 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / Diseases and Disorders / Cancer / February 2008Oxidative Stress In Lung Cancer
Esme H, Cemek M, Sezer M, Saglam H, Demir A, Melek H, Unlu M High levels of oxidative stress in patients with advanced lung cancer. [Journal Article] Respirology 2008 Jan; 13(1):112-6. Background and objective: The aim of this study was to investigate oxidative stress status in different stages and histological types of lung cancer. Methods: Forty-nine lung cancer patients, who had not received any therapy, and 20 healthy subjects were chosen for the study. Lung cancer patients were divided into those with early stage or advanced stage disease. The tumour type was adenocarcinoma in 24 patients, squamous cell carcinoma in 21 and large cell carcinoma in four. We measured serum nitrite, nitrate, ascorbic acid, retinol, beta-carotene and ceruloplasmin levels, and whole-blood malondialdehyde, reduced glutathione levels and catalase activity in patients with non-small cell lung carcinoma and healthy subjects. Results: Statistically significant differences between the patient group and the control group were detected for all biochemical parameters. Mean malondialdehyde, nitrite, nitrate and ceruloplasmin levels and catalase activity were significantly higher in the group with advanced stage disease than in the control group. Mean beta-carotene, ascorbic acid and reduced glutathione levels were significantly lower in the group with advanced stage disease than in the control group. Mean malondialdehyde and nitrite levels were significantly higher in the patients with squamous cell carcinoma than in those with adenocarcinoma, and mean malondialdehyde level was also significantly higher in patients with squamous cell carcinoma than in those with large cell carcinoma. Conclusions: These results suggest that with advancing stage of lung cancer, the levels of oxidative stress increase, while levels of antioxidant molecules decrease. Patients with squamous cell carcinoma have higher oxidative stress as reflected by higher levels of malondialdehyde and nitrite. -------------------------------------------------------------------------------- More from this journal Respirology (Carlton, Vic.) [Respirology] Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On Feb 7, 3:58 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote: lung cancer << Calışkan-Can E, Fırat H, Ardıç S, Simşek B, Torun M, Yardim-Akaydin S Increased levels of 8-hydroxydeoxyguanosine and its relationship with lipid peroxidation and antioxidant vitamins in lung cancer. [JOURNAL ARTICLE] Clin Chem Lab Med 2008 Jan; 46(1):107-112. Abstract Background: Reactive oxygen species produced either endogenously or exogenously can attack lipids, proteins and DNA in human cells and cause potentially deleterious consequences. In recent years, their role in the pathogenesis of lung cancer and the preventive effect of antioxidants have been studied extensively. In this study, our aim was to investigate the levels of 8-hydroxy-2'-deoxyguanosine (8OHdG) and malondialdehyde as a marker for the effects of reactive oxygen species on DNA and lipids, the levels of antioxidant vitamins and the correlations between these oxidative stress markers and antioxidants in lung cancer. Methods: Serum malondialdehyde, beta-carotene, retinol, and vitamins C and E were measured by high-performance liquid chromatography methods in fasting blood samples and 8OHdG was measured by gas chromatography- mass spectrometry in 24-h urine samples of patients with lung cancer (n=39) and healthy controls (n=31). Results: The levels of 8OHdG and malondialdehyde were significantly higher (p<0.05 and p<0.005, respectively) and beta-carotene, retinol, and vitamins C and E (p<0.0001, p<0.0001, p<0.0001, and p<0.05, respectively) were significantly lower in patients than in controls. There was a significantly positive correlation between 8OHdG and malondialdehyde (r=0.463, p=0.01) and a negative correlation between the levels of 8OHdG and retinol (r=-0.419, p=0.021) in the patient group. Conclusions: Our results demonstrate that the oxidant/antioxidant balance was spoiled in favor of lipid peroxidation and DNA damage in lung cancer patients. Significant increases in the levels of malondialdehyde and 8OHdG and decreases in the levels of antioxidants suggest the possible involvement of oxidative stress in lung cancer. Clin Chem Lab Med 2008;46:107-12. -------------------------------------------------------------------------------- More from this journal Clin Chem Lab Med Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Esme H, Cemek M, Sezer M, Saglam H, Demir A, Melek H, Unlu M > High levels of oxidative stress in patients with advanced lung cancer. [quoted text clipped - 46 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk On Feb 7, 4:01 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote: Increased levels of 8-hydroxydeoxyguanosine and its relationship with lipid peroxidation and antioxidant vitamins << Empty the .. lactoferrin .. ? Tsubota A, Yoshikawa T, Nariai K, Mitsunaga M, Yumoto Y, Fukushima K, Hoshina S, Fujise K Bovine lactoferrin potently inhibits liver mitochondrial 8-OHdG levels and retrieves hepatic OGG1 activities in Long-Evans Cinnamon rats. [JOURNAL ARTICLE] J Hepatol 2007 Dec 27. BACKGROUND/AIMS: To assess the effect of lactoferrin on oxidative liver damage and its mechanism, we used Long-Evans Cinnamon (LEC) rats that spontaneously develop fulminant-like hepatitis and lethal hepatic failure. METHODS: Four-week-old female LEC rats were divided into the untreated and treated groups. The latter was fed bovine lactoferrin at 2% mixed with conventional diet. RESULTS: The cumulative survival rates were 75.0% vs. 100% at 14 weeks, 37.5% vs. 91.7% at 15 weeks, and 12.5% vs. 91.7% at 16 weeks, respectively, for untreated and treated rats (P=0.0008). The 8-OHdG levels in liver mitochondrial DNA and malondialdehyde in plasma and liver tissues were significantly lower in treated than untreated rats (P<0.001, =0.017 and 0.034, respectively). Mitochondrial DNA mutations were more common in untreated rats. OGG1 mRNA and protein expression levels were significantly lower in untreated than treated rats (P=0.003 and 0.007, respectively). Hypermethylation of the second CpG island located upstream of OGG1 gene was observed in untreated rats. CONCLUSIONS: Our findings indicated that lactoferrin inhibits oxidative liver damage in LEC rats. Lactoferrin could be potentially useful for the treatment of oxidative stress-induced liver diseases. -------------------------------------------------------------------------------- More from this journal J Hepatol Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Feb 7, 3:58 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote: > lung cancer << [quoted text clipped - 105 lines] > > - Show quoted text - |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2008 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.