On Apr 13, 7:53 pm, "ironjust...@aol.com" <ironjust...@aol.com>
wrote:lupeol <<

Sooo .. I wonder if the absorption of this is enhanced when one takes
oil with it .. ?

Clinical Cancer Research 14, 2119-2127, April 1, 2008. doi:
10.1158/1078-0432.CCR-07-4413
(c) 2008 American Association for Cancer Research

Cancer Therapy: Preclinical

Lupeol Inhibits Growth of Highly Aggressive Human Metastatic Melanoma
Cells In vitro and In vivo by Inducing Apoptosis
Mohammad Saleem, Nityanand Maddodi, Mohammad Abu Zaid, Naghma Khan,
Bilal bin Hafeez, Mohammad Asim, Yewseok Suh, Jung-Mi Yun,
Vijayasaradhi Setaluri and Hasan Mukhtar
Authors' Affiliation: Department of Dermatology, University of
Wisconsin, Madison, Wisconsin

Requests for reprints: Hasan Mukhtar, Department of Dermatology,
University of Wisconsin, 1300 University Avenue, MSC-25B, Madison, WI
53706. Phone: 608-263-3927; Fax: 608-263-5223; E-mail:
hmukhtar@wisc.edu.

Purpose: Poor prognosis of metastatic melanoma mandates the
development of novel strategies for its treatment and prevention. In
this study, the effect of lupeol, a diet-based triterpene, was
determined on the growth and tumorigenicity of human melanoma cells in
vitro and in vivo.

Experimental Design: Normal human melanocytes, and human metastatic
(451Lu) and nonmetastatic (WM35) cells were treated with lupeol; its
effect on growth, proliferation, and apoptosis were evaluated. Further
athymic nude mice bearing 451Lu cell-originated tumors were
administered with lupeol thrice a week, and its effect on tumor growth
and surrogate biomarkers was evaluated.

Results: Lupeol significantly decreased the viability of 451Lu and
WM35 melanoma cells but had only a marginal effect on normal human
melanocyte cells at similar doses. Lupeol treatment of 451Lu cells
caused (a) G1-S phase cell cycle arrest and apoptosis; (b) down-
regulation of Bcl2 and up-regulation of Bax; (c) activation of
caspase-3 and induction of poly(ADP)ribose polymerase cleavage; (d)
decreased expression of cyclin D1, cyclin D2, and cdk2; and (e)
increased expression of p21 protein. Next, lupeol significantly
reduced 451Lu tumor growth in athymic nude mice and modulated the
expression of proliferation markers, apoptotic markers, and cell cycle
regulatory molecules in tumor xenografts.

Conclusion: Our findings showed the anticancer efficacy of lupeol with
mechanistic rationale against metastatic human melanoma cells. We
suggest that lupeol, alone or as an adjuvant to current therapies,
could be useful for the management of human melanoma.

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On Apr 13, 7:53 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
fruit and vegetable based triterpene <<

Further Research On Resveratrol Shows Promise For Treatment Of
Pancreatic Cancer
Main Category: Cancer / Oncology
Also Included In: Nutrition / Diet
Article Date: 14 Apr 2008 - 2:00 PDT

Baywood International, Inc. (OTCBB:BAYW) ("Company") announced that
resveratrol, the antioxidant found in grape skins and red wine, can
cripple the function of pancreatic cancer cells while sensitizing them
to chemotherapy, says new research. This study, published in March
2008 in Advances in Experimental Medicine and Biology, looked at the
way the antioxidant may aid pancreatic cancer treatment and how it
also contributes to the growing knowledge on the health benefits
arising from ingredients of red wine.

While disabling the function of the cancer cells by reaching and
reacting with the mitochondria (the cell's energy source), researchers
found that when they were pre-treated with resveratrol before being
irradiated, it resulted in a type of cell death called apoptosis. This
is an important goal of cancer therapy.

