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Medical Forum / Diseases and Disorders / Cancer / October 2008

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Cancer vaccines show great promise.

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Old Bill - 18 Oct 2008 17:42 GMT
I recently received a letter from Cancer Research UK
saying :

  "It's true.We are on the brink of developing new
    cancer vaccines."

It goes on that their team have had encouraging results
with a vaccine to treat lymphoma and myeloma, and
are, they hope, to go on to develop vaccines against
cancers like prostate,bowel,breast,and lung.

  ...   ...   ...
  ...   ...   ...

"This could have a huge impact saving many thousands of
lives in the future.  ... "

"   ...   saving many thousands of lives ...  ."

This sounds wonderful news, and we are "on the brink"
of this great advance.

This new approach is one of great merit and already shows
promise.It deserves every support. So long as our desperation
does not carry us away with false expectations. CRUK do not
say  "  ...   It will save many thousands of lives  ...  ", they say
" ...   It could save many thousands of lives ...  ".There is a world
of difference between the two,and I hope their work will soon
enable them to change the "could" to will".
I really truly sincerely do.

Go for it CRUK!

There is no abstract available for their trials, but this link
to Cancer Research UK will tell you more:

         http://tinyurl.com/3kr4vw

Old Bill.
J - 23 Oct 2008 00:23 GMT
> I recently received a letter from Cancer Research UK
> saying :
[quoted text clipped - 14 lines]
> This sounds wonderful news, and we are "on the brink"
> of this great advance.

http://www.cancer.gov/newscenter/pressreleases [Excerpt]
In a previous study involving the same prostate cancer vaccine, IL-2 was
given to 19 patients daily for five days during each 28-day vaccine
treatment cycle, and a large majority of the patients had to have the dose
of IL-2 reduced or discontinued, primarily because of fatigue.

In this new study, the researchers sought to decrease the side effects
associated with IL-2. To do this, the team treated 18 patients with the
vaccine and radiation therapy, but with lower doses of IL-2 given over a
longer period of time. The patients received the same total amount of IL-2
as in the previous study, but it was administered in smaller daily doses
for 14 days of each 28-day treatment cycle.

With metronomic dosing, less than a quarter of the patients had side
effects that required their dose of IL-2 to be reduced.

The research team also found that metronomic dosing of IL-2 produced
effects on immune cell populations and immune responses that were similar
to those observed previously with the standard dosing method. Five of
eight evaluated patients had at least a three-fold increase in immune
cells that were directed against PSA. The researchers also noted that,
similar to the standard dosing method, metronomic dosing of IL-2 induced
immune responses against other prostate cancer antigens in some patients.
J - 24 Oct 2008 21:36 GMT
> I recently received a letter from Cancer Research UK
> saying :
[quoted text clipped - 6 lines]
> are, they hope, to go on to develop vaccines against
> cancers like prostate,bowel,breast,and lung.

Subject: Clinical Trials
Date: Fri, 24 Oct 2008 06:18:23 -0700 (PDT)
From: Locochat <munged>
Newsgroups: alt.support.cancer.prostate

Scientific American, November 2008 issue, page 22.
"Clinical trials testing various cancer vaccines have failed
miserably."
Some researchers say that the agents have been examined in the wrong
way, resulting in erroneous conclusions.
The article focuses on the excuses that are provided by researchers.
If the vaccines were effective, the trials would be continuing. Seems
like the researchers want to protect their grants and to hell with
whether the items they tout are effective or not.
Old Bill - 25 Oct 2008 19:10 GMT
| > I recently received a letter from Cancer Research UK
| > saying :
| >
| >    "It's true.We are on the brink of developing new
| >      cancer vaccines."

                  [snip]

| Subject: Clinical Trials
| Date: Fri, 24 Oct 2008 06:18:23 -0700 (PDT)
[quoted text clipped - 10 lines]
| like the researchers want to protect their grants and to hell with
| whether the items they tout are effective or not.

|   Locochat is correct in what he quotes from Scientific American
  but he is cherry-picking and does not give the full picture.
  If you want the full picture here is a link to the entire article:

        http://www.sciam.com/article.cfm?id=cancer-vaccine-looking-beyond

  If he can cherry-pick then so can I :

                 [quote]

     Schlom, who lived through a decade of negativity over monoclonal
antibodies, sees much of the nay-saying as par for the     course. When it
comes to new medicines, "there is always a period of skepticism," he
recounts. "I have absolutely no doubt that several years from now there will
be several vaccines approved for several cancer indications."

                    [end quote]

This is from the same article.

Old Bill
J - 26 Oct 2008 01:33 GMT
> | > I recently received a letter from Cancer Research UK
> | > saying :
[quoted text clipped - 38 lines]
>
> This is from the same article.

provenge median 4.5 months looks like a failure to me.
http://www.prostateprogram.org/metastatic.html
Half of men treated with hormonal therapy will develop disease that no longer
responds to hormone treatment within three years of instituting therapy."

The lung one
http://clinicaltrials.gov/ct2/show/NCT00480025
GSK1572932A Antigen-Specific Cancer Immunotherapeutic as Adjuvant Therapy in
Patients With Resectable MAGE-A3 Positive Non-Small Cell Lung Cancer
Disease-free survival at 2, 3, 4 and 5 year [ Time Frame: After first study
treatment.
The purpose of this clinical trial is to demonstrate the benefit of the
immunotherapeutic product GSK1572932A when given to patients with Non-Small Cell
Lung Cancer, after removal of their tumor. A course of 13 injections will be
administered over 27 months. The Protocol Posting has been updated in order to
comply with the FDA Amendment Act, Sep 2007.
Male or female patient with completely resected, pathologically proven stage IB,
II or IIIA NSCLC.
Administration of adjuvant platinum-based chemotherapy for the treatment of the
current NSCLC is allowed between surgery and randomization.
The surgical technique for resection of the patient's tumor is anatomical,
involving at least a lobectomy or a sleeve lobectomy;

They're cherry-picking. We'll see. I don't have the medians for those at hand
Nor the (results of) Phase I and II trial results..
J
J - 26 Oct 2008 01:58 GMT
> "J" <xewsnswex@nalid;"no> wrote in message
> ..
[quoted text clipped - 6 lines]
> | >
>                    [snip]

Here's the answer about vaccines.
We Fought Cancer…And Cancer Won.
http://www.newsweek.com/id/157548/page/1
After billions spent on research and decades of hit-or-miss treatments, it's
time to rethink the war on cancer.
Fighting Cancer: A Timeline

http://www.newsweek.com/id/157548/page/2
In the high-powered labs funded by the war on cancer, molecular biologists
thought they could change that. By discovering how genetic and other changes let
cancer cells multiply like frisky rabbits, they reasoned, they could find ways
to stop the revved-up replication at its source. That promised to be more
effective, and easier on healthy cells than chemotherapy drugs, which also kill
normal dividing cells, notably in the gut, bone marrow, mouth and hair
follicles. In the 1970s, cancer scientists discovered cancer viruses that alter
DNA in animals, and for a while the idea that viruses cause cancer in people,
too, was all the rage. (The human papilloma virus causes cervical cancer, but
other human cancers have nothing to do with viruses, it would turn out.) In the
1970s and 1980s they discovered human genes that, when mutated, trigger or
promote cancer, as well as tumor suppressor genes that, when healthy, do as
their name implies but when damaged release the brakes on pathways leading to
cancer.

It made for a lot of elegant science and important research papers. But it "all
seemed to have little or no impact on the methods used by clinicians to diagnose
and treat cancers," wrote Varmus. Basic-science studies of the mechanisms
leading to cancer and efforts to control cancer, he observed, "often seemed to
inhabit separate worlds." Indeed, it is possible (and common) for cancer
researchers to achieve extraordinary acclaim and success, measured by grants,
awards, professorships and papers in leading journals, without ever helping a
single patient gain a single extra day of life. There is no pressure within
science to make that happen. It is no coincidence that the ratio of useful
therapy per basic discovery is abysmal. For other diseases, about 20 percent of
new compounds arising from basic biological discoveries are eventually approved
as new drugs by the FDA. For cancer, only 8 percent are.
 
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