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Medical Forum / Diseases and Disorders / Cancer / August 2009Iron Loss Anticancer Mechanism
Aspirin-associated iron loss as an anticancer mechanism Medical Hypotheses Luca Mascitelli a, , Francesca Pezzetta b, and Jerome L. Sullivan c, , aMedical Service, Comando Brigata Alpina “Julia”, Udine, Italy bCardiology Service, Ospedale di Tolmezzo, Tolmezzo, Italy cUniversity of Central Florida, College of Medicine, Orlando, Florida, United States Received 23 July 2009; accepted 26 July 2009. Available online 18 August 2009. Summary A consensus view has emerged favoring an anticancer effect of long- term aspirin use. Aspirin-induced loss of stored iron from chronic gastrointestinal bleeding is proposed as a mechanism underlying this beneficial effect. In iron depletion, less iron may be available for carcinogenesis through free-radical mediated mechanisms and for promotion of tumor growth. Low-dose aspirin increases gastrointestinal losses of transfused radiolabeled autologous red cells. Observational studies report lower serum ferritin values with regular aspirin use. A protective effect of induced iron reduction against cancer mortality has been confirmed in a recent trial (FeAST) with subjects randomized to iron reduction or observation. Serum ferritin reductions in the FeAST trial were within conventionally normal reference ranges and were quantitatively similar to ferritin reductions in observational studies in regular aspirin users. Delayed anticancer effects of aspirin are compatible with the proposed mechanism, as continual microbleeding has a gradual cumulative effect on stored iron. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Ho hum, one more time. All cells depend absolutely on iron for several things. Among them is cell division. Cancer is run away cell division not caused by iron but requireing it like all cell division does. Reducing iron would reduce one of the substances required for cell division. Iron did not cause the cancer. Aspirin-associated iron loss as an anticancer mechanism Medical Hypotheses Luca Mascitelli a, , Francesca Pezzetta b, and Jerome L. Sullivan c, , aMedical Service, Comando Brigata Alpina “Julia”, Udine, Italy bCardiology Service, Ospedale di Tolmezzo, Tolmezzo, Italy cUniversity of Central Florida, College of Medicine, Orlando, Florida, United States Received 23 July 2009; accepted 26 July 2009. Available online 18 August 2009. Summary A consensus view has emerged favoring an anticancer effect of long- term aspirin use. Aspirin-induced loss of stored iron from chronic gastrointestinal bleeding is proposed as a mechanism underlying this beneficial effect. In iron depletion, less iron may be available for carcinogenesis through free-radical mediated mechanisms and for promotion of tumor growth. Low-dose aspirin increases gastrointestinal losses of transfused radiolabeled autologous red cells. Observational studies report lower serum ferritin values with regular aspirin use. A protective effect of induced iron reduction against cancer mortality has been confirmed in a recent trial (FeAST) with subjects randomized to iron reduction or observation. Serum ferritin reductions in the FeAST trial were within conventionally normal reference ranges and were quantitatively similar to ferritin reductions in observational studies in regular aspirin users. Delayed anticancer effects of aspirin are compatible with the proposed mechanism, as continual microbleeding has a gradual cumulative effect on stored iron. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk |
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