According to Paul Okunieff, chief of radiation oncology at the
University of Rochester Medical Centre, "Antioxidant research is very
active and very seductive right now [and] the challenge lies in
finding the right concentration and how it works inside the cell.
Resveratrol seems to have a therapeutic gain by making tumor cells
more sensitive to radiation and making normal tissue less sensitive."

Okunieff began studying resveratrol as a tumor sensitizer, which is
when the link to the mitochondria was uncovered. Researchers divided
pancreatic cancer cells into two groups: cells treated without
resveratrol then iodized, and ones treated with resveratrol at a
relatively high dose of 50mg per ml before being iodized. The amount
of resveratrol in red wine can vary between types of grapes and
growing seasons, and ranges can be as high as 30 mg per ml. But the
researchers said higher doses are expected to be safe as long as a
physician monitors the patient. The study found that resveratrol
reduced the function of proteins in the pancreatic cancer cell
membranes responsible for pumping chemotherapy out of the cell,
therefore making them more sensitive to the treatment. Additionally,
the antioxidant triggered the production of reactive oxygen species
(ROS), causing apoptosis, and depolarized the mitochondrial membranes,
indicating a decrease in the cell's potential to function. The
researchers said the discovery is important because the mitochondria
contains its own DNA and can continuously supply the cell with energy
when functioning fully. Stopping the energy flow can therefore help
stop cancer.

Okunieff further stated that, "While additional studies are needed,
this research indicated that resveratrol has a promising future as
part of the treatment for cancer."

The Company's wholly-owned subsidiary, Nutritional Specialties, Inc./
dba LifeTime(R), launched Resveratrol Life Tonic(tm) in liquid form for
enhanced bioavailability. The product's powerful antioxidant
properties include 300 mg of resveratrol extract in each one ounce
serving, which is equivalent to 1,300 glasses of red wine.(a)

About Baywood

Baywood International, Inc. (OTC BB: BYWD) ("Baywood") is a
nutritional science company that develops, markets and sells
nutraceutical and nutritionally enhanced products and new age
beverages under its own brands. Baywood merges its expertise in
nutritional formulation with its leverage in sales and distribution to
deliver the most effective and progressive products to market.
Currently, Baywood's products are sold under three brands that are
distributed into retail markets nationwide and internationally as
follows:

- LifeTime(R) - Available in independent and chain health food stores,
natural grocery stores, and other direct-to-consumer channels both
internationally and domestically (http://www.lifetimevitamins.com)

- Baywood PURECHOICE(R), Baywood SOLUTIONS(R) and Complete La Femme(R) -
Available in independent and chain health food stores, natural grocery
stores, and other direct-to-consumer channels both internationally and
domestically (http://www.baywoodproducts.com)

- Mamajuana Energy(tm) - Available in select convenience stores and chain
stores nationwide (http://www.mamajuanaenergy.com)

For more information, call (888) 350-0799, or for more information,
visit Baywood's corporate website at http://www.bywd.com.

(a) These statements have not been evaluated by the Food & Drug
Administration. This product is not intended to diagnose, treat, cure
or prevent any disease. The contents of this press release are not
meant to be incorporated into the Company's website.

SOURCES: Advances in Experimental Medicine and Biology 2008;614:179-86
"Anti-cancer effect of resveratrol is associated with induction of
apoptosis via a mitochondrial pathway alignment" Authors: Paul
Okunieff, Weimin Sun, Wei Wang, Jung Kim, Shanmin Yang

This press release may contain forward-looking statements, made in
reliance upon Section 21D of the Exchange Act of 1934, which involve
known and unknown risks, uncertainties or other factors that could
cause actual results to differ materially from the results,
performance, or expectations implied by these forward-looking
statements. The Company's expectations, among other things, are
dependent upon general economic conditions, continued demand for its
products, the availability of raw materials, retention of its key
management and operating personnel, its ability to operate its
subsidiary companies effectively, need for and availability of
additional capital as well as other uncontrollable or unknown factors
which are more fully disclosed in the Company's Form 10-KSBs and 10-
QSBs on file with the United States Securities and Exchange
Commission.

Baywood International, Inc.

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk