Medical Forum / Diseases and Disorders / Cancer / October 2008
Cancer vaccines show great promise.
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Old Bill - 18 Oct 2008 17:42 GMT I recently received a letter from Cancer Research UK saying :
"It's true.We are on the brink of developing new cancer vaccines."
It goes on that their team have had encouraging results with a vaccine to treat lymphoma and myeloma, and are, they hope, to go on to develop vaccines against cancers like prostate,bowel,breast,and lung.
... ... ... ... ... ...
"This could have a huge impact saving many thousands of lives in the future. ... "
" ... saving many thousands of lives ... ."
This sounds wonderful news, and we are "on the brink" of this great advance.
This new approach is one of great merit and already shows promise.It deserves every support. So long as our desperation does not carry us away with false expectations. CRUK do not say " ... It will save many thousands of lives ... ", they say " ... It could save many thousands of lives ... ".There is a world of difference between the two,and I hope their work will soon enable them to change the "could" to will". I really truly sincerely do.
Go for it CRUK!
There is no abstract available for their trials, but this link to Cancer Research UK will tell you more:
http://tinyurl.com/3kr4vw
Old Bill.
J - 23 Oct 2008 00:23 GMT > I recently received a letter from Cancer Research UK > saying : [quoted text clipped - 14 lines] > This sounds wonderful news, and we are "on the brink" > of this great advance. http://www.cancer.gov/newscenter/pressreleases [Excerpt] In a previous study involving the same prostate cancer vaccine, IL-2 was given to 19 patients daily for five days during each 28-day vaccine treatment cycle, and a large majority of the patients had to have the dose of IL-2 reduced or discontinued, primarily because of fatigue.
In this new study, the researchers sought to decrease the side effects associated with IL-2. To do this, the team treated 18 patients with the vaccine and radiation therapy, but with lower doses of IL-2 given over a longer period of time. The patients received the same total amount of IL-2 as in the previous study, but it was administered in smaller daily doses for 14 days of each 28-day treatment cycle.
With metronomic dosing, less than a quarter of the patients had side effects that required their dose of IL-2 to be reduced.
The research team also found that metronomic dosing of IL-2 produced effects on immune cell populations and immune responses that were similar to those observed previously with the standard dosing method. Five of eight evaluated patients had at least a three-fold increase in immune cells that were directed against PSA. The researchers also noted that, similar to the standard dosing method, metronomic dosing of IL-2 induced immune responses against other prostate cancer antigens in some patients.
J - 24 Oct 2008 21:36 GMT > I recently received a letter from Cancer Research UK > saying : [quoted text clipped - 6 lines] > are, they hope, to go on to develop vaccines against > cancers like prostate,bowel,breast,and lung. Subject: Clinical Trials Date: Fri, 24 Oct 2008 06:18:23 -0700 (PDT) From: Locochat <munged> Newsgroups: alt.support.cancer.prostate
Scientific American, November 2008 issue, page 22. "Clinical trials testing various cancer vaccines have failed miserably." Some researchers say that the agents have been examined in the wrong way, resulting in erroneous conclusions. The article focuses on the excuses that are provided by researchers. If the vaccines were effective, the trials would be continuing. Seems like the researchers want to protect their grants and to hell with whether the items they tout are effective or not.
Old Bill - 25 Oct 2008 19:10 GMT | > I recently received a letter from Cancer Research UK | > saying : | > | > "It's true.We are on the brink of developing new | > cancer vaccines." [snip]
| Subject: Clinical Trials | Date: Fri, 24 Oct 2008 06:18:23 -0700 (PDT) [quoted text clipped - 10 lines] | like the researchers want to protect their grants and to hell with | whether the items they tout are effective or not.
| Locochat is correct in what he quotes from Scientific American but he is cherry-picking and does not give the full picture. If you want the full picture here is a link to the entire article:
http://www.sciam.com/article.cfm?id=cancer-vaccine-looking-beyond
If he can cherry-pick then so can I :
[quote]
Schlom, who lived through a decade of negativity over monoclonal antibodies, sees much of the nay-saying as par for the course. When it comes to new medicines, "there is always a period of skepticism," he recounts. "I have absolutely no doubt that several years from now there will be several vaccines approved for several cancer indications."
