On Mar 12, 11:49 am, "ironjust...@aol.com" <ironjust...@aol.com>
wrote:exerts its antitumoral effects
through modulation of the LOX pathway <<

Effect of catechol derivatives on cell growth and lipoxygenase
activity

Julie Simpson, Rebecca Forrester, Michael J. Tisdale, David C.
Billington† and Daniel L. Rathbone,
School of Life and Health Sciences, Aston University, Birmingham B4
7ET, UK
Received 28 February 2003;  revised 1 May 2003;  accepted 22 May
2003. ; Available online 24 June 2003.
Abstract
Derivatives of salicylic acid have been synthesized as potential
lipoxygenase inhibitors.
Agents containing a phenolic dihydroxy moiety showed potent (IC5010−6–
10−7 M) inhibition of the growth of murine colonic tumour cells in
vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in
intact cells.
The catechols were also potent inhibitors of rabbit reticulocyte 15-
lipoxygenase (IC50 1 μM).
Potent (IC50 10−6–10−7 M) inhibition of the growth of murine colonic
tumour cells in vitro was observed along with inhibition of 5-, 12-
and 15-lipoxygenase in intact cells and inhibition of rabbit
reticulocyte 15- lipoxygenase (IC50 1 μM).

Corresponding author. Tel.: +44-121-359-3611; fax: +44-121-359-0572

† Present address: L'Oréal Recherche, Recherche Avancée Sciences de la
Matière, 1, Avenue Eugène Schueller, BP 22, Aulnay sous Bois, Cedex,
France.

Bioorganic & Medicinal Chemistry Letters
Volume 13, Issue 15, 4 August 2003, Pages 2435-2439
Dedicated to Professor David Crout to mark the occastion of his
retirement.

doi:10.1016/S0960-894X(03)00528-6
Copyright © 2003 Elsevier Ltd. All rights reserved.

-------------------------------

Lipoxygenases (LOXs) are nonheme iron-containing enzymes.

http://circres.ahajournals.org/cgi/content/abstract/94/12/1527

--------------------------------------------
http://www.nature.com/cdd/journal/v8/n8/full/4400908a.html

Lipoxygenases and their involvement in programmed cell death

M Maccarrone, G Melino and A Finazzi-Agro

Department of Experimental Medicine and Biochemical Sciences,
University of Rome Tor Vergata, I-00133 Rome, Italy
Correspondence to: M MaccarroneA Finazzi-Agro, Department of
Experimental Medicine and Biochemical Sciences, University of Rome Tor
Vergata, Via di Tor Vergata 135, I-00133 Rome, Italy. Tel: +39 06
72596468; Fax: +39 06 72596468; E-mail: Finazzi@uniroma2.it or
Maccarrone@med.uniroma2.it

Edited by H Ichijo
Abstract

Lipoxygenases are a family of enzymes which dioxygenate unsaturated
fatty acids, thus initiating lipoperoxidation of membranes and the
synthesis of signaling molecules. Consequently, they induce structural
and metabolic changes in the cell in a number of pathophysiological
conditions. Recently, a pro-apoptotic effect of lipoxygenase, and of
the hydroperoxides produced thereof, has been reported in different
cells and tissues, leading to cell death. Anti-apoptotic effects of
lipoxygenases have also been reported; however, this has often been
based on the use of enzyme inhibitors. Here we review the
characteristics of the lipoxygenase family and its involvement in the
initiation of oxidative stress-induced apoptosis. Finally, we discuss
the role of lipoxygenase activation in apoptosis of animal and plant
cells, suggesting a common signal transduction pathway in cell death
conserved through evolution of both kingdoms. Cell Death and
Differentiation (2001) 8, 776-784

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk