so dramatically. Years ago I asked the same thing. I had surgery when I was 20 years old; and it didn't go well, so I have had to take medication and be under a doctor's care for 30 something years. About 25 years ago I asked my doctor Why? He said, "Well, I guess it was because I need a new Cadillac." I suppose it was his way of telling me that there is no way to answer that question, but I never went back to him. At the time I really wanted to know Why? Thirty-three years later I don't wonder about it anymore; it is just my reality.
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