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Medical Forum / Diseases and Disorders / Cancer / February 2008Iron Intake and Aggressive Prostate Cancer
Choi JY, Neuhouser ML, Barnett M, Hong CC, Kristal AR, Thornquist M, King IB, Goodman G, Ambrosone CB Iron intake, oxidative stress-related genes (MnSOD and MPO), and prostate cancer risk in CARET cohort. [JOURNAL ARTICLE] Carcinogenesis 2008 Feb 22. Iron overload may increase prostate cancer risk through stimulation of oxidative stress, and endogenous pro- and antioxidant capabilities i.e., manganese superoxide dismutase (MnSOD) and myeloperoxidase (MPO), may modify these associations. We investigated this hypothesis in the Carotene and Retinol Efficacy Trial cohort in a nested case control study. Although there was no association between iron intake and risk overall, there was a suggestion of increased risk of clinically aggressive prostate cancer with higher iron intake (OR=1.4, 95% CI=0.9-2.0). Associations were most notable for men with aggressive prostate cancer who were below the median consumption of total fruits and vegetables (OR=1.8, 95% CI=1.1-3.2). Associations between MPO -463 G to A genotype (rs2333227) and prostate cancer risk were only noted among men with aggressive cancer, with more than a two- fold risk reduction among men with AA genotypes (OR=0.4, 95% CI=0.2-1.0); MnSOD was not associated with risk overall, but the MnSOD T to C (Val-9Ala, rs4880) polymorphism modified associations between risk of clinically aggressive prostate cancer and dietary iron intake (p for interaction=0.02). Among aggressive cancer cases with the TT genotype, higher iron intake level was associated with more than 2- fold increase in risk (OR=2.3, 95% CI=1.0-4.9), whereas there was no association among men with CC genotypes (OR=0.9; 95% CI=0.4-2.3). Although interactions were not significant, there were similar patterns for MPO genotype, iron intake and risk. These findings suggest that higher iron intake may be associated with risk of clinically aggressive prostate cancer, and that endogenous antioxidant capabilities may modify these associations. Carcinogenesis [Carcinogenesis] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On 26 Feb, 16:22, "ironjust...@aol.com" <ironjust...@aol.com> wrote: > Choi JY, Neuhouser ML, Barnett M, Hong CC, Kristal AR, Thornquist M, > King IB, Goodman G, Ambrosone CB [quoted text clipped - 40 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk Yeh, old news really, but excessive iron intake is definatly something everyone should avoid, men especially! ----------------------------------- http://mesothelioma.mypressonline.com/index.html - Information and advice on Mesothelioma cancer On Feb 26, 11:38 am, new...@googlemail.com wrote:Yeh, old news really, but excessive iron intake is definatly something everyone should avoid, men especially! http://mesothelioma.mypressonline.com/index.html << Since mesothelioma is caused by iron .. I suppose what you just said was .. "I don't know mesothelioma is caused by iron" .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On 26 Feb, 16:22, "ironjust...@aol.com" <ironjust...@aol.com> wrote: > [quoted text clipped - 50 lines] > > - Show quoted text - On Feb 26, 7:10 pm, ironjustice <teamtan...@hotmail.com> wrote:mesothelioma is caused by iron" .. ? << http://tinyurl.com/zk9fk A role for iron-derived ROS was suggested by the finding that phytic acid, an iron chelator, blocked asbestos-induced reductions in A549 cell delta(psi)m and attenuated apoptosis. PMID: 12162428 [PubMed - indexed for MEDLINE] http://tinyurl.com/2n873 <<snip>> A role for iron-derived ROS was suggested by the finding that phytic acid, an iron chelator, blocked asbestos-induced reductions in A549 cell delta(psi)m and attenuated apoptosis. <<snip>> Mol Cell Biochem 2002 May-Jun;234-235(1-2):153-60 Asbestos-induced alveolar epithelial cell apoptosis: role of mitochondrial dysfunction caused by iron-derived free radicals. Kamp DW, Panduri V, Weitzman SA, Chandel N Veterans Administration Chicago Health Care System: Lakeside Division, Northwestern University Medical School, IL, USA. [Medline record in process] Asbestos causes asbestosis and malignancies by mechanisms that are not fully understood. Alveolar epithelial cell (AEC) injury by iron-derived reactive oxygen species (ROS) is one important mechanism implicated. We previously showed that iron-catalyzed ROS in part mediate asbestos-inducedAEC DNA damage and apoptosis. Mitochondria have a critical role in regulating apoptosis after exposure to agents causing DNA damage but their role in regulating asbestos-induced apoptosis is unknown. To determine whether asbestos causes AEC mitochondrial dysfunction, we exposed A549 cells to amosite asbestos and assessed mitochondrial membrane potential changes (delta(psi)m) using a fluorometric technique involving tetremethylrhodamine ethyl ester (TMRE) and mitotracker green. We show that amosite asbestos, but not an inert particulate, titanium dioxide, reduces delta(psi)m after a 4 h exposure period. Further, the delta(psi)m after 4 h was inversely proportional to the levels of apoptosis noted at 24 h as assessed by nuclear morphology as well as by DNA nucleosome formation. A role for iron-derived ROS was suggested by the finding that phytic acid, an iron chelator, blocked asbestos-induced reductions in A549 cell delta(psi)m and attenuated apoptosis. Finally, overexpression of Bcl- xl, an anti-apoptotic protein that localizes to the mitochondria, prevented asbestos-induced decreases in A549 cell delta(psi)m after 4 h and diminished apoptosis. We conclude that asbestos alters AEC mitochondrial function in part by generating iron-derived ROS, which in turn can result in apoptosis. This suggests that the mitochondrial death pathway is important in regulating pulmonary toxicity from asbestos. PMID: 12162428, UI: 22152072 Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING > On Feb 26, 11:38 am, new...@googlemail.com wrote:Yeh, old news really, > but excessive iron intake is definatly something [quoted text clipped - 69 lines] > > - Show quoted text - |
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