[end quote]
This is from the same article.
Old Bill
J - 26 Oct 2008 01:33 GMT > | > I recently received a letter from Cancer Research UK > | > saying : [quoted text clipped - 38 lines] > > This is from the same article. provenge median 4.5 months looks like a failure to me. http://www.prostateprogram.org/metastatic.html Half of men treated with hormonal therapy will develop disease that no longer responds to hormone treatment within three years of instituting therapy."
The lung one http://clinicaltrials.gov/ct2/show/NCT00480025 GSK1572932A Antigen-Specific Cancer Immunotherapeutic as Adjuvant Therapy in Patients With Resectable MAGE-A3 Positive Non-Small Cell Lung Cancer Disease-free survival at 2, 3, 4 and 5 year [ Time Frame: After first study treatment. The purpose of this clinical trial is to demonstrate the benefit of the immunotherapeutic product GSK1572932A when given to patients with Non-Small Cell Lung Cancer, after removal of their tumor. A course of 13 injections will be administered over 27 months. The Protocol Posting has been updated in order to comply with the FDA Amendment Act, Sep 2007. Male or female patient with completely resected, pathologically proven stage IB, II or IIIA NSCLC. Administration of adjuvant platinum-based chemotherapy for the treatment of the current NSCLC is allowed between surgery and randomization. The surgical technique for resection of the patient's tumor is anatomical, involving at least a lobectomy or a sleeve lobectomy;
They're cherry-picking. We'll see. I don't have the medians for those at hand Nor the (results of) Phase I and II trial results.. J
J - 26 Oct 2008 01:58 GMT > "J" <xewsnswex@nalid;"no> wrote in message > .. [quoted text clipped - 6 lines] > | > > [snip] Here's the answer about vaccines. We Fought Cancer
And Cancer Won. http://www.newsweek.com/id/157548/page/1 After billions spent on research and decades of hit-or-miss treatments, it's time to rethink the war on cancer. Fighting Cancer: A Timeline
http://www.newsweek.com/id/157548/page/2 In the high-powered labs funded by the war on cancer, molecular biologists thought they could change that. By discovering how genetic and other changes let cancer cells multiply like frisky rabbits, they reasoned, they could find ways to stop the revved-up replication at its source. That promised to be more effective, and easier on healthy cells than chemotherapy drugs, which also kill normal dividing cells, notably in the gut, bone marrow, mouth and hair follicles. In the 1970s, cancer scientists discovered cancer viruses that alter DNA in animals, and for a while the idea that viruses cause cancer in people, too, was all the rage. (The human papilloma virus causes cervical cancer, but other human cancers have nothing to do with viruses, it would turn out.) In the 1970s and 1980s they discovered human genes that, when mutated, trigger or promote cancer, as well as tumor suppressor genes that, when healthy, do as their name implies but when damaged release the brakes on pathways leading to cancer.
It made for a lot of elegant science and important research papers. But it "all seemed to have little or no impact on the methods used by clinicians to diagnose and treat cancers," wrote Varmus. Basic-science studies of the mechanisms leading to cancer and efforts to control cancer, he observed, "often seemed to inhabit separate worlds." Indeed, it is possible (and common) for cancer researchers to achieve extraordinary acclaim and success, measured by grants, awards, professorships and papers in leading journals, without ever helping a single patient gain a single extra day of life. There is no pressure within science to make that happen. It is no coincidence that the ratio of useful therapy per basic discovery is abysmal. For other diseases, about 20 percent of new compounds arising from basic biological discoveries are eventually approved as new drugs by the FDA. For cancer, only 8 percent are.
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